Abstract：
:Damage to intestine is a serious problem after accidental radiation exposure. To examine substances to ameliorate damage by postirradiation administration, we focused on the regeneration process after irradiation of the intestine. Using experimental systems, the effects of clinically used sex hormones on regeneration were compared. An anabolic steroid, nandrolone (19-nortestosterone), stimulated proliferation in IEC-6 epithelial cells. A single injection of 19-nortestosterone ester with prolonged action into mice 24 h after abdominal irradiation at a lethal dose of 15.7 Gy showed significant life-saving effects. Regeneration indicators such as microcolonies of BrdU-incorporated cells at day 5 and c-myb mRNA expression levels at day 4 were enhanced by 19-nortestosterone administration. In contrast, high concentrations of estradiol inhibited growth of IEC-6 cells. Treatment of abdominally irradiated mice with estradiol ester decreased levels of regeneration indicators and survival. These results suggest the effectiveness of the anabolic steroid as well as the importance of manipulation of steroid receptors in the recovery of mucosa damaged by radiation.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Ishihara H,Tanaka I,Yakumaru H,Tanaka M,Satoh A,Ishiwata A,Yokochi K,Kurematsu A,Ueda J,Shibata T,Hachiya M,Akashi Mdoi
10.1667/RR2154.1subject
Has Abstractpub_date
2011-03-01 00:00:00pages
367-74issue
3eissn
0033-7587issn
1938-5404pii
10.1667/RR2154.1journal_volume
175pub_type
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journal_title：Radiation research
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journal_title：Radiation research
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doi：
更新日期：1990-02-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
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doi：
更新日期：1989-01-01 00:00:00
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journal_title：Radiation research
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doi：
更新日期：1994-02-01 00:00:00
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doi：
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doi：
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journal_title：Radiation research
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doi：
更新日期：1996-01-01 00:00:00
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doi：
更新日期：1999-12-01 00:00:00
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journal_title：Radiation research
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doi：
更新日期：1995-05-01 00:00:00
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