Strand breaks in plasmid DNA after positional changes of Auger electron-emitting iodine-125: direct compared to indirect effects.

abstract：:Nuclear protein and DNA content of HeLa cells was determined as a function of time following hyperthermia by staining isolated nuclei with two fluorescent dyes: fluorescein isothiocyanate (FITC) for protein content and propidium iodide (PI) for DNA content. Bivariate FITC and PI histograms were obtained by flow cytome...

journal_title：Radiation research

authors： Roti Roti JL,Uygur N,Higashikubo R

更新日期：1986-08-01 00:00:00

abstract：:A plasma membrane-rich fraction has been separated from liver cells and cells of two solid rat tumors. D23 hepatoma and MC7 sarcoma. On the basis of marker enzyme activity the membranes separating at the 31-41% interface on the discontinuous sucrose gradient were enriched 15- to 19-fold. No significant differences in ...

journal_title：Radiation research

authors： Barker CJ,Bowler K

更新日期：1991-01-01 00:00:00

abstract：:Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy and environmental nuclear contamination as well as for Earth-orbit and space missions. Analyses of transcriptome prof...

journal_title：Radiation research

authors： Lowe XR,Bhattacharya S,Marchetti F,Wyrobek AJ

更新日期：2009-01-01 00:00:00

abstract：:To examine more fully the nature of chromosomal radiosensitivity in ataxia telangiectasia (AT) cells, we employed 24-color combinatorial painting to visualize 137Cs gamma-ray-induced chromosome-type aberrations in cells of two AT and one normal primary human fibroblast strains irradiated in log-phase growth. As a meas...

journal_title：Radiation research

authors： Loucas BD,Cornforth MN

更新日期：2004-11-01 00:00:00

abstract：:Our goal was to determine whether esophageal progenitor cells could be isolated from adult mouse esophagus or bone marrow and shown to home to and proliferate in the irradiated esophagus of recipient mice. Esophageal progenitor cells were isolated from adult male C3H/HeNsd or C57BL/6J green fluorescent protein (GFP(+)...

journal_title：Radiation research

authors： Epperly MW,Guo H,Shen H,Niu Y,Zhang X,Jefferson M,Sikora CA,Greenberger JS

更新日期：2004-09-01 00:00:00

abstract：:Vascular change by the combined treatments of radiation and hyperthermia was studied. The legs of rats were irradiated with 2000 rad of X rays in a single dose and heated at 43.0 degrees C for 1 hr at various times after irradiation, and the blood flow and vascular volume in the skin and muscle were determined with 12...

journal_title：Radiation research

authors： Song CW,Kim JH,Rhee JG,Levitt SH

更新日期：1983-05-01 00:00:00

abstract：:In a series of Russian and Ukrainian papers published from 1974-1986, it was reported that 30-day whole-body exposures to continuous-wave (CW) radiofrequency (RF) radiation at 2375 MHz and 5 W/m(2) disrupted the antigenic structure of rat brain tissue. The authors suggested that this action caused an autoimmune respon...

journal_title：Radiation research

authors： de Gannes FP,Taxile M,Duleu S,Hurtier A,Haro E,Geffard M,Ruffié G,Billaudel B,Lévêque P,Dufour P,Lagroye I,Veyret B

更新日期：2009-11-01 00:00:00

abstract：:Aberrant expression of microRNAs (miRNAs) is frequently associated with a variety of cancers, including breast cancer. We and others have demonstrated that radiation-induced rat mammary cancer exhibits a characteristic gene expression profile and a random increase in aberrant DNA copy number; however, the role of aber...

journal_title：Radiation research

authors： Iizuka D,Imaoka T,Nishimura M,Kawai H,Suzuki F,Shimada Y

更新日期：2013-02-01 00:00:00

abstract：:Many studies have shown the importance of altered cellular proto-oncogene expression in contributing to changes in cell survival, cell transformation, and cell cycle progression. In these experiments we examined the effects of total-body exposure of BCF1 mice to gamma rays (3 Gy) in modulating expression of cellular o...

journal_title：Radiation research

authors： Anderson A,Woloschak GE

更新日期：1992-06-01 00:00:00

abstract：:We have tested chronic exposure to 90Y beta radiation for its action as a complete tumor promoter, a stage I tumor promoter, or a stage II tumor promoter in SENCAR mouse skin. In skin initiated with a single application of 7,12,dimethylbenz[a]anthracene (DMBA, 10 nmol), chronic exposure to beta radiation as a complete...

journal_title：Radiation research

authors： Mitchel RE,Trivedi A

更新日期：1992-02-01 00:00:00

abstract：:A standard Fricke dosimeter was used to measure the absorbed dose via the oxidation yields of Fe3+ ions in an aqueous environment induced by soft X rays within the "water window" spectral range. We also exploited the property of a neutral solution containing terephthalic acid as a tool for selective detection of OH ra...

journal_title：Radiation research

authors： Vyšín L,Wachulak P,Toufarová M,Medvedev N,Voronkov RA,Bartnik A,Fiedorowicz H,Juha L

更新日期：2020-04-01 00:00:00

abstract：:The binding kinetics of the hypoxia marker EF5 can be quantified by uptake of (14)C-labeled drug or calibrated flow cytometry using antibodies specific for drug adducts. Maximum EF5 binding is cell-line dependent and varies directly with drug exposure (area under the curve; concentration integrated over time) but inve...

journal_title：Radiation research

authors： Koch CJ

更新日期：2008-06-01 00:00:00

abstract：:Radiation-induced neurotoxicity is a well-characterized phenomenon. However, the underlying mechanism of this toxicity is poorly understood. In the central nervous system (CNS), excitotoxic mechanisms are implicated in many neurodegenerative disease processes. Pivotal to the excitotoxic pathway is dysfunction of gluta...

journal_title：Radiation research

authors： Sanchez MC,Nelson GA,Green LM

更新日期：2010-12-01 00:00:00

abstract：:Resistance to radiation is considered to be an important reason for local failure after radiotherapy and tumor recurrence. However, the exact mechanisms of tumor resistance remain poorly understood. Current investigations of microRNAs as potential diagnostic and therapeutic tools for cancer treatment have shown promis...

journal_title：Radiation research

authors： Mueller AK,Lindner K,Hummel R,Haier J,Watson DI,Hussey DJ

更新日期：2016-06-01 00:00:00

abstract：:The detection of (41)Ca atoms in tooth enamel using accelerator mass spectrometry is suggested as a method capable of reconstructing thermal neutron exposures from atomic bomb survivors in Hiroshima and Nagasaki. In general, (41)Ca atoms are produced via thermal neutron capture by stable (40)Ca. Thus any (41)Ca atoms ...

journal_title：Radiation research

authors： Wallner A,Rühm W,Rugel G,Nakamura N,Arazi A,Faestermann T,Knie K,Maier HJ,Korschinek G

更新日期：2010-08-01 00:00:00

abstract：:Hemodynamic shear stress is defined as the physical force exerted by the continuous flow of blood in the vascular system. Endothelial cells, which line the inner layer of blood vessels, sense this physiological force through mechanotransduction signaling and adapt to maintain structural and functional homeostasis. Hem...

journal_title：Radiation research

authors： Natarajan M,Aravindan N,Sprague EA,Mohan S

更新日期：2016-08-01 00:00:00

abstract：:In this study, we investigated the effect of (131)I gelatin microspheres ((131)I-GMSs) on human hepatocellular carcinoma cells (HepG2) in nude mice (Balb/c) and the biodistribution of (131)I-GMSs after intratumoral injection. The treatment group and control group animals received intratumoral injections of 1 mCi (131)...

journal_title：Radiation research

authors： Chi JL,Li CC,Xia CQ,Li L,Ma Y,Li JH,Chen Z,Chen XL

更新日期：2014-04-01 00:00:00

abstract：:Flynn, A. A., Green, A. J., Pedley, R. B., Boxer, G. M., Boden, R. and Begent, R. H. J. A Mouse Model for Calculating the Absorbed Beta-Particle Dose from (131)I- and (90)Y-Labeled Immunoconjugates, Including a Method for Dealing with Heterogeneity in Kidney and Tumor. Radiat. Res. 156, 28-35 (2001). Conventional inte...

journal_title：Radiation research

authors： Flynn AA,Green AJ,Pedley RB,Boxer GM,Boden R,Begent RH

更新日期：2001-07-01 00:00:00

abstract：:The effects of X irradiation on oligodendrocyte-type-2-astrocyte (O-2A) progenitor cells derived from different regions of the perinatal central nervous system (CNS) of rats were investigated in vitro. The O-2A progenitor cells can differentiate into either oligodendrocytes or type-2 astrocytes. The depletion of these...

journal_title：Radiation research

authors： van der Maazen RW,Kleiboer BJ,Verhagen I,van der Kogel AJ

更新日期：1991-10-01 00:00:00

abstract：:Following X irradiation of 3',5'-cyclic guanosine monophosphate single crystals at 10 K, several free radicals were trapped and detected by ESR/ENDOR/FSE spectroscopy. The two dominant species both have unpaired spin located on the guanine base. One is the product of net hydrogen atom loss from the exocyclic amino gro...

journal_title：Radiation research

authors： Hole EO,Sagstuen E,Nelson WH,Close DM

更新日期：1992-01-01 00:00:00

abstract：:We demonstrate by western analysis that the expression levels of TP53 (formerly known as p53), CDKN1A (formerly known as p21Waf1), CDC2 (formerly known as p34cdc2), CCNB1 (cyclin B1) and RAD51 are significantly modulated in confluent, density-inhibited human diploid cell populations exposed to doses where only a small...

journal_title：Radiation research

authors： Azzam EI,de Toledo SM,Gooding T,Little JB

更新日期：1998-11-01 00:00:00

abstract：:Radiation therapy for the treatment of thoracic cancers may be associated with radiation-induced heart disease (RIHD), especially in long-term cancer survivors. Mechanisms by which radiation causes heart disease are largely unknown. To identify potential long-term contributions of mitochondria in the development of ra...

journal_title：Radiation research

authors： Sridharan V,Aykin-Burns N,Tripathi P,Krager KJ,Sharma SK,Moros EG,Corry PM,Nowak G,Hauer-Jensen M,Boerma M

更新日期：2014-03-01 00:00:00

abstract：:To clarify the information in the Radiation Effects Research Foundation data regarding cancer risks of low radiation doses, we focus on survivors with doses less than 0.5 Sv. For reasons indicated, we also restrict attention mainly to survivors within 3, 000 m of the hypocenter of the bombs. Analysis is of solid cance...

journal_title：Radiation research

authors： Pierce DA,Preston DL

更新日期：2000-08-01 00:00:00

abstract：:The intrinsic radiosensitivity of tumor cells is most frequently reported for asynchronous populations, although cell cycle variation in radiosensitivity is known to be significant. Linear-quadratic analyses of survival data for asynchronous human tumor cells show wide variations in the alpha coefficient with smaller ...

journal_title：Radiation research

authors： Biade S,Stobbe CC,Chapman JD

更新日期：1997-04-01 00:00:00

abstract：:Chinese hamster V79 cells show a complex X-ray survival response which is characterized by hypersensitivity followed by increased resistance as the dose increases to 1 Gy. This hypersensitivity can be eliminated by pretreating cells with X rays or hydrogen peroxide. Accordingly, the protective effect that results from...

journal_title：Radiation research

authors： Marples B,Skov KA

更新日期：1996-10-01 00:00:00

abstract：:The toxicity of 137Cs in the beagle dog was investigated at the Inhalation Toxicology Research Institute (ITRI) and Argonne National Laboratory (ANL) as part of programs to evaluate the biological effects of both radionuclides in atomic bomb fallout and internally deposited fission-product radionuclides. In the ITRI s...

journal_title：Radiation research

authors： Nikula KJ,Muggenburg BA,Griffith WC,Carlton WW,Fritz TE,Boecker BB

更新日期：1996-11-01 00:00:00

abstract：:The cellular sites for damage in mammalian cells caused by 193-nm radiation from an argon fluoride excimer laser were investigated. The ability of Chinese hamster ovary cells to reduce a tetrazolium dye (MTT) was decreased to 37% of unirradiated control by 2.5 x 10(3) J/m2 of 193-nm radiation when measured either 4 or...

journal_title：Radiation research

authors： Kochevar IE,Walsh AA,Held KD,Gallo RL,Mirro J

更新日期：1990-05-01 00:00:00

abstract：:Incorporation of bromodeoxyuridine (BrdU) into DNA in both Chinese hamster ovary (CHO) cells and human melanoma (U1) cells reduced the rate of DNA migration in transverse alternating-field electrophoresis (TAFE) agarose gel optimized for separating molecules larger than 2 Mb. This "BrdU migration effect" was independe...

journal_title：Radiation research

authors： Latz DL,Trinh MM,Thompson LL,Gardiner K,Zhu Y,Bodell WJ,Dewey WC

更新日期：1994-04-01 00:00:00

abstract：:To study the acquired radioresistance of tumor cells, a model system of two cell lines, Djungarian hamster fibroblasts (DH-TK-) and their radioresistant progeny, was established. The progeny of irradiated cells were isolated by treating the parental cell monolayer with a single dose of 20 Gy (PIC-20). The genetic and ...

journal_title：Radiation research

authors： Tyrsina EG,Slanina SV,Kakpakova ES,Kalendo GS,Kan NG,Tyrsin OY,Ryskov AP

更新日期：2005-12-01 00:00:00

abstract：:Radiation of the esophagus of C3H/HeNsd mice with 35 or 37 Gy of 6 MV X rays induces significantly increased RNA transcription for interleukin 1 (Il1), tumor necrosis factor alpha (Tnf), interferon gamma inducing factor (Ifngr), and interferon gamma (Ifng). These elevations are associated with DNA damage that is detec...

journal_title：Radiation research

authors： Epperly MW,Gretton JA,DeFilippi SJ,Greenberger JS,Sikora CA,Liggitt D,Koe G

更新日期：2001-01-01 00:00:00