abstract：:Numerous studies have shown that histone deacetylase inhibitors (HDACis) improve cellular acetylation while also enhancing the radiation sensitivity. In this work, however, we confirmed that low-dose trichostatin A (TSA) as a typical HDACi could reduce rather than increase the radiosensitivity of cancer cells, while t...

journal_title：Radiation research

authors： Zhang F,Shao C,Chen Z,Li Y,Jing X,Huang Q

更新日期：2021-01-29 00:00:00

abstract：:The success of boron neutron capture therapy (BNCT) mainly depends on the boron concentration in the tumor and a high tumor/normal tissue (T/N) boron ratio or a high tumor/blood (T/B) boron ratio. Therefore, the effective enhancement of boron ratios is the first priority. Our study investigated whether a low-dose of γ...

journal_title：Radiation research

authors： Lin YC,Chou FI,Liao JW,Liu YH,Hwang JJ

更新日期：2021-01-29 00:00:00

abstract：:Identification of medical countermeasures (MCM) to mitigate radiation damage and/or protect first responders is a compelling unmet medical need. The prostaglandin E2 (PGE2) analog, 16,16 dimethyl-PGE2 (dmPGE2), has shown efficacy as a radioprotectant and radiomitigator that can enhance hematopoiesis and ameliorate int...

journal_title：Radiation research

authors： Patterson AM,Wu T,Chua HL,Sampson CH,Fisher A,Singh P,Guise TA,Feng H,Muldoon J,Wright L,Plett PA,Pelus LM,Orschell CM

更新日期：2020-12-10 00:00:00

abstract：:Octacalcium phosphate (OCP) {Ca8H2(PO4)6×5H2O] has attracted increasing attention over the last decade as a transient intermediate to the biogenic apatite for bone engineering and in studies involving the processes of pathological calcification. In this work, OCP powders obtained by hydrolysis of dicalcium phosphate d...

journal_title：Radiation research

authors： Shurtakova DV,Yavkin BV,Mamin GV,Orlinskii SB,Sirotinkin VP,Fedotov AY,Shinkarev A,Antuzevics A,Smirnov IV,Tovtin VI,Starostin EE,Gafurov MR,Komlev VS

更新日期：2020-12-10 00:00:00

abstract：:FLASH radiation therapy (FLASH-RT) reference dosimetry to obtain traceability, repeatability and stability of irradiations cannot be performed with conventional dosimetric methods, such as monitor chambers or ionization chambers. Until now, only passive dosimeters have provided the necessary dosimetric data. Alanine d...

journal_title：Radiation research

authors： Gondré M,Jorge PG,Vozenin MC,Bourhis J,Bochud F,Bailat C,Moeckli R

更新日期：2020-12-01 00:00:00

abstract：:Inhalation and ingestion of 137Cs and other long-lived radionuclides can occur after large-scale accidental or malicious radioactive contamination incidents, resulting in a complex temporal pattern of radiation dose/dose rate, influenced by radionuclide pharmacokinetics and chemical properties. High-throughput radiati...

journal_title：Radiation research

authors： Shuryak I,Ghandhi SA,Turner HC,Weber W,Melo D,Amundson SA,Brenner DJ

更新日期：2020-10-16 00:00:00

abstract：:This work provides a description of a new interaction, cross-section-based model for radiation-induced cellular inactivation, sublethal damage, DNA repair and cell survival, with the ability to more accurately elucidate different radiation-response phenomena. The principal goal of this work is to describe the damage-i...

journal_title：Radiation research

authors： Brahme A

更新日期：2020-09-16 00:00:00

abstract：:Cataract is one of the major morbidities in the U.S. population and it has long been appreciated that high and acutely delivered radiation doses of 1 Gy or more can induce cataract. Some more recent studies, in particular those of the U.S. Radiologic Technologists, have suggested that cataract may be induced by much l...

journal_title：Radiation research

authors： Little MP,Patel A,Hamada N,Albert P

更新日期：2020-08-01 00:00:00

abstract：:Breast tissue is very susceptible to radiation-induced carcinogenesis, and mammary stem/progenitor cells are potentially important targets of this. The mammary epithelium is maintained as two mostly independent lineages of luminal and basal cells. To elucidate their immediate radiation responses, we analyzed the mamma...

journal_title：Radiation research

authors： Kudo KI,Takabatake M,Nagata K,Nishimura Y,Daino K,Iizuka D,Nishimura M,Suzuki K,Kakinuma S,Imaoka T

更新日期：2020-07-08 00:00:00

abstract：:Genetic and epigenetic profile changes associated with individual radiation sensitivity are well documented and have led to enhanced understanding of the mechanisms of the radiation-induced DNA damage response. However, the search continues to identify reliable biomarkers of individual radiation sensitivity. Herein, w...

journal_title：Radiation research

authors： Bryant J,White L,Coen N,Shields L,McClean B,Meade AD,Lyng FM,Howe O

更新日期：2020-06-01 00:00:00

abstract：:A standard Fricke dosimeter was used to measure the absorbed dose via the oxidation yields of Fe3+ ions in an aqueous environment induced by soft X rays within the "water window" spectral range. We also exploited the property of a neutral solution containing terephthalic acid as a tool for selective detection of OH ra...

journal_title：Radiation research

authors： Vyšín L,Wachulak P,Toufarová M,Medvedev N,Voronkov RA,Bartnik A,Fiedorowicz H,Juha L

更新日期：2020-04-01 00:00:00

abstract：:Radiation therapy is an essential component of cancer treatment. Currently, tumor control and normal tissue complication probabilities derived from a general patient population guide radiation treatment. Its outcome could be improved if radiation biomarkers could be incorporated into approaches to treatment. A substan...

journal_title：Radiation research

authors： Prasanna PGS,Narayanan D,Zhang K,Rahbar A,Coleman CN,Vikram B

更新日期：2020-03-01 00:00:00

abstract：:Mixed radiation fields comprise the most common form of radiation exposure. Given their relevance in radiation protection, cancer radiotherapy and space research, accurate predictions of the corresponding radiation effects are essential. The local effect model (LEM) allows the prediction of cell survival after ion irr...

journal_title：Radiation research

authors： Pfuhl T,Friedrich T,Scholz M

更新日期：2020-02-01 00:00:00

abstract：:Evaluating the risk for central nervous system (CNS) effects after whole-body or partial-body irradiation presents challenges due in part to the varied exposure scenarios in the context of occupational, accidental or wartime releases. Risk estimations are further complicated by the fact that robust changes in brain fu...

journal_title：Radiation research

authors： Baddour AAD,Apodaca LA,Alikhani L,Lu C,Minasyan H,Batra RS,Acharya MM,Baulch JE

更新日期：2020-01-01 00:00:00

abstract：:We collected initial quantitative information on the effects of high-dose carbon (12C) ions compared to photons on vascular damage in anaplastic rat prostate tumors, with the goal of elucidating differences in response to high-LET radiation, using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Syngene...

journal_title：Radiation research

authors： Bendinger AL,Seyler L,Saager M,Debus C,Peschke P,Komljenovic D,Debus J,Peter J,Floca RO,Karger CP,Glowa C

更新日期：2020-01-01 00:00:00

abstract：:The goal of radiation therapy is to provide the highest probability of tumor control while minimizing normal tissue toxicity. Recently, it has been discovered that ultra-high dose rates of ionizing radiation may preferentially spare normal tissue over tumor tissue. This effect, referred to as FLASH radiotherapy, has b...

journal_title：Radiation research

authors： Colangelo NW,Azzam EI

更新日期：2020-01-01 00:00:00

abstract：:Radiation-induced acute myeloid leukemia (rAML) in C3H mice is commonly developed through inactivation of PU.1 transcription factor encoded in Sfpi1 on chromosome 2. PU.1 inactivation involves two steps: hemizygous deletion of the Sfpi1 gene (DSG) and point mutation of the allele Sfpi1 gene (PMASG). In this study, we ...

journal_title：Radiation research

authors： Ojima M,Hirouchi T,Etani R,Ariyoshi K,Fujishima Y,Kai M

更新日期：2019-12-01 00:00:00

abstract：:While the link between risk of leukemia and acute radiation exposure is well established for large doses received acutely, uncertainty remains around the translation of these risk estimates to occupational exposure scenarios where the doses are low and accumulated over time, possibly over many years. We present leukem...

journal_title：Radiation research

authors： Gillies M,Haylock R,Hunter N,Zhang W

更新日期：2019-11-01 00:00:00

abstract：:There has been ongoing debate and discussion concerning whether the funding source influenced the outcome of research on human health effects from exposure to radiofrequency fields (RF, electromagnetic waves that carry energy as they propagate in air and dense media). In a study of 225 publications, in which we sought...

journal_title：Radiation research

authors： Vijayalaxmi,Prihoda TJ

更新日期：2019-10-01 00:00:00

abstract：:Based on encouraging results from several early-phase clinical trials, there is renewed interest in the use of pharmacological ascorbate (i.e., intravenous administration resulting in >≈10 mM plasma ascorbate concentrations) in combination with standard-of-care cancer treatments including radiation and/or chemotherapy...

journal_title：Radiation research

authors： Petronek MS,Wagner BA,Hollenbeck NJ,Caster JM,Spitz DR,Cullen JJ,Buettner GR,Allen BG

更新日期：2019-06-01 00:00:00

abstract：:After a planned or unplanned radiation exposure, determination of absorbed dose has great clinical importance, informing treatment and triage decisions in the exposed individuals. Biodosimetry approaches allow for determination of dose in the absence of physical measurement apparatus. The current state-of-the-art biod...

journal_title：Radiation research

authors： Pujol-Canadell M,Young E,Smilenov L

更新日期：2019-05-01 00:00:00

abstract：:We have previously shown significant pathology in the heart and kidney of murine hematopoietic-acute radiation syndrome (H-ARS) survivors of 8.7-9.0 Gy total-body irradiation (TBI). The goal of this study was to determine temporal relationships in the development of vasculopathy and the progression of renal and cardio...

journal_title：Radiation research

authors： Unthank JL,Ortiz M,Trivedi H,Pelus LM,Sampson CH,Sellamuthu R,Fisher A,Chua HL,Plett A,Orschell CM,Cohen EP,Miller SJ

更新日期：2019-05-01 00:00:00

abstract：:Evaluation of the characteristics of accelerator-based thermal neutron fields is recognized as an important issue when discussing the effectiveness of boron neutron capture therapy (BNCT). In this study, we propose that the radiation chemical yield (G value) of hydroxyl radicals (Goh•) can be considered a universal pa...

journal_title：Radiation research

authors： Kusumoto T,Ogawara R

更新日期：2019-05-01 00:00:00

abstract：:In this study, we sought to determine how diffusion-weighted imaging (DWI) and proton magnetic resonance spectroscopy (1H-MRS) features are associated with histopathological results, and explored the cellular mechanisms of DWI and 1H-MRS in early radiosensitivity of transplanted liver tumors. VX2 tumors were implanted...

journal_title：Radiation research

authors： Li Y,Lin D,Weng Y,Weng S,Yan C,Xu X,Chen J,Ye R,Hong J

更新日期：2019-01-01 00:00:00

abstract：:On future missions into deep space, astronauts will be required to work more autonomously than on previous missions, and thus their ability to perform executive functions could be critical to mission success. In this study, we determined the effect that ≤15 cGy of 600 MeV/n 56Fe particles has on attentional set-shifti...

journal_title：Radiation research

authors： Jewell JS,Duncan VD,Fesshaye A,Tondin A,Macadat E,Britten RA

更新日期：2018-12-01 00:00:00

abstract：:The risk of a radiological or nuclear public health emergency is a major growing concern of the U.S. government. To address a potential incident and ensure that the government is prepared to respond to any subsequent civilian or military casualties, the U.S. Department of Health and Human Services and the Department o...

journal_title：Radiation research

authors： DiCarlo AL,Cassatt DR,Dowling WE,Esker JL,Hewitt JA,Selivanova O,Williams MS,Price PW

更新日期：2018-12-01 00:00:00

abstract：:It is well known that ionizing radiation-induced toxicity to normal tissue has functional consequences in the brain. However, the underlying molecular alterations have yet to be elucidated. We have previously reported cognitive impairments with concomitant changes in dendritic complexity, spine density and inflammatio...

journal_title：Radiation research

authors： Hinzman CP,Baulch JE,Mehta KY,Gill K,Limoli CL,Cheema AK

更新日期：2018-11-01 00:00:00

abstract：:Radiation-induced complications of the respiratory system are a common side effect of thoracic radiotherapy with no viable treatment option. Here, we investigated the potential therapeutic effect of the orphan drug pirfenidone for treating radiation-induced pulmonary fibrosis. C57BL/6 mice received a single fraction o...

journal_title：Radiation research

authors： Qin W,Liu B,Yi M,Li L,Tang Y,Wu B,Yuan X

更新日期：2018-10-01 00:00:00

abstract：:In previous studies we determined a gene expression signature in baboons for predicting the severity of hematological acute radiation syndrome. We subsequently validated a set of eight of these genes in leukemia patients undergoing total-body irradiation. In the current study, we addressed the effect of intra-individu...

journal_title：Radiation research

authors： Agbenyegah S,Abend M,Atkinson MJ,Combs SE,Trott KR,Port M,Majewski M

更新日期：2018-09-01 00:00:00

abstract：:During the pulsed-electron beam direct grafting of neat styrene onto poly(tetrafluoroethylene-co-hexafluoropropylene) (FEP) substrate, the radiolytically-produced styryl and carbon-centered FEP radicals undergo various desired and undesired competing reactions. In this study, a high-dose rate is used to impede the und...

journal_title：Radiation research

authors： Kim B,Weaver A,Chumakov M,Pazos IM,Poster DL,Gaskell K,Han DH,Scherer G,Yandrasits MA,Lee BC,Al-Sheikhly M

更新日期：2018-09-01 00:00:00

abstract：:Deep underground laboratories (DULs) were originally created to host particle, astroparticle or nuclear physics experiments requiring a low-background environment with vastly reduced levels of cosmic-ray particle interference. More recently, the range of science projects requiring an underground experiment site has gr...

journal_title：Radiation research

authors： Morciano P,Cipressa F,Porrazzo A,Esposito G,Tabocchini MA,Cenci G

更新日期：2018-09-01 00:00:00

abstract：:Vascular injury after radiation exposure contributes to multiple types of tissue injury through a cascade of events. Some of the earliest consequences of radiation damage include increased vascular permeability and promotion of inflammation, which is partially manifested by increased leukocyte-endothelial (L/E) intera...

journal_title：Radiation research

authors： Ashcraft KA,Choudhury KR,Birer SR,Hendargo HC,Patel P,Eichenbaum G,Dewhirst MW

更新日期：2018-07-01 00:00:00

abstract：:Accurate assessment of risks of long-term space missions is critical for human space exploration. It is essential to have a detailed understanding of the biological effects on humans living and working in deep space. Ionizing radiation from galactic cosmic rays (GCR) is a major health risk factor for astronauts on ext...

journal_title：Radiation research

authors： Beheshti A,Miller J,Kidane Y,Berrios D,Gebre SG,Costes SV

更新日期：2018-06-01 00:00:00

abstract：:In this study, we assessed the efficacy of unilamellar 110-nm liposomes encapsulating the chelating agent diethylenetriaminepentaacetic acid (DTPA) in plutonium-exposed rats. Rats were contaminated by intravenous administration of the soluble citrate form of plutonium. The comparative effects of liposomal and free DTP...

journal_title：Radiation research

authors： Grémy O,Miccoli L,Lelan F,Bohand S,Cherel M,Mougin-Degraef M

更新日期：2018-05-01 00:00:00

abstract：:In a scenario involving a nuclear detonation during war or a terrorist attack, acute radiation exposure combined with thermal and blast effects results in severe skin injury. Although the cutaneous injury in such a scenario may not be lethal, it may lead to inflammation, delayed wound healing and loss of the skin barr...

journal_title：Radiation research

authors： Albrecht H,Yang HY,Kiuru M,Maksaereekul S,Durbin-Johnson B,Wong MS,Stevenson TR,Rocke DM,Isseroff RR

更新日期：2018-04-01 00:00:00

abstract：:There has been increased interest in the immune stimulatory properties of ionizing radiation based on several preclinical models and recently completed clinical studies performed in combination with checkpoint inhibitors. This is a paradigm shift in that it considers the role of radiation beyond its direct cytotoxic e...

journal_title：Radiation research

authors： Iyer SP,Hunt CR,Pandita TK

更新日期：2018-03-01 00:00:00

abstract：:In this study, we investigated microvascular perfusion status, changes to fat content and fatty acid composition in the bone marrow of rat femurs after total-body irradiation by quantitative permeability parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and ex vivo high-resolution magic angl...

journal_title：Radiation research

authors： Wang K,Zha Y,Lei H,Xu X

更新日期：2018-02-01 00:00:00

abstract：:There is experimental evidence that ultrasoft X rays (0.1-5 keV) show a higher biological effectiveness than high-energy photons. Similar to high-LET radiation, this is attributed to a rather localized dose distribution associated with a considerably smaller range of secondary electrons, which results in an increasing...

journal_title：Radiation research

authors： Buch T,Scifoni E,Krämer M,Durante M,Scholz M,Friedrich T

更新日期：2018-01-01 00:00:00

abstract：:Radiation nephropathy is one of the common late effects in cancer survivors who received radiotherapy as well as in victims of radiation accidents. The clinical manifestations of radiation nephropathy occur months after exposure. To date, there are no known early biomarkers to predict the future development of radiati...

journal_title：Radiation research

authors： Bhayana S,Song F,Jacob J,Fadda P,Denko NC,Xu-Welliver M,Chakravarti A,Jacob NK

更新日期：2017-12-01 00:00:00

abstract：:The threat of exposure to ionizing radiation from a nuclear reactor accident or deliberate terrorist actions is a significant public health concern. The lung is particularly susceptible to radiation-induced injury from external sources or inhalation of radioactive particles from radioactive fallout. Radiation-induced ...

journal_title：Radiation research

authors： Christofidou-Solomidou M,Pietrofesa RA,Arguiri E,Koumenis C,Segal R

更新日期：2017-11-01 00:00:00