Abstract:
:Pulse radiolysis and 60Co gamma radiolysis were used to study the effects of ionizing radiations on the activity of glutamate dehydrogenase. Hydroxyl radicals are considerably more effective than hydrated electrons in causing loss of enzymatic activity. Evidence is also presented that the free radical anions (SCN)-.2, (Br)-.2, and (I)-.2 react with the enzyme and cause a loss of enzymatic activity. The results implicate the possible involvement of cysteine, tyrosine, and tryptophan residues in the activity of glutamate dehydrogenase.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Abu El Failat RR,Moore JS,Davies JVsubject
Has Abstractpub_date
1983-01-01 00:00:00pages
62-70issue
1eissn
0033-7587issn
1938-5404journal_volume
93pub_type
杂志文章abstract::Hypoadrenocorticism, known as Addison's disease in humans, was diagnosed in six beagles after inhalation of at least 1.7 kBq/g lung of 238PuO2. Histological examination of adrenal gland specimens obtained at necropsy revealed marked adrenal cortical atrophy in all cases. Autoradiographs showed only slight alpha-partic...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract::The induction of chromosome aberrations in human lymphocytes irradiated in vitro with X rays generated at a tube voltage of 29 kV was examined to assess the maximum low-dose RBE (RBE(M)) relative to higher-energy X rays or 60Co gamma rays. Since blood was taken from the same male donor whose blood had been used for pr...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2002)158[0771:teokxr]2.0.co;2
更新日期:2002-12-01 00:00:00
abstract::The acute effects of proton whole-body irradiation on the distribution and function of leukocyte populations in the spleen and blood were examined and compared to the effects of photons derived from a (60)Co gamma-ray source. Adult female C57BL/6 mice were exposed to a single dose (3 Gy at 0.4 Gy/min) of protons at sp...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2000)153[0587:aeowbp]2.0.co;2
更新日期:2000-05-01 00:00:00
abstract::In recent years, there has been increasing concern over the possibility of a radiological or nuclear incident occurring somewhere in the world. Intelligence agencies frequently report that terrorist groups and rogue nations are seeking to obtain radiological or nuclear weapons of mass destruction. In addition, there e...
journal_title:Radiation research
pub_type:
doi:10.1667/RR14810.1
更新日期:2017-08-01 00:00:00
abstract::A histopathological study was carried out on the spinal cord of rats after boron neutron capture (BNC) irradiation. Rats were irradiated with thermal neutrons alone or in combination with borocaptate sodium (BSH) or p-boronophenylalanine (BPA). Spinal cords were examined 1 year after irradiation, or at earlier times i...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::In this study, we investigated the accuracy of using off-line bioluminescence imaging (BLI) and tomography (BLT) to guide irradiation of small soft tissue targets on a small animal radiation research platform (SARRP) with on-board cone beam CT (CBCT) capability. A small glass bulb containing BL cells was implanted as ...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR2999.1
更新日期:2013-02-22 00:00:00
abstract::Tumor radiotherapy with large-field irradiation results in an increase of p53-dependent apoptosis of the radiosensitive hematopoietic stem cells. Proapoptotic PUMA is a transcriptional target of p53. Thus suppression of PUMA expression by gene therapy with the transcription repressor SNAI2 as transgene might be a pote...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR1952.1
更新日期:2010-05-01 00:00:00
abstract::We have previously proposed that survival curves for cells of murine NFSa fibrosarcomas after exposure to fast neutrons might demonstrate curvature when the neutron doses reach a level high enough to cure the fibrosarcomas. We report here that this is the case. Murine NFSa fibrosarcomas growing in the hind legs of syn...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract::We have previously observed time- and dose-dependent increases in matrix metalloproteinase 2 (Mmp2) protein levels in rat tubule epithelial cells (NRK52E) after irradiation. However, the mechanism(s) involved remains unclear. In the present study, irradiating NRK52E cells with 0-20 Gy gamma rays was associated with ti...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/3155
更新日期:2004-04-01 00:00:00
abstract::Cytokines function in many roles that are highly relevant to radiation research. This review focuses on how cytokines are structurally organized, how they are induced by radiation, and how they orchestrate mesenchymal, epithelial and immune cell interactions in irradiated tissues. Pro-inflammatory cytokines are the ...
journal_title:Radiation research
pub_type: 杂志文章,评审
doi:10.1667/RR3031.1
更新日期:2012-12-01 00:00:00
abstract::The purpose of this paper is to validate a metabolic model describing the kinetics of tritium in man. The validation is based on measurements of background levels of loose and bound tritium in Italian subjects and their diets. Model predictions are compared with empirical measurements of tritium in human urine and tis...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1984-12-01 00:00:00
abstract::Hemodynamic shear stress is defined as the physical force exerted by the continuous flow of blood in the vascular system. Endothelial cells, which line the inner layer of blood vessels, sense this physiological force through mechanotransduction signaling and adapt to maintain structural and functional homeostasis. Hem...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR14410.1
更新日期:2016-08-01 00:00:00
abstract::DNA double-strand breaks (DSBs) are 2.9 times more frequently induced in yeast cells exposed to sparsely ionizing 30-MeV electrons under oxic compared to anoxic conditions. The rejoining of DSBs induced under anoxic conditions was investigated under conditions allowing repair of potentially lethal damage and compared ...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract::There is experimental evidence that ultrasoft X rays (0.1-5 keV) show a higher biological effectiveness than high-energy photons. Similar to high-LET radiation, this is attributed to a rather localized dose distribution associated with a considerably smaller range of secondary electrons, which results in an increasing...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR14653.1
更新日期:2018-01-01 00:00:00
abstract::Human blood cultures were exposed to a 1.9 GHz continuous-wave (CW) radiofrequency (RF) field for 2 h using a series of six circularly polarized, cylindrical waveguides. Mean specific absorption rates (SARs) of 0.0, 0.1, 0.26, 0.92, 2.4 and 10 W/kg were achieved, and the temperature within the cultures during a 2-h ex...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2002)158[0523:ddamii]2.0.co;2
更新日期:2002-10-01 00:00:00
abstract::A subline of a rat mammary carcinoma (MATB 13762), selected for resistance to melphalan, is cross-resistant to other alkylating drugs, to unrelated drugs and to ionizing radiation. The difference in radioresponse between the sensitive wild-type cell line and the melphalan- and radiation-resistant line (MLNr) is relate...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::A new model for the survival of bacteria exposed to ionizing radiation is constructed in the framework of a target theory based on microdosimetric concepts, where single- and double-strand breaks of DNA and their repair in vivo can be described consistently in terms of the microdosimetric quantity j (number of effecti...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
abstract::In this study, we investigated microvascular perfusion status, changes to fat content and fatty acid composition in the bone marrow of rat femurs after total-body irradiation by quantitative permeability parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and ex vivo high-resolution magic angl...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR14865.1
更新日期:2018-02-01 00:00:00
abstract::The first hundred years of radiation studies have greatly clarified the chemical processes that are induced by radiation. While the fundamental ionization processes are similar in all systems, properties of the medium such as phase, polarity and composition can greatly affect the chemistry. In all systems, one needs t...
journal_title:Radiation research
pub_type: 历史文章,杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract::To estimate the effect of 50 Hz magnetic-field exposure on genome-wide gene expression, the yeast Saccharomyces cerevisiae was used as a model for eukaryotes. 2D PAGE (about 1,000 spots) for protein and cDNA microarray (about 5,900 genes) analysis for mRNA were performed. The cells were exposed to 50 Hz vertical magne...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3006
更新日期:2003-07-01 00:00:00
abstract::There is a need for minimally invasive biomarkers that can accurately and quickly quantify radiation exposure. Radiation-responsive proteins have applications in clinical medicine and for mass population screenings after a nuclear or radiological incident where the level of radiation exposure and exposure pattern comp...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR13927.1
更新日期:2015-07-01 00:00:00
abstract::The development of image-guided small animal irradiators represents a significant improvement over standard irradiators by enabling preclinical studies to mimic radiotherapy in humans. The ability to deliver tightly collimated targeted beams, in conjunction with gantry or animal couch rotation, has the potential to ma...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR14753.1
更新日期:2017-09-01 00:00:00
abstract::We have tested chronic exposure to 90Y beta radiation for its action as a complete tumor promoter, a stage I tumor promoter, or a stage II tumor promoter in SENCAR mouse skin. In skin initiated with a single application of 7,12,dimethylbenz[a]anthracene (DMBA, 10 nmol), chronic exposure to beta radiation as a complete...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1992-02-01 00:00:00
abstract::These studies examined the effects of X radiation and interleukin 3 (IL-3), which is an effective cytokine for the generation of megakaryocytopoiesis from X-irradiated hematopoietic stem/progenitor cells, on the terminal process of human megakaryocytopoiesis and thrombopoiesis. Mature megakaryocytes were induced by cu...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR1519.1
更新日期:2009-09-01 00:00:00
abstract::The goal of radiation therapy is to provide the highest probability of tumor control while minimizing normal tissue toxicity. Recently, it has been discovered that ultra-high dose rates of ionizing radiation may preferentially spare normal tissue over tumor tissue. This effect, referred to as FLASH radiotherapy, has b...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR15537.1
更新日期:2020-01-01 00:00:00
abstract::This study investigated whether the clonogenic ability of tumor cells to establish subcutaneous tumors and the tumor-associated macrophage (TAM) content correlate with the development and extent of the tumor bed effect (TBE). Ten tumors, five sarcomas and five carcinomas, syngeneic to C3Hf/Kam mice were used. Tumors w...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract::The distribution and kinetics of proximal tubular cells with abnormally large nuclei, which were observed in irradiated mouse kidneys before any other obvious histological effects, were investigated. Six months after the administration of 13 or 15 Gy, little histopathological change was noted, in the kidneys of C3H mi...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
abstract::The use of tritium-labeled thymidine (3H-TdR) in biological research made it necessary to develop a quick and accurate method for determination of tritium activity in tissue. After 3H-TdR incorporation into the root tip meristem of Vicia faba, total 3H activity as well as 3H-DNA activity was measured by liquid scintil...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1968-12-01 00:00:00
abstract::In this study, we assessed the efficacy of unilamellar 110-nm liposomes encapsulating the chelating agent diethylenetriaminepentaacetic acid (DTPA) in plutonium-exposed rats. Rats were contaminated by intravenous administration of the soluble citrate form of plutonium. The comparative effects of liposomal and free DTP...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR14968.1
更新日期:2018-05-01 00:00:00
abstract::Previous investigations have demonstrated an increased release of von Willebrand factor (VWF; also known as vWF) in endothelial cells after high single-dose irradiation in vitro. We have also found increased levels of Vwf protein in mouse glomeruli after a high single dose of renal irradiation in vivo. In addition, in...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2000)154[0375:ivaive]2.0.co;2
更新日期:2000-10-01 00:00:00