Abstract：
:Metallothionein (MT), the synthesis of which can be induced by metalloelement administration, is a known radical scavenger. This study investigated the possible protective effect of MT against acute radiation injury. Manganese chloride (10 mg of manganese/kg) was administered intraperitoneally to male C3H/He mice 24 h prior to irradiation. The paw of each mouse was irradiated locally, and the acute skin reaction was scored daily and averaged. Acute radiation injury of the small intestine was studied using an LD50/8 assay and a gut microcolony assay after abdominal irradiation. An LD50/8 value represents the radiation dose required to kill 50% of animals within 8 days. The number of microcolonies per tissue section was counted 3.5 days after irradiation. The level of MT in the liver, skin and intestine was determined by a modified 203Hg-binding assay. Acute skin reaction was not prevented by manganese pre-administration. The LD50/8 values of manganese-pretreated and control mice were 19.4 and 18.4 Gy, respectively. However, the difference was not significant. The number of microcolonies was not significantly different for these two groups in the dose range of 13-19 Gy. The level of MT in the skin and intestine was not increased by administration of manganese, although a sixfold increase was observed in the liver. In conclusion, manganese chloride treatment of mice 24 h prior to irradiation did not significantly protect skin and small intestine against acute radiation injury, because such a treatment did not result in increased levels of MT in the skin and small intestine.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Murata R,Nishimura Y,Hiraoka M,Abe M,Satoh Msubject
Has Abstractpub_date
1995-09-01 00:00:00pages
316-9issue
3eissn
0033-7587issn
1938-5404journal_volume
143pub_type
杂志文章abstract：:After total-body exposure to various doses of ionizing radiation, the ability of lymphocytes to interact specifically with high endothelial venules of rat cervical and mesenteric lymph nodes was analyzed in frozen sections. Following a radiation dose of 1.5 Gy, high endothelial venules remained intact and the binding ...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR15456.1
更新日期：2020-02-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2009-06-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR14305.1
更新日期：2016-07-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1128.1
更新日期：2007-12-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3006
更新日期：2003-07-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1983-08-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2001)156[0668:gerilc]2.0.co;2
更新日期：2001-11-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1983-12-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR3070.1
更新日期：2013-04-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/0033-7587(2001)155[0002:morice]2.0.co;2
更新日期：2001-01-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1519.1
更新日期：2009-09-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr2657.1
更新日期：2012-05-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1985-09-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3096
更新日期：2003-12-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR13452.1
更新日期：2014-03-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR15566.1
更新日期：2020-07-08 00:00:00
abstract：:The physical and biological basis of our model to calculate the biological effects of charged particles, termed the local effect model (LEM), has recently been questioned in a commentary by R. Katz. Major objections were related to the definition of the target size and the use of the term cross section. Here we show t...
journal_title：Radiation research
pub_type： 评论,杂志文章
doi：10.1667/rr3174
更新日期：2004-05-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR0578.1
更新日期：2007-03-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3255
更新日期：2004-11-01 00:00:00
