Abstract:
:The recent demonstration of nanoscale scintillators has led to interest in the combination of radiation and photodynamic therapy. In this model, scintillating nanoparticles conjugated to photosensitizers and molecular targeting agents would enhance the targeting and improve the efficacy of radiotherapy and extend the application of photodynamic therapy to deeply seated tumors. In this study, we calculated the physical parameters required for these nanoparticle conjugates to deliver cytotoxic levels of singlet oxygen at therapeutic radiation doses, drawing on the published literature from several disparate fields. Although uncertainties remain, it appears that the light yield of the nanoscintillators, the efficiency of energy transfer to the photosensitizers, and the cellular uptake of the nanoparticles all need to be fairly well optimized to observe a cytotoxic effect. Even so, the efficacy of the combination therapy will likely be restricted to X-ray energies below 300 keV, which limits the application to brachytherapy.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Morgan NY,Kramer-Marek G,Smith PD,Camphausen K,Capala Jdoi
10.1667/RR1470.1subject
Has Abstractpub_date
2009-02-01 00:00:00pages
236-44issue
2eissn
0033-7587issn
1938-5404journal_volume
171pub_type
杂志文章,评审abstract::Radiation-induced free radical damage in solid-state DNA arises from direct-type damage mechanisms. In the present study, free radical yields in film and lyophilized Na DNA model systems are compared. The free radical yields in lyophilized samples are significantly greater than those in films. Since DNA conformation c...
journal_title:Radiation research
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journal_title:Radiation research
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journal_title:Radiation research
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1985-05-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
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journal_title:Radiation research
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doi:
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doi:
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doi:
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journal_title:Radiation research
pub_type: 杂志文章
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journal_title:Radiation research
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doi:
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journal_title:Radiation research
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doi:
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journal_title:Radiation research
pub_type: 杂志文章
doi:
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