Urinary miRNAs as Biomarkers for Noninvasive Evaluation of Radiation-Induced Renal Tubular Injury.

abstract：:Diethylenetriaminepentaacetic acid (DTPA) is currently still the only known chelating drug that can be used for decorporation of internalized plutonium (Pu) and americium (Am). It is generally assumed that chelation occurs only in biological fluids, thus preventing Pu/Am deposition in target tissues. We postulate that...

journal_title：Radiation research

authors： Grémy O,Laurent D,Coudert S,Griffiths NM,Miccoli L

更新日期：2016-06-01 00:00:00

abstract：:A historical cohort mortality study was conducted among 28,008 white male employees who had worked for at least 1 month in Oak Ridge, Tennessee, during World War II. The workers were employed at two plants that were producing enriched uranium and a research and development laboratory. Vital status was ascertained thro...

journal_title：Radiation research

authors： Frome EL,Cragle DL,McLain RW

更新日期：1990-08-01 00:00:00

abstract：:The reactions of free and DNA-bound 2,2,5,5-tetramethylpyrrolidine-N-oxyl (PROXYL) probes with radicals generated during radiolysis of dilute aqueous solutions of DNA were examined. For the free PROXYL probe in deaerated solution with each of the four nucleotides (dAMP, dCMP, dGMP, and TMP) it was found that the pyrim...

journal_title：Radiation research

authors： Swarts SG,Sevilla MD

更新日期：1987-10-01 00:00:00

abstract：:While nontargeted and low-dose effects such as the bystander effect are now accepted, the mechanisms underlying the response have yet to be elucidated. It has been shown that the transfer of irradiated cell conditioned medium (ICCM) can kill cells that are not directly irradiated; however, to date the effect of ICCM c...

journal_title：Radiation research

authors： Ryan LA,Smith RW,Seymour CB,Mothersill CE

更新日期：2008-02-01 00:00:00

abstract：:Well-defined protocols and quality management standards are indispensable for biological dosimetry laboratories. Participation in periodic proficiency testing by interlaboratory comparisons is also required. This harmonization is essential if a cooperative network is used to respond to a mass casualty event. Here we p...

journal_title：Radiation research

authors： Di Giorgio M,Barquinero JF,Vallerga MB,Radl A,Taja MR,Seoane A,De Luca J,Oliveira MS,Valdivia P,Lima OG,Lamadrid A,Mesa JG,Aguilera IR,Cardoso TM,Carvajal YC,Maldonado CA,Espinoza ME,Martínez-López W,Méndez-Acuña L,

更新日期：2011-05-01 00:00:00

abstract：:This continues the series of periodic general reports on cancer mortality in the cohort of A-bomb survivors followed by the Radiation Effects Research Foundation. The follow-up is extended by the 5 years 1986-1990, and analysis includes an additional 10,500 survivors with recently estimated radiation doses. Together t...

journal_title：Radiation research

authors： Pierce DA,Shimizu Y,Preston DL,Vaeth M,Mabuchi K

更新日期：1996-07-01 00:00:00

abstract：:The model of radiation action that is presented relates the surviving fraction of irradiated cells to unrepaired DNA double-strand breaks (DSBs). The following assumptions are made in the model: (i) A DNA fragment created by the induced DSBs may move out of its chromosome (become lost), and the probability of that pro...

journal_title：Radiation research

authors： Ostashevsky JY

更新日期：1989-06-01 00:00:00

abstract：:Topical applications of MEA (beta-mercaptoethylamine or cysteamine), WR-2721 [S-2-(3-aminopropylamino)-ethylphosphorothioic acid], and N-acetylcysteine (NAC) were tested for their ability to protect the normal skin of the hind legs of mice against acute and late damage from single doses of 137Cs radiation. No signific...

journal_title：Radiation research

authors： Verhey LJ,Sedlacek R

更新日期：1983-01-01 00:00:00

abstract：:Caffeine was found to potentiate X-ray-induced killing of human diploid fibroblasts from a normal subject and an ataxia-telangiectasia (AT) patient when it was present at 2 mM concentration for 30 to 66 hr postirradiation. The dose-modifying factor for caffeine-treated normal cells had an average value of 1.26 +/- 0.1...

journal_title：Radiation research

authors： Furcinitti PS

更新日期：1983-07-01 00:00:00

abstract：:Previous studies showed that a 6-week pretreatment of rats with testosterone plus estradiol enhanced the recovery of spermatogenesis 9 weeks after gamma irradiation, resulting in a dose-modifying factor (DMF) of about 2. To test whether the effect of the hormone treatment was mediated through changes in oxygen tension...

journal_title：Radiation research

authors： Wilson G,Kangasniemi M,Meistrich ML

更新日期：1999-07-01 00:00:00

abstract：:In higher eukaryotes, DNA double-strand breaks (DSBs) induced by ionizing radiation activate checkpoints that delay progression through the cell cycle. Compared to delays in other phases of the cell cycle, delays induced in G(2) are longer and frequently correlate with resistance to killing by radiation. Therefore, mo...

journal_title：Radiation research

authors： Fan X,Cheong N,Iliakis G

更新日期：2010-10-01 00:00:00

abstract：:There are public concerns regarding possible carcinogenic or cancer-promoting effects of electromagnetic fields (EMFs) from mobile phones and base stations. The objective of the present study was to investigate whether chronic exposure to EMFs of the UMTS (Universal Mobile Telecommunication System) influences the deve...

journal_title：Radiation research

authors： Sommer AM,Bitz AK,Streckert J,Hansen VW,Lerchl A

更新日期：2007-07-01 00:00:00

abstract：:The space environment consists of a varying field of radiation particles including high-energy ions, with spacecraft shielding material providing the major protection to astronauts from harmful exposure. Unlike low-LEpsilonTau gamma or X rays, the presence of shielding does not always reduce the radiation risks for en...

journal_title：Radiation research

authors： Wu H,Hada M,Meador J,Hu X,Rusek A,Cucinotta FA

更新日期：2006-10-01 00:00:00

abstract：:Pepleomycin is a derivative of bleomycin, which is less toxic to the host but possesses greater antitumor activity. Experiments are described here in which Chinese hamster V-79 cells in culture and a murine squamous cell carcinoma in vivo have been used to obtain survival curves for pepleomycin alone or in combination...

journal_title：Radiation research

authors： Sakamoto K,Komatsu K,Matsumoto Y

更新日期：1985-05-01 00:00:00

abstract：:Experiments were performed to determine whether diurnal variations in apoptosis in the mouse small intestine after irradiation with 2.5 Gy gamma rays depended on the time of day that the mice were irradiated, the time of day that the mice were sacrificed or the interval between irradiation and sacrifice. Experiments w...

journal_title：Radiation research

authors： Ruifrok AC,Weil MM,Thames HD,Mason KA

更新日期：1998-04-01 00:00:00

abstract：:During the pulsed-electron beam direct grafting of neat styrene onto poly(tetrafluoroethylene-co-hexafluoropropylene) (FEP) substrate, the radiolytically-produced styryl and carbon-centered FEP radicals undergo various desired and undesired competing reactions. In this study, a high-dose rate is used to impede the und...

journal_title：Radiation research

authors： Kim B,Weaver A,Chumakov M,Pazos IM,Poster DL,Gaskell K,Han DH,Scherer G,Yandrasits MA,Lee BC,Al-Sheikhly M

更新日期：2018-09-01 00:00:00

abstract：:The hypothesis of boron neutron capture therapy (BNCT) research has been that the short-range, high-linear energy transfer radiation produced by the capture of thermal neutrons by (10)B will potentially control tumor and spare normal tissue only if the boron compound selectively targets tumor tissue within the treatme...

journal_title：Radiation research

authors： Trivillin VA,Heber EM,Nigg DW,Itoiz ME,Calzetta O,Blaumann H,Longhino J,Schwint AE

更新日期：2006-08-01 00:00:00

abstract：:The relationship between binucleate cell formation and the loss of colony-forming ability was examined in several cultured mammalian cell lines irradiated with X rays. The maximum fraction of binucleate cells after X irradiation increased dose-dependently within the range in which reproductive cell death might predomi...

journal_title：Radiation research

authors： Sasaki H,Yoshinaga H,Kura S

更新日期：1986-12-01 00:00:00

abstract：:Gleevec, a selective tyrosine kinase inhibitor, retarded the growth of anaplastic thyroid cancer cell lines in vitro and in vivo through selective inhibition of ABL tyrosine kinase activity. In the present study, we investigated the ability of Gleevec to modulate the in vitro and in vivo radiation response of anaplast...

journal_title：Radiation research

authors： Podtcheko A,Ohtsuru A,Namba H,Saenko V,Starenki D,Palona I,Sedliarou I,Rogounovitch T,Yamashita S

更新日期：2006-01-01 00:00:00

abstract：:Differentiation of Friend erythroleukemia cells (FELC) was induced with 1.5% dimethyl sulfoxide (DMSO) in the culture medium. Cell growth, erythroid differentiation, and radiosensitivity of the proliferative capacity of the cells were measured and compared to a noninduced control culture of identical age. Induced cell...

journal_title：Radiation research

authors： Einspenner M,Boulton JE,Borsa J

更新日期：1984-01-01 00:00:00

abstract：:Currently available treatments for radiation-induced nausea and vomiting either are ineffective or reduce performance. The new antiemetic and gastrokinetic agent zacopride was tested in rhesus monkeys to assess its behavioral toxicity and its ability to inhibit radiation-induced emesis. Zacopride (intragastric, 0.3 mg...

journal_title：Radiation research

authors： Dubois A,Fiala N,Boward CA,Bogo V

更新日期：1988-09-01 00:00:00

abstract：:We studied the effects of extremely low-frequency (50 Hz) electromagnetic fields (EMFs) on peripheral human blood lymphocytes and DBY747 Saccharomyces cerevisiae. Graded exposure to 50 Hz magnetic flux density was obtained with a Helmholtz coil system set at 1, 10 or 100 microT for 18 h. The effects of EMFs on DNA dam...

journal_title：Radiation research

authors： Luceri C,De Filippo C,Giovannelli L,Blangiardo M,Cavalieri D,Aglietti F,Pampaloni M,Andreuccetti D,Pieri L,Bambi F,Biggeri A,Dolara P

更新日期：2005-09-01 00:00:00

abstract：:Clustered DNA damage is considered an important factor in determining the biological consequences of ionizing radiation. In this study, we successfully estimated the localization of abasic sites (APs) in DNA exposed to ionizing radiation using fluorescence resonance energy transfer (FRET) without any involvement of re...

journal_title：Radiation research

authors： Akamatsu K,Shikazono N,Saito T

更新日期：2015-01-01 00:00:00

abstract：:Experimentally derived optical constants and X-ray attenuation cross sections were used to construct the complete dipole oscillator strength distribution for solid, dry DNA. Monte Carlo simulations of the energy loss by electrons of initial energy 5 keV to 1 MeV in DNA were performed using cumulative inelastic cross s...

journal_title：Radiation research

authors： LaVerne JA,Pimblott SM

更新日期：1995-02-01 00:00:00

abstract：:The non-human primate has been a useful model for studies of human acute radiation syndrome (ARS). However, to date structural changes in various parts of the intestine after total body irradiation (TBI) have not been systematically studied in this model. Here we report on our current study of TBI-induced intestinal s...

journal_title：Radiation research

authors： Wang J,Shao L,Hendrickson HP,Liu L,Chang J,Luo Y,Seng J,Pouliot M,Authier S,Zhou D,Allaben W,Hauer-Jensen M

更新日期：2015-11-01 00:00:00

abstract：:Numerous experimental and clinical studies have been completed regarding the effects of carbogen and nicotinamide on tumor oxygenation and radiosensitivity. The current study incorporates three physiological measurement techniques to further define spatial variations in oxygen availability and development of hypoxia a...

journal_title：Radiation research

authors： Fenton BM,Lord EM,Paoni SF

更新日期：2000-01-01 00:00:00

abstract：:We describe a rapid assay to predict intrinsic radiosensitivity of normal tissues based on the radiation-induced cytotoxic response of a number of types of white blood cells. Twenty-four hours after irradiation, leukocytes were prepared for analysis by flow cytometry. Radiation-induced cytotoxicity was characterized b...

journal_title：Radiation research

authors： Crompton NE,Ozsahin M

更新日期：1997-01-01 00:00:00

abstract：:Vascular change by the combined treatments of radiation and hyperthermia was studied. The legs of rats were irradiated with 2000 rad of X rays in a single dose and heated at 43.0 degrees C for 1 hr at various times after irradiation, and the blood flow and vascular volume in the skin and muscle were determined with 12...

journal_title：Radiation research

authors： Song CW,Kim JH,Rhee JG,Levitt SH

更新日期：1983-05-01 00:00:00

abstract：:The cellular sites for damage in mammalian cells caused by 193-nm radiation from an argon fluoride excimer laser were investigated. The ability of Chinese hamster ovary cells to reduce a tetrazolium dye (MTT) was decreased to 37% of unirradiated control by 2.5 x 10(3) J/m2 of 193-nm radiation when measured either 4 or...

journal_title：Radiation research

authors： Kochevar IE,Walsh AA,Held KD,Gallo RL,Mirro J

更新日期：1990-05-01 00:00:00

abstract：:The possibility of a large-scale acute radiation exposure necessitates the development of new methods that could provide rapid individual dose estimates with high sample throughput. The focus of the study was an intercomparison of laboratories' dose-assessment performances using gene expression assays. Lithium-heparin...

journal_title：Radiation research

authors： Badie C,Kabacik S,Balagurunathan Y,Bernard N,Brengues M,Faggioni G,Greither R,Lista F,Peinnequin A,Poyot T,Herodin F,Missel A,Terbrueggen B,Zenhausern F,Rothkamm K,Meineke V,Braselmann H,Beinke C,Abend M

更新日期：2013-08-01 00:00:00