Abstract:
:Pulmonary carcinomas were recorded in a life-span experiment of male Sprague-Dawley rats exposed to fission neutrons. Mortality-corrected prevalences are obtained by the method of isotonic regression. In a second part of the paper a comparison is made with data obtained earlier for radon-daughter inhalations in the same strain of rats. A simultaneous maximum likelihood analysis is applied jointly to all experimental groups from the radon inhalation and the fission neutron study. The dependence of the resulting coefficients for the different groups on absorbed dose or inhalation dose permits a derivation of equivalence ratios. At low doses the equivalence ratio is 3 WLM (working level months) of radon-daughter exposure to 1 mGy of fission neutrons. At higher doses the equivalence ratio decreases. The neutron data are also utilized to derive mortality-corrected lifetime incidences of pulmonary carcinomas in the exposed animals. At low doses the relation is consistent with linearity, but sublinearity (dose exponent less than 1) cannot be excluded.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Chmelevsky D,Kellerer AM,Lafuma J,Morin M,Masse Rsubject
Has Abstractpub_date
1984-06-01 00:00:00pages
519-35issue
3eissn
0033-7587issn
1938-5404journal_volume
98pub_type
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doi:
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pub_type: 杂志文章
doi:
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更新日期:1983-03-01 00:00:00
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更新日期:1987-10-01 00:00:00
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