Modification of radiation sensitivity by salts of the metals beryllium and indium and the rare earths cerium, lanthanum and scandium.

Abstract:

:The LD50 of 46 salts of metals and rare earths (lanthanoids) was determined in mice. Half the LD50 of the compounds was then combined with lethal radiation (10.5 Gy) and the modification of survival time was scored. Only the metals beryllium and indium and the rare earths cerium, lanthanum and scandium displayed activity in our assay. They were then tested at a wider range of lower doses and reduced survival time in a dose-dependent fashion. This appears to be compatible with enhancement of radiation sensitivity. The interaction of these metals and rare earths with radiation adds a new facet to their toxicological spectrum and, by enhancing radiation effects, may influence estimates of risk. On the other hand, the radiosensitizing properties of the metals may be useful for further development of compounds to be used as adjuncts in specific situations of cancer radiotherapy.

journal_name

Radiat Res

journal_title

Radiation research

authors

Floersheim GL

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

318-23

issue

3

eissn

0033-7587

issn

1938-5404

journal_volume

141

pub_type

杂志文章
  • Uptake of tritiated thymidine in the root tip meristem of Vicia faba (L).

    abstract::The use of tritium-labeled thymidine (3H-TdR) in biological research made it necessary to develop a quick and accurate method for determination of tritium activity in tissue. After 3H-TdR incorporation into the root tip meristem of Vicia faba, total 3H activity as well as 3H-DNA activity was measured by liquid scintil...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Scheuermann W,Tägder K

    更新日期:1968-12-01 00:00:00

  • Radiation-induced mutagenicity and lethality in ames tester strains of salmonella.

    abstract::Mutation and killing induced by X radiation and 60CO gamma radiation were studied in six different histidine-requiring auxotrophs of Salmonella typhimurium. Strain TA100, which is sensitive to base-pair substitutions, and strains TA2637 and TA98, which are sensitive to frameshifts, carry the pKM101 plasmid and exhibit...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Isildar M,Bakale G

    更新日期:1984-11-01 00:00:00

  • Cerebrovascular Remodeling and Neuroinflammation is a Late Effect of Radiation-Induced Brain Injury in Non-Human Primates.

    abstract::Fractionated whole-brain irradiation (fWBI) is a mainstay of treatment for patients with intracranial neoplasia; however late-delayed radiation-induced normal tissue injury remains a major adverse consequence of treatment, with deleterious effects on quality of life for affected patients. We hypothesize that cerebrova...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR14616.1

    authors: Andrews RN,Metheny-Barlow LJ,Peiffer AM,Hanbury DB,Tooze JA,Bourland JD,Hampson RE,Deadwyler SA,Cline JM

    更新日期:2017-05-01 00:00:00

  • IPW-5371 Proves Effective as a Radiation Countermeasure by Mitigating Radiation-Induced Late Effects.

    abstract::There is an ongoing and significant need for radiation countermeasures to reduce morbidities and mortalities associated with exposure of the heart and lungs from a radiological or nuclear incidents. Radiation-induced late effects occur months to years after exposure, stemming from significant tissue damage and remodel...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR14403.2

    authors: Rabender C,Mezzaroma E,Mauro AG,Mullangi R,Abbate A,Anscher M,Hart B,Mikkelsen R

    更新日期:2016-11-01 00:00:00

  • Absence of contact effects in irradiated EMT6-Rw tumors.

    abstract::Some cells have been reported to show greater resistance to drugs or radiation when growing with close intercellular contacts in spheroids or in solid tumors than when growing with few intercellular contacts in sparse cultures. In some cases this increased resistance reflects an increased capacity of cells in close co...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Rockwell S

    更新日期:1986-09-01 00:00:00

  • Radiation Chemical Yield of Hydroxyl Radicals for Accelerator-based Boron Neutron Capture Therapy: Dose Assessment of 10B(n,α)7Li Reaction Using Coumarin-3-Carboxilic Solution.

    abstract::Evaluation of the characteristics of accelerator-based thermal neutron fields is recognized as an important issue when discussing the effectiveness of boron neutron capture therapy (BNCT). In this study, we propose that the radiation chemical yield (G value) of hydroxyl radicals (Goh•) can be considered a universal pa...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR15318.1

    authors: Kusumoto T,Ogawara R

    更新日期:2019-05-01 00:00:00

  • Increased frequency of CD4-8-T cells bearing T-cell receptor alpha beta chains in peripheral blood of atomic bomb survivors exposed to high doses.

    abstract::A rare T-cell subpopulation, CD4-8- alpha beta T cells, may be differentiated through a pathway (or pathways) different from the pathway(s) of conventional CD4+ or CD8+ T cells. In the present study, the frequencies of CD4-8-T cells in peripheral-blood alpha beta T cells in 409 atomic bomb survivors (160 estimated to ...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Kusunoki Y,Kyoizumi S,Hirai Y,Fujita S,Akiyama M

    更新日期:1994-07-01 00:00:00

  • Analytical description of the LET dependence of cell survival using the repairable-conditionally repairable damage model.

    abstract::In light-ion radiation therapy, both the dose and the local energy spectrum, which is often characterized with the linear energy transfer (LET), must be considered. In treatment optimization, it is advantageous to use a radiobiological model that analytically accounts for both dose and LET for the ion type of interest...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR2045.1

    authors: Wedenberg M,Lind BK,Toma-Daşu I,Rehbinder H,Brahme A

    更新日期:2010-10-01 00:00:00

  • A short history of the radiation chemistry of water.

    abstract::The first hundred years of radiation studies have greatly clarified the chemical processes that are induced by radiation. While the fundamental ionization processes are similar in all systems, properties of the medium such as phase, polarity and composition can greatly affect the chemistry. In all systems, one needs t...

    journal_title:Radiation research

    pub_type: 历史文章,杂志文章

    doi:

    authors: Jonah CD

    更新日期:1995-11-01 00:00:00

  • Initial Characterization of the Growth Stimulation and Heat-Shock-Induced Adaptive Response in Developing Lake Whitefish Embryos after Ionizing Radiation Exposure.

    abstract::Ionizing radiation is known to effect development during early life stages. Lake whitefish (Coregonus clupeaformis) represent a unique model organism for examining such effects. The purpose of this study was to examine how ionizing radiation affects development in lake whitefish embryos and to investigate the presence...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR14574.1

    authors: Thome C,Mitz C,Hulley EN,Somers CM,Manzon RG,Wilson JY,Boreham DR

    更新日期:2017-10-01 00:00:00

  • Prevention of interphase death in rat thymocytes by bisulfite.

    abstract::The effect of sodium bisulfite, a specific inhibitor of chromatin proteolysis, on radiation damage in rat thymocytes in vitro was examined. Rat thymocytes irradiated with 1 kR X rays in vitro were incubated at 37 degrees C with 10 mM glucose for 4 to 6 hr. During that time development of interphase death as judged by ...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Ohyama H,Shimizu M,Yamada T

    更新日期:1983-07-01 00:00:00

  • Role of guanosine triphosphate in ferric ion-linked Fenton chemistry.

    abstract::We measured the production of reactive hydroxyl radical (OH.) by Fe2+ itself or complexed with nucleotide triphosphates or tripolyphosphate (TPP). Coumarin-3-carboxylic acid (3-CCA) reacts with the OH. produced by Fe2+, Fe3+ or Cu2+ plus ascorbate and with various iron complexes. We measured in real time the increased...

    journal_title:Radiation research

    pub_type: 杂志文章,评审

    doi:

    authors: Biaglow JE,Held KD,Manevich Y,Tuttle S,Kachur A,Uckun F

    更新日期:1996-05-01 00:00:00

  • Dose estimation for atomic bomb survivor studies: its evolution and present status.

    abstract::In the decade after the bombings of Hiroshima and Nagasaki, several large cohorts of survivors were organized for studies of radiation health effects. The U.S. Atomic Bomb Casualty Commission (ABCC) and its U.S./Japan successor, the Radiation Effects Research Foundation (RERF), have performed continuous studies since ...

    journal_title:Radiation research

    pub_type: 杂志文章,评审

    doi:10.1667/RR3546.1

    authors: Cullings HM,Fujita S,Funamoto S,Grant EJ,Kerr GD,Preston DL

    更新日期:2006-07-01 00:00:00

  • A mouse model for calculating the absorbed beta-particle dose from (131)I- and (90)Y-labeled immunoconjugates, including a method for dealing with heterogeneity in kidney and tumor.

    abstract::Flynn, A. A., Green, A. J., Pedley, R. B., Boxer, G. M., Boden, R. and Begent, R. H. J. A Mouse Model for Calculating the Absorbed Beta-Particle Dose from (131)I- and (90)Y-Labeled Immunoconjugates, Including a Method for Dealing with Heterogeneity in Kidney and Tumor. Radiat. Res. 156, 28-35 (2001). Conventional inte...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/0033-7587(2001)156[0028:ammfct]2.0.co;2

    authors: Flynn AA,Green AJ,Pedley RB,Boxer GM,Boden R,Begent RH

    更新日期:2001-07-01 00:00:00

  • The delayed manifestation of T-cell receptor (TCR) variants in X-irradiated mice depends on Trp53 status.

    abstract::The influence of Trp53 on the radiation-induced elevation of T-cell receptor (TCR) variant fractions was examined in splenic T lymphocytes of Trp53-proficient and -deficient mice. Wild-type Trp53+/+, heterozygous Trp53+/- and null Trp53-/- mice were exposed to 3 Gy of X rays at 8 weeks of age. The fraction of TCR-defe...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR3583.1

    authors: Igari K,Igari Y,Okazaki R,Kato F,Ootsuyama A,Norimura T

    更新日期:2006-07-01 00:00:00

  • A model of cell killing by low-dose-rate radiation including repair of sublethal damage, G2 block, and cell division.

    abstract::A computer model that simulates the killing of exponentially growing cells by low-dose-rate radiation is described. The model incorporates cell killing by single-hit damage and double-hit (sublethal) damage, as well as repair of sublethal damage, delay of cell cycle progression, blockage and increased sensitivity of c...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Dillehay LE

    更新日期:1990-11-01 00:00:00

  • Bone sarcoma characteristics and distribution in beagles injected with radium-226.

    abstract::A total of 155 primary bone sarcomas were found in 131 of the 246 beagles injected with 226Ra and 5 primary bone sarcomas were found in 4 of the 158 unexposed controls. Of these 155 bone sarcomas, 146 (94%) were osteosarcomas and 9 were non-osteosarcomas. An additional 31 primary bone sarcomas (28 osteosarcomas) devel...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: White RG,Raabe OG,Culbertson MR,Parks NJ,Samuels SJ,Rosenblatt LS

    更新日期:1994-03-01 00:00:00

  • A lower dose threshold for the in vivo protective adaptive response to radiation. Tumorigenesis in chronically exposed normal and Trp53 heterozygous C57BL/6 mice.

    abstract::Low doses of ionizing radiation to cells and animals may induce adaptive responses that reduce the risk of cancer. However, there are upper dose thresholds above which these protective adaptive responses do not occur. We have now tested the hypothesis that there are similar lower dose thresholds that must be exceeded ...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR1414.1

    authors: Mitchel RE,Burchart P,Wyatt H

    更新日期:2008-12-01 00:00:00

  • Up-regulation and activation of proteinase-activated receptor 2 in early and delayed radiation injury in the rat intestine: influence of biological activators of proteinase-activated receptor 2.

    abstract::Proteinase-activated receptor 2 (Par2, F2rl1, also designated PAR-2 or PAR2) is prominently expressed in the intestine and has been suggested as a mediator of inflammatory, mitogenic and fibrogenic responses to injury. Mast cell proteinases and pancreatic trypsin, both of which have been shown to affect the intestinal...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/rr3080

    authors: Wang J,Zheng H,Hollenberg MD,Wijesuriya SJ,Ou X,Hauer-Jensen M

    更新日期:2003-11-01 00:00:00

  • Hiroshima-like neutrons from A-bomb replica: physical basis for their use in biological experiments.

    abstract::The lineal energy distribution and several other dosimetric parameters were measured for the neutrons emitted from a replica of the Hiroshima bomb to determine their usefulness in biological experiments designed to estimate the effectiveness of actual Hiroshima neutrons. The "Little-Boy" replica (LBR) was constructed ...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Straume T,McDonald JC,Pederson RA,Brenner DJ,Dobson RL

    更新日期:1991-11-01 00:00:00

  • Studies of the mortality of atomic bomb survivors, Report 14, 1950-2003: an overview of cancer and noncancer diseases.

    abstract::This is the 14th report in a series of periodic general reports on mortality in the Life Span Study (LSS) cohort of atomic bomb survivors followed by the Radiation Effects Research Foundation to investigate the late health effects of the radiation from the atomic bombs. During the period 1950-2003, 58% of the 86,611 L...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/rr2629.1

    authors: Ozasa K,Shimizu Y,Suyama A,Kasagi F,Soda M,Grant EJ,Sakata R,Sugiyama H,Kodama K

    更新日期:2012-03-01 00:00:00

  • 1H NMR studies of gamma-irradiated polynucleotides and DNA in N2O-saturated aqueous solutions: release of undamaged and modified bases.

    abstract::In the 400-MHz 1H NMR spectra of gamma-irradiated, N2O-saturated aqueous solutions of polyuridylic acid (polyU), polycytidylic acid (polyC), polyadenylic acid (polyA), and single-stranded DNA from calf thymus, well-resolved signals of the undamaged free bases were identified. Upon incubation of the solutions at 95 deg...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Hildenbrand K,Mirtsch S,Schulte-Frohlinde D

    更新日期:1993-06-01 00:00:00

  • An orthotopic lung tumor model for image-guided microirradiation in rats.

    abstract::The purpose of this study was to develop a rat orthotopic lung tumor model with a solitary intrapulmonary nodule to study the effects of high-dose radiation. A549-Luc non-small cell lung cancer (NSCLC) cells were implanted into nude rats in the intercostal space between ribs 5 and 6 of the right lung. Bioluminescence ...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR2157.1

    authors: Saha D,Watkins L,Yin Y,Thorpe P,Story MD,Song K,Raghavan P,Timmerman R,Chen B,Minna JD,Solberg TD

    更新日期:2010-07-01 00:00:00

  • Radiotoxicity of Auger electron-emitting estrogens in MCF-7 spheroids: a potential treatment for estrogen receptor-positive tumors.

    abstract::To approach treatment of micrometastases of steroid receptor-rich cancers using estrogen receptor-directed therapy with Auger electrons, multicellular spheroids of the estrogen receptor-rich human breast cancer cell line, MCF-7, were prepared and exposed to a range of concentrations of an Auger electron-emitting estro...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Kearney T,Hughes A,Hanson RN,DeSombre ER

    更新日期:1999-05-01 00:00:00

  • Lipid composition of the membranes from cells of two rat tumors and its relationship to tumor thermosensitivity.

    abstract::A plasma membrane-rich fraction has been separated from liver cells and cells of two solid rat tumors. D23 hepatoma and MC7 sarcoma. On the basis of marker enzyme activity the membranes separating at the 31-41% interface on the discontinuous sucrose gradient were enriched 15- to 19-fold. No significant differences in ...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Barker CJ,Bowler K

    更新日期:1991-01-01 00:00:00

  • Dose-dependent transformation of cells of human fibroblast cell strain MSU-1.1 by cobalt-60 gamma radiation and characterization of the transformed cells.

    abstract::Cells from an infinite-life-span near-diploid human fibroblast cell strain, MSU-1.1, were transformed after a single exposure to 60Co gamma radiation. The frequency of transformation as measured by the number of induced foci per 10(6) cells was a linear function of dose. Cells from 13 independent foci from gamma-irrad...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: O'Reilly S,Walicka M,Kohler SK,Dunstan R,Maher VM,McCormick JJ

    更新日期:1998-11-01 00:00:00

  • Live cell imaging of heavy-ion-induced radiation responses by beamline microscopy.

    abstract::To study the dynamics of protein recruitment to DNA lesions, ion beams can be used to generate extremely localized DNA damage within restricted regions of the nuclei. This inhomogeneous spatial distribution of lesions can be visualized indirectly and rapidly in the form of radiation-induced foci using immunocytochemic...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/rr3374

    authors: Jakob B,Rudolph JH,Gueven N,Lavin MF,Taucher-Scholz G

    更新日期:2005-06-01 00:00:00

  • Macrophage depletion of mouse lung following inhalation of 239PuO2.

    abstract::Changes in the free-cell population of the lungs of two strains of mice (SAS/4 and CBA/H) were studied up to 4 months after inhalation exposure to a sized fraction of 239PuO2 particles (1.5 micron AMAD) to give initial alveolar depositions (IADs) ranging from 17 to 810 Bq. A sample of the free-cell population of the l...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Moores SR,Talbot RJ,Evans N,Lambert BE

    更新日期:1986-03-01 00:00:00

  • Comparison of (125)I stereotactic brachytherapy and LINAC radiosurgery modalities based on physical dose distribution and radiobiological efficacy.

    abstract::The goal of this study was to make a comparison between stereotactic brachytherapy implants and linear accelerator-based radiosurgery of brain tumors with respect to physical dose distributions and radiobiological efficacy. Twenty-four treatment plans made for irradiation of brain tumors with low-dose-rate (125)I brac...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR3529.1

    authors: Viola A,Major T,Julow J

    更新日期:2006-06-01 00:00:00

  • On the question of the cause of the initial slope of survival curves.

    abstract::In the double-strand break (DSB) model, the initial slope (alpha) of the survival curve is determined by the number of DSBs remaining unrepaired at a certain time after irradiation. There are three types of calculations which confirm the validity of this approach. First, the model quite reasonably predicts the low-LET...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Ostashevsky JY

    更新日期:1993-02-01 00:00:00