Up-regulation and activation of proteinase-activated receptor 2 in early and delayed radiation injury in the rat intestine: influence of biological activators of proteinase-activated receptor 2.

abstract：:Some recent epidemiological studies have shown a positive association between cancer incidence and exposure to electromagnetic (EM) fields. Evidence from in vitro studies indicates that this effect could be due to synergistic interaction between EM fields and tumor promoters. However, no dose-response data related dir...

journal_title：Radiation research

authors： Balcer-Kubiczek EK,Harrison GH

更新日期：1991-04-01 00:00:00

abstract：:The effect of hypoxia on the induction of and recovery from damage by radiation alone and in combination with heat has been investigated using plateau-phase Chinese hamster ovary (CHO) cells. Postirradiation hypoxia reduced the potentially lethal damage recovery (PLDR) in cells irradiated under an euoxic state and com...

journal_title：Radiation research

authors： Rao BS,Hopwood LE

更新日期：1985-02-01 00:00:00

abstract：:The functional and morphological response of the remaining hypertrophied kidney in unilaterally nephrectomized rats to single doses of 0-20 Gy X rays was investigated. Functional and histological end points were assessed serially 4-24 weeks postirradiation. Renal irradiation led to time- and dose-dependent reductions ...

journal_title：Radiation research

authors： Robbins ME,O'Malley Y,Zhao W,Davis CS,Bonsib SM

更新日期：2001-03-01 00:00:00

abstract：:To evaluate the usefulness of the transgenic Muta mouse for investigating radiation-induced mutations in vivo, we have examined the effects of whole-body X irradiation and compared them to the effects of ultraviolet light. The spontaneous mutation frequencies in young adults were about 7 x 10(-5) in the spleen, liver ...

journal_title：Radiation research

authors： Ono T,Ikehata H,Hosoi Y,Shung BS,Kurishita A,Wang X,Yamamoto K,Suzuki T,Sofuni T

更新日期：1997-08-01 00:00:00

abstract：:Following X irradiation of 3',5'-cyclic guanosine monophosphate single crystals at 10 K, several free radicals were trapped and detected by ESR/ENDOR/FSE spectroscopy. The two dominant species both have unpaired spin located on the guanine base. One is the product of net hydrogen atom loss from the exocyclic amino gro...

journal_title：Radiation research

authors： Hole EO,Sagstuen E,Nelson WH,Close DM

更新日期：1992-01-01 00:00:00

abstract：:In the event of a radiation accident or attack, it will be imperative to quickly assess the amount of radiation exposure to accurately triage victims for appropriate care. RNA-based radiation dosimetry assays offer the potential to rapidly screen thousands of individuals in an efficient and cost-effective manner. Howe...

journal_title：Radiation research

authors： Pogosova-Agadjanyan EL,Fan W,Georges GE,Schwartz JL,Kepler CM,Lee H,Suchanek AL,Cronk MR,Brumbaugh A,Engel JH,Yukawa M,Zhao LP,Heimfeld S,Stirewalt DL

更新日期：2011-02-01 00:00:00

abstract：:Fanconi anemia (FA) is an inherited disorder characterized by defective DNA repair and cellular sensitivity to DNA crosslinking agents. Clinically, FA is associated with high risk for marrow failure, leukemia and head and neck squamous cell carcinoma (HNSCC). Radiosensitivity in FA patients compromises the use of tota...

journal_title：Radiation research

authors： Bernard ME,Kim H,Berhane H,Epperly MW,Franicola D,Zhang X,Houghton F,Shields D,Wang H,Bakkenist CJ,Frantz MC,Forbeck EM,Goff JP,Wipf P,Greenberger JS

更新日期：2011-11-01 00:00:00

abstract：:It was reported by others that hands-free accessories increase the absorption of RF energy in a human head compared to a handset alone. The results of this study show that the opposite is observed when proper dosimetric methods are employed. It is pointed out that for correct estimation of the exposure level it is nec...

journal_title：Radiation research

authors： Bit-Babik G,Chou CK,Faraone A,Gessner A,Kanda M,Balzano Q

更新日期：2003-04-01 00:00:00

abstract：:Normal human fibroblasts in plateau phase ( congruent with 95% G(1) phase) were stained with the vital nuclear dye Hoechst 33342 (blue fluorescence) or the vital cytoplasmic dye Cell Tracker Orange (orange fluorescence) and plated at a ratio of 1:1. Only the blue-fluorescing nuclei were microbeam-irradiated with a def...

journal_title：Radiation research

authors： Ponnaiya B,Jenkins-Baker G,Brenner DJ,Hall EJ,Randers-Pehrson G,Geard CR

更新日期：2004-10-01 00:00:00

abstract：:Radiation-induced endothelial cell apoptosis is involved in the development of many radiation injuries, including radiation-induced skin ulcers. The proangiogenic growth factors basic fibroblast growth factor (bFGF, NUDT6) and VEGF enhance endothelial cell survival. In the present study, we used primary cultured human...

journal_title：Radiation research

authors： Gu Q,Wang D,Wang X,Peng R,Liu J,Jiang T,Wang Z,Wang S,Deng H

更新日期：2004-06-01 00:00:00

abstract：:The relationship between binucleate cell formation and the loss of colony-forming ability was examined in several cultured mammalian cell lines irradiated with X rays. The maximum fraction of binucleate cells after X irradiation increased dose-dependently within the range in which reproductive cell death might predomi...

journal_title：Radiation research

authors： Sasaki H,Yoshinaga H,Kura S

更新日期：1986-12-01 00:00:00

abstract：:Resistance to radiation is considered to be an important reason for local failure after radiotherapy and tumor recurrence. However, the exact mechanisms of tumor resistance remain poorly understood. Current investigations of microRNAs as potential diagnostic and therapeutic tools for cancer treatment have shown promis...

journal_title：Radiation research

authors： Mueller AK,Lindner K,Hummel R,Haier J,Watson DI,Hussey DJ

更新日期：2016-06-01 00:00:00

abstract：:Eisenia fetida were exposed continuously to (60)Co gamma radiation during two generations (F(0) and F(1)). Adult F(0) reproduction capacity (i.e., number of cocoons produced, hatchability and number of F(1) hatchlings) in controls and at five dose rates (0.18, 1.7, 4, 11 and 43 mGy/h) was measured over a 13-week expos...

journal_title：Radiation research

authors： Hertel-Aas T,Oughton DH,Jaworska A,Bjerke H,Salbu B,Brunborg G

更新日期：2007-11-01 00:00:00

abstract：:There is evidence indicating that low-level exposures to low- LET radiation may inhibit the development of tumors, but the mechanism of this effect is virtually unknown. In the present study, BALB/c mice were irradiated with single doses of 0.1 or 0.2 Gy X rays and injected intravenously 2 h later with syngeneic L1 sa...

journal_title：Radiation research

authors： Cheda A,Wrembel-Wargocka J,Lisiak E,Nowosielska EM,Marciniak M,Janiak MK

更新日期：2004-03-01 00:00:00

abstract：:Puskin, J. S. What Can Epidemiology Tell Us about Risks at Low Doses? Radiat. Res. 169, 122-124 (2008). Limitations on statistical power preclude direct detection and quantification of radiogenic cancer risks at very low (environmental) levels of low-LET radiation through epidemiological studies. Given this limitation...

journal_title：Radiation research

authors： Puskin JS

更新日期：2008-01-01 00:00:00

abstract：:A standardized dichlorofluorescin (DCF) fluorometric assay capable of measuring radiation-induced oxidative stress was used to determine the effectiveness of protons and high-mass, high-atomic number (Z) and high-energy (HZE) particles to produce oxidative stress in vitro. Protons were found to be about equally as eff...

journal_title：Radiation research

authors： Wan XS,Bloch P,Ware JH,Zhou Z,Donahue JJ,Guan J,Stewart J,Kennedy AR

更新日期：2005-04-01 00:00:00

abstract：:Three experiments failed to provide consistent evidence for an effect of 2.70 GHz pulsed microwave radiation up to 20 mW/cm2 on pentylenetetrazol-induced seizures or on the efficacy of chlordiazepoxide for counteracting such seizures. Microwave radiation counteracted the hypothermic effects of chlordiazepoxide without...

journal_title：Radiation research

authors： Pappas BA,Anisman H,Ings R,Hill DA

更新日期：1983-12-01 00:00:00

abstract：:Radiation of the esophagus of C3H/HeNsd mice with 35 or 37 Gy of 6 MV X rays induces significantly increased RNA transcription for interleukin 1 (Il1), tumor necrosis factor alpha (Tnf), interferon gamma inducing factor (Ifngr), and interferon gamma (Ifng). These elevations are associated with DNA damage that is detec...

journal_title：Radiation research

authors： Epperly MW,Gretton JA,DeFilippi SJ,Greenberger JS,Sikora CA,Liggitt D,Koe G

更新日期：2001-01-01 00:00:00

abstract：:The effects of the methylxanthine, caffeine, on heat sensitization was investigated using Chinese hamster ovary (CHO) cells. Caffeine sensitized CHO cells to heat killing by reducing both the shoulder and the slope of the 44 degrees C survival curve. Heating was performed in suspension by addition of cells to preheate...

journal_title：Radiation research

authors： Coss RA,Smith NN

更新日期：1991-09-01 00:00:00

abstract：:Growth retardation due to exposure to the atomic bomb has been evaluated using repeated measurements of stature from 10 to 18 years of age. A highly significant growth retardation due to the DS86 uterine dose was observed in all trimesters combined and in the first and second trimesters of pregnancy. In the first trim...

journal_title：Radiation research

authors： Otake M,Fujikoshi Y,Schull WJ,Izumi S

更新日期：1993-04-01 00:00:00

abstract：:Previous work from our laboratory suggested that neuronal chromatin structure may be altered immediately after exposure to ionizing radiation. In the present study, whole brains of 4-month-old male Fisher 344 rats were irradiated with a dose of 25 Gy. The kinetics of restoring the chromatin structure to its unirradiat...

journal_title：Radiation research

authors： Jaberaboansari A,Nelson GB,Roti Roti JL,Wheeler KT

更新日期：1988-04-01 00:00:00

abstract：:Fluorescence in situ hybridization procedures were used to examine the influence of chromosome locus on the frequency and type of chromosome aberrations induced by 60Co gamma rays in the human lymphoblastoid cell line TK6. Aberrations involving the X chromosome were compared to those involving the similarly sized auto...

journal_title：Radiation research

authors： Jordan R,Schwartz JL

更新日期：1994-03-01 00:00:00

abstract：:The German Thorotrast study comprises 2,326 patients and 1,890 controls. Forty-eight Thorotrast patients and 239 controls are still alive and are invited for a follow-up examination every 2 years. In the deceased patients, the following neoplastic diseases with excess rates were registered (Thorotrast/controls): liver...

journal_title：Radiation research

authors： van Kaick G,Dalheimer A,Hornik S,Kaul A,Liebermann D,Lührs H,Spiethoff A,Wegener K,Wesch H

更新日期：1999-12-01 00:00:00

abstract：:Long-term retention of 133Ba in the trachea from intratracheally administered BaSO4 particles was determined by both serial sacrifice and external scanning methods up to 6 months after injection. The amount of 133Ba retained 1 week after injection in the caudal region of the trachea, where the tip of the cannula had b...

journal_title：Radiation research

authors： Takahashi S,Patrick G

更新日期：1987-06-01 00:00:00

abstract：:After a planned or unplanned radiation exposure, determination of absorbed dose has great clinical importance, informing treatment and triage decisions in the exposed individuals. Biodosimetry approaches allow for determination of dose in the absence of physical measurement apparatus. The current state-of-the-art biod...

journal_title：Radiation research

authors： Pujol-Canadell M,Young E,Smilenov L

更新日期：2019-05-01 00:00:00

abstract：:Biological response to ionizing radiation depends not only on the type of radiation and dose, but also on the duration and dose rate of treatment. For a given radiation dose, the biological response may differ based on duration and dose rate. We studied the properties of two human cell lines, M059K glioma and U2OS ost...

journal_title：Radiation research

authors： Nakajima H,Furukawa C,Chang YC,Ogata H,Magae J

更新日期：2017-08-01 00:00:00

abstract：:Previous work showed that treatment of plateau-phase Chinese hamster ovary cells with the radiomimetic double-strand cleaving agent bleomycin induced very small deletions as well as interchromosomal reciprocal translocations, both of which could be ascribed to errors in end joining of DNA double-strand breaks. In an a...

journal_title：Radiation research

authors： Yu Y,Inamdar KV,Turner K,Jackson-Cook CK,Povirk LF

更新日期：2002-09-01 00:00:00

abstract：:The (11)B(p,alpha)(8)Be* nuclear reaction was assessed for its ability to quantitatively map the in vivo subcellular distribution of boron within gliosarcomas treated with a boronated neutron capture therapy agent. Intracranial 9L gliosarcomas were produced in Fischer 344 rats. Fourteen days later, the majority of the...

journal_title：Radiation research

authors： Bench G,Grant PG,Ueda DL,Autry-Conwell SA,Hou Y,Boggan JE

更新日期：2003-12-01 00:00:00

abstract：:Many studies have shown the importance of altered cellular proto-oncogene expression in contributing to changes in cell survival, cell transformation, and cell cycle progression. In these experiments we examined the effects of total-body exposure of BCF1 mice to gamma rays (3 Gy) in modulating expression of cellular o...

journal_title：Radiation research

authors： Anderson A,Woloschak GE

更新日期：1992-06-01 00:00:00

abstract：:Previous surveys of radiation therapy among the Life Span Study (LSS) population at the Radiation Effects Research Foundation (RERF) revealed that 1,670 (1.4%) of the LSS participants received radiation treatments before 1984. The data on therapeutic radiation doses are indispensable for studying the relationship betw...

journal_title：Radiation research

authors： Kato K,Antoku S,Kodama K,Kawamura S,Fujita Y,Komatsu K,Awa AA

更新日期：2001-06-01 00:00:00