当前位置： SCI文献检索 > BRAIN RESEARCH BULLETIN期刊下所有文献 > The effects of CRF and the urocortins on [3H]GABA release from the rat amygdala--an in vitro superfusion study.

The effects of CRF and the urocortins on [3H]GABA release from the rat amygdala--an in vitro superfusion study.

Abstract：

:Corticotropin-releasing factor (CRF) is the major neuromodulator of the hypothalamic-pituitary-adrenal axis, regulating the behavioural, endocrine, autonomic and immune responses to stress. Together with the recently discovered members of the CRF peptide family, urocortin 1, urocortin 2 and urocortin 3, it also has neurotransmitter actions. Previous publication has demonstrated that stress induces CRF release in the paraventricular nucleus of the hypothalamus and the release of both CRF and GABA in the amygdala. Accordingly, the aim of the present study was to determine the effects of the members of the CRF peptide family on GABA release from the amygdala by using an in vitro superfusion system. In order to study the participation of different CRF receptors (CRF1 and CRF2) in this process, rat amygdalar slices were pretreated with selective CRF1 and CRF2 antagonists. CRF and urocortin 1 significantly increased the release of [(3)H]GABA from the slices following electrical stimulation, whereas urocortin 2 and urocortin 3 were ineffective. The actions of CRF and urocortin 1 were blocked by the selective CRF1 receptor antagonist antalarmin, but were not inhibited by the selective CRF2 receptor antagonist astressin 2B, both administered in equimolar doses. Our results demonstrate that the release of GABA from the amygdala is mediated by CRF and urocortin 1 through the activation of CRF1 receptors.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Bagosi Z,Jászberényi M,Szabó G,Telegdy G

doi

10.1016/j.brainresbull.2007.07.003

subject

Has Abstract

pub_date

2008-01-31 00:00:00

pages

15-7

issue

1

eissn

0361-9230

issn

1873-2747

pii

S0361-9230(07)00213-4

journal_volume

75

pub_type

杂志文章

相关文献

BRAIN RESEARCH BULLETIN文献大全
  • Comparison of thalamic populations in mammals and birds: expression of ErbB4 mRNA.

    abstract：:The expression of ErbB4 mRNA was examined in dorsal thalamic regions of chicks and rats. In rats, ErbB4 expression was observed in the habenular nuclei, the paraventricular nucleus, intermediodorsal nucleus, the central medial thalamic nucleus, the posterior nucleus, the parafascicular nucleus, the subparafascicular n...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/s0361-9230(01)00678-5

    authors： Bruce LL,Kornblum HI,Seroogy KB

    更新日期：2002-02-01 00:00:00

  • A neuroproteomic and systems biology analysis of rat brain post intracerebral hemorrhagic stroke.

    abstract：:Intracerebral hemorrhage (ICH) is a devastating form of stroke leading to a high rate of death and disability worldwide. Although it has been hypothesized that much of the IHC insult occurs in the subacute period mediated via a series of complex pathophysiological cascades, the molecular mechanisms involved in ICH hav...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/j.brainresbull.2014.02.005

    authors： Ren C,Guingab-Cagmat J,Kobeissy F,Zoltewicz S,Mondello S,Gao M,Hafeez A,Li N,Geng X,Larner SF,Anagli J,Hayes RL,Ji X,Ding Y

    更新日期：2014-03-01 00:00:00

  • Effects of severe dopamine depletion on dopamine neuronal impulse flow and on tyrosine hydroxylase regulation.

    abstract：:Reserpine depletes dopamine (DA) levels and increases tyrosine hydroxylase (TH) activity in the rat corpus striatum. TH is activated not only by enhancement of DA neuronal impulse flow, but also by cessation of impulse flow. To assist in the understanding of the relative contribution of impulse flow to the regulation ...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/s0361-9230(81)80037-8

    authors： German DC,McMillen BA,Sanghera MK,Saffer SI,Shore PA

    更新日期：1981-02-01 00:00:00

  • Infant rats: hypothalamic unit activity.

    abstract：:Single-unit recordings were made from lateral hypothalamic area (LHA) neurons of infant (8 through 21 days of age) male and female albino rats. Basal (or spontaneous) firing rates of LHA neurons were recorded for 20 min from rats 8 through 21 days of age, and mean basal firing rates did not differ across ages. Basal f...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/0361-9230(76)90081-2

    authors： Almli CR,McMullen NT,Golden GT

    更新日期：1976-11-01 00:00:00

  • The effect of environmental odors emanating from commercial swine operations on the mood of nearby residents.

    abstract：:The effect of environmental odors emanating from large-scale hog operations on the mood of nearby residents was determined using the POMS (Profile of Mood States). The scores for six POMS factors and the TMD (total mood disturbance score) for 44 experimental subjects were compared to those of 44 control subjects who w...

    journal_title：Brain research bulletin

    pub_type： 临床试验,杂志文章

    doi：10.1016/0361-9230(95)00015-1

    authors： Schiffman SS,Miller EA,Suggs MS,Graham BG

    更新日期：1995-01-01 00:00:00

  • Reevaluation of the plasticity in the rat supraoptic nucleus after chronic dehydration using immunogold for oxytocin and vasopressin at the ultrastructural level.

    abstract：:It has been shown that during physiological stimuli, such as dehydration, supraoptic nucleus (SON) neurons undergo profound morphological changes. However, little is known about how much each type of cell, oxytocin (OT) or vasopressin (VP), contributes to this plasticity during dehydration. Using postembedding immunog...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/0361-9230(92)90256-w

    authors： Marzban F,Tweedle CD,Hatton GI

    更新日期：1992-05-01 00:00:00

  • Inhibition of brain NOS activity impair spatial learning acquisition in fish.

    abstract：:Nitric oxide plays a role in the long term potentiation mechanisms produced in the mammalian hippocampus during spatial learning. A great deal of data has demonstrated that the dorsolateral telencephalon of fish could be homologous to the mammalian hippocampus sharing functional similarities. In the present study, we ...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/j.brainresbull.2020.08.007

    authors： Gómez Y,Vargas JP,López JC,Portavella M

    更新日期：2020-11-01 00:00:00

  • 3D modelling, gene expression mapping and post-mapping image analysis in the developing human brain.

    abstract：:As human brain development proceeds, there are complex changes in size and shape, most notably in the developing forebrain. Molecular technologies enable us to characterise the gene expression patterns that underlie these changes. To interpret these patterns the location of expression must be identified and, often, ge...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/j.brainresbull.2005.05.022

    authors： Sarma S,Kerwin J,Puelles L,Scott M,Strachan T,Feng G,Sharpe J,Davidson D,Baldock R,Lindsay S

    更新日期：2005-09-15 00:00:00

  • Identical responses of the two hippocampal theta generators to physiological and pharmacological activation.

    abstract：:The possible existence of two separate RSA generators in the dorsal hippocampus raises questions as to the degree of coupling or independence of both. In order to answer these questions bipolar EEG recording were made in the CA1 and dentate gyrus of freely moving rats during conditions of RSA generation by different m...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/s0361-9230(81)80063-9

    authors： Krug M,Brödemann R,Ott T

    更新日期：1981-01-01 00:00:00

  • Lipopolysaccharide induced increase in seizure activity in two animal models of absence epilepsy WAG/Rij and GAERS rats and Long Evans rats.

    abstract：:We showed previously that the number and time of spike-wave discharges (SWDs) were increased after intraperitoneal (i.p.) injection of lipopolysaccharide (LPS), an effect, which was completely abolished by cyclooxygenase-2 (COX-2) inhibitor indomethacin (IND) pretreatment in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/j.brainresbull.2014.03.003

    authors： Kovács Z,Dobolyi A,Juhász G,Kékesi KA

    更新日期：2014-05-01 00:00:00

  • Factors controlling adrenal weight and corticosterone secretion in male rats as revealed by median eminence lesions and pharmacological alteration of prolactin secretion.

    abstract：:To determine whether or not prolactin, as well as ACTH, was involved in the control of adrenal weight and steroid release, lesions in the median eminence which had previously resulted in impaired steroid release and atrophy of the adrenal were placed in animals in which the plasma prolactin was allowed to rise as a re...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/0361-9230(87)90066-9

    authors： Marubayashi U,McCann SM,Antunes-Rodrigues J

    更新日期：1987-11-01 00:00:00

  • Sex differences in interhemispheric correlation and spectral power of EEG activity.

    abstract：:EEG activity was recorded from left and right parietal cortex in adult male and female rats on a daily basis during 3 days. Absolute and relative power and interhemispheric correlation of the EEG activity were calculated and compared between males and females. Interhemispheric correlation of the theta rhythm was highe...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/0361-9230(95)00081-o

    authors： Juárez J,Corsi-Cabrera M

    更新日期：1995-01-01 00:00:00

  • Systemic Interleukin-1beta stimulates the simultaneous release of norepinephrine in the paraventricular nucleus and the median eminence.

    abstract：:Interleukin-1beta (IL-1beta), a cytokine with pronounced central effects such as fever, anorexia, analgesia, etc., is also known to activate the hypothalamo-pituitary-adrenal (HPA) axis. Corticotropin releasing hormone (CRH) neurons located in the hypothalamus are important for HPA activation. The cell bodies of CRH n...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/j.brainresbull.2005.02.021

    authors： MohanKumar SM,MohanKumar PS

    更新日期：2005-05-15 00:00:00

  • Bidirectional control of palatable food consumption through a common benzodiazepine receptor: theory and evidence.

    abstract：:A classical approach to the control of food consumption has been to assume separate mechanisms for the arousal to eat, on the one hand, and the satiation of feeding responses, on the other. The present paper is concerned with a single, and a comparatively simple, neuronal mechanism which is endowed with properties to ...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/0361-9230(85)90008-5

    authors： Cooper SJ

    更新日期：1985-10-01 00:00:00

  • Biochemical markers for post-operative fatigue after major surgery.

    abstract：OBJECTIVE:To establish a link between tryptophan (a precursor for 5-hydroxytryptamine (5-HT) or serotonin, involved in sleep and fatigue) and post-operative fatigue after major surgery. BACKGROUND:There is a link between tryptophan (the precursor for the neurotransmitter 5-hydroxytryptamine), and its competitive bindi...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/s0361-9230(03)00021-2

    authors： McGuire J,Ross GL,Price H,Mortensen N,Evans J,Castell LM

    更新日期：2003-04-15 00:00:00

  • Nerve fibre regeneration across the PNS-CNS interface at the root-spinal cord junction.

    abstract：:Root-spinal cord regeneration was investigated in immature and adult rats. The elongation in the dorsal root of regrowing dorsal root axons, rerouted ventral root nerve fibres (cholinergic neurons) or hypogastric nerve fibres (catecholaminergic neurons) is impeded as they meet the astrocyte dominated CNS tissue of the...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/0361-9230(89)90133-0

    authors： Carlstedt T,Cullheim S,Risling M,Ulfhake B

    更新日期：1989-01-01 00:00:00

  • Supersensitivity of spinal dopaminergic receptors in rat after chronic haloperidol.

    abstract：:In order to examine the effect of chronic neuroleptics on spinal dopaminergic system, rats were treated with haloperidol (0.5 mg/kg IP) for 21 days and the monosynaptic mass reflex (MMR) as well as dopamine (DA) metabolism were investigated. MMR, recorded from ventral root L6 following supramaximal stimulation to ipsi...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/0361-9230(92)90240-x

    authors： Maitra KK,Seth P,Mohanakumar KP,Ganguly DK

    更新日期：1992-01-01 00:00:00

  • In vivo down-regulation of rat striatal opioid receptors by chronic enkephalin.

    abstract：:Administration of methionine enkephalin (ICV) to rats for 5 days resulted in the development of physical dependence as exemplified by a hypothermic response which peaked 2-8 hours after initiation of withdrawal. Twenty-four hours post-withdrawal, opioid receptor binding was determined in the striatum using a selective...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/0361-9230(86)90123-1

    authors： Steece KA,DeLeon-Jones FA,Meyerson LR,Lee JM,Fields JZ,Ritzmann RF

    更新日期：1986-08-01 00:00:00

  • Chemical stimulation of the ST36 acupoint reduces both formalin-induced nociceptive behaviors and spinal astrocyte activation via spinal alpha-2 adrenoceptors.

    abstract：:Spinal astrocytes have emerged as important mechanistic contributors to pathological and chronic pain. Recently, we have demonstrated that injection of diluted bee venom (DBV) into the Zusanli (ST36) acupoint produces a potent anti-nociceptive effect via the activation of spinal alpha-2 adrenoceptors. However, it is u...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/j.brainresbull.2011.08.012

    authors： Kang SY,Kim CY,Roh DH,Yoon SY,Park JH,Lee HJ,Beitz AJ,Lee JH

    更新日期：2011-11-25 00:00:00

  • Triplet repeats, over-expanded in neuromuscular diseases, are under-represented in mammalian DNA: a survey of models.

    abstract：:Simple tandem repeats represent more than 1% of the human genome: occasionally they exhibit intergenerational expansibility and are associated with neuromuscular diseases. In transgenic mice the same sequences elicit similar symptoms, but do not expand. We have searched for di-, tri-, and tetra-repeats in the publishe...

    journal_title：Brain research bulletin

    pub_type： 杂志文章,评审

    doi：10.1016/s0361-9230(01)00581-0

    authors： Astolfi P,Bellizzi D,Losso MA,Sgaramella V

    更新日期：2001-10-01 00:00:00

  • Computational modeling of the baroreflex arc: nucleus tractus solitarius.

    abstract：:In this study, we examine the utility of computational modeling in understanding nervous system function. We start by examining the reasons for, and major approaches to, computational modeling. We then chose a modeling approach and applied different variations to understanding nucleus tractus solitarius (NTS) neuronal...

    journal_title：Brain research bulletin

    pub_type： 杂志文章,评审

    doi：10.1016/s0361-9230(99)00242-7

    authors： Rogers RF,Rybak IA,Schwaber JS

    更新日期：2000-01-15 00:00:00

  • Dose-dependent brainstem neuropathology following repeated arteether administration in rats.

    abstract：:Histopathological effects of the artemisinin antimalarial, beta-arteether, were evaluated in rats. Arteether (3.125-12.5 mg/kg/day, IM, in sesame oil) was administered for 7 consecutive days. Seven days following the last injection, histological evaluation of the brainstem was performed. Rats treated with 12.5 mg/kg s...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/s0361-9230(97)00339-0

    authors： Genovese RF,Newman DB,Li Q,Peggins JO,Brewer TG

    更新日期：1998-01-01 00:00:00

  • Clinical relevance of polymerase chain reaction (PCR) assays and antigen-driven immunoblots for the diagnosis of neurological infectious diseases.

    abstract：:Polymerase chain reaction assays are a powerful tool for detecting the presence of infectious genomes in the cerebrospinal fluid. Positive results always mean a current or pending infection of the central nervous system. Subacute (>7 days) or chronic infections induce an intrathecal humoral immune response and the app...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/s0361-9230(03)00093-5

    authors： Sindic CJ,Van Antwerpen MP,Goffette S

    更新日期：2003-08-15 00:00:00

  • Protective effects of trans-2, 4-dimethoxystibene on cognitive, impairments induced by Abeta(25-35) in, hypercholesterolemic rats.

    abstract：:Trans-2, 4-dimethoxystibene (S3) is a synthetic stilbenes. In the present study, S3 was investigated to assess its neuroprotective effect against the toxicity induced by Abeta(25-35) in hypercholesterolemic rats. Rats were fed with hypercholesterolemic chow for six weeks, and then received a single intracerebroventric...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/j.brainresbull.2010.04.016

    authors： Ruan CJ,Li Z,Zhang L,Chen DH,Du GH,Sun L

    更新日期：2010-07-30 00:00:00

  • Sex difference in sensitization to the locomotor effects of mazindol in rats.

    abstract：:Male and female rats were treated daily for 7 days with mazindol (5, 10, and 20 mg/kg), an anorectic drug, and tested in the open field. Mazindol developed sensitization to its locomotor stimulatory effect in both sexes on day 7 with a nondose-dependent pattern of response. However, the locomotor activity appeared to ...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/0361-9230(94)90034-5

    authors： Zanin M,Takahashi RN

    更新日期：1994-01-01 00:00:00

  • Changes in retention of a visual discrimination task following unilateral and bilateral transections of temporo-entorhinal connections in rats.

    abstract：:In a previous study, it was shown that the lateral entorhinal cortex (LEC) in the left hemisphere contains higher concentration of glutamate than in the right hemisphere. The purpose of the present study was to examine potential relationship between this neurochemical asymmetry and behavior. Rats with either left, rig...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/0361-9230(90)90074-a

    authors： Myhrer T,Iversen EG

    更新日期：1990-08-01 00:00:00

  • Increased vasopressinergic activity following DOCA administration in the rat.

    abstract：:The dynamics of hypothalamic arginine vasopressin (AVP) release was examined during the development of hypertension in rats with deoxycorticosterone (DOCA)-NaCL induced hypertension. Experiments were performed in four groups of uninephrectomized Sprague-Dawley rats 3, 7, 14 and 21 days after treatment with: (I) DOCA a...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/0361-9230(86)90016-x

    authors： Chen YF,Lindheimer MD,Oparil S

    更新日期：1986-01-01 00:00:00

  • Efficiency of liposomal ATP in cerebral ischemia: bioavailability features.

    abstract：:This study was performed to elucidate the mechanism by which adenosine triphosphate (ATP) encapsulated into liposomes was able to protect against experimental brain ischemia in the rat. After intracarotidal administration of liposomally entrapped ATP, the ATP blood level increased dramatically whereas no change was ob...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/0361-9230(91)90004-4

    authors： Chapat S,Frey V,Claperon N,Bouchaud C,Puisieux F,Couvreur P,Rossignol P,Delattre J

    更新日期：1991-03-01 00:00:00

  • Cultured human and canine endothelial cells from brain microvessels.

    abstract：:Cultures of endothelial cells (EC) derived from human (autopsy) and canine brain microvessels were characterized with respect to growth, morphology, and biochemical features. The endothelial nature of these cells was confirmed by analyses of angiotensin-converting enzyme activity, Factor VIII-related antigen, and ultr...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/0361-9230(88)90047-0

    authors： Gerhart DZ,Broderius MA,Drewes LR

    更新日期：1988-11-01 00:00:00

  • Involvement of the serotonergic system in the hypoactive and antinociceptive effects of nicotine in mice.

    abstract：:Pretreatment with the 5-HT2 antagonist ketanserin and the 5-HT1A/2 antagonist spiperone did not reduce nicotine-induced hypomotility in mice, nor did MDL 7222, a selective 5-HT3 antagonist. In addition, 8-OH-DPAT and buspirone, 5-HT1A agonists, had no significant effects on nicotine-induced hypomotility. However, 8-OH...

    journal_title：Brain research bulletin

    pub_type： 杂志文章

    doi：10.1016/0361-9230(94)90252-6

    authors： Damaj MI,Glennon RA,Martin BR

    更新日期：1994-01-01 00:00:00