Abstract:
:In this study, we investigated the effect of (131)I gelatin microspheres ((131)I-GMSs) on human hepatocellular carcinoma cells (HepG2) in nude mice (Balb/c) and the biodistribution of (131)I-GMSs after intratumoral injection. The treatment group and control group animals received intratumoral injections of 1 mCi (131)I-GMSs and GMSs unlabeled (131)I, respectively. The size of the implanted tumor was measured once a week for 8 weeks, and the survival time was calculated from the day of injection to 64 days post-injection. Another 35 animals received intratumoral injections of 0.2 mCi (131)I-GMSs and were subject to single-photon emission computed tomography (SPECT) on days 1, 8, 16, 24 and 32 post-injection. Samples of various organs were collected and used to calculate tissue concentrations on days 1, 4, 8, 16 and 24. Free thyroxine (FT4) in fetal bovine serum was tested to evaluate thyroid function. The tumors were collected for histological examination. (131)I-GMSs produced a pronounced reduction in HepG2 tumor volume, and the overall survival was 73.3% in the treatment group and only 13.3% in the control group (P < 0.001). Tissue radioactivity concentration measurements and SPECT demonstrated that the injected (131)I-GMSs mainly accumulated within the tumors. The concentration of FT4 was stable during the observation period. The microspheres could be observed by histological methods on day 32. (131)I-GMSs suppressed the growth of HepG2 in the nude mice and were retained in the tumor for a long period of time after injection. Direct intratumoral injection of (131)I-GMSs offers a promising modality for the treatment of hepatocellular carcinoma.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Chi JL,Li CC,Xia CQ,Li L,Ma Y,Li JH,Chen Z,Chen XLdoi
10.1667/RR13539.1subject
Has Abstractpub_date
2014-04-01 00:00:00pages
416-24issue
4eissn
0033-7587issn
1938-5404journal_volume
181pub_type
杂志文章abstract::We recently reported that daily dietary supplementation with 100 µg selenium (a dose exceeding a rat's nutritional requirement by about 33-fold) initiated immediately after total-body irradiation (TBI) and maintained for 21 weeks mitigates radiation nephropathy in a rat model as indicated by blood urea nitrogen (BUN) ...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr2456.1
更新日期:2011-09-01 00:00:00
abstract::The (11)B(p,alpha)(8)Be* nuclear reaction was assessed for its ability to quantitatively map the in vivo subcellular distribution of boron within gliosarcomas treated with a boronated neutron capture therapy agent. Intracranial 9L gliosarcomas were produced in Fischer 344 rats. Fourteen days later, the majority of the...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3085
更新日期:2003-12-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR1487.1
更新日期:2009-04-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract::This report presents the results of an investigation of changes in the number of erythroid and granulocyte-macrophage colony-forming cells (GM-CFC) that had occurred in tissues of normal B6D2F1 mice 20 h after administration of a radioprotective dose (150 ng) of human recombinant interleukin-1 (rIL-1). Neutrophilia in...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1990-02-01 00:00:00
abstract::To study the acquired radioresistance of tumor cells, a model system of two cell lines, Djungarian hamster fibroblasts (DH-TK-) and their radioresistant progeny, was established. The progeny of irradiated cells were isolated by treating the parental cell monolayer with a single dose of 20 Gy (PIC-20). The genetic and ...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3443.1
更新日期:2005-12-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2003)159[0154:henswt]2.0.co;2
更新日期:2003-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1986-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3224
更新日期:2004-09-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::The development of image-guided small animal irradiators represents a significant improvement over standard irradiators by enabling preclinical studies to mimic radiotherapy in humans. The ability to deliver tightly collimated targeted beams, in conjunction with gantry or animal couch rotation, has the potential to ma...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR14753.1
更新日期:2017-09-01 00:00:00
abstract::New Zealand rabbits, fasted for 12 hours, were subjected to 500 rads of whole-body irradiation. K+-palmitate-1-14C oxidation was assayed with the 600 X g supernatant of thymus and liver homogenates, in the presence of ATP, at various time intervals from irradiation. For a period of 24 hours following irradiation, oxid...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1968-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1968-12-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract::The mechanisms underlying hepatocellular damage after irradiation are obscure. We identified genes induced by radiation in isolated rat hepatocytes in vitro by cDNA array gene expression analysis and then screened in vivo experiments with those same genes using real-time PCR and Western blotting. Hepatocytes were irra...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3503.1
更新日期:2006-03-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3255
更新日期:2004-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1990-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr2624.1
更新日期:2011-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR1687.1
更新日期:2009-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR14968.1
更新日期:2018-05-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::Following X irradiation of 3',5'-cyclic guanosine monophosphate single crystals at 10 K, several free radicals were trapped and detected by ESR/ENDOR/FSE spectroscopy. The two dominant species both have unpaired spin located on the guanine base. One is the product of net hydrogen atom loss from the exocyclic amino gro...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2002)158[0424:tsgbac]2.0.co;2
更新日期:2002-10-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1987-08-01 00:00:00