Abstract:
:Survival of colony-forming units-spleen (CFU-S) was measured after single doses of photons or heavy charged particles from the BEVALAC. The purposes were to define the radiosensitivity to heavy ions used medically and to evaluate relationships between relative biological effectiveness (RBE) and dose-averaged linear energy transfer (LET infinity). In in vitro irradiation experiments. CFU-S suspensions were exposed to 220 kVp X rays or to 20Ne (372 MeV/micron) or 40Ar (447 MeV/micron) particles in the plateau portion of the Bragg curve. In in vivo irradiation experiments, donor mice from which CFU-S were harvested were exposed to 12C (400 MeV/micron). 20Ne (400 or 670 MeV/micron), or 40Ar (570 MeV/micron) particles in Bragg peaks spread to 4 or 10 cm by spiral ridge filters. Based on RBE at 10 survival, the maximum RBE of 2.1 was observed for 40Ar particles characterized by an LET infinity of approximately 100 keV/micron. Lower RBEs were determined at lower or higher estimated values of LET infinity and ranged from 1.1 for low energy 40Ar particles to 1.5-1.6 for low energy 12C and 20Ne. The responses of CFU-S are compared with responses of other model systems to heavy charged particles and with the reported sensitivity of CFU-S to neutrons of various energies. The maximum RBE reported here, 2.1 for high energy 40Ar particles, is somewhat lower than values reported for fission-spectrum neutrons, and is appreciably lower than values for monoenergetic 0.43-1.8 MeV neutrons. Low energy 12C and 20Ne particles have RBEs in the range of values reported for 14.7 MeV neutrons.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Ainsworth EJ,Kelly LS,Mahlmann LJ,Schooley JC,Thomas RH,Howard J,Alpen ELsubject
Has Abstractpub_date
1983-10-01 00:00:00pages
180-97issue
1eissn
0033-7587issn
1938-5404journal_volume
96pub_type
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journal_title:Radiation research
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更新日期:1994-11-01 00:00:00
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更新日期:1992-05-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
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journal_title:Radiation research
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doi:
更新日期:1983-11-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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更新日期:1988-06-01 00:00:00
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更新日期:2005-12-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
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更新日期:1988-05-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
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