Abstract:
:To investigate whether exposure to atomic bomb radiation altered the prevalence of hepatitis C virus (HCV) infection or accelerated the progress toward chronic hepatitis after HCV infection, the seropositivity of antibody to hepatitis C virus (anti-HCV) was determined for 6,121 participants in the Adult Health Study of atomic bomb survivors in Hiroshima and Nagasaki. The seropositivity of anti-HCV antibody was 2.5 times higher among those with a history of blood transfusion and 1.2 times higher among those with a family history of liver disease, whereas acupuncture showed no association with anti-HCV. Although the prevalence of anti-HCV was lower for survivors with positive dose estimates than for those with 0 dose (relative prevalence 0.84, P = 0.022), there was no evidence of a smooth dose-response relationship. However, these data suggested that the radiation dose response for chronic liver disease among HCV antibody-positive survivors may be greater than that among HCV antibody-negative survivors (slope ratio 20). In conclusion, no dose-response relationship was found between anti-HCV positivity and radiation dose; a possible increase in the radiation dose response of chronic liver disease among anti-HCV-positive individuals was found. Thus radiation exposure may accelerate the progress of chronic liver disease associated with hepatitis C virus infection.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Fujiwara S,Kusumi S,Cologne J,Akahoshi M,Kodama K,Yoshizawa Hdoi
10.1667/0033-7587(2000)154[0012:poahcv]2.0.co;2subject
Has Abstractpub_date
2000-07-01 00:00:00pages
12-9issue
1eissn
0033-7587issn
1938-5404journal_volume
154pub_type
杂志文章abstract::The risk of a radiological or nuclear public health emergency is a major growing concern of the U.S. government. To address a potential incident and ensure that the government is prepared to respond to any subsequent civilian or military casualties, the U.S. Department of Health and Human Services and the Department o...
journal_title:Radiation research
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journal_title:Radiation research
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journal_title:Radiation research
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journal_title:Radiation research
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journal_title:Radiation research
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更新日期:2000-09-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
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更新日期:1983-03-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
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更新日期:2013-02-22 00:00:00
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pub_type: 杂志文章
doi:
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更新日期:2008-08-01 00:00:00
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更新日期:2001-01-01 00:00:00
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更新日期:2004-11-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1987-07-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1985-12-01 00:00:00
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journal_title:Radiation research
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
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journal_title:Radiation research
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