Brain reward circuitry: a case for separate systems.

abstract：:Over the last 15 years, many publications described the use of peptide sequences that have been dubbed cell penetrating peptides (CPP), Trojan Horse peptides, protein transduction domains, or membrane-translocating sequences. These mostly positively charged domains bring attached cargo across biological membranes. One...

journal_title：Brain research bulletin

authors： Dietz GP,Bähr M

更新日期：2005-12-15 00:00:00

abstract：:Prostaglandin E2 may not be solely responsible for hyperthermia produced by central administration of sodium arachidonate. To determine its effect, if any, on body temperature prostacyclin sodium salt, another product of prostaglandin endoperoxides, was injected into the third cerebral ventricle of unrestrained, unane...

journal_title：Brain research bulletin

authors： Clark WG,Lipton JM

更新日期：1979-01-01 00:00:00

abstract：:In the present study, cellular tropism and relative transduction efficiency of AAV2/6, AAV2/8 and AAV2/9 vectors have been tested for the cornea using primary cultures of human corneal fibroblasts. The AAV6, AAV8 and AAV9 serotypes having AAV2 ITR plasmid encoding for alkaline phosphatase (AP) gene were generated by t...

journal_title：Brain research bulletin

authors： Sharma A,Ghosh A,Hansen ET,Newman JM,Mohan RR

更新日期：2010-02-15 00:00:00

abstract：:Cerebral ischemic damage in gerbils was assessed by locomotor activity studies and histopathological examination of the hippocampal CA1 pyramidal cell layer. Pretreatment with AICAr (50 and 500 mg/kg) 30 min prior to a 5-min ischemic episode in unanesthetized gerbils, significantly attenuated the degree of ischemic ne...

journal_title：Brain research bulletin

authors： Clough-Helfman C,Phillis JW

更新日期：1990-07-01 00:00:00

abstract：:Sleep EEG in the sigma and delta frequency bands was subjected to spectral analysis in 8 normal young adults. In each subject, power density of sigma and delta oscillated reciprocally during NREM sleep, confirming an observation made initially with period/amplitude analysis. In REM sleep, power density for both freque...

journal_title：Brain research bulletin

authors： Uchida S,Maloney T,March JD,Azari R,Feinberg I

更新日期：1991-07-01 00:00:00

abstract：:The effects of Fe(2+) and Fe(3+) on glycine-activated chloride current (IGly) were studied in rat isolated pyramidal hippocampal neurons using patch-clamp technique in whole-cell configuration. 25, 100 or 500 μM glycine was applied for 600 ms with 40s intervals. Fe(2+) and Fe(3+) were co-applied with glycine in the ra...

journal_title：Brain research bulletin

authors： Solntseva EI,Bukanova JV,Kondratenko RV,Skrebitsky VG

更新日期：2015-06-01 00:00:00

abstract：:There have been studies of the discriminative effects of intracerebroventricularly (ICV)-administered morphine (MOR) in rats trained to discriminate MOR systemically, but the converse has not been done. In this study, rats were trained to discriminate between ICV (1-10 microg/3 microl, 1 h) or subcutaneous (SC) (3.0 m...

journal_title：Brain research bulletin

authors： Easterling KW,Holtzman SG

更新日期：2001-12-01 00:00:00

abstract：:Multiple lines of investigation have explored the role of dopaminergic systems in mental depression. Chronic treatment with antidepressant drugs has been reported to alter dopaminergic neurotransmission, most notably a sensitization of behavioural responses to agonists acting at D2/D3 dopamine receptors within the nuc...

journal_title：Brain research bulletin

authors： Dhir A,Kulkarni SK

更新日期：2007-09-14 00:00:00

abstract：:Neonatal post-hemorrhagic hydrocephalus is associated with cognitive decline and a serious deterioration in the patient's quality of life. The underlying impairments to neurons are not well understood. Here, we used the method described by Cherian et al. to construct a model of hydrocephalus after intra-ventricular he...

journal_title：Brain research bulletin

authors： Chen X,Huang X,Li B,Zhao Z,Jiang L,Huang C,Lu Y

更新日期：2010-08-30 00:00:00

abstract：:Here we have investigated whether differences in levels of dopamine D1-like, D2-like receptors, dopamine D3 receptors, and dopamine transporter could be related to behaviors such as immobility response and locomotion between Wistar rats and Sprague-Dawley rats. The levels of the dopamine receptors and transporter were...

journal_title：Brain research bulletin

authors： Zamudio S,Fregoso T,Miranda A,De La Cruz F,Flores G

更新日期：2005-04-30 00:00:00

abstract：:Gonadal hormones exert a critical influence over the architecture of specific brain areas affecting the formation of neuronal contacts. Cellular mechanisms mediating gonadal hormone actions on synapses have been studied extensively in the rat arcuate nucleus, a hypothalamic center involved in the feed-back regulation ...

journal_title：Brain research bulletin

authors： Fernandez-Galaz MC,Morschl E,Chowen JA,Torres-Aleman I,Naftolin F,Garcia-Segura LM

更新日期：1997-01-01 00:00:00

abstract：:The attempt of this study was to investigate the direct effects of increasing doses of morphine on the neuronal activity of the periaqueductal gray in morphine-naive and morphine-dependent rats. The microiontophoresis technique was used for this purpose. The four different responses induced by morphine exhibited dose-...

journal_title：Brain research bulletin

authors： Schurr A,Rigor BM,Ho BT,Dafny N

更新日期：1981-06-01 00:00:00

abstract：:The purinergic signaling system, including P2 receptors, plays an important role in various central nervous system (CNS) disorders. Over the last few decades, a substantial amount of accumulated data suggest that most P2 receptor subtypes (P2X1, 2, 3, 4, 6, and 7, and P2Y1, 2, 6, 12, and 13) regulate neuronal/neurogli...

journal_title：Brain research bulletin

authors： Huang L,Otrokocsi L,Sperlágh B

更新日期：2019-09-01 00:00:00

abstract：:To investigate the effect of stimulus presentation rate on the activity of primary somatosensory cortex, we performed echo-planar functional magnetic resonance imaging using a 1.5-tesla magnetic resonance system. Eight right-handed normal volunteers underwent functional magnetic resonance imaging during somatosensory ...

journal_title：Brain research bulletin

authors： Takanashi M,Abe K,Yanagihara T,Oshiro Y,Watanabe Y,Tanaka H,Hirabuki N,Nakamura H,Fujita N

更新日期：2001-01-15 00:00:00

abstract：PURPOSE:We assessed the potential of resting-state fMRI lag analysis (RSLA) in detecting epileptic activation and in estimating anti-epileptic effects of Levetiracetam (LEV) in Rolandic epilepsy. METHODS:Forty-three children with Rolandic epilepsy underwent simultaneous EEG-fMRI. They were grouped into LEV vs drug-naï...

journal_title：Brain research bulletin

authors： Xu Q,Hu Z,Yang F,Bernhardt BC,Zhang Q,Stufflebeaskm SM,Zhang Z,Lu G

更新日期：2020-09-01 00:00:00

abstract：:Previously obtained data suggests that noradrenaline (NE) released from the efferent locus coeruleus (LC) endings in hippocampal formation (HPC) may serve as an important modulating signal involved in the pharmacological mechanisms responsible for the production of type 2 theta rhythm in rats. Hence, two distinct hypo...

journal_title：Brain research bulletin

authors： Broncel A,Bocian R,Kłos-Wojtczak P,Konopacki J

更新日期：2020-09-01 00:00:00

abstract：:Calcium channels affect many neuronal functions, including membrane electrical excitability, synaptic transmission, cellular homeostasis, gene transcription, growth, and development. We used recently developed methods for serum-free culture of adult and embryonic rat neurons to study the development of voltage-sensiti...

journal_title：Brain research bulletin

authors： Collings MA,Brewer GJ,Evans MS

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:Parkinson's disease (PD) is a frequent degenerative disease of the nervous system with undefined pathogenesis. This study explored the protective effect of microRNA (miR)-218-5p on dopaminergic neuron injury in substantia nigra (SN) of rats with PD through the regulation of LIM and SH3 domain protein 1 (LASP1...

journal_title：Brain research bulletin

authors： Ma X,Zhang H,Yin H,Geng S,Liu Y,Liu C,Zhao J,Liu Y,Wang X,Wang Y

更新日期：2021-01-01 00:00:00

abstract：:The topographical distribution of cholinergic cell bodies has been studied in the rat brain and spinal cord by choline acetyltransferase (ChAT)-immunohistochemistry and acetylcholinesterase (AChE)-pharmacohistochemistry using diisopropylfluorophosphate (DFP). The ChAT-containing cells and the cells that stained intens...

journal_title：Brain research bulletin

authors： Satoh K,Armstrong DM,Fibiger HC

更新日期：1983-12-01 00:00:00

abstract：:Sequence variations in genes involved in inflammation system are known to contribute to the risk of cardiovascular diseases (CVD) including stroke. In this study, we performed a genetic association study on the single nucleotide polymorphisms (SNPs) present in the genes CD14 (-159 C/T), TNFalpha (-308 G/A), IL-1alpha ...

journal_title：Brain research bulletin

authors： Banerjee I,Gupta V,Ahmed T,Faizaan M,Agarwal P,Ganesh S

更新日期：2008-01-31 00:00:00

abstract：:Endogenous adrenergic drive regulates the firing rate of serotonergic neurons. However, advocates of feedback theory assert that 5-hydroxytryptamine (5-HT) released in the somatodendritic region of raphe neurons regulates both rate and release of 5-HT. Experiments were done to determine if the somatodendritic region m...

journal_title：Brain research bulletin

authors： Kalsner S,Abdali SA

更新日期：2001-08-01 00:00:00

abstract：:The olfactory bulbectomized (OBX) rat model of depression has been widely used in studies on the behavioral and neurochemical aspects of human depression. The objective of the present investigation was to assess open field (OF) activity and the brain regional 5-HT(1A) receptor densities of the sham operated (SHX) and ...

journal_title：Brain research bulletin

authors： Sato H,Skelin I,Debonnel G,Diksic M

更新日期：2008-03-28 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in people over 60 years of age in the US and many other developed countries. Increasingly sophisticated methods for the diagnosis and treatment of macular degeneration are not effective for the majority of patients in whom late stage...

journal_title：Brain research bulletin

authors： Rowe-Rendleman C,Glickman RD

更新日期：2004-02-15 00:00:00

abstract：:Zinc is a basic trace element that plays important roles in brain and, consequently, its homeostasis needs to be critically controlled. High zinc concentrations in the interneuron synaptic space may induce neuronal death through mechanisms still partially solved. Undifferentiated pheochromocytoma (PC12) cells have bee...

journal_title：Brain research bulletin

authors： Sánchez-Martín FJ,Valera E,Casimiro I,Merino JM

更新日期：2010-03-16 00:00:00

abstract：:We investigated the effects of mild hyperglycemia and insulin treatment on the metabolism of the ischemic brain in spontaneously hypertensive rats with acute hyperglycemia (n = 9), acute hyperglycemia treated with insulin during ischemia (n = 10), and normoglycemia (n = 10). Cerebral blood flow was measured by the H2 ...

journal_title：Brain research bulletin

authors： Sugimori H,Ibayashi S,Fujii K,Nagao T,Sadoshima S,Fujishima M

更新日期：1996-01-01 00:00:00

abstract：:Constant light exposure (LL) can result in "splitting" of circadian rhythms into two components coupled about 12 hr apart. Splitting has been interpreted as evidence for the presence of two main oscillators or groups of oscillators underlying circadian rhythms. Abolition of splitting after unilateral suprachiasmatic n...

journal_title：Brain research bulletin

authors： Harrington ME,Eskes GA,Dickson P,Rusak B

更新日期：1990-04-01 00:00:00

abstract：:The Tac4 gene-derived hemokinin-1 (HK-1) is present in pain-related regions and activates the tachykinin NK1 receptor, but with binding site and signaling pathways different from Substance P (SP). NK1 receptor is involved in nociception, but our earlier data showed that it has no role in chronic neuropathic hyperalges...

journal_title：Brain research bulletin

authors： Hunyady Á,Hajna Z,Gubányi T,Scheich B,Kemény Á,Gaszner B,Borbély É,Helyes Z

更新日期：2019-04-01 00:00:00

abstract：:Image analysis methods are being developed for measuring the density and distribution of perivascular noradrenergic nerves and their varicosities, demonstrated by fluorescence histochemistry. Image analysis is recommended in comparison with other methods for the quantitation of fluorescence, because image resolution i...

journal_title：Brain research bulletin

authors： Cowen T,Burnstock G

更新日期：1982-07-01 00:00:00

abstract：:Progesterone receptor (PR) isoforms expression was determined in several regions of the prepuberal and adult male rat brain by using reverse transcription coupled to polymerase chain reaction. Rats under a 14:10-h light-dark cycle, with lights on at 0600 h were used. We found that in the hypothalamus of prepuberal ani...

journal_title：Brain research bulletin

authors： Guerra-Araiza C,Reyna-Neyra A,Salazar AM,Cerbón MA,Morimoto S,Camacho-Arroyo I

更新日期：2001-01-01 00:00:00

abstract：:Adult female Zucker lean and obese rats were treated for 14 days with 3.5 nm/kg oleoyl-estrone (OE) in liposomes (Merlin-2) through continuous i.v. injection with osmotic minipumps. Rat wt. and food intake were measured daily. On days 0, 3, 6, 10, and 14, groups of rats were killed and their hypothalamic nuclei [later...

journal_title：Brain research bulletin

authors： Cabot C,del Mar Grasa M,Estruch J,Fernández-López JA,Remesar X,Alemany M

更新日期：1998-08-01 00:00:00