Lung cancer in French and Czech uranium miners: Radon-associated risk at low exposure rates and modifying effects of time since exposure and age at exposure.

abstract：:Abstract Double-strand breaks (DSBs) can be generated in the DNA of mammalian cells when heat-labile sites induced by ionizing radiation within a clustered DNA damage site are thermally transformed to single-strand breaks (SSBs) and combine with other SSBs or heat-labile sites in the opposite DNA strand. When this the...

journal_title：Radiation research

authors： Singh SK,Wu W,Wu W,Wang M,Iliakis G

更新日期：2009-08-01 00:00:00

abstract：:Total-body irradiation (TBI) induces an increase in levels of granulocytes and cortisol in blood. To explore the underlying mechanisms, we studied 26 patients who had TBI prior to bone marrow transplantation. Our findings suggest that only a high dose of TBI (10 Gy) was capable of activating the hypothalamo-pituitary ...

journal_title：Radiation research

authors： Girinsky TA,Pallardy M,Comoy E,Benassi T,Roger R,Ganem G,Cosset JM,Socié G,Magdelenat H

更新日期：1994-09-01 00:00:00

abstract：:Soil microorganisms in general and biocontrol agents in particular are very sensitive to UV light. The packaging of biocontrol microorganisms into cellular solids has been developed as a means of reducing loss caused by exposure to environmental UV radiation. The bacterial and fungal biocontrol agents Pantoea agglomer...

journal_title：Radiation research

authors： Zohar-Perez C,Chernin L,Chet I,Nussinovitch A

更新日期：2003-08-01 00:00:00

abstract：:Synthetic lysophospholipids represent a variety of analogs of the naturally occurring 2-lysophosphatidylcholine. Some of these compounds showed significant therapeutic effects on the survival of mice following radiation injury when administered after various doses of whole-body X irradiation. Such therapeutic effects ...

journal_title：Radiation research

authors： Berdel WE,Schick P,Sedlmeier H,Fink U,Rastetter J,Messerschmidt O

更新日期：1983-04-01 00:00:00

abstract：:We have previously observed time- and dose-dependent increases in matrix metalloproteinase 2 (Mmp2) protein levels in rat tubule epithelial cells (NRK52E) after irradiation. However, the mechanism(s) involved remains unclear. In the present study, irradiating NRK52E cells with 0-20 Gy gamma rays was associated with ti...

journal_title：Radiation research

authors： Zhao W,Goswami PC,Robbins ME

更新日期：2004-04-01 00:00:00

abstract：:Tumor radiotherapy with large-field irradiation results in an increase of p53-dependent apoptosis of the radiosensitive hematopoietic stem cells. Proapoptotic PUMA is a transcriptional target of p53. Thus suppression of PUMA expression by gene therapy with the transcription repressor SNAI2 as transgene might be a pote...

journal_title：Radiation research

authors： Maier P,Herskind C,Barzan D,Zeller WJ,Wenz F

更新日期：2010-05-01 00:00:00

abstract：:Radiation of the esophagus of C3H/HeNsd mice with 35 or 37 Gy of 6 MV X rays induces significantly increased RNA transcription for interleukin 1 (Il1), tumor necrosis factor alpha (Tnf), interferon gamma inducing factor (Ifngr), and interferon gamma (Ifng). These elevations are associated with DNA damage that is detec...

journal_title：Radiation research

authors： Epperly MW,Gretton JA,DeFilippi SJ,Greenberger JS,Sikora CA,Liggitt D,Koe G

更新日期：2001-01-01 00:00:00

abstract：:In boron neutron capture therapy, the absorbed dose from the (10)B(n,alpha)(7)Li reaction depends on the (10)B concentration and (10)B distribution in the irradiated volume. Thus compounds used in BNCT should have tumor-specific uptake and low accumulation in normal tissues. This study compares in a mouse model the (1...

journal_title：Radiation research

authors： Wittig A,Huiskamp R,Moss RL,Bet P,Kriegeskotte C,Scherag A,Hilken G,Sauerwein WA

更新日期：2009-10-01 00:00:00

abstract：:Transforming growth factor-β-activated kinase 1 (TAK1) appears to play a role in inhibiting apoptotic death in response to multiple stresses. To assess the role of TAK1 in X-ray induced apoptosis and cell death, we irradiated parental and siRNA-TAK1-knockdown HeLa cells. Changes in gene expression levels with and with...

journal_title：Radiation research

authors： Furusawa Y,Wei ZL,Sakurai H,Tabuchi Y,Li P,Zhao QL,Nomura T,Saiki I,Kondo T

更新日期：2012-06-01 00:00:00

abstract：:1. A survival curve for the colony-forming ability of mouse bone marrow cells irradiated in vivo with Co60 gamma-rays has been obtained. The curve may be characterized by D0 of 95 rads and an extrapolation number of 1.5. 2. Comparison with the survival curve obtained for irradiated in vitro indicated a statistically s...

journal_title：Radiation research

authors： McCulloch EA,Till JE

更新日期：1962-06-01 00:00:00

abstract：:To examine the role of radiation energy deposition in DNA on cellular effects, we investigated the ability of 125IdUrd and 131IdUrd to kill cells and induce mutations at the hprt locus. We employed human lymphoblastoid cells proficient (TK6) or deficient (SE30) in the ability to incorporate a thymidine analog into DNA...

journal_title：Radiation research

authors： Whaley JM,Little JB

更新日期：1990-07-01 00:00:00

abstract：:Chinese hamster ovary (CHO) cells were exposed to various concentrations of diethylmaleate (DEM) during a 42 degrees C incubation to determine if glutathione (GSH) compartmentalization was a factor in modification of thermal sensitivity. Cytoplasmic and mitochondrial GSH were isolated from CHO cells immediately after ...

journal_title：Radiation research

authors： Freeman ML,Meredith MJ

更新日期：1988-09-01 00:00:00

abstract：:The detection of (41)Ca atoms in tooth enamel using accelerator mass spectrometry is suggested as a method capable of reconstructing thermal neutron exposures from atomic bomb survivors in Hiroshima and Nagasaki. In general, (41)Ca atoms are produced via thermal neutron capture by stable (40)Ca. Thus any (41)Ca atoms ...

journal_title：Radiation research

authors： Wallner A,Rühm W,Rugel G,Nakamura N,Arazi A,Faestermann T,Knie K,Maier HJ,Korschinek G

更新日期：2010-08-01 00:00:00

abstract：:Many studies have shown the importance of altered cellular proto-oncogene expression in contributing to changes in cell survival, cell transformation, and cell cycle progression. In these experiments we examined the effects of total-body exposure of BCF1 mice to gamma rays (3 Gy) in modulating expression of cellular o...

journal_title：Radiation research

authors： Anderson A,Woloschak GE

更新日期：1992-06-01 00:00:00

abstract：:Radiotherapy is one of the major treatment modalities for the management of various cancers, however, it is limited by the severe side effects and complications experienced by some patients. Nicaraven, a chemically synthesized hydroxyl radical-specific scavenger, has been shown to protect normal tissues from radiation...

journal_title：Radiation research

authors： Yan C,Luo L,Urata Y,Goto S,Guo CY,Li TS

更新日期：2017-02-22 00:00:00

abstract：:Hypoxic BP-8 murine sarcoma cells were exposed to misonidazole and/or radiation and the kinetics and extent of cell death were evaluated with the [125I]iododeoxyuridine-prelabeling assay. Cell death after treatment with lethal doses of misonidazole was rapid and essentially complete within 2 or 3 days after drug expos...

journal_title：Radiation research

authors： Hofer KG,Friedland JL,Dynlacht J,Hofer MG

更新日期：1987-07-01 00:00:00

abstract：:While the risk of lung cancer associated separately with smoking and radiation exposure has been widely reported, it is not clear how smoking and radiation together contribute to the risk of specific lung cancer histological types. With individual smoking histories and radiation dose estimates, we characterized the jo...

journal_title：Radiation research

authors： Egawa H,Furukawa K,Preston D,Funamoto S,Yonehara S,Matsuo T,Tokuoka S,Suyama A,Ozasa K,Kodama K,Mabuchi K

更新日期：2012-09-01 00:00:00

abstract：:Using an electron storage ring as a source of radiation, the wavelength dependence of inactivation and membrane damage in yeast cells (Saccharomyces cerevisiae) was investigated in the range from 145 to 254 nm, with special reference to the effects of vacuum-uv radiation. The cells were irradiated on a Millipore filte...

journal_title：Radiation research

authors： Ito T,Ito A,Hieda K,Kobayashi K

更新日期：1983-12-01 00:00:00

abstract：:Several studies over recent years have highlighted the possibility that radiation can induce transmissible genomic instability. Most of these involve in vitro irradiation and usually in vitro culture. Here it is reported that the short-half-life bone-seeking alpha-particle emitter (224)Ra did not induce excess transmi...

journal_title：Radiation research

authors： Bouffler SD,Haines JW,Edwards AA,Harrison JD,Cox R

更新日期：2001-02-01 00:00:00

abstract：:Dose-response curves were measured for the formation of direct-type DNA products in X-irradiated d(GCACGCGTGC)(2)prepared as dry films and as crystalline powders. Damage to deoxyribose (dRib) was assessed by HPLC measurements of strand break products containing 3' or 5' terminal phosphate and free base release. Base d...

journal_title：Radiation research

authors： Swarts SG,Gilbert DC,Sharma KK,Razskazovskiy Y,Purkayastha S,Naumenko KA,Bernhard WA

更新日期：2007-09-01 00:00:00

abstract：:Impaired fluid and electrolyte transport in the intestine is a well-recognized characteristic of radiation-induced pathologies in the gastrointestinal tract. The aim of this study was to investigate the responsiveness of the epithelium of the colon of the rat to electrical and pharmacological (serotonin, carbachol) st...

journal_title：Radiation research

authors： François A,Dublineau I,Lebrun F,Ksas B,Griffiths NM

更新日期：1999-04-01 00:00:00

abstract：:The mutagenic activity of green (532 nm) and infrared (1064 nm) ultra-short laser light pulses was tested in cultured Syrian hamster fibroblasts by a hypoxanthine phosphoribosyl-transferase (HPRT) mutagenesis assay. In 18 irradiation trials, cells were exposed to eight consecutive 100-ps pulses of either 532 nm or 106...

journal_title：Radiation research

authors： Leavitt J,Fatone M,Hestdalen C,Obringer JW,Tillinghast HS Jr

更新日期：1997-04-01 00:00:00

abstract：:After total-body exposure to various doses of ionizing radiation, the ability of lymphocytes to interact specifically with high endothelial venules of rat cervical and mesenteric lymph nodes was analyzed in frozen sections. Following a radiation dose of 1.5 Gy, high endothelial venules remained intact and the binding ...

journal_title：Radiation research

authors： Hale ML,Briggs R,McCarthy KF

更新日期：1991-02-01 00:00:00

abstract：:Relatively few data are available on the prevalence of hyperthyroidism (TSH concentrations of <0.3 mIU/liter, with normal or elevated concentrations of free T4) in individuals exposed to radioiodines at low levels. The accident at the Chornobyl (Chernobyl) nuclear plant in Ukraine on April 26, 1986 exposed large numbe...

journal_title：Radiation research

authors： Hatch M,Furukawa K,Brenner A,Olinjyk V,Ron E,Zablotska L,Terekhova G,McConnell R,Markov V,Shpak V,Ostroumova E,Bouville A,Tronko M

更新日期：2010-12-01 00:00:00

abstract：:Single crystals of anhydrous inosine were studied subsequent to exposure to high and low doses of X radiation at 10 K using K-band, EPR, ENDOR, and field-swept-ENDOR (FSE) techniques. Immediately following high radiation doses at 10 K at least eight different radicals, RI-RVIII, were observed. All radicals, except for...

journal_title：Radiation research

authors： Hole EO,Nelson WH,Sagstuen E,Close DM

更新日期：1992-05-01 00:00:00

abstract：:There has been increased interest in the immune stimulatory properties of ionizing radiation based on several preclinical models and recently completed clinical studies performed in combination with checkpoint inhibitors. This is a paradigm shift in that it considers the role of radiation beyond its direct cytotoxic e...

journal_title：Radiation research

authors： Iyer SP,Hunt CR,Pandita TK

更新日期：2018-03-01 00:00:00

abstract：:A computer model that simulates the killing of exponentially growing cells by low-dose-rate radiation is described. The model incorporates cell killing by single-hit damage and double-hit (sublethal) damage, as well as repair of sublethal damage, delay of cell cycle progression, blockage and increased sensitivity of c...

journal_title：Radiation research

authors： Dillehay LE

更新日期：1990-11-01 00:00:00

abstract：:Statistical analysis of Monte Carlo simulations of positive ion track structure is presented for 1 MeV protons passing outside an absorbing region of interest. Energy deposition and production of ionization within the region occur only by delta-ray transport from the ion's path. Depositions in spherical absorber regio...

journal_title：Radiation research

authors： Wilson WE

更新日期：1994-12-01 00:00:00

abstract：:Normal human fibroblasts in plateau phase ( congruent with 95% G(1) phase) were stained with the vital nuclear dye Hoechst 33342 (blue fluorescence) or the vital cytoplasmic dye Cell Tracker Orange (orange fluorescence) and plated at a ratio of 1:1. Only the blue-fluorescing nuclei were microbeam-irradiated with a def...

journal_title：Radiation research

authors： Ponnaiya B,Jenkins-Baker G,Brenner DJ,Hall EJ,Randers-Pehrson G,Geard CR

更新日期：2004-10-01 00:00:00

abstract：:In previous studies we determined a gene expression signature in baboons for predicting the severity of hematological acute radiation syndrome. We subsequently validated a set of eight of these genes in leukemia patients undergoing total-body irradiation. In the current study, we addressed the effect of intra-individu...

journal_title：Radiation research

authors： Agbenyegah S,Abend M,Atkinson MJ,Combs SE,Trott KR,Port M,Majewski M

更新日期：2018-09-01 00:00:00