Abstract:
:A rare T-cell subpopulation, CD4-8- alpha beta T cells, may be differentiated through a pathway (or pathways) different from the pathway(s) of conventional CD4+ or CD8+ T cells. In the present study, the frequencies of CD4-8-T cells in peripheral-blood alpha beta T cells in 409 atomic bomb survivors (160 estimated to have been exposed to 1.5 Gy or more and 249 controls) were determined to investigate late effects of radiation on the composition of human T-cell subpopulations. The frequency of CD4-8- alpha beta T-cell decreased significantly with the subject's age and was higher in females than males. A significant increase in the frequency was found in the survivors exposed to more than 1.5 Gy, suggesting that the previous radiation exposure altered differentiation and development of T cells.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Kusunoki Y,Kyoizumi S,Hirai Y,Fujita S,Akiyama Msubject
Has Abstractpub_date
1994-07-01 00:00:00pages
67-72issue
1eissn
0033-7587issn
1938-5404journal_volume
139pub_type
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