Abstract：
:The exposure of peripheral blood mononuclear cells (PBMCs) was performed in a 10-T static magnetic field. Without lymphocyte stimulation, there were no significant differences in the viability of the exposed and unexposed CD4(+) T cells, CD8(+) T cells, B cells, and natural killer (NK) cells. The expression of Th1 type chemokine receptor, CXCR3, and Th2 type receptor, CCR3, was unaltered after magnetic-field exposure. No differences were observed in the naive T cells and memory T-cell subclasses in either CD4(+) or CD8(+) T cells. In contrast to the unstimulated condition, the magnetic-field exposure reduced the viability of phytohemagglutinin (PHA)-activated T cells in both the CD4(+) and CD8(+) subclasses. In particular, the number of PHA-treated naive CD8(+) T cells (CD45RA(+)CD4(-)CD8(+)) was markedly decreased after the magnetic-field exposure, while PHA-treated memory CD8(+) cells (CD45RA(-)CD4(-)CD8(+)) were resistant to the exposure. The number of PHA-treated naive CD4(+) T cells (CD45RA(+)CD4(+)CD8(-)) and memory cells (CD45RA(-)CD4(+)CD8(-)) was markedly decreased to a similar degree. Thus the susceptibility of lymphocytes to the magnetic-field exposure differed among activated T-cell subtypes. The magnetic-field exposure significantly increased the death of PHA-stimulated lymphocytes by apoptosis. These results suggest that a strong static magnetic field has acute effects on immune cells during cell division, while the field exposure has a minimal effect on immune cells in a nondividing phase.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Onodera H,Jin Z,Chida S,Suzuki Y,Tago H,Itoyama Ydoi
10.1667/0033-7587(2003)159[0775:eotsmf]2.0.co;2subject
Has Abstractpub_date
2003-06-01 00:00:00pages
775-9issue
6eissn
0033-7587issn
1938-5404journal_volume
159pub_type
杂志文章abstract：:There is evidence indicating that low-level exposures to low- LET radiation may inhibit the development of tumors, but the mechanism of this effect is virtually unknown. In the present study, BALB/c mice were irradiated with single doses of 0.1 or 0.2 Gy X rays and injected intravenously 2 h later with syngeneic L1 sa...
journal_title：Radiation research
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journal_title：Radiation research
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doi：
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
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journal_title：Radiation research
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journal_title：Radiation research
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doi：
更新日期：1995-10-01 00:00:00
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更新日期：2005-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2002-05-01 00:00:00
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更新日期：2017-05-01 00:00:00
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更新日期：2001-07-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2001-08-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14443.1
更新日期：2016-11-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2017-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1667/RR15568.1
更新日期：2020-12-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr0724.1
更新日期：2007-02-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:Aqueous solutions of calf thymus deoxyribonucleic acid (DNA) were exposed to hydrogen peroxide in the presence of air. Base products formed in DNA were identified and quantitated following acid hydrolysis and trimethylsilylation using gas chromatography-mass spectrometry. The yields of these products were dependent up...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
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journal_title：Radiation research
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doi：10.1667/RR2927.1
更新日期：2013-02-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2003-08-01 00:00:00
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journal_title：Radiation research
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doi：
更新日期：1991-10-01 00:00:00
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更新日期：2012-04-01 00:00:00
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journal_title：Radiation research
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doi：
更新日期：1983-04-01 00:00:00
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更新日期：2003-07-01 00:00:00
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更新日期：2000-05-01 00:00:00
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更新日期：2014-11-01 00:00:00
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journal_title：Radiation research
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doi：
更新日期：1997-11-01 00:00:00
abstract：:The risk of a radiological or nuclear public health emergency is a major growing concern of the U.S. government. To address a potential incident and ensure that the government is prepared to respond to any subsequent civilian or military casualties, the U.S. Department of Health and Human Services and the Department o...
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更新日期：2018-12-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：:Radiation-induced neurotoxicity is a well-characterized phenomenon. However, the underlying mechanism of this toxicity is poorly understood. In the central nervous system (CNS), excitotoxic mechanisms are implicated in many neurodegenerative disease processes. Pivotal to the excitotoxic pathway is dysfunction of gluta...
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更新日期：2010-12-01 00:00:00
