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Persistent alterations in GABAA receptor binding and function after prenatal lorazepam administration in the chick.

Abstract：

:Behavioral abnormalities have been reported in young and adult animals exposed to benzodiazepines prenatally. The presence of neurochemical alterations in the GABAergic system after prenatal benzodiazepine exposure was assessed in a chick model which avoids prenatal and postnatal maternal effects. The GABAA receptor complex, the presumed site of benzodiazepine action, was altered in adult chickens previously exposed to lorazepam for 10 days in ovo. Binding was decreased at the putative chloride channel site labeled by [35S]TBPS, coupling was decreased between this site and the GABA binding site, and function of the GABAA receptor in chloride uptake was diminished in animals exposed to prenatal lorazepam. Persistent neurochemical alterations in the GABAergic system accompany prenatal benzodiazepine exposure, and may influence subsequent behavior and development.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Miller LG,Roy RB,Weill CL,Lopez F

doi

10.1016/0361-9230(89)90143-3

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

171-4

issue

3

eissn

0361-9230

issn

1873-2747

pii

0361-9230(89)90143-3

journal_volume

23

pub_type

杂志文章

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