Abstract：
:The ontogeny of sensorimotor behaviors of albino rats were evaluated from birth through adulthood (Experiment 1). Sensorimotor behaviors (e.g., visual and tactile orientation, forelimb and hindlimb hopping, righting reflexes) achieved mature (adultlike) characteristics at various ages during ontogeny and a rostral-caudal developmental pattern was revealed. In Experiment 2, the substantia nigra was bilaterally or unilaterally destroyed in rats at 10 or 25 days of age and the ontogeny of sensorimotor and regulatory (feeding, drinking, body weight regulation) behaviors were evaluated. Bilateral destruction of the substantia nigra, zona compacta, at 10 and 25 days of age resulted in transient cessation of suckling and/or feeding and drinking followed by recovery. Male brain-damaged rats had reduced body weight through 150-170 days of age. Specific feeding and drinking tests revealed the presence of residual regulatory deficits which seemed permanent. Sensorimotor testing revealed transient dysfunction for a variety of sensorimotor behaviors, with eventual recovery of normal sensorimotor capacity. The results are related to sensorimotor ontogeny and recovery from infant brain damage.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Almli CR,Fisher RSdoi
10.1016/0361-9230(77)90052-1subject
Has Abstractpub_date
1977-11-01 00:00:00pages
425-59issue
6eissn
0361-9230issn
1873-2747pii
0361-9230(77)90052-1journal_volume
2pub_type
杂志文章abstract：:Urethane is often used as a central anaesthetic in neurophysiological studies of drug effects. In this experiment, the effect of morphine on cortical EEG and single units of hippocampus and medial thalamus were compared in urethane-anaesthetized and paralyzed-awake rats. In each case, there was evidence of a morphine-...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(80)90183-5
更新日期：1980-03-01 00:00:00
abstract：:Several studies have demonstrated that a descending dopaminergic pathway innervates the dorsal and the intermediate gray matter of the spinal cord and have suggested that this pathway is involved in pain modulation and in the control of autonomic functions. Other studies have also demonstrated the presence of dopamine...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(93)90259-e
更新日期：1993-01-01 00:00:00
abstract：OBJECTIVE:Transcranial near-infrared stimulation (tNIRS) can penetrate the scalp and skull and can reach the superficial layers of the cerebral cortex. In this study, we evaluated whether an 820-nm tNIRS can modulate the excitability of the primary motor cortex (M1) as measured by transcranial magnetic stimulation (TMS...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2019.12.007
更新日期：2020-02-01 00:00:00
abstract：:An abundant recall of dreams has been observed in clinical studies on patients with narcolepsy-cataplexy (NC), a neurological disorder characterized by an altered sleep architecture. Laboratory studies have shown that dream experiences developed during 1st-rapid eye movement (REM) sleep by NC patients are longer and m...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2009.10.021
更新日期：2010-01-15 00:00:00
abstract：:Catecholaminergic systems, specifically in the region of the lateral perifornical hypothalamus (PFH), have been linked to the inhibition of feeding behavior. The present studies examined the effects of d-amphetamine (AMPH), which is believed to act through the release of endogenous catecholamines (CAs), on spontaneous...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(86)90200-5
更新日期：1986-11-01 00:00:00
abstract：:beta-endorphin-like immunoreactivity was measured by radioimmunoassay in the brains of adult rats treated neonatally with beta-endorphin, naloxone, or vehicle. After treatment with beta-endorphin, the decreases observed in beta-endorphin-like immunoreactivity in the hypothalamus, pineal, midbrain, pons-medulla, hippoc...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(81)90118-0
更新日期：1981-12-01 00:00:00
abstract：:Rats were unilaterally deprived of odor stimulation by surgically sealing one naris 1, 30 or 60 days after birth. Thirty days later the laminar volumes of the olfactory bulb ipsilateral to the occluded naris were compared with those ipsilateral to the normal side. Deprivation from days 1-30 resulted in approximately 2...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(83)90121-1
更新日期：1983-11-01 00:00:00
abstract：:The effects of post-training intra-hippocampal injections of group I mGluR agonists and antagonists, were examined in the contextual fear test, in rats. It was found that (S)-3,5-dihydroxyphenylglycine (DHPG) (a mGluR1-5 agonist) decreased, and (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) (a mGluR1 antagonist) incre...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2003.08.003
更新日期：2003-11-15 00:00:00
abstract：:Brief cerebral ischemia leads to selective neuronal necrosis (SNN), which is characterized by neuronal death with sparing of glial and vascular elements of the central nervous system. Understanding the pathophysiology of SNN may help elucidating the mechanisms and consequences of neuronal injury in humans following br...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2008.11.005
更新日期：2009-03-16 00:00:00
abstract：:Cardiolipin is a mitochondrial membrane phospholipid with several well-defined metabolic roles. Cardiolipin can be released extracellularly by damaged cells and has been shown to affect peripheral immune functions. We hypothesized that extracellular cardiolipin can also regulate functions of microglia, the resident im...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2019.01.002
更新日期：2019-03-01 00:00:00
abstract：:The conditions under which amyloid is toxic to primary rat hippocampal neurons were investigated. Synthetic A beta (1-42) peptide elicited neurotoxic activity following "aging" for 7 to 14 days at 37 degrees C in Modified Eagles Media. Neurotoxicity included decreases in neurite length, cell number, and a loss in 3-[4...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(95)02034-x
更新日期：1995-01-01 00:00:00
abstract：:Depression is associated with uncontrolled diabetes, which indicates a lack of insulin effect, yet the role of the insulin receptor in mediating depression is not clearly established because insulin receptors are not required for glucose entry into the brain. However, insulin receptors are important for brain function...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2018.09.017
更新日期：2018-10-01 00:00:00
abstract：:To elucidate whether pineal melatonin secretion is affected by changes in day length, we determined the concentration of melatonin in human pineal glands obtained at autopsy from 66 male subjects, aged 16-84 years over a period of 12 consecutive months. Based on the time of death, a day-night difference in pineal mela...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(98)00105-1
更新日期：1998-10-01 00:00:00
abstract：:Diabetes mellitus (DM) is considered the primary cause of neuropathic pain. Osthole (7-methoxy-8[3-methylpent 2-enyl]coumarin) is a component extracted from Cnidium monnieri (L.) cusson plant seeds and has anti-inflammatory and anti-oxidative properties. The aim of the present study was to investigate the effects of o...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2018.08.008
更新日期：2018-09-01 00:00:00
abstract：:Spinal NMDA receptors contribute to control of the cardiovascular system by the ventrolateral medulla. However, little is known about the contribution of these receptors to suprabulbar regulation of hemodynamics and sympathetic outflow. Hence, the involvement of spinal NMDA receptors in regulation of the cardiovascula...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(93)90169-c
更新日期：1993-01-01 00:00:00
abstract：:Individual cardiac nerves from which stimulation elicited cardioinhibition (bradycardia and negative inotropism) were identified in 24 of 38 dogs. Subsequently, 3-25 microliters of 30% horseradish peroxidase (HRP) were injected into an identified cardiac nerve. After a 3-day survival period, the medulla oblongata was ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(82)90073-9
更新日期：1982-04-01 00:00:00
abstract：:Waxing and waning electrographic responses (augmenting) and primary evoked responses could be induced in restricted regions of hippocampus, thalamus, and skeletal muscle by bipolar, low-frequency (7-10 Hz), low-amplitude (35 mV-4V) stimulation of selected sites within the hippocampus or thalamus of rabbits. Induction ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(77)90003-x
更新日期：1977-03-01 00:00:00
abstract：:In this study, we compared the depression-like symptoms induced by olfactory bulbectomy (OBX) in the two inbred Wistar and Long Evans rat strains. We also analyzed the self-regulated oral intake of nicotine in these strains and the effect of nicotine on the depression-like symptoms of olfactory bulbectomy. Furthermore...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2008.05.007
更新日期：2008-09-05 00:00:00
abstract：:Previous studies using a pharmacological approach suggested a neural pathway emanating from the periaqueductal gray (PAG) to the nucleus accumbens relevant to antinociception. This was investigated with neurochemical and histochemical methods in the present study. Push-pull perfusion and radioimmunoassay were used to ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(92)90215-j
更新日期：1992-06-01 00:00:00
abstract：:The aim of this study was to investigate whether primary vestibular afferent fibers establish direct connections with the motor and sensory trigeminal system in the brainstem of the frog. The experiments were carried out on Rana esculenta. In anaesthetized animals the trigeminal and vestibular nerves were prepared, an...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2007.10.049
更新日期：2008-03-18 00:00:00
abstract：:An inexpensive multielectrode voltammetry system designed for in vivo neurochemical studies of the awake, unanesthetized primate has been developed. Consisting of an Apple II Plus microcomputer, parallel operational amplifier circuitry for six working electrodes, and commercially available interface boards, the system...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(83)90097-7
更新日期：1983-03-01 00:00:00
abstract：:An increasing number of studies suggest that nicotine/tobacco addiction is modulated by ovarian hormones. The levels of estrogen and progesterone appear to be important in the success of quit attempts and smoking cessation. In women smokers with the diagnosis or risk of breast cancer, the estrogen receptor modulator t...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2011.01.013
更新日期：2011-04-05 00:00:00
abstract：:In this study we investigated the ability of the dentate gyrus to independently generate cholinergically induced theta rhythm in vitro. Two different experiments were performed. In Experiment I, new laminar profiles of theta phase, amplitude, and current sources and sinks were constructed. In this experiment a gradual...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2009.07.003
更新日期：2009-09-28 00:00:00
abstract：:We quantitated the activity of ornithine decarboxylase (ODC) in homogenates and subcellular fractions of inner ear tissues from the rat and guinea pig and demonstrate inhibition of cochlear ODC by the aminoglycoside neomycin. Subcellular fractionation showed the enzyme associated with the post-mitochondrial supernatan...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(87)90056-6
更新日期：1987-12-01 00:00:00
abstract：:Sex differences are prominent influences on spatial performance. One of the most common tasks to assess sex differences in spatial navigation in rodents is the Morris water task (MWT). In this task rats swim in a pool of water to locate a hidden platform employing the topographical relationships among the distal visua...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2009.10.017
更新日期：2010-01-15 00:00:00
abstract：:Single unit recordings were used to map the spatial distribution of motor (MI) cortical influences on thalamic somatosensory relay nuclei in the rat. A total of 215 microelectrode penetrations were made to record single neurons in tracks through the medial and lateral ventroposterior (VPM and VPL), ventrolateral (VL),...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(90)90213-j
更新日期：1990-02-01 00:00:00
abstract：:Rats self-administered cocaine or received saline during 3 daily 5 h sessions and were euthanized 1 h after the final session. Quantitative in situ hybridization revealed that cocaine self-administration increased levels of preprodynorphin, but not preproenkephalin, c-fos, or zif/268 mRNAs in a patchy pattern in the d...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(95)00049-k
更新日期：1995-01-01 00:00:00
abstract：:Several studies have demonstrated alterations in the dopamine (DA) system after traumatic brain injury (TBI). Additionally, the existence of significant sex-related differences in the dopaminergic system has long been recognized. Accordingly, the purpose of the present study was to investigate whether TBI would differ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2016.05.010
更新日期：2016-06-01 00:00:00
abstract：:Nitric oxide (NO) is the main activator of the soluble guanylate cyclase (sGC)-guanosine 3'5' cyclic monophosphate (cGMP) pathway. The level of cGMP is regulated by phosphodiesterases (PDEs), which break down cGMP. It has been reported that levels of NO in the central nervous system (CNS) can greatly increase during d...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2014.04.002
更新日期：2014-05-01 00:00:00
abstract：:4-Hydroxy-4-phenylcaproamide (HPhCA), at high doses or rates of IV injection depressed the ventral root reflexes elicited by nerve or dorsal root stimulation. The D (direct) and I (synaptic) ventral root waves and the antidromic (A) dorsal root wave evoked by intraspinal stimulation were also depressed. Similar effect...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(94)90242-9
更新日期：1994-01-01 00:00:00
