Dose-Rate-Dependent PU.1 Inactivation to Develop Acute Myeloid Leukemia in Mice Through Persistent Stem Cell Proliferation After Acute or Chronic Gamma Irradiation.

abstract：:Cellular and molecular repair was studied at 23 degrees C using split-dose recovery and alkaline elution techniques, respectively, as a function of cellular oxygen and nutrient conditions. Hypoxic cells (0.001% O2) in full medium showed a partial reduction in the level of sublethal damage (SLD) repair relative to aera...

journal_title：Radiation research

authors： Spiro IJ,Kennedy KA,Stickler R,Ling CC

更新日期：1985-01-01 00:00:00

abstract：:Energy deposition clusters in the nanometer scale have been investigated systematically in electron, proton, and alpha-particle tracks. The mean absolute frequency distributions of ionization clusters in nanometer sites have been computed. For locally multiply damaged sites and especially for double-strand breaks, the...

journal_title：Radiation research

authors： Michalik V

更新日期：1993-06-01 00:00:00

abstract：:Phosphorylated ATM immunofluorescence staining was used to investigate the dose-response relationship for the number of DNA double-strand breaks (DSBs) induced in primary normal human fibroblasts irradiated with doses from 1.2 to 200 mGy. The induction of DSBs showed a supralinear dose-response relationship. Radiation...

journal_title：Radiation research

authors： Ojima M,Ban N,Kai M

更新日期：2008-09-01 00:00:00

abstract：:Pulmonary carcinomas were recorded in a life-span experiment of male Sprague-Dawley rats exposed to fission neutrons. Mortality-corrected prevalences are obtained by the method of isotonic regression. In a second part of the paper a comparison is made with data obtained earlier for radon-daughter inhalations in the sa...

journal_title：Radiation research

authors： Chmelevsky D,Kellerer AM,Lafuma J,Morin M,Masse R

更新日期：1984-06-01 00:00:00

abstract：:This study investigated whether the clonogenic ability of tumor cells to establish subcutaneous tumors and the tumor-associated macrophage (TAM) content correlate with the development and extent of the tumor bed effect (TBE). Ten tumors, five sarcomas and five carcinomas, syngeneic to C3Hf/Kam mice were used. Tumors w...

journal_title：Radiation research

authors： Milas L

更新日期：1990-08-01 00:00:00

abstract：:Well-defined protocols and quality management standards are indispensable for biological dosimetry laboratories. Participation in periodic proficiency testing by interlaboratory comparisons is also required. This harmonization is essential if a cooperative network is used to respond to a mass casualty event. Here we p...

journal_title：Radiation research

authors： Di Giorgio M,Barquinero JF,Vallerga MB,Radl A,Taja MR,Seoane A,De Luca J,Oliveira MS,Valdivia P,Lima OG,Lamadrid A,Mesa JG,Aguilera IR,Cardoso TM,Carvajal YC,Maldonado CA,Espinoza ME,Martínez-López W,Méndez-Acuña L,

更新日期：2011-05-01 00:00:00

abstract：:Solid thymidylyl-(3'-->5')-thymidine (dTpdT) was irradiated in a vacuum with monochromatic photons from 150 to 300 nm; the photoproducts were analyzed quantitatively by high-performance liquid chromatography. The results of the experiment were as follows: (1) above 210 nm the major photoproducts were three dithymine p...

journal_title：Radiation research

authors： Saitou M,Hieda K

更新日期：1994-11-01 00:00:00

abstract：:These studies examined the effects of X radiation and interleukin 3 (IL-3), which is an effective cytokine for the generation of megakaryocytopoiesis from X-irradiated hematopoietic stem/progenitor cells, on the terminal process of human megakaryocytopoiesis and thrombopoiesis. Mature megakaryocytes were induced by cu...

journal_title：Radiation research

authors： Monzen S,Osuda K,Miyazaki Y,Hayashi N,Takahashi K,Kashiwakura I

更新日期：2009-09-01 00:00:00

abstract：:Animal models of hematopoietic and gastrointestinal acute radiation syndromes (ARS) have been characterized to develop medical countermeasures. Acute radiation-induced decrease of intestinal absorptive function has been correlated to a decrease in the number of intestinal crypt cells resulting from apoptosis and enter...

journal_title：Radiation research

authors： Bujold K,Hauer-Jensen M,Donini O,Rumage A,Hartman D,Hendrickson HP,Stamatopoulos J,Naraghi H,Pouliot M,Ascah A,Sebastian M,Pugsley MK,Wong K,Authier S

更新日期：2016-07-01 00:00:00

abstract：:To evaluate the function of the reticuloendothelial system and macrophage-monocyte system, blood samples from Thorotrast patients and age-matched healthy controls were used to determine the titer of plasma antibodies to lipid A and the numbers of several lymphocyte subclasses in peripheral blood and for an autoradiogr...

journal_title：Radiation research

authors： Abe H,Kawahara T,Gondou K,Sakisaka S,Sata M

更新日期：1999-12-01 00:00:00

abstract：:Radiotherapy is one of the major treatment modalities for the management of various cancers, however, it is limited by the severe side effects and complications experienced by some patients. Nicaraven, a chemically synthesized hydroxyl radical-specific scavenger, has been shown to protect normal tissues from radiation...

journal_title：Radiation research

authors： Yan C,Luo L,Urata Y,Goto S,Guo CY,Li TS

更新日期：2017-02-22 00:00:00

abstract：:The incidence of micronuclei was evaluated to assess the induction of an adaptive response to non-ionizing radiofrequency (RF) radiation in peripheral blood lymphocytes collected from five different human volunteers. After stimulation with phytohemagglutinin for 24 h, the cells were exposed to an adaptive dose of 900 ...

journal_title：Radiation research

authors： Sannino A,Sarti M,Reddy SB,Prihoda TJ,Vijayalaxmi,Scarfì MR

更新日期：2009-06-01 00:00:00

abstract：:C57BL/6J male mice were inoculated with 5 X 10(5) B16a melanoma cells. Seven days post-inoculation, when the tumor had grown to 8.0-10.0 mm in diameter, 120 tumor-bearing mice were randomly divided into three groups: (1) sham-irradiated controls, (2) mice receiving 200 cGy five times a week for 6 weeks, and (3) mice r...

journal_title：Radiation research

authors： Shen RN,Hornback NB,Shidnia H,Lu L,Montebello JF,Brahmi Z

更新日期：1988-05-01 00:00:00

abstract：:Experiments were performed to determine whether diurnal variations in apoptosis in the mouse small intestine after irradiation with 2.5 Gy gamma rays depended on the time of day that the mice were irradiated, the time of day that the mice were sacrificed or the interval between irradiation and sacrifice. Experiments w...

journal_title：Radiation research

authors： Ruifrok AC,Weil MM,Thames HD,Mason KA

更新日期：1998-04-01 00:00:00

abstract：:Previous work showed that treatment of plateau-phase Chinese hamster ovary cells with the radiomimetic double-strand cleaving agent bleomycin induced very small deletions as well as interchromosomal reciprocal translocations, both of which could be ascribed to errors in end joining of DNA double-strand breaks. In an a...

journal_title：Radiation research

authors： Yu Y,Inamdar KV,Turner K,Jackson-Cook CK,Povirk LF

更新日期：2002-09-01 00:00:00

abstract：:Radon is recognized as a public health concern for indoor exposure. Precise quantification derived from occupational exposure in miners is still needed for estimating the risk and the factors that modify the dependence on cumulated exposure. The present paper reports on relationship between radon exposure and lung can...

journal_title：Radiation research

authors： Tomasek L,Rogel A,Tirmarche M,Mitton N,Laurier D

更新日期：2008-02-01 00:00:00

abstract：:Current and potential shortfalls in the number of radiation scientists stand in sharp contrast to the emerging scientific opportunities and the need for new knowledge to address issues of cancer survivorship and radiological and nuclear terrorism. In response to these challenges, workshops organized by the Radiation R...

journal_title：Radiation research

authors： Coleman CN,Stone HB,Alexander GA,Barcellos-Hoff MH,Bedford JS,Bristow RG,Dynlacht JR,Fuks Z,Gorelic LS,Hill RP,Joiner MC,Liu FF,McBride WH,McKenna WG,Powell SN,Robbins ME,Rockwell S,Schiff PB,Shaw EG,Siemann DW,Tr

更新日期：2003-12-01 00:00:00

abstract：:Identification of medical countermeasures (MCM) to mitigate radiation damage and/or protect first responders is a compelling unmet medical need. The prostaglandin E2 (PGE2) analog, 16,16 dimethyl-PGE2 (dmPGE2), has shown efficacy as a radioprotectant and radiomitigator that can enhance hematopoiesis and ameliorate int...

journal_title：Radiation research

authors： Patterson AM,Wu T,Chua HL,Sampson CH,Fisher A,Singh P,Guise TA,Feng H,Muldoon J,Wright L,Plett PA,Pelus LM,Orschell CM

更新日期：2020-12-10 00:00:00

abstract：:The health consequences of exposure to low-dose radiation combined with a solar particle event during space travel remain unresolved. The goal of this study was to determine whether protracted radiation exposure alters gene expression and oxidative burst capacity in the liver, an organ vital in many biological process...

journal_title：Radiation research

authors： Gridley DS,Coutrakon GB,Rizvi A,Bayeta EJ,Luo-Owen X,Makinde AY,Baqai F,Koss P,Slater JM,Pecaut MJ

更新日期：2008-03-01 00:00:00

abstract：:Normal human fibroblasts in plateau phase ( congruent with 95% G(1) phase) were stained with the vital nuclear dye Hoechst 33342 (blue fluorescence) or the vital cytoplasmic dye Cell Tracker Orange (orange fluorescence) and plated at a ratio of 1:1. Only the blue-fluorescing nuclei were microbeam-irradiated with a def...

journal_title：Radiation research

authors： Ponnaiya B,Jenkins-Baker G,Brenner DJ,Hall EJ,Randers-Pehrson G,Geard CR

更新日期：2004-10-01 00:00:00

abstract：:The effects of 60Co gamma rays on calcitonin gene-related peptide (CGRP)-immunoreactive nerve fibers and neuropeptide Y (NPY)-immunoreactive nerve fibers were examined in mesenteric blood vessels of rats. Using a free-floating immunostaining streptavidin-biotin peroxidase complex method combined with a nickel-enhancem...

journal_title：Radiation research

authors： Zhang CG,Cai WQ,Li Y,Huang WQ,Su HC

更新日期：1998-01-01 00:00:00

abstract：:In the 400-MHz 1H NMR spectra of gamma-irradiated, N2O-saturated aqueous solutions of polyuridylic acid (polyU), polycytidylic acid (polyC), polyadenylic acid (polyA), and single-stranded DNA from calf thymus, well-resolved signals of the undamaged free bases were identified. Upon incubation of the solutions at 95 deg...

journal_title：Radiation research

authors： Hildenbrand K,Mirtsch S,Schulte-Frohlinde D

更新日期：1993-06-01 00:00:00

abstract：:The structural maintenance of chromosome 1 (Smc1) protein is a member of the highly conserved cohesin complex and is involved in sister chromatid cohesion. In response to ionizing radiation, Smc1 is phosphorylated at two sites, Ser-957 and Ser-966, and these phosphorylation events are dependent on the ATM protein kina...

journal_title：Radiation research

authors： Ivey RG,Moore HD,Voytovich UJ,Thienes CP,Lorentzen TD,Pogosova-Agadjanyan EL,Frayo S,Izaguirre VK,Lundberg SJ,Hedin L,Badiozamani KR,Hoofnagle AN,Stirewalt DL,Wang P,Georges GE,Gopal AK,Paulovich AG

更新日期：2011-03-01 00:00:00

abstract：:These assessment of the consequences of irradiation on chromatin is complicated by endogenous nucleases. Isolation and prolonged storage of rat liver nuclei in buffers containing divalent metal ions activates these enzymes and promotes the degradation of chromatin. Irradiation of rat liver nuclei to dose levels of 20,...

journal_title：Radiation research

authors： Gelderblom D,Smit BJ,Böhm L

更新日期：1984-08-01 00:00:00

abstract：:To ensure the high-fidelity transmission by reproductive cells of genetic information from generation to generation, cells have evolved surveillance systems to eliminate genomic lesions by inducing cell suicide and/or DNA repair. In this report, gamma-ray-induced cell death was investigated using the medaka fish, Oryz...

journal_title：Radiation research

authors： Kuwahara Y,Shimada A,Mitani H,Shima A

更新日期：2002-04-01 00:00:00

abstract：:Clinicians involved in conventional radiation therapy are very concerned about the dose-response relationships of normal tissues. Before proceeding to new clinical protocols, radiation biologists involved with conformal proton therapy believe it is necessary to quantify the dose response and tolerance of the organs an...

journal_title：Radiation research

authors： Kubínová L,Mao X,Janácek J,Archambeau JO

更新日期：2003-07-01 00:00:00

abstract：:Sequential examinations were done on the pulmonary cytokinetics and pulmonary lesions in rats after inhalation exposure to (239)PuO(2) aerosols to investigate the pathogenesis of lung tumors. Total cell yields of lavaged bronchoalveolar cells as well as the estimated numbers of pulmonary alveolar macrophages were sign...

journal_title：Radiation research

authors： Oghiso Y,Yamada Y

更新日期：2000-09-01 00:00:00

abstract：:Numerous experimental and clinical studies have been completed regarding the effects of carbogen and nicotinamide on tumor oxygenation and radiosensitivity. The current study incorporates three physiological measurement techniques to further define spatial variations in oxygen availability and development of hypoxia a...

journal_title：Radiation research

authors： Fenton BM,Lord EM,Paoni SF

更新日期：2000-01-01 00:00:00

abstract：:The increasingly wider use of microdosimetry in fields other than pure radiobiological research, especially in "practical" domains such as radiation protection and medical physics, has created a number of new practitioners who are not fully acquainted with many of the experimental pitfalls which beset the aspiring mic...

journal_title：Radiation research

authors： Kliauga P

更新日期：1990-10-01 00:00:00

abstract：:Radiation-induced neurotoxicity is a well-characterized phenomenon. However, the underlying mechanism of this toxicity is poorly understood. In the central nervous system (CNS), excitotoxic mechanisms are implicated in many neurodegenerative disease processes. Pivotal to the excitotoxic pathway is dysfunction of gluta...

journal_title：Radiation research

authors： Sanchez MC,Nelson GA,Green LM

更新日期：2010-12-01 00:00:00