Abstract：
:In this study, we investigated microvascular perfusion status, changes to fat content and fatty acid composition in the bone marrow of rat femurs after total-body irradiation by quantitative permeability parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and ex vivo high-resolution magic angle spinning (HRMAS) 1H nuclear magnetic resonance spectroscopy (NMRS). Thirty-six Sprague-Dawley rats were randomly assigned to either an irradiated or nonirradiated control group. Permeability imaging using DCE-MRI and HRMAS 1H NMRS was performed before irradiation, as well as at days 4 and 7 postirradiation. The volume transfer constant (Ktrans) values increased to 2.219 ± 0.418/min ( P < 0.01) at day 4 and to 2.760 ± 0.217/min at day 7 ( P < 0.01) postirradiation. The plasma fraction (vp) values gradually decreased. The proportion of (n-6) polyunsaturated fatty acids (PUFA) gradually reached a peak at day 7, the proportion of (n-3) PUFA gradually decreased and the proportion of saturated fatty acids gradually increased. After irradiation, Ktrans at different times showed significant negative correlation with (n-3) PUFA ( r = -0.6393, P < 0.01) and significant positive correlation with (n-6) PUFA ( r = 0.6841, P < 0.05). These findings indicate that bone marrow microcirculation perfusion and vascular permeability correlated with fat content at an early time point after irradiation. A pathophysiological mechanism may exist based on fat-vascular permeability in the case of injury to bone marrow microcirculation.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Wang K,Zha Y,Lei H,Xu Xdoi
10.1667/RR14865.1subject
Has Abstractpub_date
2018-02-01 00:00:00pages
205-212issue
2eissn
0033-7587issn
1938-5404journal_volume
189pub_type
杂志文章abstract：:The physical and biological basis of our model to calculate the biological effects of charged particles, termed the local effect model (LEM), has recently been questioned in a commentary by R. Katz. Major objections were related to the definition of the target size and the use of the term cross section. Here we show t...
journal_title：Radiation research
pub_type： 评论,杂志文章
doi：10.1667/rr3174
更新日期：2004-05-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2000-10-01 00:00:00
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journal_title：Radiation research
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doi：10.1667/RR1541.1
更新日期：2009-11-01 00:00:00
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journal_title：Radiation research
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pub_type： 杂志文章
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更新日期：2006-09-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2017-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-07-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3299
更新日期：2005-02-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2011-03-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1667/RR13927.1
更新日期：2015-07-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
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更新日期：2018-05-01 00:00:00
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doi：
更新日期：1992-04-01 00:00:00
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更新日期：2016-11-01 00:00:00
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更新日期：2003-03-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2000-04-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2003-06-01 00:00:00
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journal_title：Radiation research
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更新日期：2004-07-01 00:00:00
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