The sensitivity of cells from normal mouse bone marrow to gamma radiation in vitro and in vivo.

abstract：:Chinese hamster ovary cells in suspension cultures were heated for various times at 41.5, 43.5, and 45.5 degrees C, and quantitative determinations of microblebbing and macroblebbing of the cell membrane were performed for cells maintained at 4, 25, and 37 degrees C after hyperthermia. The percentage of cells with ble...

journal_title：Radiation research

authors： Kapiszewska M,Hopwood LE

更新日期：1986-03-01 00:00:00

abstract：:Statistical analysis of Monte Carlo simulations of positive ion track structure is presented for 1 MeV protons passing outside an absorbing region of interest. Energy deposition and production of ionization within the region occur only by delta-ray transport from the ion's path. Depositions in spherical absorber regio...

journal_title：Radiation research

authors： Wilson WE

更新日期：1994-12-01 00:00:00

abstract：:To investigate whether exposure to atomic bomb radiation altered the prevalence of hepatitis C virus (HCV) infection or accelerated the progress toward chronic hepatitis after HCV infection, the seropositivity of antibody to hepatitis C virus (anti-HCV) was determined for 6,121 participants in the Adult Health Study o...

journal_title：Radiation research

authors： Fujiwara S,Kusumi S,Cologne J,Akahoshi M,Kodama K,Yoshizawa H

更新日期：2000-07-01 00:00:00

abstract：:In the double-strand break (DSB) model, the initial slope (alpha) of the survival curve is determined by the number of DSBs remaining unrepaired at a certain time after irradiation. There are three types of calculations which confirm the validity of this approach. First, the model quite reasonably predicts the low-LET...

journal_title：Radiation research

authors： Ostashevsky JY

更新日期：1993-02-01 00:00:00

abstract：:This work provides a description of a new interaction, cross-section-based model for radiation-induced cellular inactivation, sublethal damage, DNA repair and cell survival, with the ability to more accurately elucidate different radiation-response phenomena. The principal goal of this work is to describe the damage-i...

journal_title：Radiation research

authors： Brahme A

更新日期：2020-09-16 00:00:00

abstract：:In previous studies, flavonoids, orientin and vicenin, that were isolated from the leaf extract of Ocimum sanctum, were found to protect mice against radiation injury. Several flavonoids are known to be good antioxidants. Therefore, the effect of orientin and vicenin on radiation-induced lipid peroxidation in vivo and...

journal_title：Radiation research

authors： Uma Devi P,Ganasoundari A,Vrinda B,Srinivasan KK,Unnikrishnan MK

更新日期：2000-10-01 00:00:00

abstract：:In an attempt to elucidate mechanisms underlying the variation in radiosensitivity during the cell cycle, mutations in the HPRT gene were selected with 6-thioguanine, quantified and characterized in synchronous human bladder carcinoma cells (EJ30-15) that were irradiated in G1 or S phase with 3 or 6 Gy. Synchronous ce...

journal_title：Radiation research

authors： Leonhardt EA,Trinh M,Forrester HB,Johnson RT,Dewey WC

更新日期：1997-12-01 00:00:00

abstract：:Phosphorylated ATM immunofluorescence staining was used to investigate the dose-response relationship for the number of DNA double-strand breaks (DSBs) induced in primary normal human fibroblasts irradiated with doses from 1.2 to 200 mGy. The induction of DSBs showed a supralinear dose-response relationship. Radiation...

journal_title：Radiation research

authors： Ojima M,Ban N,Kai M

更新日期：2008-09-01 00:00:00

abstract：:Numerous studies have shown that histone deacetylase inhibitors (HDACis) improve cellular acetylation while also enhancing the radiation sensitivity. In this work, however, we confirmed that low-dose trichostatin A (TSA) as a typical HDACi could reduce rather than increase the radiosensitivity of cancer cells, while t...

journal_title：Radiation research

authors： Zhang F,Shao C,Chen Z,Li Y,Jing X,Huang Q

更新日期：2021-01-29 00:00:00

abstract：:The goal of radiation therapy is to provide the highest probability of tumor control while minimizing normal tissue toxicity. Recently, it has been discovered that ultra-high dose rates of ionizing radiation may preferentially spare normal tissue over tumor tissue. This effect, referred to as FLASH radiotherapy, has b...

journal_title：Radiation research

authors： Colangelo NW,Azzam EI

更新日期：2020-01-01 00:00:00

abstract：:To determine whether systemic administration of MnSOD-PL protected mice from the acute hematopoietic syndrome and delayed death after total-body irradiation (TBI), C57BL/ 6J mice were injected intravenously with 100 microl liposomes containing 100 microg of human MnSOD-transgene plasmid 24 h prior to irradiation with ...

journal_title：Radiation research

authors： Epperly MW,Dixon T,Wang H,Schlesselman J,Franicola D,Greenberger JS

更新日期：2008-10-01 00:00:00

abstract：:It is well known that ionizing radiation-induced toxicity to normal tissue has functional consequences in the brain. However, the underlying molecular alterations have yet to be elucidated. We have previously reported cognitive impairments with concomitant changes in dendritic complexity, spine density and inflammatio...

journal_title：Radiation research

authors： Hinzman CP,Baulch JE,Mehta KY,Gill K,Limoli CL,Cheema AK

更新日期：2018-11-01 00:00:00

abstract：:The capacity of plateau-phase Chinese hamster V79 and normal and transformed C3H-10T1/2 cells for repair of potentially lethal radiation damage (PLD) was evaluated for cells irradiated alone or given combined treatments of heat and radiation. The data show that all cell lines tested could repair PLD and that transform...

journal_title：Radiation research

authors： Raaphorst GP,Azzam EI,Feeley M

更新日期：1988-01-01 00:00:00

abstract：:Although tissue mast cells are derived from the bone marrow, some descendants of bone marrow-derived precursors retain the ability to proliferate and differentiate into mast cells even after localization in the skin. The purpose of the present study was to determine the D0 values for mast-cell precursors in the bone m...

journal_title：Radiation research

authors： Kitamura Y,Yokoyama M,Sonoda T,Mori KJ

更新日期：1983-01-01 00:00:00

abstract：:After total-body exposure to various doses of ionizing radiation, the ability of lymphocytes to interact specifically with high endothelial venules of rat cervical and mesenteric lymph nodes was analyzed in frozen sections. Following a radiation dose of 1.5 Gy, high endothelial venules remained intact and the binding ...

journal_title：Radiation research

authors： Hale ML,Briggs R,McCarthy KF

更新日期：1991-02-01 00:00:00

abstract：:The nature of the primary biochemical defect in the human radiosensitive and cancer-prone syndrome, ataxia telangiectasia (AT), has remained obscure despite many efforts to elucidate it. In this study, AT complementation group D cells and a nearly isogenic corrected AT-hamster hybrid derivative have been analyzed for ...

journal_title：Radiation research

authors： Kysela BP,Lohrer H,Arrand JE

更新日期：1995-12-01 00:00:00

abstract：:A histopathological study was carried out on the spinal cord of rats after boron neutron capture (BNC) irradiation. Rats were irradiated with thermal neutrons alone or in combination with borocaptate sodium (BSH) or p-boronophenylalanine (BPA). Spinal cords were examined 1 year after irradiation, or at earlier times i...

journal_title：Radiation research

authors： Morris GM,Coderre JA,Bywaters A,Whitehouse E,Hopewell JW

更新日期：1996-09-01 00:00:00

abstract：:Eisenia fetida were exposed continuously to (60)Co gamma radiation during two generations (F(0) and F(1)). Adult F(0) reproduction capacity (i.e., number of cocoons produced, hatchability and number of F(1) hatchlings) in controls and at five dose rates (0.18, 1.7, 4, 11 and 43 mGy/h) was measured over a 13-week expos...

journal_title：Radiation research

authors： Hertel-Aas T,Oughton DH,Jaworska A,Bjerke H,Salbu B,Brunborg G

更新日期：2007-11-01 00:00:00

abstract：:Angiogenesis defines the many steps involved in the growth and migration of endothelial cell-derived blood vessels. This process is necessary for the growth and metastasis of tumors, and considerable effort is being expended to find inhibitors of tumor angiogenesis. This usually involves screening of potential anti-an...

journal_title：Radiation research

authors： Newton DL,Kaur G,Rhim JS,Sausville EA,Rybak SM

更新日期：2001-01-01 00:00:00

abstract：:The molecular basis of radiotherapy-related multidrug resistance (MDR) is still unclear. Here we report on a study investigating the effect of fractionated irradiation on expression of the MDR-associated proteins P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), and lung resistance-related protein ...

journal_title：Radiation research

authors： Bottke D,Koychev D,Busse A,Heufelder K,Wiegel T,Thiel E,Hinkelbein W,Keilholz U

更新日期：2008-07-01 00:00:00

abstract：:Using atomic force microscopy (AFM), we have investigated neutron-induced DNA double-strand breaks in plasmids in aqueous solution. AFM permits direct measurement of individual DNA molecules with an accuracy of a few nanometers. Furthermore, the analysis of the DNA fragment size distribution is non-parametric, whereas...

journal_title：Radiation research

authors： Pang D,Berman BL,Chasovskikh S,Rodgers JE,Dritschilo A

更新日期：1998-12-01 00:00:00

abstract：:Three somatic mutation assays were evaluated in men exposed to low-dose, whole-body, ionizing radiation. Blood samples were obtained between 1992 and 1999 from 625 Russian Chernobyl cleanup workers and 182 Russian controls. The assays were chromosome translocations in lymphocytes detected by FISH, hypoxanthine phospho...

journal_title：Radiation research

authors： Jones IM,Galick H,Kato P,Langlois RG,Mendelsohn ML,Murphy GA,Pleshanov P,Ramsey MJ,Thomas CB,Tucker JD,Tureva L,Vorobtsova I,Nelson DO

更新日期：2002-10-01 00:00:00

abstract：:The response of the testes of two strains of adult rats (Sprague-Dawley and Wistar) to graded single doses and split doses of 230 kVp X rays has been investigated. A marked difference was noted between the strains in the response of the clonogenic spermatogonia to irradiation, as measured histologically by the repopul...

journal_title：Radiation research

authors： Delic JI,Schlappack OK,Harwood JR,Stanley JA

更新日期：1987-10-01 00:00:00

abstract：:To evaluate the function of the reticuloendothelial system and macrophage-monocyte system, blood samples from Thorotrast patients and age-matched healthy controls were used to determine the titer of plasma antibodies to lipid A and the numbers of several lymphocyte subclasses in peripheral blood and for an autoradiogr...

journal_title：Radiation research

authors： Abe H,Kawahara T,Gondou K,Sakisaka S,Sata M

更新日期：1999-12-01 00:00:00

abstract：:The lactose operon functions under the control of the repressor-operator system. Binding of the repressor to the operator prevents the expression of the structural genes. This interaction can be destroyed by the binding of an inducer to the repressor. If ionizing radiations damage the partners, a dramatic dysfunction ...

journal_title：Radiation research

authors： Gillard N,Spotheim-Maurizot M,Charlier M

更新日期：2005-04-01 00:00:00

abstract：:The reactions of free and DNA-bound 2,2,5,5-tetramethylpyrrolidine-N-oxyl (PROXYL) probes with radicals generated during radiolysis of dilute aqueous solutions of DNA were examined. For the free PROXYL probe in deaerated solution with each of the four nucleotides (dAMP, dCMP, dGMP, and TMP) it was found that the pyrim...

journal_title：Radiation research

authors： Swarts SG,Sevilla MD

更新日期：1987-10-01 00:00:00

abstract：:The level and distribution of radiofrequency energy absorbed in a child's head during the use of a mobile phone compared to those in an adult head has been a controversial issue in recent years. It has been suggested that existing methods that are used to determine specific absorption rate (SAR) and assess compliance ...

journal_title：Radiation research

authors： Bit-Babik G,Guy AW,Chou CK,Faraone A,Kanda M,Gessner A,Wang J,Fujiwara O

更新日期：2005-05-01 00:00:00

abstract：:The success of boron neutron capture therapy (BNCT) mainly depends on the boron concentration in the tumor and a high tumor/normal tissue (T/N) boron ratio or a high tumor/blood (T/B) boron ratio. Therefore, the effective enhancement of boron ratios is the first priority. Our study investigated whether a low-dose of γ...

journal_title：Radiation research

authors： Lin YC,Chou FI,Liao JW,Liu YH,Hwang JJ

更新日期：2021-01-29 00:00:00

abstract：:To determine whether exposure to radiofrequency (RF) radiation can induce DNA damage or apoptosis, Molt-4 T lymphoblastoid cells were exposed with RF fields at frequencies and modulations of the type used by wireless communication devices. Four types of frequency/modulation forms were studied: 847.74 MHz code-division...

journal_title：Radiation research

authors： Hook GJ,Zhang P,Lagroye I,Li L,Higashikubo R,Moros EG,Straube WL,Pickard WF,Baty JD,Roti Roti JL

更新日期：2004-02-01 00:00:00

abstract：:Proteinase-activated receptor 2 (Par2, F2rl1, also designated PAR-2 or PAR2) is prominently expressed in the intestine and has been suggested as a mediator of inflammatory, mitogenic and fibrogenic responses to injury. Mast cell proteinases and pancreatic trypsin, both of which have been shown to affect the intestinal...

journal_title：Radiation research

authors： Wang J,Zheng H,Hollenberg MD,Wijesuriya SJ,Ou X,Hauer-Jensen M

更新日期：2003-11-01 00:00:00