Abstract:
:The appearance of prostaglandins and thromboxane in mouse serum after X irradiation was observed by simultaneous quantitative analysis using gas chromatography/mass spectrometry/selected ion monitoring with stable isotope dilution methods. Mice of two strains (C57BL/CN Jcl and BALB/c) showed similar responses to X irradiation. In C57BL/6N Jcl mice, 0.2 Gy irradiation elicited a significant increase in generation of prostanoids: Immediately after irradiation, the 6-keto PGF1 alpha:TXB2 ratio and the level of PGE2 increased, after 20 min 6-keto PGF1 alpha and PGE2 increased, and after 4 h PGE1 and PGE2 increased. In BALB/c mice, generation of prostanoids was increased significantly immediately after irradiation (6-keto PGF1 alpha, 6-keto PGF1 alpha:TXB2 ratio, PGE2), and the increase was maintained from 20 min to 4 h (PGE1, PGE2) after 0.2 Gy irradiation. In C57BL/6N Jcl mice, a significant increase in production of 9alpha,11beta-PGF2 was observed at 20 min after irradiation. In BALB/c mice, a significant increase in 9alpha,11beta-PGF2 was seen immediately after irradiation and was maintained for 20 min. In C57BL/6N Jcl mice, the level of 8-epi PGF2 alpha was clearly increased 4 h after 4 Gy irradiation. A slight and slow increase was also seen after 0.2 Gy irradiation. In BALB/c mice, 8-epi PGF2 alpha was increased significantly at 20 min and 4 h after 4 Gy irradiation. These results show that 0.2 Gy irradiation stimulates production of prostanoids related to the inflammatory response in mice.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Yamaoka K,Obata T,Iriyama K,Iwasaki T,Hoshi Ysubject
Has Abstractpub_date
1998-01-01 00:00:00pages
103-6issue
1eissn
0033-7587issn
1938-5404journal_volume
149pub_type
杂志文章abstract::Hyperthermic sensitivities of Escherichia coli B/r and Bs-1 were determined for lag-, midlog-, and stationary-phase cells at 47, 48, and 49 degrees C. In both strains midlog-phase cells were strikingly more heat sensitive (100-fold greater killing after 4 h at 48 degrees C) than stationary-phase cells, with intermedia...
journal_title:Radiation research
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doi:
更新日期:1986-04-01 00:00:00
abstract::To determine whether different agents that enhance the expression of potentially lethal X-ray damage (PLD) interact with the same or different lesions (or spectrum of lesions), cell killing was measured in three kinds of experiments: (1) When cells were irradiated in G1 phase and treated with caffeine or hydroxyurea a...
journal_title:Radiation research
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更新日期:1991-11-01 00:00:00
abstract::The high-energy neutron component of the space radiation environment in thick structures such as the International Space Station contributes to the total radiation dose received by an astronaut. Detector design constraints such as size and mass have limited the energy range of neutron spectrum measurements in orbit to...
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1985-12-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Radiation research
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更新日期:2005-10-01 00:00:00
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更新日期:2013-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1991-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR14614.1
更新日期:2017-02-22 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR15358.1
更新日期:2019-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2000)154[0375:ivaive]2.0.co;2
更新日期:2000-10-01 00:00:00
abstract::Chomentowski, M., Kellerer, A. M. and Pierce, D. A. Radiation Dose Dependences in the Atomic Bomb Survivor Cancer Mortality Data: A Model-Free Visualization. The standard approach to obtaining nominal risk coefficients for radiation-related cancer involves fitting linear or linear-quadratic dose-response functions. Th...
journal_title:Radiation research
pub_type: 杂志文章
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更新日期:2000-03-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
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更新日期:2010-05-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR14655.1
更新日期:2017-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
abstract::Three experiments failed to provide consistent evidence for an effect of 2.70 GHz pulsed microwave radiation up to 20 mW/cm2 on pentylenetetrazol-induced seizures or on the efficacy of chlordiazepoxide for counteracting such seizures. Microwave radiation counteracted the hypothermic effects of chlordiazepoxide without...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1983-12-01 00:00:00
abstract::The neon beam at 250 MeV/nucleon from the Bevalac at the Lawrence Berkeley Laboratory is bombarded in nuclear emulsion. The experimental interaction cross section of the neon beam in emulsion is 1078 +/- 35 mb, in agreement with the calculations from the modified Bradt and Peters formula. The secondary fragments were ...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1985-09-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-02-01 00:00:00
abstract::The radiation environment in low-Earth orbit is a complex mixture of galactic cosmic radiation, particles of trapped belts and secondary particles generated in both the spacecraft and Earth's atmosphere. Infrequently, solar energetic particles are injected into the Earth's magnetosphere and can penetrate into low-Eart...
journal_title:Radiation research
pub_type: 杂志文章,评审
doi:
更新日期:1997-11-01 00:00:00
abstract::Sequential examinations were done on the pulmonary cytokinetics and pulmonary lesions in rats after inhalation exposure to (239)PuO(2) aerosols to investigate the pathogenesis of lung tumors. Total cell yields of lavaged bronchoalveolar cells as well as the estimated numbers of pulmonary alveolar macrophages were sign...
journal_title:Radiation research
pub_type: 杂志文章
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更新日期:2000-09-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
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更新日期:2002-08-01 00:00:00
abstract::The effects of multiple-dose gamma irradiation on the shape of survival curves were studied with mouse C3H 10T1/2 cells maintained in contact-inhibited plateau phase. The dose-fractionation intervals included 3, 6, and 24 h. Following three fractionated doses (5 Gy per dose) of exposures, cells responded to further ir...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1986-06-01 00:00:00
abstract::The success of boron neutron capture therapy (BNCT) mainly depends on the boron concentration in the tumor and a high tumor/normal tissue (T/N) boron ratio or a high tumor/blood (T/B) boron ratio. Therefore, the effective enhancement of boron ratios is the first priority. Our study investigated whether a low-dose of γ...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RADE-20-00102.1
更新日期:2021-01-29 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-05-01 00:00:00