Abstract:
:Radiation-induced free radical damage in solid-state DNA arises from direct-type damage mechanisms. In the present study, free radical yields in film and lyophilized Na DNA model systems are compared. The free radical yields in lyophilized samples are significantly greater than those in films. Since DNA conformation cannot account for the differences in free radical yields between different DNA preparations, it is proposed that the intermolecular spacing of DNA is a critical variable. The differences in the hydration dependence of free radical yields between the film and lyophilized DNA model systems are consistent with this thesis. The relatively large free radical yields observed in lyophilized DNA emphasize the fact that DNA is an extremely effective electron and hole scavenger, more so than previously thought.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Milano MT,Bernhard WAsubject
Has Abstractpub_date
1999-08-01 00:00:00pages
196-201issue
2eissn
0033-7587issn
1938-5404journal_volume
152pub_type
杂志文章abstract::There has been ongoing debate and discussion concerning whether the funding source influenced the outcome of research on human health effects from exposure to radiofrequency fields (RF, electromagnetic waves that carry energy as they propagate in air and dense media). In a study of 225 publications, in which we sought...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR15364.1
更新日期:2019-10-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1990-09-01 00:00:00
abstract::Pulmonary carcinomas were recorded in a life-span experiment of male Sprague-Dawley rats exposed to fission neutrons. Mortality-corrected prevalences are obtained by the method of isotonic regression. In a second part of the paper a comparison is made with data obtained earlier for radon-daughter inhalations in the sa...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1984-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR3232.1
更新日期:2013-06-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR1389.1
更新日期:2009-01-01 00:00:00
abstract::Acute thermotolerance was induced in Chinese hamster ovary cells by heating at 43 degrees C for 45 min followed by incubation at 37 degrees C for up to 85 h. The degree of thermotolerance induced was quantified by a second heat exposure at 43 degrees C. To study the interaction of thermotolerance and thermosensitizati...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::Sequential examinations were done on the pulmonary cytokinetics and pulmonary lesions in rats after inhalation exposure to (239)PuO(2) aerosols to investigate the pathogenesis of lung tumors. Total cell yields of lavaged bronchoalveolar cells as well as the estimated numbers of pulmonary alveolar macrophages were sign...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2000)154[0253:ppolti]2.0.co;2
更新日期:2000-09-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2000)154[0326:todiiq]2.0.co;2
更新日期:2000-09-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2000)154[0178:rrcral]2.0.co;2
更新日期:2000-08-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR1173.1
更新日期:2008-04-01 00:00:00
abstract::Male rabbits were exposed to a single irradiation dose of 1000-5000 rad when 12, 15, 16, and 17 months old and were killed when 18 months old (i.e., 1, 2, 3, and 6 months after irradiation). Even after this long interval after irradiation, abdominal aortic prostacyclin formation was significantly depressed, whereas th...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2000)154[0375:ivaive]2.0.co;2
更新日期:2000-10-01 00:00:00
abstract::After total-body exposure to various doses of ionizing radiation, the ability of lymphocytes to interact specifically with high endothelial venules of rat cervical and mesenteric lymph nodes was analyzed in frozen sections. Following a radiation dose of 1.5 Gy, high endothelial venules remained intact and the binding ...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1991-02-01 00:00:00
abstract::Using atomic force microscopy (AFM), we have investigated neutron-induced DNA double-strand breaks in plasmids in aqueous solution. AFM permits direct measurement of individual DNA molecules with an accuracy of a few nanometers. Furthermore, the analysis of the DNA fragment size distribution is non-parametric, whereas...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract::The effect of hypoxia on the induction of and recovery from damage by radiation alone and in combination with heat has been investigated using plateau-phase Chinese hamster ovary (CHO) cells. Postirradiation hypoxia reduced the potentially lethal damage recovery (PLDR) in cells irradiated under an euoxic state and com...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1985-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR14614.1
更新日期:2017-02-22 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1989-02-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2001)155[0785:odfrti]2.0.co;2
更新日期:2001-06-01 00:00:00
abstract::Base damage flanking a radiation-induced DNA double-strand break (DSB) may contribute to DSB complexity and affect break repair. However, to date, an isolated radiation-induced DSB has not been assessed for such structures at the molecular level. In this study, an authentic site-specific radiation-induced DSB was prod...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR0628.1
更新日期:2006-11-01 00:00:00
abstract::Intestinal microbiota affect cell responses to ionizing radiation at the molecular level and can be linked to the development of the immune system, controlled cell death or apoptosis. We have developed a microbiota mouse model and report here that high-linear energy transfer (LET) radiation induced the repair of chrom...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR13837.1
更新日期:2015-06-01 00:00:00
abstract::We have previously proposed that survival curves for cells of murine NFSa fibrosarcomas after exposure to fast neutrons might demonstrate curvature when the neutron doses reach a level high enough to cure the fibrosarcomas. We report here that this is the case. Murine NFSa fibrosarcomas growing in the hind legs of syn...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract::Thymic explant cultures were used to study the radiosensitivity of nonlymphoid thymic components in dogs. Thymic fragments from fetal (50 days gestation), newborn, and juvenile (70 days old) dogs were irradiated in vitro at 0, 0.5, 1, 2, or 4 Gy prior to culture. Colonies were classified as epithelial, spindle, or mix...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
abstract::We have studied the effects of dose rate and dose fractionation on murine pulmonary alveolar macrophage colony-forming cells (AL-CFC). The dose-response curve of AL-CFC to ionizing irradiation has a Dq of about 100 rad, reflecting the cells' ability to repair sublethal damage. For comparison, we investigated the effec...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1985-08-01 00:00:00
abstract::This commentary considers modulation as a factor of potential biological importance in assessment of risk of radiofrequency (RF) energy emitted by communications systems and other technologies. Modulation introduces a spread of frequencies into a carrier waveform, but in nearly all cases this spread is small compared ...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3191
更新日期:2004-08-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00