Basic fibroblast growth factor inhibits radiation-induced apoptosis of HUVECs. I. The PI3K/AKT pathway and induction of phosphorylation of BAD.

abstract：:The effects of multiple-dose gamma irradiation on the shape of survival curves were studied with mouse C3H 10T1/2 cells maintained in contact-inhibited plateau phase. The dose-fractionation intervals included 3, 6, and 24 h. Following three fractionated doses (5 Gy per dose) of exposures, cells responded to further ir...

journal_title：Radiation research

authors： Ngo FQ,Youngman K,Suzuki S,Koumoundouros I,Iliakis G

更新日期：1986-06-01 00:00:00

abstract：:Experimental measurements of the radial restricted linear energy transfer (LETr) for alpha beams of 18.3 MeV/n in tissue-equivalent gas were presented. The radial dose distribution for the alpha beam was deduced from the restricted LET measurements. A differential W value for the alpha particle in the tissue-equivalen...

journal_title：Radiation research

authors： Kanai T,Kawachi K

更新日期：1987-12-01 00:00:00

abstract：:The hyperthermic inhibition of cellular DNA synthesis, i.e., reduction in replicon initiation and delay in DNA chain elongation, was previously postulated to be involved in the induction of chromosomal aberrations believed to be largely responsible for killing S-phase cells. Utilizing asynchronous Chinese hamster ovar...

journal_title：Radiation research

authors： Wong RS,Thompson LL,Dewey WC

更新日期：1988-04-01 00:00:00

abstract：:Late radiation damage to pig skin has been assessed at 104 weeks after exposure to sources of 90Sr/90Y (Emax 2.2 MeV) and 170Tm (Emax 0.9 MeV). Damage was assessed from measurements of dermal thickness in histological sections of irradiated skin and was compared with that of unirradiated skin to establish the relative...

journal_title：Radiation research

authors： Hopewell JW,Sieber VK,Heryet JC,Wells J,Charles MW

更新日期：1993-03-01 00:00:00

abstract：:Comparatively high exposures to power-frequency electric and magnetic fields produce established biological effects that are explained by accepted mechanisms and that form the basis of exposure guidelines. Lower exposures to magnetic fields (< 1 microT average in the home) are classified as "possibly carcinogenic" on ...

journal_title：Radiation research

authors： Swanson J,Kheifets L

更新日期：2006-04-01 00:00:00

abstract：:We used Restriction Landmark Genome Scanning (RLGS) to assess, on a genome-wide basis, the mutation induction rate in mouse germ cells after radiation exposure. Analyses of 1,115 autosomal NotI DNA fragments per mouse for reduced spot intensity, indicative of loss of one copy, in 506 progeny derived from X-irradiated ...

journal_title：Radiation research

authors： Asakawa J,Kuick R,Kodaira M,Nakamura N,Katayama H,Pierce D,Funamoto S,Preston D,Satoh C,Neel JV,Hanash S

更新日期：2004-04-01 00:00:00

abstract：:In previous studies, flavonoids, orientin and vicenin, that were isolated from the leaf extract of Ocimum sanctum, were found to protect mice against radiation injury. Several flavonoids are known to be good antioxidants. Therefore, the effect of orientin and vicenin on radiation-induced lipid peroxidation in vivo and...

journal_title：Radiation research

authors： Uma Devi P,Ganasoundari A,Vrinda B,Srinivasan KK,Unnikrishnan MK

更新日期：2000-10-01 00:00:00

abstract：:Results from several laboratories, including ours, have suggested that measurements of radiation-induced DNA strand breaks and DNA-protein crosslinks (DPCs) may be used to estimate the hypoxic fraction or fractional hypoxic volume of tumors and normal tissues. This suggestion has been predicted on both published and u...

journal_title：Radiation research

authors： Zhang H,Koch CJ,Wallen CA,Wheeler KT

更新日期：1995-05-01 00:00:00

abstract：:To clarify the information in the Radiation Effects Research Foundation data regarding cancer risks of low radiation doses, we focus on survivors with doses less than 0.5 Sv. For reasons indicated, we also restrict attention mainly to survivors within 3, 000 m of the hypocenter of the bombs. Analysis is of solid cance...

journal_title：Radiation research

authors： Pierce DA,Preston DL

更新日期：2000-08-01 00:00:00

abstract：:To date, there are no safe and effective drugs available for protection against ionizing radiation damage. Therefore, a great need exists to identify and develop non-toxic agents that will be useful as radioprotectors or postirradiation therapies under a variety of operational scenarios. We have developed a new pharma...

journal_title：Radiation research

authors： Singh VK,Ducey EJ,Fatanmi OO,Singh PK,Brown DS,Purmal A,Shakhova VV,Gudkov AV,Feinstein E,Shakhov A

更新日期：2012-05-01 00:00:00

abstract：:Resistance to radiation is considered to be an important reason for local failure after radiotherapy and tumor recurrence. However, the exact mechanisms of tumor resistance remain poorly understood. Current investigations of microRNAs as potential diagnostic and therapeutic tools for cancer treatment have shown promis...

journal_title：Radiation research

authors： Mueller AK,Lindner K,Hummel R,Haier J,Watson DI,Hussey DJ

更新日期：2016-06-01 00:00:00

abstract：:Pentamidine is similar to rhodamine-123 in chemical structure and state of electron charge, and rhodamine-123 was previously shown to be a hyperthermic sensitizer under appropriate cell culture conditions. The present experiments were carried out to determine whether pentamidine would potentiate hyperthermic cell kill...

journal_title：Radiation research

authors： Kim SH,Hong SS,Alfieri AA,Kim JH

更新日期：1988-11-01 00:00:00

abstract：:Identification of medical countermeasures (MCM) to mitigate radiation damage and/or protect first responders is a compelling unmet medical need. The prostaglandin E2 (PGE2) analog, 16,16 dimethyl-PGE2 (dmPGE2), has shown efficacy as a radioprotectant and radiomitigator that can enhance hematopoiesis and ameliorate int...

journal_title：Radiation research

authors： Patterson AM,Wu T,Chua HL,Sampson CH,Fisher A,Singh P,Guise TA,Feng H,Muldoon J,Wright L,Plett PA,Pelus LM,Orschell CM

更新日期：2020-12-10 00:00:00

abstract：:At the Swiss Institute for Nuclear Research (SIN) cancer patients are irradiated with negatively charged pi mesons using a 60-beam medical pion generator, the Piotron. A low-pressure tissue-equivalent proportional counter was used to measure absorbed dose and microdosimetric spectra. A method was developed to allow di...

journal_title：Radiation research

authors： Schuhmacher H,Menzel HG,Blattmann H,Muth H

更新日期：1985-01-01 00:00:00

abstract：:Ionizing radiation can induce chromosome instability that is transmitted over many generations after irradiation in the progeny of surviving cells, but it remains unclear why this instability can be transmitted to the progeny. To acquire knowledge about the transmissible nature of genomic instability, we transferred a...

journal_title：Radiation research

authors： Mukaida N,Kodama S,Suzuki K,Oshimura M,Watanabe M

更新日期：2007-06-01 00:00:00

abstract：:The efficiency of boron neutron capture therapy (BNCT) for malignant gliomas depends on the selective and absolute accumulation of (10)B atoms in tumor tissues. Only two boron compounds, BPA and BSH, currently can be used clinically. However, the detailed distributions of these compounds have not been determined. Here...

journal_title：Radiation research

authors： Yokoyama K,Miyatake S,Kajimoto Y,Kawabata S,Doi A,Yoshida T,Okabe M,Kirihata M,Ono K,Kuroiwa T

更新日期：2007-01-01 00:00:00

abstract：:In this study, we investigated microvascular perfusion status, changes to fat content and fatty acid composition in the bone marrow of rat femurs after total-body irradiation by quantitative permeability parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and ex vivo high-resolution magic angl...

journal_title：Radiation research

authors： Wang K,Zha Y,Lei H,Xu X

更新日期：2018-02-01 00:00:00

abstract：:After total-body exposure to various doses of ionizing radiation, the ability of lymphocytes to interact specifically with high endothelial venules of rat cervical and mesenteric lymph nodes was analyzed in frozen sections. Following a radiation dose of 1.5 Gy, high endothelial venules remained intact and the binding ...

journal_title：Radiation research

authors： Hale ML,Briggs R,McCarthy KF

更新日期：1991-02-01 00:00:00

abstract：:Ionizing radiations induce mutations which can be detected both in coding sequences (Hprt locus) by measuring the frequency of 6-thioguanine-resistant cells and in minisatellite sequences by DNA fingerprint analysis. We analyzed the effects of irradiation with low-energy protons (31 keV/pm) and, for comparison, with u...

journal_title：Radiation research

authors： Ogheri S,Bruna V,Cera F,Favaretto S,Cherubini R,Celotti L

更新日期：1997-09-01 00:00:00

abstract：:Ketogenic diets are low in carbohydrates and high in fat, which forces cells to rely more heavily upon mitochondrial oxidation of fatty acids for energy. Relative to normal cells, cancer cells are believed to exist under a condition of chronic mitochondrial oxidative stress that is compensated for by increases in gluc...

journal_title：Radiation research

authors： Zahra A,Fath MA,Opat E,Mapuskar KA,Bhatia SK,Ma DC,Rodman SN III,Snyders TP,Chenard CA,Eichenberger-Gilmore JM,Bodeker KL,Ahmann L,Smith BJ,Vollstedt SA,Brown HA,Hejleh TA,Clamon GH,Berg DJ,Szweda LI,Spitz DR,Buat

更新日期：2017-06-01 00:00:00

abstract：:Technological developments in radiation therapy and other cancer therapies have led to a progressive increase in five-year survival rates over the last few decades. Although acute effects have been largely minimized by both technical advances and medical interventions, late effects remain a concern. Indeed, the need t...

journal_title：Radiation research

authors： Robbins ME,Brunso-Bechtold JK,Peiffer AM,Tsien CI,Bailey JE,Marks LB

更新日期：2012-04-01 00:00:00

abstract：:A dose-response relationship was established in normal unanesthetized cats for emetic incidence, latency to onset of vomiting, and duration of emetic activity over a period of 24 h after whole-body exposure to 60Co radiation at selected doses between 7.5 and 90 Gy. Each episode of vomiting, i.e., retching and expulsio...

journal_title：Radiation research

authors： Borison HL,McCarthy LE,Douple EB,Johnson J,Borison R

更新日期：1987-03-01 00:00:00

abstract：:Chinese hamster V79 cells show a complex X-ray survival response which is characterized by hypersensitivity followed by increased resistance as the dose increases to 1 Gy. This hypersensitivity can be eliminated by pretreating cells with X rays or hydrogen peroxide. Accordingly, the protective effect that results from...

journal_title：Radiation research

authors： Marples B,Skov KA

更新日期：1996-10-01 00:00:00

abstract：:A spherical graphite calorimeter was used to determine the ratio of kerma to influence (kerma factor) for neutrons whose mean energy was approximately 14.6 MeV. The calorimeter was used to measure carbon kerma, while activation foils of Al and Au were used to determine the neutron fluence. The calorimeter was construc...

journal_title：Radiation research

authors： McDonald JC

更新日期：1987-01-01 00:00:00

abstract：:We studied the spatial and temporal distributions of foci of the phosphorylated form of the histone protein H2AX (gamma-H2AX), which is known to be activated by double-strand breaks after irradiation of human fibroblast cells with high-energy silicon (54 keV/microm) and iron (176 keV/microm) ions. Here we present data...

journal_title：Radiation research

authors： Desai N,Davis E,O'Neill P,Durante M,Cucinotta FA,Wu H

更新日期：2005-10-01 00:00:00

abstract：:The present paper describes experiments conducted over the last several years which have focused primarily on the development of mammary tumors in BALB/c mice after neutron and gamma irradiation. Time-dose relationships for induction of mammary and lung tumors following irradiation with fission-spectrum neutrons and 1...

journal_title：Radiation research

authors： Ullrich RL

更新日期：1991-10-01 00:00:00

abstract：:Currently, there is a serious absence of pharmaceutically attractive small molecules that mitigate the lethal effects of an accidental or intentional public exposure to toxic doses of ionizing radiation. Moreover, cellular systems that emulate the radiobiologically relevant cell populations and that are suitable for h...

journal_title：Radiation research

authors： Zellefrow CD,Sharlow ER,Epperly MW,Reese CE,Shun T,Lira A,Greenberger JS,Lazo JS

更新日期：2012-09-01 00:00:00

abstract：:The mutagenic activity of green (532 nm) and infrared (1064 nm) ultra-short laser light pulses was tested in cultured Syrian hamster fibroblasts by a hypoxanthine phosphoribosyl-transferase (HPRT) mutagenesis assay. In 18 irradiation trials, cells were exposed to eight consecutive 100-ps pulses of either 532 nm or 106...

journal_title：Radiation research

authors： Leavitt J,Fatone M,Hestdalen C,Obringer JW,Tillinghast HS Jr

更新日期：1997-04-01 00:00:00

abstract：:Exposure to ionizing radiation or a variety of chemical agents is known to increase the risk of developing malignancy and many tumors have been linked to inflammatory processes. In most studies, the potentially harmful effects of ionizing radiation or other agents are considered in isolation, mainly due to the large n...

journal_title：Radiation research

authors： McAllister KA,Lorimore SA,Wright EG,Coates PJ

更新日期：2012-05-01 00:00:00

abstract：:Peroxidation of unconjugated polyunsaturated fatty acids such as linolenic acid proceeds through a free radical chain mechanism and is accompanied by the formation of conjugated dienes such as hydroperoxides. In an investigation of radiation-induced oxidation of aqueous linolenate, we have measured two indexes of pero...

journal_title：Radiation research

authors： Hindo J,Hauville C,Rémita S,Thérond P,Couturier M,Jore D,Gardès-Albert M

更新日期：2000-02-01 00:00:00