Naltrexone induces down- and upregulation of delta opioid receptors in rat brain regions.

Abstract:

:Opioid antagonists such as naltrexone, naloxone, and ICI174864 induce a transient downregulation of delta opioid receptors prior to upregulation in NG108-15 cells. Here we show that naltrexone can also elicit a transient downregulation of delta 2 opioid receptors preceding upregulation in brain. A 1 h treatment of rats with naltrexone (IP, 10 mg/kg) resulted in lowered 3H-[D-Ser2,L-Leu5]enkephalyl-Thr Bmax values in hindbrain, but not in striatum, hippocampus, or cortex. The decrease in hindbrain delta 2 receptor density was not accompanied by changes in Kd values, indicating that downregulation rather than receptor blockade occurred. Longer naltrexone treatment (48 h), caused twofold upregulation of delta opioid binding in all four regions. These data suggest that the process of upregulation of delta opioid receptors by antagonists in vivo can entail an initial, transient downregulation.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Belcheva MM,Barg J,Mchale R,Coscia CJ

doi

10.1016/0361-9230(94)90218-6

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

69-72

issue

1

eissn

0361-9230

issn

1873-2747

pii

0361-9230(94)90218-6

journal_volume

35

pub_type

杂志文章
  • Early postnatal development of basolateral amygdala in kitten: a Golgi morphometric analysis.

    abstract::The development of the lateral, basomedial and basolateral nuclei of the amygdala in 1-28 day old kittens was studied using Golgi morphometric methods. The major finding of this study is the growth of neurons within each of the nuclei of the amygdala examined occurs during the same time period, between 5-14 and 16-18 ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(85)90075-9

    authors: Wakefield CL,Levine MS

    更新日期:1985-02-01 00:00:00

  • The periventricular anteroventral third ventricle (AV3V): its relationship with the subfornical organ and neural systems involved in maintaining body fluid homeostasis.

    abstract::The periventricular tissue surrounding the anteroventral third ventricle (AV3V) is critically involved in the maintenance of normal body fluid balance and distribution. The present review examines the anatomical, neurochemical, and functional relationship of the AV3V with neural systems subserving body fluid homeostas...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/0361-9230(85)90209-6

    authors: Johnson AK

    更新日期:1985-12-01 00:00:00

  • Somatic labeling of the medial terminal nucleus of the accessory optic system with WGA-HRP injected into the rat occipital cortex.

    abstract::Neuronal cell bodies in the medial terminal nucleus of the accessory optic system (MTN) were labeled with WGA-HRP which was injected ipsilaterally into the occipital cortex in the rat. We suggest that the label was first transported anterogradely to the pretectal nucleus of the optic tract, then moved transneuronally ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(87)90043-8

    authors: Takada M,Li ZK,Hattori T

    更新日期:1987-01-01 00:00:00

  • Dural neuropeptide changes after subarachnoid hemorrhage in rats.

    abstract::The effect of subarachnoid hemorrhage (SAH) on the neuropeptides and mast cells of the rat dura mater has not been reported. We examined the outcome of SAH on the rat supratentorial dura mater to determine whether dural nerves undergo effects similar to those of nerves accompanying cerebral blood vessels after SAH. Fo...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(93)90146-3

    authors: Keller JT,Mullen BG,Zuccarello M

    更新日期:1993-01-01 00:00:00

  • Effects of colchicine on hexokinase activity in the paraventricular and supraoptic nuclei of spontaneously hypertensive and normotensive rats.

    abstract::The effects of intracerebroventricular (ICV) colchicine (70 micrograms per rat) on systolic pressures and levels of hexokinase activity in the hypothalamic paraventricular (PVH) and supraoptic (SON) nuclei were investigated in adult normotensive and spontaneously hypertensive rats (SHR). One day after colchicine injec...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(89)90162-7

    authors: Krukoff TL,Vincent DH

    更新日期:1989-07-01 00:00:00

  • A retinal projection to the paraventricular nuclei of the hypothalamus in the Syrian hamster (Mesocricetus auratus).

    abstract::The retino-hypothalamic tract of the Syrian hamster (Mesocricetus auratus) was examined using intraocular injections of horseradish peroxidase conjugated to cholera toxin. In addition to the retinal input to the suprachiasmatic nuclei (SCN), a retinal projection to the caudal paraventricular nuclei was identified. Thi...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(87)90063-3

    authors: Youngstrom TG,Weiss ML,Nunez AA

    更新日期:1987-12-01 00:00:00

  • Neuroprotective effects of penehyclidine hydrochloride against cerebral ischemia/reperfusion injury in mice.

    abstract::Various reports have suggested that penehyclidine hydrochloride (PHC), a new cholinergic antagonist, exhibits a variety of biological actions such as anti-tumor and cardioprotective effects. This study aimed to investigate the effects of PHC on cerebral ischemia/reperfusion (I/R) injury and evaluate whether the c-Jun ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2016.01.008

    authors: Shu Y,Yang Y,Zhang P

    更新日期:2016-03-01 00:00:00

  • Effects of dietary preference and galanin administration in the paraventricular or amygdaloid nucleus on diet self-selection.

    abstract::Microinjection of galanin into the paraventricular nucleus (PVN) of the hypothalamus has been reported to predominantly increase dietary fat consumption during the light or late dark periods. However, there have been no studies of the macronutrient-specific effects of galanin administered into the amygdala (AMY). We u...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(95)02086-1

    authors: Smith BK,York DA,Bray GA

    更新日期:1996-01-01 00:00:00

  • Immunohistochemical and chromatographic identification of peptides derived from proneuropeptide Y in the human frontal cortex.

    abstract::Proneuropeptide Y (proNPY) is posttranslationally processed to NPY(1-36)amide and the C-terminal flanking peptide of NPY (CPON). Antisera directed against the N-terminal part of NPY, CPON, or CysNPY(32-36)amide were used to identify peptide fragments processed from proNPY in biopsies of human frontal cortical specimen...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(93)90235-4

    authors: Mikkelsen JD,Larsen PJ,Kruse-Larsen C,O'Hare MM,Schwartz TW

    更新日期:1993-01-01 00:00:00

  • Caudal neurosecretory system synaptic morphology following deafferentation: an electron microscopic degeneration study.

    abstract::The caudal neurosecretory system of Poecilia sphenops (molly) is an isolated population of neurosecretory cells located in the caudal most aspect of the teleost spinal cord. The structure of this neuroendocrine system is favorable for studies on the synaptic control of neurosecretory mechanisms. Little is known about ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(83)90079-5

    authors: O'Brien JP,Kriebel RM

    更新日期:1983-01-01 00:00:00

  • Depressed excitability and integrated EEGs following hippocampal afterdischarges.

    abstract::Rats with chronic hippocampal electrode implants had afterdischarges induced with electrical stimulus intensities of 115, 200, and 800% of a previously determined threshold. Afterdischarge duration, postictal EEG depression duration, and the duration of postictal electrical hypoexcitability were assessed. After discha...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(80)90254-3

    authors: Swartzwelder HS,Wegener ST,Johnson CT,Dyer RS

    更新日期:1980-09-01 00:00:00

  • Reevaluation of the plasticity in the rat supraoptic nucleus after chronic dehydration using immunogold for oxytocin and vasopressin at the ultrastructural level.

    abstract::It has been shown that during physiological stimuli, such as dehydration, supraoptic nucleus (SON) neurons undergo profound morphological changes. However, little is known about how much each type of cell, oxytocin (OT) or vasopressin (VP), contributes to this plasticity during dehydration. Using postembedding immunog...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(92)90256-w

    authors: Marzban F,Tweedle CD,Hatton GI

    更新日期:1992-05-01 00:00:00

  • Nutritional influences on dietary selection patterns of obese and lean Zucker rats.

    abstract::Little is known about the behavioral, nutritional, and metabolic events that control dietary intake quality. Two experiments are described that manipulate nutritional conditions that have been hypothesized to affect dietary item choice so as to assess what effect, if any, the added factor of genetic obesity has in mod...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(85)90112-1

    authors: Castonguay TW,Rowland NE,Stern JS

    更新日期:1985-06-01 00:00:00

  • Enhancing effects of binary mixtures of acid with salt on the gustatory neural activity in the clawed toad, Xenopus laevis.

    abstract::Binary mixtures of acid with salt were observed to produce enhancing effects on oral chemoreceptor responses by recording the activity of the whole glossopharyngeal nerve of the clawed toad (Xenopus laevis). The mixtures of HCl with various inorganic salts elicited responses larger than the sum of the responses to ind...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(96)00326-7

    authors: Yamashita S,Hisadome K,Yotsumata Y,Kiyohara S

    更新日期:1997-01-01 00:00:00

  • The effect of exercise and nettle supplementation on oxidative stress markers in the rat brain.

    abstract::Chronic swimming training and phytotherapeutic supplementation are assumed to alleviate oxidative damage, and support cell survival in the brain. The effect of forced, chronic swimming training, and enriched lab chow containing 1% (w/w) dried nettle (Urtica dioica) leaf were investigated for oxidative stress, inflamma...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2005.02.028

    authors: Toldy A,Stadler K,Sasvári M,Jakus J,Jung KJ,Chung HY,Berkes I,Nyakas C,Radák Z

    更新日期:2005-05-30 00:00:00

  • Activity of thermosensitive neurons of monkey preoptic hypothalamus during thermoregulatory operant behavior.

    abstract::Unit activities of thermosensitive (TS) and non-TS neurons in the medial preoptic area (MPO) of the monkey were investigated during a high fixed-ratio (FR 12-30) bar press behavior to seek cool air (CT) in a warm environment. The monkey performed the task when ambient temperature (Ta) was raised (35-43 degrees C) and ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(87)90134-1

    authors: Hori T,Kiyohara T,Oomura Y,Nishino H,Aou S,Fujita I

    更新日期:1987-05-01 00:00:00

  • Temporal changes in c-Fos activation patterns induced by conditioned fear.

    abstract::Mechanisms underlying shock-induced conditioned fear - a paradigm frequently used to model posttraumatic stress disorder, PTSD - are usually studied shortly after shocks. Some of the brain regions relevant to conditioned fear were activated in all the c-Fos studies published so far, but the overlap between the activat...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2012.04.001

    authors: Tulogdi A,Sörös P,Tóth M,Nagy R,Biró L,Aliczki M,Klausz B,Mikics E,Haller J

    更新日期:2012-07-01 00:00:00

  • Sexually diergic hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine, continuous nicotine infusion, and nicotine withdrawal by mecamylamine in rats.

    abstract::Hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine (NIC) are sexually diergic: Female rats have higher adrenocorticotropic hormone (ACTH) and corticosterone (CORT) responses than do males. In the present study we determined HPA responses in male and female rats following single doses of NIC, a sing...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2011.03.001

    authors: Gentile NE,Andrekanic JD,Karwoski TE,Czambel RK,Rubin RT,Rhodes ME

    更新日期:2011-05-30 00:00:00

  • Subthalamic local field potential oscillations during ongoing deep brain stimulation in Parkinson's disease.

    abstract::How deep brain stimulation (DBS) acts and how the brain responds to it remains unclear. To investigate the mechanisms involved, we analyzed changes in local field potentials from the subthalamic area (STN-LFPs) recorded through the deep brain macroelectrode during monopolar DBS of the subthalamic nucleus area (STN-DBS...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2008.01.023

    authors: Rossi L,Marceglia S,Foffani G,Cogiamanian F,Tamma F,Rampini P,Barbieri S,Bracchi F,Priori A

    更新日期:2008-07-30 00:00:00

  • A stereotaxic atlas of the grey lesser mouse lemur brain (Microcebus murinus).

    abstract::In response to the growing interest in the prosimian Microcebus murinus for studies on cerebral aging, the stereotaxic atlas of its brain was carried out in view of further anatomical, biochemical, electrophysiological, and behavioral investigations as well as for therapeutic experiments. This primate, which could be ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(97)00458-9

    authors: Bons N,Silhol S,Barbié V,Mestre-Francés N,Albe-Fessard D

    更新日期:1998-05-01 00:00:00

  • Role of P2 receptors in normal brain development and in neurodevelopmental psychiatric disorders.

    abstract::The purinergic signaling system, including P2 receptors, plays an important role in various central nervous system (CNS) disorders. Over the last few decades, a substantial amount of accumulated data suggest that most P2 receptor subtypes (P2X1, 2, 3, 4, 6, and 7, and P2Y1, 2, 6, 12, and 13) regulate neuronal/neurogli...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainresbull.2019.01.030

    authors: Huang L,Otrokocsi L,Sperlágh B

    更新日期:2019-09-01 00:00:00

  • The conduction velocity and central projections of retinofugal fibers in the rabbit.

    abstract::IN anesthetized and paralyzed rabbits, action potentials were elicited antidromically following electrical stimulation of optic tract terminals at the geniculate level (LGN). The conduction velocity spectrum extended from 7 m.s-1 to 34 m.s-1. The distribution of conduction velocities indicated four major modes at 10, ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(80)90207-5

    authors: Molotchnikoff S,Lessard I

    更新日期:1980-11-01 00:00:00

  • Aluminium incorporation into the brain of rat fetuses and sucklings.

    abstract::Aluminium is highly neurotoxic and inhibits prenatal and postnatal development of the brain in humans and experimental animals. However, the incorporation of aluminium into the brain of fetuses and sucklings during gestation and lactation has not been well clarified because aluminium lacks a suitable isotope for a tra...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(01)00509-3

    authors: Yumoto S,Nagai H,Matsuzaki H,Matsumura H,Tada W,Nagatsuma E,Kobayashi K

    更新日期:2001-05-15 00:00:00

  • Effects of intraplantar injection of carrageenan on central dopamine release.

    abstract::The present study examined the changes of extracellular concentration of dopamine and its metabolite homovanillic acid in the striatum, the periaqueductal gray and the dorsal horn of lumbar spinal cord following intraplantar injection of carrageenan. In vivo microdialysis and high-performance liquid chromatography wit...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(00)00460-3

    authors: Gao X,Zhang YQ,Zhang LM,Wu GC

    更新日期:2001-03-01 00:00:00

  • Thyroid hormone state and the incorporation of (14C) leucine by brain microsomes in developing rats.

    abstract::Cell-free incorporation of (14C) leucine into protein was 38% greater for cerebral cortical microsomes from 22-day old neonatally thyroidectomized rats compared to littermate controls. In contrast, incorporation by liver microsomes of hypothyroid rats was 33% lower compared to controls, confirming their deficient horm...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(80)90275-0

    authors: Gonzales LW,Geel SE

    更新日期:1980-01-01 00:00:00

  • Neurochemical studies of the nucleus of the solitary tract, dorsal motor nucleus of the vagus and the hypoglossal nucleus in rat: topographical distribution of glutamate uptake, GABA uptake and glutamic acid decarboxylase activity.

    abstract::The topographical distribution of glutamate uptake, GABA uptake, and GAD activity was studied in caudal, intermediate and rostral areas of the nucleus of the solitary tract (NTS), dorsal motor nucleus of the vagus (DMN) and the of the solitary tract (NTS), dorsal motor nucleus of the vagus (DMN) and the hypoglossal nu...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(85)90176-5

    authors: Simon JR,DiMicco SK,Aprison MH

    更新日期:1985-01-01 00:00:00

  • The medullary dorsal reticular nucleus facilitates acute nociception in the rat.

    abstract::The influence on pain processing caused by destruction or stimulation of the dorsal reticular nucleus (DRt) was studied using the tail-flick and the increasing temperature hot-plate tests. Lesions of the DRt were obtained by injecting quinolinic acid (180 nmol/microliters) unilaterally or bilaterally, and nociceptive ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(95)02027-6

    authors: Almeida A,Tjølsen A,Lima D,Coimbra A,Hole K

    更新日期:1996-01-01 00:00:00

  • Characterization of spatial performance in male and female Long-Evans rats by means of the Morris water task and the ziggurat task.

    abstract::Sex differences are prominent influences on spatial performance. One of the most common tasks to assess sex differences in spatial navigation in rodents is the Morris water task (MWT). In this task rats swim in a pool of water to locate a hidden platform employing the topographical relationships among the distal visua...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2009.10.017

    authors: Faraji J,Metz GA,Sutherland RJ

    更新日期:2010-01-15 00:00:00

  • Effect of phenylephrine injected into the nucleus tractus solitarius of Sprague-Dawley rats and spontaneously hypertensive rats.

    abstract::In alpha-chloralose-anesthetized Sprague-Dawley (SD) rats with unilateral nucleus tractus solitarius (NTS) lesions, injection of the alpha(1)-adrenergic receptor agonist phenylephrine into the contralateral NTS dose-dependently increased arterial pressure (AP). Bunazosin (0.1 nmol) or prazosin (0.36 nmol), an alpha(1)...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(02)00757-8

    authors: Tsukamoto K,Ito S,Katsunuma N,Hiratsuka M,Masubuchi Y,Kanai T,Kawabe T,Yajima Y,Kanmatsuse K

    更新日期:2002-08-15 00:00:00

  • Effect of a low protein diet on the anatomical development of subcortical formations.

    abstract::The effects of a low protein diet during gestation, lactation, and after weaning on the anatomical development of a subcortical nucleate formation, the neostriatum, and a reticulate formation, the diagonal band of Broca, were studied. At 10, 30, and 90 days the volume of the neostriatum was decreased in the experiment...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(78)90073-4

    authors: Kemper TL,Pasquier DA,Drazen S

    更新日期:1978-09-01 00:00:00