Abstract：
:The health consequences of exposure to low-dose radiation combined with a solar particle event during space travel remain unresolved. The goal of this study was to determine whether protracted radiation exposure alters gene expression and oxidative burst capacity in the liver, an organ vital in many biological processes. C57BL/6 mice were whole-body irradiated with 2 Gy simulated solar particle event (SPE) protons over 36 h, both with and without pre-exposure to low-dose/low-dose-rate photons ((57)Co, 0.049 Gy total at 0.024 cGy/h). Livers were excised immediately after irradiation (day 0) or on day 21 thereafter for analysis of 84 oxidative stress-related genes using RT-PCR; genes up or down-regulated by more than twofold were noted. On day 0, genes with increased expression were: photons, none; simulated SPE, Id1; photons + simulated SPE, Bax, Id1, Snrp70. Down-regulated genes at this same time were: photons, Igfbp1; simulated SPE, Arnt2, Igfbp1, Il6, Lct, Mybl2, Ptx3. By day 21, a much greater effect was noted than on day 0. Exposure to photons + simulated SPE up-regulated completely different genes than those up-regulated after either photons or the simulated SPE alone (photons, Cstb; simulated SPE, Dctn2, Khsrp, Man2b1, Snrp70; photons + simulated SPE, Casp1, Col1a1, Hspcb, Il6st, Rpl28, Spnb2). There were many down-regulated genes in all irradiated groups on day 21 (photons, 13; simulated SPE, 16; photons + simulated SPE, 16), with very little overlap among groups. Oxygen radical production by liver phagocytes was significantly enhanced by photons on day 21. The results demonstrate that whole-body irradiation with low-dose-rate photons, as well as time after exposure, had a great impact on liver response to a simulated solar particle event.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Gridley DS,Coutrakon GB,Rizvi A,Bayeta EJ,Luo-Owen X,Makinde AY,Baqai F,Koss P,Slater JM,Pecaut MJdoi
10.1667/RR1155.1subject
Has Abstractpub_date
2008-03-01 00:00:00pages
280-7issue
3eissn
0033-7587issn
1938-5404pii
RR1155journal_volume
169pub_type
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journal_title：Radiation research
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更新日期：1993-10-01 00:00:00
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更新日期：2000-05-01 00:00:00
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更新日期：1985-06-01 00:00:00
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更新日期：1990-02-01 00:00:00
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更新日期：2007-08-01 00:00:00
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journal_title：Radiation research
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更新日期：1985-08-01 00:00:00
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更新日期：1994-12-01 00:00:00
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更新日期：2003-05-01 00:00:00
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doi：
更新日期：1998-02-01 00:00:00
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更新日期：2014-06-01 00:00:00
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更新日期：2012-02-01 00:00:00
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更新日期：2009-12-01 00:00:00
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更新日期：2011-01-01 00:00:00
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更新日期：2008-01-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-03-01 00:00:00
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doi：
更新日期：1990-07-01 00:00:00
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更新日期：2021-01-29 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
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更新日期：2008-07-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：1988-12-01 00:00:00
abstract：:Hypoadrenocorticism, known as Addison's disease in humans, was diagnosed in six beagles after inhalation of at least 1.7 kBq/g lung of 238PuO2. Histological examination of adrenal gland specimens obtained at necropsy revealed marked adrenal cortical atrophy in all cases. Autoradiographs showed only slight alpha-partic...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：1997-11-01 00:00:00
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journal_title：Radiation research
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更新日期：1999-12-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
