Abstract：
:Statistical analysis of Monte Carlo simulations of positive ion track structure is presented for 1 MeV protons passing outside an absorbing region of interest. Energy deposition and production of ionization within the region occur only by delta-ray transport from the ion's path. Depositions in spherical absorber regions of 2 to 100 nm diameter in unit density tissue were scored. It is shown that production of delta rays sufficiently energetic to reach the region is infrequent and the delta rays are therefore relatively far apart along the ion path compared to their average range. The probability for any delta-ray energy deposition in a distant site is small and proportional to the solid angle intercepted by the site. The functional dependence of the frequency density distributions in energy imparted and in ionization number, conditional on there being some interaction, is approximately exponential, and the first and second moments of the distributions are largely independent of distance from the ion path. These findings confirm similar conclusions from experimental measurements on the track structure of germanium, iron and uranium ions.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Wilson WEsubject
Has Abstractpub_date
1994-12-01 00:00:00pages
375-81issue
3eissn
0033-7587issn
1938-5404journal_volume
140pub_type
杂志文章abstract：:Existence of a substantial fraction of replicon initiation events refractory to the effects of X irradiation in Chinese hamster cells has been reported by several laboratories. The work reported here examined whether this apparently refractive fraction resulted from a delayed inhibition of initiation events. Data obta...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1984-11-01 00:00:00
abstract：:Ionizing radiation is known to effect development during early life stages. Lake whitefish (Coregonus clupeaformis) represent a unique model organism for examining such effects. The purpose of this study was to examine how ionizing radiation affects development in lake whitefish embryos and to investigate the presence...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14574.1
更新日期：2017-10-01 00:00:00
abstract：:We have previously proposed that survival curves for cells of murine NFSa fibrosarcomas after exposure to fast neutrons might demonstrate curvature when the neutron doses reach a level high enough to cure the fibrosarcomas. We report here that this is the case. Murine NFSa fibrosarcomas growing in the hind legs of syn...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:Radiation exposure from a number of terrestrial sources is associated with an increased risk for atherosclerosis. Recently, concern over whether exposure to cosmic radiation might pose a similar risk for astronauts has increased. To address this question, we examined the effect of 2 to 5 Gy iron ions ((56)Fe), a parti...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR2482.1
更新日期：2011-06-01 00:00:00
abstract：:Many studies have demonstrated the effect of oncogene transfection on the radiation sensitivity of primary rat embryo fibroblasts. Our results indicate that transformation by H-ras plus v-myc oncogenes confers radiation resistance to a much greater extent than transformation by either gene alone. We have further shown...
journal_title：Radiation research
pub_type： 杂志文章,评审
doi：
更新日期：1994-04-01 00:00:00
abstract：:The non-human primate has been a useful model for studies of human acute radiation syndrome (ARS). However, to date structural changes in various parts of the intestine after total body irradiation (TBI) have not been systematically studied in this model. Here we report on our current study of TBI-induced intestinal s...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14191.1
更新日期：2015-11-01 00:00:00
abstract：:CD34 antigen is a novel marker for human hematopoietic stem/progenitor cells. In the present study, two cell fractions, CD34low and CD34high, were prepared from steady-state human peripheral blood on the basis of CD34 antigen expression. The colony-forming unit megakaryocytes (CFU-Meg) contained in each cell fraction ...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3396
更新日期：2005-07-01 00:00:00
abstract：:We studied the LET and ion species dependence of the RBE for cell killing to clarify the differences in the biological effects caused by the differences in the track structure that result from the different energy depositions for different ions. Normal human skin fibroblasts were irradiated with heavy-ion beams such a...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3360
更新日期：2005-05-01 00:00:00
abstract：:Currently available treatments for radiation-induced nausea and vomiting either are ineffective or reduce performance. The new antiemetic and gastrokinetic agent zacopride was tested in rhesus monkeys to assess its behavioral toxicity and its ability to inhibit radiation-induced emesis. Zacopride (intragastric, 0.3 mg...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-09-01 00:00:00
abstract：:Single crystals of anhydrous inosine were studied subsequent to exposure to high and low doses of X radiation at 10 K using K-band, EPR, ENDOR, and field-swept-ENDOR (FSE) techniques. Immediately following high radiation doses at 10 K at least eight different radicals, RI-RVIII, were observed. All radicals, except for...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：:Hyperthermic sensitivities of Escherichia coli B/r and Bs-1 were determined for lag-, midlog-, and stationary-phase cells at 47, 48, and 49 degrees C. In both strains midlog-phase cells were strikingly more heat sensitive (100-fold greater killing after 4 h at 48 degrees C) than stationary-phase cells, with intermedia...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
abstract：:Previous studies identified radiation therapy as a key modifier of basal cell carcinoma (BCC) risk in survivors of hematopoietic cell transplantation (HCT). In the present analysis, risk of BCC was analyzed in relation to age at transplant, attained age, race, total-body irradiation (TBI), and radiation fractionation ...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1469.1
更新日期：2009-02-01 00:00:00
abstract：:Involvement of gap junctional intercellular communication (GJIC) in bystander responses of confluent human fibroblasts irradiated with a carbon-ion beam was investigated. It was found that the lower the radiation dose, the higher the yield of radiation-induced micronuclei per nuclear traversal, suggesting the existenc...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3044
更新日期：2003-09-01 00:00:00
abstract：:Experimental data from laboratory animals indicate that the same extent of DNA damage or the same mutations in oncogenes and tumor suppressor genes in different hosts result in widely differing cancer development because of numerous polymorphic tumor susceptibility genes. Similarly, recent epidemiological data indicat...
journal_title：Radiation research
pub_type： 杂志文章,评审
doi：10.1667/rr3333.1
更新日期：2005-10-01 00:00:00
abstract：:Base damage flanking a radiation-induced DNA double-strand break (DSB) may contribute to DSB complexity and affect break repair. However, to date, an isolated radiation-induced DSB has not been assessed for such structures at the molecular level. In this study, an authentic site-specific radiation-induced DSB was prod...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR0628.1
更新日期：2006-11-01 00:00:00
abstract：:Dose assessment after radiological disasters is imperative to decrease mortality through rationally directed medical intervention. Our goal was to identify biomarkers capable of qualitative (nonirradiated/irradiated) and/or quantitative (dose) assessment of radiation exposure. Using real-time quantitative PCR, biodosi...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR2419.1
更新日期：2011-07-01 00:00:00
abstract：:The effects of amiloride (an inhibitor of Na+/H+ antiport), DIDS (an inhibitor of Na(+)-coupled and Na(+)-independent HCO3-/Cl- exchange) and nigericin (K+/H+ ionophore) alone and in various combinations on the intracellular pH (pHi) and thermosensitivity of SCK tumor cells were studied. Hyperthermia alone at 43 degre...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:We collected initial quantitative information on the effects of high-dose carbon (12C) ions compared to photons on vascular damage in anaplastic rat prostate tumors, with the goal of elucidating differences in response to high-LET radiation, using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Syngene...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR15459.1
更新日期：2020-01-01 00:00:00
abstract：:The monohydroxylated fatty acid content of peripheral blood mononuclear cells from 23 cleanup workers and 16 unexposed individuals was studied in relation to their immune status after the Chernobyl accident. Men with absorbed doses below 0.32 Gy showed higher levels of free and esterified 12-hydroxyeicosatetraenoic ac...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2001)156[0476:mfacip]2.0.co;2
更新日期：2001-11-01 00:00:00
abstract：:The effect of heat exposure on the repair of radiation-induced DNA damage which inhibits the ability of nuclear DNA to undergo supercoiling changes was studied using the fluorescent halo assay in thermotolerant and nonthermotolerant (normal) cells. The assay utilizes an intercalating, fluorescent dye to unwind and rew...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:Relationships based on the microdosimetric-kinetic model are presented that calculate the average number of lethal lesions, and the associated cell survival, produced in mammalian cells by exposure to protracted continuous irradiation by temporary and permanent implantation of radioactive sources. The influence of cel...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR13558.1
更新日期：2014-07-01 00:00:00
abstract：:The experimentally observed survival of a heterogeneous mixture of cells, each component of which obeys a different linear-quadratic survival response to ionizing radiation, is examined. It is shown that the survival relationship for the mixed population approaches a linear-quadratic form for low doses. The linear par...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2000)153[0840:soamoc]2.0.co;2
更新日期：2000-06-01 00:00:00
abstract：:Previous work from our laboratory suggested that neuronal chromatin structure may be altered immediately after exposure to ionizing radiation. In the present study, whole brains of 4-month-old male Fisher 344 rats were irradiated with a dose of 25 Gy. The kinetics of restoring the chromatin structure to its unirradiat...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
abstract：:The presence of low levels of oxygen may have profound effects on the cytotoxic activity of radiation, radiosensitizers, and bioreductive alkylating agents. As others have shown, low oxygen tensions may significantly alter rates of cellular and chemical oxygen consumption. When experiments are performed at very low ox...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1986-10-01 00:00:00
abstract：:Using five transplantable murine tumors (SCC-VII, B16F1, KHT-C, KHT-LP1, RIF-1), measurements of tumor hypoxia have been made with two techniques which have the potential to be used for assessing oxygenation in human tumors (the Eppendorf pO2 Histograph and binding of [3H]misonidazole) and have been compared with an e...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:We previously described an enhanced sensitivity for cell killing and gamma-H2AX focus induction after both high-dose-rate and continuous low-dose-rate gamma irradiation in 14 primary fibroblast strains derived from hereditary-type retinoblastoma family members (both affected RB1(+/-) probands and unaffected RB1(+/+) p...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1943.1
更新日期：2010-01-01 00:00:00
abstract：:We have tested chronic exposure to 90Y beta radiation for its action as a complete tumor promoter, a stage I tumor promoter, or a stage II tumor promoter in SENCAR mouse skin. In skin initiated with a single application of 7,12,dimethylbenz[a]anthracene (DMBA, 10 nmol), chronic exposure to beta radiation as a complete...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：:While impairment of thyroid function has been demonstrated for high-dose external radiation (e.g., for Hodgkin's disease), the long-term functional effects of low-dose external radiation have not been fully explored. One hundred fifty-three subjects with a past history of thymic irradiation during infancy were stratif...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1987-06-01 00:00:00
abstract：:Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy and environmental nuclear contamination as well as for Earth-orbit and space missions. Analyses of transcriptome prof...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1389.1
更新日期：2009-01-01 00:00:00
abstract：:The presence of oxygen-deficient tumor cells is a critical issue in cancer therapy. To identify tumor hypoxia, tissue partial oxygen pressure (pO2) can be measured directly. The OxyLite system allows determination of pO2 in tumors and permits continuous measurements of pO2 at a fixed point. In this study, this system ...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR3602.1
更新日期：2006-09-01 00:00:00
