Extremely low-frequency electromagnetic fields do not affect DNA damage and gene expression profiles of yeast and human lymphocytes.

abstract：:Chinese hamster ovary cells in suspension cultures were heated for various times at 41.5, 43.5, and 45.5 degrees C, and quantitative determinations of microblebbing and macroblebbing of the cell membrane were performed for cells maintained at 4, 25, and 37 degrees C after hyperthermia. The percentage of cells with ble...

journal_title：Radiation research

authors： Kapiszewska M,Hopwood LE

更新日期：1986-03-01 00:00:00

abstract：:This study was designed to determine changes in cell numbers, proliferation (using Ki-67) and EGFR expression in mouse bladder urothelium during the early and late radiation response. Groups of mice were irradiated with a single dose of 20 Gy and assayed 0-360 days later. Urothelial cells were counted. After immunohis...

journal_title：Radiation research

authors： Jaal J,Dörr W

更新日期：2010-04-01 00:00:00

abstract：:Telomeres cap the ends of chromosomes, preventing end-to-end fusions and subsequent chromosome instability. Here we used a telomerase knockout model to investigate whether telomerase participates in the processes of DNA break repair by de novo synthesis of telomere repeats at broken chromosome ends (chromosome healing...

journal_title：Radiation research

authors： Latre L,Genescà A,Martín M,Ribas M,Egozcue J,Blasco MA,Tusell L

更新日期：2004-08-01 00:00:00

abstract：:A spherical graphite calorimeter was used to determine the ratio of kerma to influence (kerma factor) for neutrons whose mean energy was approximately 14.6 MeV. The calorimeter was used to measure carbon kerma, while activation foils of Al and Au were used to determine the neutron fluence. The calorimeter was construc...

journal_title：Radiation research

authors： McDonald JC

更新日期：1987-01-01 00:00:00

abstract：:The goal of radiation therapy is to provide the highest probability of tumor control while minimizing normal tissue toxicity. Recently, it has been discovered that ultra-high dose rates of ionizing radiation may preferentially spare normal tissue over tumor tissue. This effect, referred to as FLASH radiotherapy, has b...

journal_title：Radiation research

authors： Colangelo NW,Azzam EI

更新日期：2020-01-01 00:00:00

abstract：:Four programs have been written to enable radiobiologists to build a computer data base of cellular dose-survival data, calculate cell survival with a correction for cell multiplicity at the time of irradiation, fit various survival models to the data by iteratively weighted least squares, and calculate the ratio of s...

journal_title：Radiation research

authors： Albright N

更新日期：1987-11-01 00:00:00

abstract：:Synchrotron microbeam radiation treatment (MRT) is a preclinical radiotherapy technique with considerable clinical promise, although some of the underlying radiobiology of MRT is still not well understood. In recently reported studies, it has been suggested that MRT elicits a different tumor immune profile compared to...

journal_title：Radiation research

authors： Ibahim MJ,Yang Y,Crosbie JC,Stevenson A,Cann L,Paiva P,Rogers PA

更新日期：2016-01-01 00:00:00

abstract：:Previous studies showed that a 6-week pretreatment of rats with testosterone plus estradiol enhanced the recovery of spermatogenesis 9 weeks after gamma irradiation, resulting in a dose-modifying factor (DMF) of about 2. To test whether the effect of the hormone treatment was mediated through changes in oxygen tension...

journal_title：Radiation research

authors： Wilson G,Kangasniemi M,Meistrich ML

更新日期：1999-07-01 00:00:00

abstract：:The molecular structure of mutants induced in human lymphoblast cells by 500 cGy X rays in the presence of the radioprotector cysteamine (25 mM) has been compared with that induced by an equally mutagenic treatment of 150 cGy X rays alone. Sets of mutants at the hypoxanthine-guanine phosphoribosyl transferase locus we...

journal_title：Radiation research

authors： Liber HL,Benforado K,Little JB

更新日期：1989-05-01 00:00:00

abstract：:The ability of the aminothiol WR-1065 [N-(2-mercaptoethyl)-1,3-diaminopropane] to protect L5178Y (LY) cells against the cytotoxic and mutagenic effects of exposure to accelerated (56)Fe ions (1.08 GeV/nucleon) was determined. It was found that while WR-1065 reduced the mutagenicity in both cell lines when it was prese...

journal_title：Radiation research

authors： Evans HH,Evans TE,Horng MF

更新日期：2002-07-01 00:00:00

abstract：:Alpha-particle irradiation of cells damages not only the irradiated cells but also nontargeted bystander cells. It has been proposed that the bystander effect is caused by oxidants and free radicals generated by the radiation. Recent studies have shown that α(1)-microglobulin protects against cell damage caused by oxi...

journal_title：Radiation research

authors： Olsson MG,Nilsson EJ,Rutardóttir S,Paczesny J,Pallon J,Akerström B

更新日期：2010-11-01 00:00:00

abstract：:Trp53 heterozygous mice are radiation-sensitive and cancer-prone. Groups of 7-8-week-old female Trp53 heterozygous mice were exposed to 4 Gy of 60Co gamma radiation at high (0.5 Gy/min) or low (0.5 mGy/min) dose rate. Other groups received 10 or 100 mGy at low dose rate 24 h prior to the 4-Gy dose. Tumor frequency and...

journal_title：Radiation research

authors： Mitchel RE,Jackson JS,Carlisle SM

更新日期：2004-07-01 00:00:00

abstract：:It is well established that high-LET radiations efficiently induce chromosome aberrations. However, data on the effect of protons on telomere maintenance, as involved in genomic stability, are scarce and contradictory. Here we demonstrate that high-LET protons induce telomere lengthening in human primary fibroblasts a...

journal_title：Radiation research

authors： Berardinelli F,Antoccia A,Cherubini R,De Nadal V,Gerardi S,Cirrone GA,Tanzarella C,Sgura A

更新日期：2010-11-01 00:00:00

abstract：:Based on murine survival studies, endogenous hemopoietic spleen colony formation (E-CFU), and recovery of bone marrow and splenic granulocyte-macrophage colony-forming cells (GM-CFC), it was demonstrated that the postirradiation administration of glucan, an immunomodulator and hemopoietic stimulant, enhances the radio...

journal_title：Radiation research

authors： Patchen ML,MacVittie TJ,Jackson WE

更新日期：1989-01-01 00:00:00

abstract：:We investigated the regeneration of rat thymus after sublethal X irradiation (6 Gy). The number of thymocytes was much lower on day 3 after irradiation, and many apoptotic cells were observed. However, by day 5, there had been a rapid proliferation of thymocytes. Since cytokines are considered to be important regulato...

journal_title：Radiation research

authors： Mizutani N,Fujikura Y,Wang YH,Tamechika M,Tokuda N,Sawada T,Fukumoto T

更新日期：2002-03-01 00:00:00

abstract：:Potentially lethal damage (PLD) repair has been defined as that property conferring the ability of cells to recover from DNA damage depending on the postirradiation environment. Using a novel cyclin dependent kinase 1 inhibitor RO-3306 to arrest cells in the G2 phase of the cell cycle, examined PLD repair in G2 in cul...

journal_title：Radiation research

authors： Maeda J,Bell JJ,Genet SC,Fujii Y,Genet MD,Brents CA,Genik PC,Kato TA

更新日期：2014-10-01 00:00:00

abstract：:Cataract is one of the major morbidities in the U.S. population and it has long been appreciated that high and acutely delivered radiation doses of 1 Gy or more can induce cataract. Some more recent studies, in particular those of the U.S. Radiologic Technologists, have suggested that cataract may be induced by much l...

journal_title：Radiation research

authors： Little MP,Patel A,Hamada N,Albert P

更新日期：2020-08-01 00:00:00

abstract：:A radiation-induced bystander response, which is generally defined as a cellular response that is induced in nonirradiated cells that received bystander signals from directly irradiated cells within an irradiated cell population. In our earlier X-ray microbeam studies, bystander cell killing in normal human fibroblast...

journal_title：Radiation research

authors： Tomita M,Maeda M,Kobayashi K,Matsumoto H

更新日期：2013-02-01 00:00:00

abstract：:Previous investigations have demonstrated an increased release of von Willebrand factor (VWF; also known as vWF) in endothelial cells after high single-dose irradiation in vitro. We have also found increased levels of Vwf protein in mouse glomeruli after a high single dose of renal irradiation in vivo. In addition, in...

journal_title：Radiation research

authors： van Kleef E,Verheij M,te Poele H,Oussoren Y,Dewit L,Stewart F

更新日期：2000-10-01 00:00:00

abstract：:We collected initial quantitative information on the effects of high-dose carbon (12C) ions compared to photons on vascular damage in anaplastic rat prostate tumors, with the goal of elucidating differences in response to high-LET radiation, using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Syngene...

journal_title：Radiation research

authors： Bendinger AL,Seyler L,Saager M,Debus C,Peschke P,Komljenovic D,Debus J,Peter J,Floca RO,Karger CP,Glowa C

更新日期：2020-01-01 00:00:00

abstract：:Comparatively high exposures to power-frequency electric and magnetic fields produce established biological effects that are explained by accepted mechanisms and that form the basis of exposure guidelines. Lower exposures to magnetic fields (< 1 microT average in the home) are classified as "possibly carcinogenic" on ...

journal_title：Radiation research

authors： Swanson J,Kheifets L

更新日期：2006-04-01 00:00:00

abstract：:Many of these deaths could be prevented if there were better screening methods to uncover the disease when it is limited and most responsive to intervention. Novel biomarkers of early-stage disease are therefore needed. By applying the principle of "oncology recapitulates ontogeny", we have discovered three homeobox (...

journal_title：Radiation research

authors： Lechner JF,Fugaro JM,Wong Y,Pass HI,Harris CC,Belinsky SA

更新日期：2001-01-01 00:00:00

abstract：:We have previously proposed that survival curves for cells of murine NFSa fibrosarcomas after exposure to fast neutrons might demonstrate curvature when the neutron doses reach a level high enough to cure the fibrosarcomas. We report here that this is the case. Murine NFSa fibrosarcomas growing in the hind legs of syn...

journal_title：Radiation research

authors： Ando K,Koike S,Sato S

更新日期：1992-08-01 00:00:00

abstract：:We have investigated tumor response to low-dose-rate irradiation from an implanted 125I source alone or in conjunction with intratumoral drug administration. The drug (cis-DDP or 5-FU) was incorporated homogeneously into the co-polymer CPP-SA, 20:80, and the polymer/drug rods were implanted in the RIF-1 fibrosarcomas ...

journal_title：Radiation research

authors： Berrada M,Yang Z,Lehnert SM

更新日期：2004-07-01 00:00:00

abstract：:This study was undertaken to determine if structural alterations of the bulk chromatin and the amount of protein associated with the nuclear matrix in cerebellar neurons depend on radiation dose and a cell's state of oxygenation. After irradiation with 2.5 to 25.0 Gy under both aerobic and anoxic conditions, the sensi...

journal_title：Radiation research

authors： Jaberaboansari A,Landis MR,Wallen CA,Wheeler KT

更新日期：1989-07-01 00:00:00

abstract：:The success of boron neutron capture therapy (BNCT) mainly depends on the boron concentration in the tumor and a high tumor/normal tissue (T/N) boron ratio or a high tumor/blood (T/B) boron ratio. Therefore, the effective enhancement of boron ratios is the first priority. Our study investigated whether a low-dose of γ...

journal_title：Radiation research

authors： Lin YC,Chou FI,Liao JW,Liu YH,Hwang JJ

更新日期：2021-01-29 00:00:00

abstract：:Our data (Reddy et al., Radiat. Res. 141, 252-258, 1995) on the kinetics of the repair of potentially lethal damage in log-phase Chinese hamster V79 cells are used to test some predictions which arise from the different assumptions of the repair-misrepair (RMR) (C. A. Tobias, Radiat. Res. 104, S77-S95, 1985), lethal-p...

journal_title：Radiation research

authors： Lange CS,Mayer PJ,Reddy NM

更新日期：1997-09-01 00:00:00

abstract：:Radiation exposure leads to a risk for long-term deterministic and stochastic late effects. Two individuals exposed to protracted photon radiation in the radiological accident at the Lilo Military site in Georgia in 1997 received follow-up treatment and resection of several chronic radiation ulcers in the Bundeswehr H...

journal_title：Radiation research

authors： Scherthan H,Abend M,Müller K,Beinke C,Braselmann H,Zitzelsberger H,Köhn FM,Pillekamp H,Schiener R,Das O,Peter RU,Herzog G,Tzschach A,Dörr HD,Fliedner TM,Meineke V

更新日期：2007-05-01 00:00:00

abstract：:The induction of intracellular DNA strand breaks by X rays and various heavy charged particles was measured by the alkaline unwinding and alkaline and neutral filter elution techniques. No variations in strand break induction were found between the different cell lines under investigation. For a given particle, both t...

journal_title：Radiation research

authors： Heilmann J,Rink H,Taucher-Scholz G,Kraft G

更新日期：1993-07-01 00:00:00

abstract：:A biophysical model has been developed that is based on the assumptions that an interphase chromosome occupies a spherical territory and that chromosome exchanges are formed by the misrejoining of two DNA double-strand breaks induced within a defined interaction distance. The model is used to explain the relative freq...

journal_title：Radiation research

authors： Wu H

更新日期：2001-11-01 00:00:00