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Injection of muscimol in the posterior hypothalamus reduces the PGE1-hyperthermia in the rat.

Abstract：

:The firing rate of the nerves innervating interscapular brown adipose tissue (IBAT), IBAT and colonic temperatures (TIBAT and Tc), heart rate, and oxygen (O2) consumption were monitored in urethane-anesthetized male Sprague-Dawley rats. These variables were measured for 40 min before (baseline values) and 40 min after a 56 ng muscimol injection in the posterior hypothalamus and an intracerebroventricular administration of 500 ng prostaglandin E1 (PGE1). The same variables were monitored in other rats with muscimol injection or PGE1 administration alone. No drug was injected in control rats. The results show that muscimol injection reduces the increases in firing rate, TIBAT, Tc, heart rate, O2 consumption induced by PGE1. These findings suggest that GABAergic tone in the posterior hypothalamus is important in the control of thermogenic changes induced by PGE1.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Monda M,Amaro S,Sullo A,De Luca B

doi

10.1016/0361-9230(95)00032-a

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

575-80

issue

6

eissn

0361-9230

issn

1873-2747

pii

036192309500032A

journal_volume

37

pub_type

杂志文章

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