Abstract：
:Exposure to ionizing radiation or a variety of chemical agents is known to increase the risk of developing malignancy and many tumors have been linked to inflammatory processes. In most studies, the potentially harmful effects of ionizing radiation or other agents are considered in isolation, mainly due to the large number of experiments required to assess the effects of mixed exposures with different doses and different schedules, and the length of time and expense of studies using disease as the measure of outcome. Here, we have used short-term DNA damage responses to identify interactive effects of mixed exposures. The data demonstrate that exposure to ionizing radiation on two separate occasions ten days apart leads to an increase in the percentage of cells with a sub-G(0) DNA content compared to cells exposed only once, and this is a greater than additive effect. Short-term measurements of p53 stabilization, induction of p21/Cdkn1a and of apoptosis also identify these interactive effects. We also demonstrate similar interactive effects of radiation with the mutagenic chemical methyl-nitrosourea and with a nonspecific pro-inflammatory agent, lipopolysaccharide. The magnitude of the interactive effects is greater in cells taken from mice first exposed as juveniles compared to adults. These data indicate that short-term measurements of DNA damage and response to damage are useful for the identification of interactions between ionizing radiation and other agents.
journal_name
Radiat Resjournal_title
Radiation researchauthors
McAllister KA,Lorimore SA,Wright EG,Coates PJdoi
10.1667/rr2690.1subject
Has Abstractpub_date
2012-05-01 00:00:00pages
584-93issue
5eissn
0033-7587issn
1938-5404pii
10.1667/RR2690.1journal_volume
177pub_type
杂志文章abstract：:Polonium-210 is a naturally occurring radioactive element that decays by emitting an alpha particle. It is in the air we breathe and also a component of tobacco smoke. Polonium-210 is used as an anti-static device in printing presses and gained widespread notoriety in 2006 after the poisoning and subsequent death of a...
journal_title：Radiation research
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abstract：:Animal models of hematopoietic and gastrointestinal acute radiation syndromes (ARS) have been characterized to develop medical countermeasures. Acute radiation-induced decrease of intestinal absorptive function has been correlated to a decrease in the number of intestinal crypt cells resulting from apoptosis and enter...
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更新日期：2016-07-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR13542.1
更新日期：2014-11-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14193.1
更新日期：2016-06-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2003-04-01 00:00:00
abstract：:Cognitive impairments after brain irradiation seriously affect quality of life for patients, and there is currently no effective treatment. In this study using an irradiated rat model, the role of electroacupuncture was investigated for treatment of radiation-induced brain injury. Animals received 10 Gy exposure to th...
journal_title：Radiation research
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更新日期：2017-06-01 00:00:00
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更新日期：2012-09-01 00:00:00
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更新日期：2006-06-01 00:00:00
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journal_title：Radiation research
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更新日期：2015-11-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR13494.1
更新日期：2014-05-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:As a follow-up to the two previous surveys of radiation therapy among the atomic bomb survivors, a large-scale survey was performed to document (1) the number of radiation therapy treatments received by the atomic bomb survivors and (2) the types of radiation treatments conducted in Hiroshima and Nagasaki. The previou...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2000)153[0587:aeowbp]2.0.co;2
更新日期：2000-05-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1012.1
更新日期：2007-11-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3395.1
更新日期：2005-11-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3443.1
更新日期：2005-12-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章,评审
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更新日期：2009-02-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2006-07-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
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pub_type： 杂志文章
doi：10.1667/RR0535.1
更新日期：2006-10-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2002)157[0038:ssoatt]2.0.co;2
更新日期：2002-01-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14753.1
更新日期：2017-09-01 00:00:00
abstract：:The potential carcinogenic effects of internally deposited alpha-particle-emitting nuclides, notably plutonium, in the liver in humans are unknown but are of concern in relation to exposures from the nuclear industry. However, patients injected with the radiographic contrast medium Thorotrast are chronically exposed t...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-02-01 00:00:00
abstract：:Neither cell division nor growth of Saccharomyces cerevisiae were stimulated by the ultraviolet luminescence produced by adjacent exponential phase cultures of the yeast. The study included experiments in which the inocula (density = 5 X 10(7) cells cm-3) were irradiated and in which lag phase cultures (densities = 1 ...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1985-05-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：:The effectiveness of 5-fluorouracil (5-FU), FT-207 and FT-207 + uracil in combination with two repetitions of 43 degrees C hyperthermia in the treatment of the Meth-A-Fibrosarcoma and Sarcoma-180 was examined in vivo in BALB/c mice. The antitumor effect was evaluated in terms of inhibition of tumor growth by measuring...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
