Abstract：
:Recent studies demonstrate that activation of Ca(2+)-permeable N-methyl-D-aspartate (NMDA) receptors upregulates phosphorylation of mitogen-activated protein kinases (MAPKs) in heterologous cells and neurons. In cultured rat striatal neurons, the present work systematically evaluated the role of a number of protein kinases in forming a signaling cascade transducing NMDA receptor signals to MAPKs. It was found that a brief NMDA application consistently induced rapid and transient phosphorylation of the extracellular signal-regulated kinase 1/2 (ERK1/2), a best characterized subclass of MAPKs. This ERK1/2 phosphorylation was resistant to the inhibition of protein kinase C, p38 MAPK, cyclin-dependent kinase 5, receptor tyrosine kinase (epidermal growth factor receptors), or non-receptor tyrosine kinases (including Src) by their selective inhibitors. However, the increase in ERK1/2 phosphorylation was partially blocked by a protein kinase A (PKA) inhibitor. The inhibitors for Ca(2+)/calmodulin-dependent protein kinase (CaMK) or phosphatidylinositol 3-kinase (PI3-kinase) completely blocked the NMDA-stimulated ERK1/2 phosphorylation. In an attempt to characterize the sequential role of CaMK and PI3-kinase, we found that NMDA increased PI3-kinase phosphorylation on Tyr(508), which kinetically corresponded to the ERK1/2 phosphorylation and was blocked by the CaMK inhibitor. These results indicate that the protein kinases are differentially involved in linking NMDA receptors to ERK1/2 in striatal neurons.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Mao LM,Tang QS,Wang JQdoi
10.1016/j.brainresbull.2008.11.004subject
Has Abstractpub_date
2009-03-30 00:00:00pages
328-34issue
6eissn
0361-9230issn
1873-2747pii
S0361-9230(08)00379-1journal_volume
78pub_type
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journal_title：Brain research bulletin
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journal_title：Brain research bulletin
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Brain research bulletin
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/0361-9230(78)90058-8
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pub_type： 杂志文章
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更新日期：1993-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2015.08.001
更新日期：2015-08-01 00:00:00
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journal_title：Brain research bulletin
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更新日期：2020-08-01 00:00:00
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doi：10.1016/j.brainresbull.2005.06.018
更新日期：2005-09-30 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2004-07-30 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1996-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(03)00035-2
更新日期：2003-05-15 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1992-08-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2018.09.017
更新日期：2018-10-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
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更新日期：2012-04-10 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(91)90261-h
更新日期：1991-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2001-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：1987-06-01 00:00:00
