Single low doses of X rays inhibit the development of experimental tumor metastases and trigger the activities of NK cells in mice.

abstract：:Exposure of the major salivary glands to ionizing radiation often results in severe alterations in structure and function. The mechanism of these effects is still unknown, and no adequate prevention or treatment is yet available. The purpose of this study was to examine a mechanism based on the assumption that redox-a...

journal_title：Radiation research

authors： Nagler R,Marmary Y,Golan E,Chevion M

更新日期：1998-03-01 00:00:00

abstract：:Experimental data from laboratory animals indicate that the same extent of DNA damage or the same mutations in oncogenes and tumor suppressor genes in different hosts result in widely differing cancer development because of numerous polymorphic tumor susceptibility genes. Similarly, recent epidemiological data indicat...

journal_title：Radiation research

authors： Demant P

更新日期：2005-10-01 00:00:00

abstract：:The placental transfer and distribution of 241Am in the feto-placental system were studied in pregnant rats. Rats were injected intravenously with 241Am citrate at 15 or 18 days of gestation. Groups injected at 15 days of gestation were sacrificed 2, 24, 48, or 120 hr after injection, and the group injected at 18 days...

journal_title：Radiation research

authors： Hisamatsu S,Takizawa Y

更新日期：1983-04-01 00:00:00

abstract：:The major limitation to reaching a curative radiation dose in radioresistant tumors such as malignant gliomas is the high sensitivity to radiation and subsequent damage of the surrounding normal tissues. Novel dose delivery methods such as minibeam radiation therapy (MBRT) may help to overcome this limitation. MBRT ut...

journal_title：Radiation research

authors： Prezado Y,Deman P,Varlet P,Jouvion G,Gil S,Le Clec'H C,Bernard H,Le Duc G,Sarun S

更新日期：2015-09-01 00:00:00

abstract：:The health consequences of exposure to low-dose radiation combined with a solar particle event during space travel remain unresolved. The goal of this study was to determine whether protracted radiation exposure alters gene expression and oxidative burst capacity in the liver, an organ vital in many biological process...

journal_title：Radiation research

authors： Gridley DS,Coutrakon GB,Rizvi A,Bayeta EJ,Luo-Owen X,Makinde AY,Baqai F,Koss P,Slater JM,Pecaut MJ

更新日期：2008-03-01 00:00:00

abstract：:We have investigated tumor response to low-dose-rate irradiation from an implanted 125I source alone or in conjunction with intratumoral drug administration. The drug (cis-DDP or 5-FU) was incorporated homogeneously into the co-polymer CPP-SA, 20:80, and the polymer/drug rods were implanted in the RIF-1 fibrosarcomas ...

journal_title：Radiation research

authors： Berrada M,Yang Z,Lehnert SM

更新日期：2004-07-01 00:00:00

abstract：:Monte Carlo simulations are used in the development of a nanotechnology-based multi-pixel beam array small animal microirradiation system. The microirradiation system uses carbon nanotube field emission technology to generate arrays of individually controllable X-ray pixel beams that electronically form irregular irra...

journal_title：Radiation research

authors： Schreiber EC,Chang SX

更新日期：2009-03-01 00:00:00

abstract：:Cellular and molecular repair was studied at 23 degrees C using split-dose recovery and alkaline elution techniques, respectively, as a function of cellular oxygen and nutrient conditions. Hypoxic cells (0.001% O2) in full medium showed a partial reduction in the level of sublethal damage (SLD) repair relative to aera...

journal_title：Radiation research

authors： Spiro IJ,Kennedy KA,Stickler R,Ling CC

更新日期：1985-01-01 00:00:00

abstract：:Biological response to ionizing radiation depends not only on the type of radiation and dose, but also on the duration and dose rate of treatment. For a given radiation dose, the biological response may differ based on duration and dose rate. We studied the properties of two human cell lines, M059K glioma and U2OS ost...

journal_title：Radiation research

authors： Nakajima H,Furukawa C,Chang YC,Ogata H,Magae J

更新日期：2017-08-01 00:00:00

abstract：:The effect of X irradiation on the respiration of rat thymocytes was studied. An increase in the rate of O2 uptake was observed 1 h after cells were irradiated with doses of 6-10 Gy. The radiation-induced increase in respiration could be blocked by oligomycin, an inhibitor of mitochondrial ATP synthase, suggesting con...

journal_title：Radiation research

authors： Gudz TI,Pandelova IG,Novgorodov SA

更新日期：1994-04-01 00:00:00

abstract：:If the limited life span of hematopoietic tissues in vitro is due to a finite proliferative capacity of individual stem cells, one might expect tissues of young donors to possess a greater proliferative capacity and to contain a larger population of primitive stem cells than those of older donors. To test this hypothe...

journal_title：Radiation research

authors： Schmidt CM,Doran GA,Crouse DA,Sharp JG

更新日期：1987-10-01 00:00:00

abstract：:The goal of radiation therapy is to provide the highest probability of tumor control while minimizing normal tissue toxicity. Recently, it has been discovered that ultra-high dose rates of ionizing radiation may preferentially spare normal tissue over tumor tissue. This effect, referred to as FLASH radiotherapy, has b...

journal_title：Radiation research

authors： Colangelo NW,Azzam EI

更新日期：2020-01-01 00:00:00

abstract：:Therapeutic irradiation of the brain can cause a progressive cognitive dysfunction that may involve defects in neurogenesis. In an effort to understand the mechanisms underlying radiation-induced stem cell dysfunction, neural precursor cells isolated from the adult rat hippocampus were analyzed for acute (0-24 h) and ...

journal_title：Radiation research

authors： Limoli CL,Giedzinski E,Rola R,Otsuka S,Palmer TD,Fike JR

更新日期：2004-01-01 00:00:00

abstract：:To establish the tolerance of liver tissue to single high-dose intraoperative irradiation, the histopathological changes in the canine liver after single high-dose intraoperative irradiation were investigated by means of radionuclide imaging and light microscopy. Intraoperative irradiation at doses of 0, 10, 20, 25 or...

journal_title：Radiation research

authors： Cromheecke M,Piers BA,Beekhuis H,ter Veen H,Sluiter WJ,Grond AK,Hoekstra HJ

更新日期：2000-11-01 00:00:00

abstract：:Radiation therapy for the treatment of thoracic cancers may be associated with radiation-induced heart disease (RIHD), especially in long-term cancer survivors. Mechanisms by which radiation causes heart disease are largely unknown. To identify potential long-term contributions of mitochondria in the development of ra...

journal_title：Radiation research

authors： Sridharan V,Aykin-Burns N,Tripathi P,Krager KJ,Sharma SK,Moros EG,Corry PM,Nowak G,Hauer-Jensen M,Boerma M

更新日期：2014-03-01 00:00:00

abstract：:A nested case-control study was conducted among workers at five U.S. nuclear facilities to evaluate leukemia mortality risk (excluding chronic lymphocytic) from ionizing radiation using worksite doses and adjusting for potential confounding. Conditional logistic regression was used to estimate the relative risk (RR) o...

journal_title：Radiation research

authors： Schubauer-Berigan MK,Daniels RD,Fleming DA,Markey AM,Couch JR,Ahrenholz SH,Burphy JS,Anderson JL,Tseng CY

更新日期：2007-02-01 00:00:00

abstract：:Numerous studies have shown that histone deacetylase inhibitors (HDACis) improve cellular acetylation while also enhancing the radiation sensitivity. In this work, however, we confirmed that low-dose trichostatin A (TSA) as a typical HDACi could reduce rather than increase the radiosensitivity of cancer cells, while t...

journal_title：Radiation research

authors： Zhang F,Shao C,Chen Z,Li Y,Jing X,Huang Q

更新日期：2021-01-29 00:00:00

abstract：:Inhalation and ingestion of 137Cs and other long-lived radionuclides can occur after large-scale accidental or malicious radioactive contamination incidents, resulting in a complex temporal pattern of radiation dose/dose rate, influenced by radionuclide pharmacokinetics and chemical properties. High-throughput radiati...

journal_title：Radiation research

authors： Shuryak I,Ghandhi SA,Turner HC,Weber W,Melo D,Amundson SA,Brenner DJ

更新日期：2020-10-16 00:00:00

abstract：:These experiments were designed to study the kinetics and magnitude of cell repair and repopulation in tissues whose damage results in the tumor bed effect. The right hind thighs of mice were irradiated with single doses or two equal gamma-ray fractions. Interfraction intervals ranging from 30 min to 24 h (to measure ...

journal_title：Radiation research

authors： Terry NH,Ang KK,Hunter NR,Milas L

更新日期：1988-06-01 00:00:00

abstract：:Mycoplasma infection of mammalian cells in culture is a common occurrence that can affect the results of experimental protocols. Current methods of eliminating mycoplasma from cell cultures are usually tedious, time-consuming, and sometimes unsuccessful. In the present study, four cultured brain tumor cell lines (huma...

journal_title：Radiation research

authors： Ho JT,Deen DF

更新日期：1991-09-01 00:00:00

abstract：:Soil microorganisms in general and biocontrol agents in particular are very sensitive to UV light. The packaging of biocontrol microorganisms into cellular solids has been developed as a means of reducing loss caused by exposure to environmental UV radiation. The bacterial and fungal biocontrol agents Pantoea agglomer...

journal_title：Radiation research

authors： Zohar-Perez C,Chernin L,Chet I,Nussinovitch A

更新日期：2003-08-01 00:00:00

abstract：:Although conclusive evidence has been obtained for the presence of radiation-induced bystander effects, the mechanisms that trigger and regulate these processes are still largely unknown. The bystander effect may play a critical role in determining the biological effectiveness of low-dose exposures, but questions on h...

journal_title：Radiation research

authors： Schettino G,Folkard M,Michael BD,Prise KM

更新日期：2005-03-01 00:00:00

abstract：:Current lung cancer risk estimates after exposure to low-linear energy transfer radiation such as X rays are based on studies of people exposed to such radiation at high dose rates, for example the atomic bomb survivors. Radiobiology and animal experiments suggest that risks from exposure at low to moderate dose rates...

journal_title：Radiation research

authors： Howe GR

更新日期：1995-06-01 00:00:00

abstract：:A recent publication by Leith et al. (Cancer Res. 51, 4111-4113, 1991) showed that administration of epidermal growth factor (EGF) (0.25 mg/kg; q.i.d. x 7) to mice bearing xenografted A431 human epidermoid cancers produced increased tumor growth and a reduction of the percentage of hypoxic cells within neoplasms. In c...

journal_title：Radiation research

authors： Leith JT,Padfield G,Michelson S

更新日期：1992-11-01 00:00:00

abstract：:Previous studies identified radiation therapy as a key modifier of basal cell carcinoma (BCC) risk in survivors of hematopoietic cell transplantation (HCT). In the present analysis, risk of BCC was analyzed in relation to age at transplant, attained age, race, total-body irradiation (TBI), and radiation fractionation ...

journal_title：Radiation research

authors： Schwartz JL,Kopecky KJ,Mathes RW,Leisenring WM,Friedman DL,Deeg HJ

更新日期：2009-02-01 00:00:00

abstract：:Radiation-induced neurotoxicity is a well-characterized phenomenon. However, the underlying mechanism of this toxicity is poorly understood. In the central nervous system (CNS), excitotoxic mechanisms are implicated in many neurodegenerative disease processes. Pivotal to the excitotoxic pathway is dysfunction of gluta...

journal_title：Radiation research

authors： Sanchez MC,Nelson GA,Green LM

更新日期：2010-12-01 00:00:00

abstract：:The non-human primate has been a useful model for studies of human acute radiation syndrome (ARS). However, to date structural changes in various parts of the intestine after total body irradiation (TBI) have not been systematically studied in this model. Here we report on our current study of TBI-induced intestinal s...

journal_title：Radiation research

authors： Wang J,Shao L,Hendrickson HP,Liu L,Chang J,Luo Y,Seng J,Pouliot M,Authier S,Zhou D,Allaben W,Hauer-Jensen M

更新日期：2015-11-01 00:00:00

abstract：:The effects of reoxygenation on repair of potentially lethal radiation damage were investigated using MG-63 human osteosarcoma cells in vitro. When exponentially growing MG-63 cells were cultured under hypoxic conditions for 24 h, cells stopped growing and remained at a low density. The hypoxic cells were then reoxyge...

journal_title：Radiation research

authors： Iizuka M,Ando K,Aruga T,Furusawa Y,Itsukaichi H,Fukutsu K,Nagasawa H,Moriya H

更新日期：1997-02-01 00:00:00

abstract：:Braun, R. D., Lanzen, J. L., Turnage, J. A., Rosner, G. and Dewhirst, M. W. Effects of the Interaction between Carbogen and Nicotinamide on R3230 Ac Tumor Blood Flow in Fischer 344 Rats. Radiat. Res. 155, 724-733 (2001). The purpose of this study was to determine whether there are interactions between carbogen breathi...

journal_title：Radiation research

authors： Braun RD,Lanzen JL,Turnage JA,Rosner G,Dewhirst MW

更新日期：2001-05-01 00:00:00

abstract：:Following X irradiation of 3',5'-cyclic guanosine monophosphate single crystals at 10 K, several free radicals were trapped and detected by ESR/ENDOR/FSE spectroscopy. The two dominant species both have unpaired spin located on the guanine base. One is the product of net hydrogen atom loss from the exocyclic amino gro...

journal_title：Radiation research

authors： Hole EO,Sagstuen E,Nelson WH,Close DM

更新日期：1992-01-01 00:00:00