Peripheral lymphocyte response to PHA and T cell population among atomic bomb survivors.

abstract：:Alteration of adhesion molecule expression on endothelial cells has a direct connection with ionizing radiation-induced atherosclerosis, which is an adverse effect observed after radiotherapy. However, minimal attention has been given to monocytes/macrophages role in atherosclerosis development, which are exposed to t...

journal_title：Radiation research

authors： Yuan Y,Lee SH,Wu S

更新日期：2013-01-01 00:00:00

abstract：:Cell-cell contact is thought to be critically involved in mechanisms leading to radioresistance. Here, we assessed the influence of confluent compared to subconfluent cell culture conditions and the radiosensitizing ability of E-cadherin inhibition alone or in combination with C225-mediated EGFR inhibition in human sq...

journal_title：Radiation research

authors： Mazzeo E,Hehlgans S,Valentini V,Baumann M,Cordes N

更新日期：2012-09-01 00:00:00

abstract：:The International Commission on Radiation Protection (ICRP) has lowered the dose limits for workers and for the general public exposed to ionizing radiation. Consequently, a reliable dosimetric method for monitoring possible radiation-induced damage is of great importance in radioprotection. The counting of dicentric ...

journal_title：Radiation research

authors： Amendola R,Basso E,Pacifici PG,Piras E,Giovanetti A,Volpato C,Romeo G

更新日期：2006-05-01 00:00:00

abstract：:The effects of ionizing radiation, with or without the anti-angiogenic agent anginex (Ax), on multiple myeloma growth were tested in a SCID-rab mouse model. Mice carrying human multiple myeloma cell-containing pre-implanted bone grafts were treated weekly with various regimens for 8 weeks. Rapid multiple myeloma growt...

journal_title：Radiation research

authors： Jia D,Koonce NA,Halakatti R,Li X,Yaccoby S,Swain FL,Suva LJ,Hennings L,Berridge MS,Apana SM,Mayo K,Corry PM,Griffin RJ

更新日期：2010-06-01 00:00:00

abstract：:This study investigated the biological effects and adaptive responses induced by single and repeated in vivo computed tomography (CT) scans. We postulated that, through the induction of low-level oxidative stress, repeated low-dose CT scans (20 mGy, 2 days/week, 10 weeks) could protect mice (C57BL/6) from acute effect...

journal_title：Radiation research

authors： Phan N,De Lisio M,Parise G,Boreham DR

更新日期：2012-02-01 00:00:00

abstract：:Ionizing radiations induce mutations which can be detected both in coding sequences (Hprt locus) by measuring the frequency of 6-thioguanine-resistant cells and in minisatellite sequences by DNA fingerprint analysis. We analyzed the effects of irradiation with low-energy protons (31 keV/pm) and, for comparison, with u...

journal_title：Radiation research

authors： Ogheri S,Bruna V,Cera F,Favaretto S,Cherubini R,Celotti L

更新日期：1997-09-01 00:00:00

abstract：:Pulmonary carcinomas were recorded in a life-span experiment of male Sprague-Dawley rats exposed to fission neutrons. Mortality-corrected prevalences are obtained by the method of isotonic regression. In a second part of the paper a comparison is made with data obtained earlier for radon-daughter inhalations in the sa...

journal_title：Radiation research

authors： Chmelevsky D,Kellerer AM,Lafuma J,Morin M,Masse R

更新日期：1984-06-01 00:00:00

abstract：:Proteinase-activated receptor 2 (Par2, F2rl1, also designated PAR-2 or PAR2) is prominently expressed in the intestine and has been suggested as a mediator of inflammatory, mitogenic and fibrogenic responses to injury. Mast cell proteinases and pancreatic trypsin, both of which have been shown to affect the intestinal...

journal_title：Radiation research

authors： Wang J,Zheng H,Hollenberg MD,Wijesuriya SJ,Ou X,Hauer-Jensen M

更新日期：2003-11-01 00:00:00

abstract：:The correlation between the protein content of nuclei and heat-induced cell killing was determined for HeLa cells with various levels of thermotolerance. Thermotolerance was induced by heating cells at 45 degrees C for 15 or 30 min and then incubating them at 37 degrees C for 5 or 24 h. This procedure resulted in four...

journal_title：Radiation research

authors： Roti Roti JL,Turkel N

更新日期：1994-05-01 00:00:00

abstract：:Mortality data for B6CF1 mice exposed to 60Co gamma rays for the duration of life were used to make quantitative predictions of age-specific mortality observed in comparably exposed beagles. Simple Kaplan-Meier survival curves for the beagles and their 95% confidence intervals were computed for each dose-rate group ob...

journal_title：Radiation research

authors： Carnes BA,Olshansky SJ,Grahn D

更新日期：1998-05-01 00:00:00

abstract：:There is strong evidence that biological response to ionizing radiation has a contribution from unirradiated "bystander" cells that respond to signals emitted by irradiated cells. We discuss here an approach incorporating a radiobiological bystander response, superimposed on a direct response due to direct energy depo...

journal_title：Radiation research

authors： Brenner DJ,Little JB,Sachs RK

更新日期：2001-03-01 00:00:00

abstract：:Exposure of cells to heat induces thermotolerance, a transient resistance to subsequent heat challenges. It has been shown that thermotolerance is correlated in time with the enhanced synthesis of heat shock proteins. In this study, the association of induced heat shock proteins with various cellular fractions was inv...

journal_title：Radiation research

authors： Murnane JP,Li GC

更新日期：1985-03-01 00:00:00

abstract：:X rays have been shown to induce two forms of potentially lethal damage (PLD), "fast-repairing" PLD and "slowly repairing" PLD, whose repair is completed in 1 h and 4-6 h, respectively. In this study three modes of treatment with hypertonic solutions containing different NaCl concentrations for different durations (0....

journal_title：Radiation research

authors： Ikebuchi M,Kimura H,Hill CK,Aoyama T

更新日期：1995-01-01 00:00:00

abstract：:Ionizing radiation induces clustered DNA damage sites, whereby two or more individual DNA lesions are formed within one or two helical turns of DNA by a single radiation track. A subset of DNA clustered damage sites exist in which the lesions are located in tandem on the same DNA strand. Recent studies have establishe...

journal_title：Radiation research

authors： Lomax ME,Salje H,Cunniffe S,O'Neill P

更新日期：2005-01-01 00:00:00

abstract：:Numerous experimental and clinical studies have been completed regarding the effects of carbogen and nicotinamide on tumor oxygenation and radiosensitivity. The current study incorporates three physiological measurement techniques to further define spatial variations in oxygen availability and development of hypoxia a...

journal_title：Radiation research

authors： Fenton BM,Lord EM,Paoni SF

更新日期：2000-01-01 00:00:00

abstract：:Although conclusive evidence has been obtained for the presence of radiation-induced bystander effects, the mechanisms that trigger and regulate these processes are still largely unknown. The bystander effect may play a critical role in determining the biological effectiveness of low-dose exposures, but questions on h...

journal_title：Radiation research

authors： Schettino G,Folkard M,Michael BD,Prise KM

更新日期：2005-03-01 00:00:00

abstract：:Caffeine is a model radiosensitizing agent that is thought to work by abrogating the radiation-induced G(2)-phase checkpoint. In this study, we examined the effect that various concentrations of caffeine had on cell cycle checkpoints and apoptosis in cells of a human lung carcinoma cell line and found that a concentra...

journal_title：Radiation research

authors： Qi W,Qiao D,Martinez JD

更新日期：2002-02-01 00:00:00

abstract：:Studies have causally linked external thyroid radiation exposure in childhood with thyroid cancer. In 1995, investigators conducted relative risk analyses of pooled data from seven epidemiologic studies. Doses were mostly <10 Gy, although childhood cancer therapies can result in thyroid doses >50 Gy. We pooled data fr...

journal_title：Radiation research

authors： Veiga LH,Holmberg E,Anderson H,Pottern L,Sadetzki S,Adams MJ,Sakata R,Schneider AB,Inskip P,Bhatti P,Johansson R,Neta G,Shore R,de Vathaire F,Damber L,Kleinerman R,Hawkins MM,Tucker M,Lundell M,Lubin JH

更新日期：2016-05-01 00:00:00

abstract：:This report presents the results of an investigation of changes in the number of erythroid and granulocyte-macrophage colony-forming cells (GM-CFC) that had occurred in tissues of normal B6D2F1 mice 20 h after administration of a radioprotective dose (150 ng) of human recombinant interleukin-1 (rIL-1). Neutrophilia in...

journal_title：Radiation research

authors： Schwartz GN,Patchen ML,Neta R,MacVittie TJ

更新日期：1990-02-01 00:00:00

abstract：:We have assessed the effects of two radiomodifying conditions, glutathione (GSH) depletion and hypoxia, on the formation and repair of radiation-induced chromatin damage, specifically DNA-protein cross-links (DPC). As measured by a nitrocellulose filter-binding assay, untreated V79 cells contain a low level of DPC (1-...

journal_title：Radiation research

authors： Xue LY,Friedman LR,Oleinick NL

更新日期：1988-10-01 00:00:00

abstract：:Chromatid breaks have previously been shown to be induced in G2-phase cells after exposure to ionizing radiation (X and gamma rays) as a linear function of dose, consistent with a single-event mechanism. DNA double-strand breaks (DSBs) are thought to be the initiating lesion, and experiments with a genetically enginee...

journal_title：Radiation research

authors： Bryant PE,Jones C,Armstrong G,Frankenberg-Schwager M,Frankenberg D

更新日期：2003-02-01 00:00:00

abstract：:Differentiation of Friend erythroleukemia cells (FELC) was induced with 1.5% dimethyl sulfoxide (DMSO) in the culture medium. Cell growth, erythroid differentiation, and radiosensitivity of the proliferative capacity of the cells were measured and compared to a noninduced control culture of identical age. Induced cell...

journal_title：Radiation research

authors： Einspenner M,Boulton JE,Borsa J

更新日期：1984-01-01 00:00:00

abstract：:Whole-body exposure of mice to 2 Gy gamma radiation results in an increase in the specific and total activities of esterase and alkaline phosphatase found in the supernatant of liver and kidney. This increase developed at 1 h, reached a maximum at 24 h, and then declined at 48 h after irradiation. The increase in the ...

journal_title：Radiation research

authors： Auda H,Rashid AM,Khaleel AH,Nasser MJ

更新日期：1987-09-01 00:00:00

abstract：:Radiation of the esophagus of C3H/HeNsd mice with 35 or 37 Gy of 6 MV X rays induces significantly increased RNA transcription for interleukin 1 (Il1), tumor necrosis factor alpha (Tnf), interferon gamma inducing factor (Ifngr), and interferon gamma (Ifng). These elevations are associated with DNA damage that is detec...

journal_title：Radiation research

authors： Epperly MW,Gretton JA,DeFilippi SJ,Greenberger JS,Sikora CA,Liggitt D,Koe G

更新日期：2001-01-01 00:00:00

abstract：:We investigated delayed reproductive death and chromosome bridge formation in mitotic cells in colonies of normal human embryonic cells which survived exposure to 6 Gy of X rays. Eighteen primary clones each derived from control and irradiated cultures were isolated and secondary colonies were grown up. Six of the pri...

journal_title：Radiation research

authors： Suzuki K,Takahara R,Kodama S,Watanabe M

更新日期：1998-10-01 00:00:00

abstract：:Aqueous solutions of calf thymus deoxyribonucleic acid (DNA) were exposed to hydrogen peroxide in the presence of air. Base products formed in DNA were identified and quantitated following acid hydrolysis and trimethylsilylation using gas chromatography-mass spectrometry. The yields of these products were dependent up...

journal_title：Radiation research

authors： Blakely WF,Fuciarelli AF,Wegher BJ,Dizdaroglu M

更新日期：1990-03-01 00:00:00

abstract：:We examined the effects of X irradiation on activation of the promoter of the human HSP70B gene, which is activated only after heat shock. The HSP70B promoter was ligated to the bacterial beta-galactosidase (beta-gal) gene, and the reporter plasmid was transfected into NCI-H1299 carcinoma cells. The expression of the ...

journal_title：Radiation research

authors： Suzuki K,Kodama S,Watanabe M

更新日期：1998-02-01 00:00:00

abstract：:To establish the tolerance of liver tissue to single high-dose intraoperative irradiation, the histopathological changes in the canine liver after single high-dose intraoperative irradiation were investigated by means of radionuclide imaging and light microscopy. Intraoperative irradiation at doses of 0, 10, 20, 25 or...

journal_title：Radiation research

authors： Cromheecke M,Piers BA,Beekhuis H,ter Veen H,Sluiter WJ,Grond AK,Hoekstra HJ

更新日期：2000-11-01 00:00:00

abstract：:Several authors have reported that ionizing radiation can give rise to novel aberrations several mitotic divisions after the exposure. At our institute this phenomenon has been observed in mouse preimplantation embryos. This cell system is uniquely well suited for such investigations because the first three cell divis...

journal_title：Radiation research

authors： Wojcik A,Bonk K,Müller WU,Obe G,Streffer C

更新日期：1996-02-01 00:00:00

abstract：:Cancer mortality in relation to radiation dose was evaluated among 4153 women treated with intrauterine radium (226Ra) capsules for benign gynecologic bleeding disorders between 1925 and 1965. Average follow up was 26.5 years (maximum = 59.9 years). Overall, 2763 deaths were observed versus 2687 expected based on U.S....

journal_title：Radiation research

authors： Inskip PD,Monson RR,Wagoner JK,Stovall M,Davis FG,Kleinerman RA,Boice JD Jr

更新日期：1990-09-01 00:00:00