Abstract：
:To establish the tolerance of liver tissue to single high-dose intraoperative irradiation, the histopathological changes in the canine liver after single high-dose intraoperative irradiation were investigated by means of radionuclide imaging and light microscopy. Intraoperative irradiation at doses of 0, 10, 20, 25 or 30 Gy was applied to a part of the liver of 25 beagles. Radionuclide imaging using (99m)Tc-sulfur colloid was performed at several times during follow-up. Elective humane killing was done 3 months and 1, 2, 3 and 5 years after irradiation. Light microscopy was used to identify histopathological alterations. There was no morbidity or mortality during a maximal follow-up of 5 years. In 40% of the animals, a region of diminished uptake was observed at the irradiation site. The regions of diminished uptake of the radiopharmaceutical agent became smaller with time. Light microscopic examination revealed severe parenchymal fibrosis, liver cell atrophy, and bile duct proliferation at the irradiated area 1 to 2 years after irradiation. At 3 and 5 years, vascular changes with endothelial proliferation and focal arteriolar hyalinosis were observed. This study demonstrates that intraoperative irradiation of a part of the liver in the canine model can be applied safely. Light microscopy confirmed that histological damage was not always accompanied by diminished uptake of the radiopharmaceutical agent at the irradiation site.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Cromheecke M,Piers BA,Beekhuis H,ter Veen H,Sluiter WJ,Grond AK,Hoekstra HJdoi
10.1667/0033-7587(2000)154[0537:tdashd]2.0.co;2subject
Has Abstractpub_date
2000-11-01 00:00:00pages
537-46issue
5eissn
0033-7587issn
1938-5404journal_volume
154pub_type
杂志文章abstract：:We have studied the effects of dose rate and dose fractionation on murine pulmonary alveolar macrophage colony-forming cells (AL-CFC). The dose-response curve of AL-CFC to ionizing irradiation has a Dq of about 100 rad, reflecting the cells' ability to repair sublethal damage. For comparison, we investigated the effec...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1985-08-01 00:00:00
abstract：:We have used Escherichia coli B/r to test the proposal that hydroxyl radicals (.OH) are major contributors to lethal damage when bacteria in equilibrium with air or 100% nitrogen are exposed to ionizing radiation. In addition, we have tested the hypothesis that oxygen sensitizes bacterial cells to radiation by reactin...
journal_title：Radiation research
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更新日期：1987-02-01 00:00:00
abstract：:In pathogen-free mice, but not standard conventionally housed laboratory rodents, two distinctly different modes of early radiation lethality can be identified by modifying the irradiation technique (total-body versus abdominal irradiation) or by therapeutic intervention such as rescue of total-body-irradiated mice wi...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
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journal_title：Radiation research
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更新日期：1987-03-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1987-04-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
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更新日期：2018-02-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2004-08-01 00:00:00
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journal_title：Radiation research
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更新日期：2001-07-01 00:00:00
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更新日期：2005-12-01 00:00:00
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journal_title：Radiation research
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更新日期：2013-05-01 00:00:00
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journal_title：Radiation research
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doi：
更新日期：1983-10-01 00:00:00
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更新日期：2012-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2005-04-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
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journal_title：Radiation research
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doi：
更新日期：1995-07-01 00:00:00
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journal_title：Radiation research
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doi：
更新日期：1999-12-01 00:00:00
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journal_title：Radiation research
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更新日期：2001-01-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章,评审
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更新日期：2004-03-01 00:00:00
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journal_title：Radiation research
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更新日期：2008-02-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR13494.1
更新日期：2014-05-01 00:00:00
