Stimulation of hematopoietic cell recovery by tetrachlorodecaoxide in sublethally irradiated mice.

Abstract:

:This study investigated whether tetrachlorodecaoxide (TCDO), a potent wound-healing agent, promotes recovery of hematopoietic tissue of mice depleted by sublethal X irradiation. Mice were exposed to 3 Gy total-body irradiation and were given 1 ml/kg TCDO intravenously daily from day 1 to 5 or day 4 to 8 after irradiation. The effect was assessed by the change in the total number of nucleated cells in bone marrow and spleen, endogenous spleen colony formation, and 30-day mouse lethality. In the spleen there were profound effects on spleen weight, total organ cellularity, and endogenous colony formation. The TCDO produced radiation dose-modifying factors between 1.4 and 1.5 for endogenous spleen colony formation in mice primed with 3 Gy and reirradiated 4 days after treatment. This stimulated cellular recovery resulted in an increased protection of mice from lethality caused by subsequent total-body irradiation by factors of 1.12-1.18. The results show that TCDO is a potent stimulator of cellular recovery in the spleen of sublethally irradiated mice.

journal_name

Radiat Res

journal_title

Radiation research

authors

Mason KA,Murphy S,Milas L

subject

Has Abstract

pub_date

1993-11-01 00:00:00

pages

229-35

issue

2

eissn

0033-7587

issn

1938-5404

journal_volume

136

pub_type

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