Abstract:
:The efficiency of boron neutron capture therapy (BNCT) for malignant gliomas depends on the selective and absolute accumulation of (10)B atoms in tumor tissues. Only two boron compounds, BPA and BSH, currently can be used clinically. However, the detailed distributions of these compounds have not been determined. Here we used secondary ion mass spectrometry (SIMS) to determine the histological distribution of (10)B atoms derived from the boron compounds BSH and BPA. C6 tumor-bearing rats were given 500 mg/kg of BPA or 100 mg/kg of BSH intraperitoneally; 2.5 h later, their brains were sectioned and subjected to SIMS. In the main tumor mass, BPA accumulated heterogeneously, while BSH accumulated homogeneously. In the peritumoral area, both BPA and BSH accumulated measurably. Interestingly, in this area, BSH accumulated distinctively in a diffuse manner even 800 microm distant from the interface between the main tumor and normal brain. In the contralateral brain, BPA accumulated measurably, while BSH did not. In conclusion, both BPA and BSH each have advantages and disadvantages. These compounds are considered to be essential as boron delivery agents independently for clinical BNCT. There is some rationale for the simultaneous use of both compounds in clinical BNCT for malignant gliomas.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Yokoyama K,Miyatake S,Kajimoto Y,Kawabata S,Doi A,Yoshida T,Okabe M,Kirihata M,Ono K,Kuroiwa Tdoi
10.1667/RR0501.1subject
Has Abstractpub_date
2007-01-01 00:00:00pages
102-9issue
1eissn
0033-7587issn
1938-5404pii
RR0501journal_volume
167pub_type
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journal_title:Radiation research
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