Abstract:
:A biophysical model has been developed that is based on the assumptions that an interphase chromosome occupies a spherical territory and that chromosome exchanges are formed by the misrejoining of two DNA double-strand breaks induced within a defined interaction distance. The model is used to explain the relative frequencies of inter- and intrachromosomal exchanges and the relationship between radiation-induced aberrations in individual chromosomes and the DNA content of the chromosome. Although this simple model predicts a higher ratio of inter- to intrachromosomal exchanges for low-LET radiation than for high-LET radiation, as has been suggested by others, we argue that the comparison of the prediction of the model with experimental results is not straightforward. With the model, we also show that the probability of the formation of interchromosomal exchanges is proportional to the "surface area" of the chromosome domain plus a correction term. The correction term is small if the interaction distance is less than 1 microm for both low- and high-LET radiations.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Wu Hdoi
10.1667/0033-7587(2001)156[0603:poriia]2.0.co;2subject
Has Abstractpub_date
2001-11-01 00:00:00pages
603-6issue
5 Pt 2eissn
0033-7587issn
1938-5404journal_volume
156pub_type
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更新日期:1997-05-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1985-03-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
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更新日期:1992-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1984-11-01 00:00:00
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pub_type: 杂志文章
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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更新日期:1990-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1998-11-01 00:00:00
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