Abstract：
:Fetal mouse raphe and hippocampal tissue (from embryos with crown-rump length (CRL) 13-16 mm) was transplanted into adult and aged isogenetic mice to study the growth of serotonergic fibers between host and donor tissue. A specific antibody against serotonin (5-HT) was used to immunocytochemically visualize 5-HT containing cell bodies and fibers. Unilateral fetal transplants into the hippocampi of adult (4-6 mo.) or aged (24 mo.) mice matured and sent out processes which very densely innervated the transplant tissue itself and extended into the host hippocampus. The termination of these fibers was consistent with the known 5-HT-hippocampal lamination pattern in normal animals. Qualitative comparisons suggested that the density of outgrowth into adult hippocampus was greater than into aged hippocampus. Conversely, adult 5-HT neurons send sprouts into fetal hippocampal tissue transplanted into the lateral ventricle. Therefore, immunocytochemical procedures can be used to monitor outgrowth from the fetal tissue to the host and ingrowth from the adult host to the fetal tissue. Furthermore, the apparent normal 5-HT lamination pattern produced by fetal raphe axons in adult hippocampus is consistent with reports that neuronal transplantation is effective in reversing the anatomical and behavioral deficits produced by homotypic denervation of a terminal field.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Azmitia EC,Perlow MJ,Brennan MJ,Lauder JMdoi
10.1016/0361-9230(81)90122-2subject
Has Abstractpub_date
1981-12-01 00:00:00pages
703-10issue
6eissn
0361-9230issn
1873-2747pii
0361-9230(81)90122-2journal_volume
7pub_type
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journal_title：Brain research bulletin
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更新日期：2003-08-30 00:00:00
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journal_title：Brain research bulletin
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更新日期：2002-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2016-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：1996-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1997-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2008.01.023
更新日期：2008-07-30 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
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更新日期：2019-09-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2007.05.004
更新日期：2007-09-14 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1993-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2016.01.008
更新日期：2016-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：1993-01-01 00:00:00
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journal_title：Brain research bulletin
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pub_type： 杂志文章
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(87)90066-9
更新日期：1987-11-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2005.07.007
更新日期：2005-10-30 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
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更新日期：1998-06-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：2013-08-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(80)90181-1
更新日期：1980-03-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2012.07.011
更新日期：2012-11-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2020.12.009
更新日期：2020-12-28 00:00:00
abstract：:Creutzfeldt-Jakob disease (CJD) and other transmissible spongiform encephalopathies (TSEs) are characterised by the accumulation of a pathological conformer of PrP, named PrPsc. Molecular weight and glycosylation of the protease-resistant core of PrPsc (PrP27-30) are heterogeneous in different forms of TSEs. We analys...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(99)00077-5
更新日期：1999-08-01 00:00:00
abstract：:Massively obese males often show symptoms of hypogonadism, but the mechanism for this is unclear. Increased endogenous opioid inhibition of the hypothalamic GnRH pulse generator resulting in insufficient stimulation of the pituitary gonadotroph has been proposed as a possible mechanism. If this hypothesis is correct, ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(94)90142-2
更新日期：1994-01-01 00:00:00
abstract：:Arachidonic acid [20:4(N-6)] has been implicated in neurological damage induced by cerebral ischaemia. Membrane arachidonate concentrations can be reduced by changes in dietary fat intake. Therefore, in the present study, we have investigated the effects of N-3 fatty acid supplementation on neuronal damage induced by ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(93)90180-j
更新日期：1993-01-01 00:00:00
