Abstract：
:A radiation-induced bystander response, which is generally defined as a cellular response that is induced in nonirradiated cells that received bystander signals from directly irradiated cells within an irradiated cell population. In our earlier X-ray microbeam studies, bystander cell killing in normal human fibroblasts had a parabolic relationship to the irradiation dose. To elucidate the role of p53 in the bystander cell killing, the effects were assessed using human non-small cell lung cancer cells expressing wild-type or temperature-sensitive mutated p53. The surviving fraction of bystander wild-type p53 cells showed a parabolic relationship to the irradiation dose; survival was steeply reduced up to 0.45 Gy, recovered toward to 2 Gy, and remained at control levels up to 5 Gy. In contrast, in the mutated p53 cells at a nonpermissive temperature, the surviving fraction was steeply reduced up to 1 Gy and remained at the reduced level up to 5 Gy. When the mutated p53 cells were incubated at a permissive temperature, the decrease in the surviving fraction at 2 Gy was suppressed. The wild-type p53 cells were not only restrained in releasing bystander signals at 2 Gy, but were also resistant to the signals released by the mutated p53 cells. These results suggest that the X-ray-induced bystander cell killing depends on both the irradiation dose and the p53 status of the targeted cells and the bystander cells.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Tomita M,Maeda M,Kobayashi K,Matsumoto Hdoi
10.1667/RR3010.1subject
Has Abstractpub_date
2013-02-01 00:00:00pages
200-7issue
2eissn
0033-7587issn
1938-5404journal_volume
179pub_type
杂志文章abstract：:The appearance of prostaglandins and thromboxane in mouse serum after X irradiation was observed by simultaneous quantitative analysis using gas chromatography/mass spectrometry/selected ion monitoring with stable isotope dilution methods. Mice of two strains (C57BL/CN Jcl and BALB/c) showed similar responses to X irr...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:We studied the spatial and temporal distributions of foci of the phosphorylated form of the histone protein H2AX (gamma-H2AX), which is known to be activated by double-strand breaks after irradiation of human fibroblast cells with high-energy silicon (54 keV/microm) and iron (176 keV/microm) ions. Here we present data...
journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2005-10-01 00:00:00
abstract：:In this study, we sought to determine how diffusion-weighted imaging (DWI) and proton magnetic resonance spectroscopy (1H-MRS) features are associated with histopathological results, and explored the cellular mechanisms of DWI and 1H-MRS in early radiosensitivity of transplanted liver tumors. VX2 tumors were implanted...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR15140.1
更新日期：2019-01-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:While impairment of thyroid function has been demonstrated for high-dose external radiation (e.g., for Hodgkin's disease), the long-term functional effects of low-dose external radiation have not been fully explored. One hundred fifty-three subjects with a past history of thymic irradiation during infancy were stratif...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1987-06-01 00:00:00
abstract：:A spherical graphite calorimeter was used to determine the ratio of kerma to influence (kerma factor) for neutrons whose mean energy was approximately 14.6 MeV. The calorimeter was used to measure carbon kerma, while activation foils of Al and Au were used to determine the neutron fluence. The calorimeter was construc...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Statistical analysis of Monte Carlo simulations of positive ion track structure is presented for 1 MeV protons passing outside an absorbing region of interest. Energy deposition and production of ionization within the region occur only by delta-ray transport from the ion's path. Depositions in spherical absorber regio...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:To investigate whether exposure to atomic bomb radiation altered the prevalence of hepatitis C virus (HCV) infection or accelerated the progress toward chronic hepatitis after HCV infection, the seropositivity of antibody to hepatitis C virus (anti-HCV) was determined for 6,121 participants in the Adult Health Study o...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2000)154[0012:poahcv]2.0.co;2
更新日期：2000-07-01 00:00:00
abstract：:The lactose operon functions under the control of the repressor-operator system. Binding of the repressor to the operator prevents the expression of the structural genes. This interaction can be destroyed by the binding of an inducer to the repressor. If ionizing radiations damage the partners, a dramatic dysfunction ...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3336
更新日期：2005-04-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章,评审
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更新日期：2013-03-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2005)163[0364:doosib]2.0.co;2
更新日期：2005-04-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14896.1
更新日期：2018-07-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/3155
更新日期：2004-04-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3443.1
更新日期：2005-12-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章,评审
doi：
更新日期：1998-11-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR13395.1
更新日期：2014-02-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2001)155[0171:rdaion]2.0.co;2
更新日期：2001-01-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：:Chinese hamster ovary (CHO) cells were exposed to various concentrations of diethylmaleate (DEM) during a 42 degrees C incubation to determine if glutathione (GSH) compartmentalization was a factor in modification of thermal sensitivity. Cytoplasmic and mitochondrial GSH were isolated from CHO cells immediately after ...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-09-01 00:00:00
abstract：:Fractionated whole-brain irradiation (fWBI) is a mainstay of treatment for patients with intracranial neoplasia; however late-delayed radiation-induced normal tissue injury remains a major adverse consequence of treatment, with deleterious effects on quality of life for affected patients. We hypothesize that cerebrova...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14616.1
更新日期：2017-05-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:Phosphorylated ATM immunofluorescence staining was used to investigate the dose-response relationship for the number of DNA double-strand breaks (DSBs) induced in primary normal human fibroblasts irradiated with doses from 1.2 to 200 mGy. The induction of DSBs showed a supralinear dose-response relationship. Radiation...
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pub_type： 杂志文章
doi：10.1667/RR1255.1
更新日期：2008-09-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章,评审
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更新日期：2015-02-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：:Mycoplasma infection of mammalian cells in culture is a common occurrence that can affect the results of experimental protocols. Current methods of eliminating mycoplasma from cell cultures are usually tedious, time-consuming, and sometimes unsuccessful. In the present study, four cultured brain tumor cell lines (huma...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1991-09-01 00:00:00
