Different radiosensitive megakaryocytic progenitor cells exist in steady-state human peripheral blood.

abstract：:Cellular nonprotein thiols (NPSH) consist of glutathione (GSH) and other low molecular weight species such as cysteine, cysteamine, and coenzyme A. GSH is usually less than the total cellular NPSH, and with thiol reactive agents, such as diethyl maleate (DEM), its rate of depletion is in part dependent upon the cellul...

journal_title：Radiation research

authors： Biaglow JE,Varnes ME,Clark EP,Epp ER

更新日期：1983-09-01 00:00:00

abstract：:A histopathological study was carried out on the spinal cord of rats after boron neutron capture (BNC) irradiation. Rats were irradiated with thermal neutrons alone or in combination with borocaptate sodium (BSH) or p-boronophenylalanine (BPA). Spinal cords were examined 1 year after irradiation, or at earlier times i...

journal_title：Radiation research

authors： Morris GM,Coderre JA,Bywaters A,Whitehouse E,Hopewell JW

更新日期：1996-09-01 00:00:00

abstract：:Damage to intestine is a serious problem after accidental radiation exposure. To examine substances to ameliorate damage by postirradiation administration, we focused on the regeneration process after irradiation of the intestine. Using experimental systems, the effects of clinically used sex hormones on regeneration ...

journal_title：Radiation research

authors： Ishihara H,Tanaka I,Yakumaru H,Tanaka M,Satoh A,Ishiwata A,Yokochi K,Kurematsu A,Ueda J,Shibata T,Hachiya M,Akashi M

更新日期：2011-03-01 00:00:00

abstract：:To study the acquired radioresistance of tumor cells, a model system of two cell lines, Djungarian hamster fibroblasts (DH-TK-) and their radioresistant progeny, was established. The progeny of irradiated cells were isolated by treating the parental cell monolayer with a single dose of 20 Gy (PIC-20). The genetic and ...

journal_title：Radiation research

authors： Tyrsina EG,Slanina SV,Kakpakova ES,Kalendo GS,Kan NG,Tyrsin OY,Ryskov AP

更新日期：2005-12-01 00:00:00

abstract：:Cells that have been grown as multicell tumor spheroids exhibit radioresistance compared to the same cells grown in monolayers. Comparison of potentially lethal damage (PLD) repair and its kinetics was made between 9L cells grown as spheroids and confluent monolayers. Survival curves of cells plated immediately after ...

journal_title：Radiation research

authors： Rodriguez A,Alpen EL,Mendonca M,DeGuzman RJ

更新日期：1988-06-01 00:00:00

abstract：:Tissue ablation by ultraviolet excimer lasers results in exposure of viable cells to subablative doses of radiation. To understand the potential biological consequences better, we have studied changes in gene expression in cultured human skin fibroblasts exposed to either 193- or 248-nm laser light. Northern blot anal...

journal_title：Radiation research

authors： Rimoldi D,Flessate DM,Samid D

更新日期：1992-09-01 00:00:00

abstract：:The first hundred years of radiation studies have greatly clarified the chemical processes that are induced by radiation. While the fundamental ionization processes are similar in all systems, properties of the medium such as phase, polarity and composition can greatly affect the chemistry. In all systems, one needs t...

journal_title：Radiation research

authors： Jonah CD

更新日期：1995-11-01 00:00:00

abstract：:Ketogenic diets are low in carbohydrates and high in fat, which forces cells to rely more heavily upon mitochondrial oxidation of fatty acids for energy. Relative to normal cells, cancer cells are believed to exist under a condition of chronic mitochondrial oxidative stress that is compensated for by increases in gluc...

journal_title：Radiation research

authors： Zahra A,Fath MA,Opat E,Mapuskar KA,Bhatia SK,Ma DC,Rodman SN III,Snyders TP,Chenard CA,Eichenberger-Gilmore JM,Bodeker KL,Ahmann L,Smith BJ,Vollstedt SA,Brown HA,Hejleh TA,Clamon GH,Berg DJ,Szweda LI,Spitz DR,Buat

更新日期：2017-06-01 00:00:00

abstract：:The relationship of ionizing radiation to the age-related ophthalmological findings of the 1978-1980 ophthalmological examination of A-bomb survivors of Hiroshima and Nagasaki has been reanalyzed using DS86 eye organ dose estimates. The main purpose of this reevaluation was to determine whether age and radiation expos...

journal_title：Radiation research

authors： Otake M,Finch SC,Choshi K,Takaku I,Mishima H,Takase T

更新日期：1992-09-01 00:00:00

abstract：:The non-human primate has been a useful model for studies of human acute radiation syndrome (ARS). However, to date structural changes in various parts of the intestine after total body irradiation (TBI) have not been systematically studied in this model. Here we report on our current study of TBI-induced intestinal s...

journal_title：Radiation research

authors： Wang J,Shao L,Hendrickson HP,Liu L,Chang J,Luo Y,Seng J,Pouliot M,Authier S,Zhou D,Allaben W,Hauer-Jensen M

更新日期：2015-11-01 00:00:00

abstract：:The hyperthermic inhibition of cellular DNA synthesis, i.e., reduction in replicon initiation and delay in DNA chain elongation, was previously postulated to be involved in the induction of chromosomal aberrations believed to be largely responsible for killing S-phase cells. Utilizing asynchronous Chinese hamster ovar...

journal_title：Radiation research

authors： Wong RS,Thompson LL,Dewey WC

更新日期：1988-04-01 00:00:00

abstract：:In this study, we investigated microvascular perfusion status, changes to fat content and fatty acid composition in the bone marrow of rat femurs after total-body irradiation by quantitative permeability parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and ex vivo high-resolution magic angl...

journal_title：Radiation research

authors： Wang K,Zha Y,Lei H,Xu X

更新日期：2018-02-01 00:00:00

abstract：:Four programs have been written to enable radiobiologists to build a computer data base of cellular dose-survival data, calculate cell survival with a correction for cell multiplicity at the time of irradiation, fit various survival models to the data by iteratively weighted least squares, and calculate the ratio of s...

journal_title：Radiation research

authors： Albright N

更新日期：1987-11-01 00:00:00

abstract：:While nontargeted and low-dose effects such as the bystander effect are now accepted, the mechanisms underlying the response have yet to be elucidated. It has been shown that the transfer of irradiated cell conditioned medium (ICCM) can kill cells that are not directly irradiated; however, to date the effect of ICCM c...

journal_title：Radiation research

authors： Ryan LA,Smith RW,Seymour CB,Mothersill CE

更新日期：2008-02-01 00:00:00

abstract：:Neither cell division nor growth of Saccharomyces cerevisiae were stimulated by the ultraviolet luminescence produced by adjacent exponential phase cultures of the yeast. The study included experiments in which the inocula (density = 5 X 10(7) cells cm-3) were irradiated and in which lag phase cultures (densities = 1 ...

journal_title：Radiation research

authors： Quickenden TI,Tilbury RN

更新日期：1985-05-01 00:00:00

abstract：:To establish the tolerance of liver tissue to single high-dose intraoperative irradiation, the histopathological changes in the canine liver after single high-dose intraoperative irradiation were investigated by means of radionuclide imaging and light microscopy. Intraoperative irradiation at doses of 0, 10, 20, 25 or...

journal_title：Radiation research

authors： Cromheecke M,Piers BA,Beekhuis H,ter Veen H,Sluiter WJ,Grond AK,Hoekstra HJ

更新日期：2000-11-01 00:00:00

abstract：:The intrinsic radiosensitivity of tumor cells is most frequently reported for asynchronous populations, although cell cycle variation in radiosensitivity is known to be significant. Linear-quadratic analyses of survival data for asynchronous human tumor cells show wide variations in the alpha coefficient with smaller ...

journal_title：Radiation research

authors： Biade S,Stobbe CC,Chapman JD

更新日期：1997-04-01 00:00:00

abstract：:Exposure of cells to heat induces thermotolerance, a transient resistance to subsequent heat challenges. It has been shown that thermotolerance is correlated in time with the enhanced synthesis of heat shock proteins. In this study, the association of induced heat shock proteins with various cellular fractions was inv...

journal_title：Radiation research

authors： Murnane JP,Li GC

更新日期：1985-03-01 00:00:00

abstract：:We have used Escherichia coli B/r to test the proposal that hydroxyl radicals (.OH) are major contributors to lethal damage when bacteria in equilibrium with air or 100% nitrogen are exposed to ionizing radiation. In addition, we have tested the hypothesis that oxygen sensitizes bacterial cells to radiation by reactin...

journal_title：Radiation research

authors： Ewing D,Kubala GJ

更新日期：1987-02-01 00:00:00

abstract：:The present study was undertaken to assess the protective effect of dimethyl sulfoxide (DMSO) against the induction and rejoining of DNA double-strand breaks (DSBs) and inactivation of V79-4 Chinese hamster cells by both high- and low-linear energy transfer (LET) radiations. The cells were exposed under aerobic condit...

journal_title：Radiation research

authors： deLara CM,Jenner TJ,Townsend KM,Marsden SJ,O'Neill P

更新日期：1995-10-01 00:00:00

abstract：:Diethylenetriaminepentaacetic acid (DTPA) is currently still the only known chelating drug that can be used for decorporation of internalized plutonium (Pu) and americium (Am). It is generally assumed that chelation occurs only in biological fluids, thus preventing Pu/Am deposition in target tissues. We postulate that...

journal_title：Radiation research

authors： Grémy O,Laurent D,Coudert S,Griffiths NM,Miccoli L

更新日期：2016-06-01 00:00:00

abstract：:The mechanisms underlying the hyper-radiosensitivity of AT cells were investigated by analyzing chromosome aberrations in the G(2) and M phases of the cell cycle using a combination of chemically induced premature chromosome condensation (PCC) and fluorescence in situ hybridization (FISH) with chromosome painting prob...

journal_title：Radiation research

authors： Kawata T,Ito H,George K,Wu H,Uno T,Isobe K,Cucinotta FA

更新日期：2003-05-01 00:00:00

abstract：:Through a detailed study of cell cycle progression, protein expression, and kinase activity in gamma-irradiated synchronized cultures of human skin fibroblasts, distinct mechanisms of initiation and maintenance of G2-phase and subsequent G1-phase arrests have been elucidated. Normal and E6-expressing fibroblasts were ...

journal_title：Radiation research

authors： DeSimone JN,Bengtsson U,Wang X,Lao XY,Redpath JL,Stanbridge EJ

更新日期：2003-01-01 00:00:00

abstract：:To elucidate the nature and kinetics of DNA strand breaks caused by low-energy Auger electron emitters, we compared the yields of DNA breaks in supercoiled pUC19 DNA in the presence of the (.)OH scavenger dimethyl sulfoxide (DMSO) after the decay of (125)I (1) in proximity to DNA after minor-groove binding ((125)I-iod...

journal_title：Radiation research

authors： Kassis AI,Harapanhalli RS,Adelstein SJ

更新日期：1999-11-01 00:00:00

abstract：:A standardized dichlorofluorescin (DCF) fluorometric assay capable of measuring radiation-induced oxidative stress was used to determine the effectiveness of protons and high-mass, high-atomic number (Z) and high-energy (HZE) particles to produce oxidative stress in vitro. Protons were found to be about equally as eff...

journal_title：Radiation research

authors： Wan XS,Bloch P,Ware JH,Zhou Z,Donahue JJ,Guan J,Stewart J,Kennedy AR

更新日期：2005-04-01 00:00:00

abstract：:Cells from an infinite-life-span near-diploid human fibroblast cell strain, MSU-1.1, were transformed after a single exposure to 60Co gamma radiation. The frequency of transformation as measured by the number of induced foci per 10(6) cells was a linear function of dose. Cells from 13 independent foci from gamma-irrad...

journal_title：Radiation research

authors： O'Reilly S,Walicka M,Kohler SK,Dunstan R,Maher VM,McCormick JJ

更新日期：1998-11-01 00:00:00

abstract：:Plutonium is considered to be a carcinogen because it emits alpha particles that may result in the irradiation of stem cell population. In the present study we show that plutonium can also catalyze reactions that induce hydroxyl radicals in the absence of significant alpha-particle irradiation. Using the low specific ...

journal_title：Radiation research

authors： Claycamp HG,Luo D

更新日期：1994-01-01 00:00:00

abstract：:Infusions of boronophenylalanine-fructose complex (BPA-F), at doses up to 900 mg/kg of BPA and 860 mg/kg of fructose, have been used to deliver boron to cancer tissue for boron neutron capture therapy (BNCT). In patients with phenylketonuria (PKU), phenylalanine accumulates, which is harmful in the long run. PKU has b...

journal_title：Radiation research

authors： Laakso J,Ruokonen I,Lapatto R,Kallio M

更新日期：2003-11-01 00:00:00

abstract：:The incidence of micronuclei was evaluated to assess the induction of an adaptive response to non-ionizing radiofrequency (RF) radiation in peripheral blood lymphocytes collected from five different human volunteers. After stimulation with phytohemagglutinin for 24 h, the cells were exposed to an adaptive dose of 900 ...

journal_title：Radiation research

authors： Sannino A,Sarti M,Reddy SB,Prihoda TJ,Vijayalaxmi,Scarfì MR

更新日期：2009-06-01 00:00:00

abstract：:Breast tissue is very susceptible to radiation-induced carcinogenesis, and mammary stem/progenitor cells are potentially important targets of this. The mammary epithelium is maintained as two mostly independent lineages of luminal and basal cells. To elucidate their immediate radiation responses, we analyzed the mamma...

journal_title：Radiation research

authors： Kudo KI,Takabatake M,Nagata K,Nishimura Y,Daino K,Iizuka D,Nishimura M,Suzuki K,Kakinuma S,Imaoka T

更新日期：2020-07-08 00:00:00