The radiation inactivation of glutamate dehydrogenase.

Abstract:

:Pulse radiolysis and 60Co gamma radiolysis were used to study the effects of ionizing radiations on the activity of glutamate dehydrogenase. Hydroxyl radicals are considerably more effective than hydrated electrons in causing loss of enzymatic activity. Evidence is also presented that the free radical anions (SCN)-.2, (Br)-.2, and (I)-.2 react with the enzyme and cause a loss of enzymatic activity. The results implicate the possible involvement of cysteine, tyrosine, and tryptophan residues in the activity of glutamate dehydrogenase.

journal_name

Radiat Res

journal_title

Radiation research

authors

Abu El Failat RR,Moore JS,Davies JV

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

62-70

issue

1

eissn

0033-7587

issn

1938-5404

journal_volume

93

pub_type

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