Cancer mortality (1956-1985) among male employees of Atomic Energy of Canada Limited with respect to occupational exposure to external low-linear-energy-transfer ionizing radiation.

abstract：:We have monitored the end points of cellular survival, micronucleus formation and neoplastic transformation frequency to assess adaptation to ionizing radiation in the C3H 10T1/2 mouse embryo cell system. Plateau-phase cells were pre-exposed to an adapting dose of 0.1 to 1.5 Gy low-dose-rate gamma radiation 3.5 h prio...

journal_title：Radiation research

authors： Azzam EI,Raaphorst GP,Mitchel RE

更新日期：1994-04-01 00:00:00

abstract：:Our goal was to determine whether esophageal progenitor cells could be isolated from adult mouse esophagus or bone marrow and shown to home to and proliferate in the irradiated esophagus of recipient mice. Esophageal progenitor cells were isolated from adult male C3H/HeNsd or C57BL/6J green fluorescent protein (GFP(+)...

journal_title：Radiation research

authors： Epperly MW,Guo H,Shen H,Niu Y,Zhang X,Jefferson M,Sikora CA,Greenberger JS

更新日期：2004-09-01 00:00:00

abstract：:The hyperthermic inhibition of cellular DNA synthesis, i.e., reduction in replicon initiation and delay in DNA chain elongation, was previously postulated to be involved in the induction of chromosomal aberrations believed to be largely responsible for killing S-phase cells. Utilizing asynchronous Chinese hamster ovar...

journal_title：Radiation research

authors： Wong RS,Thompson LL,Dewey WC

更新日期：1988-04-01 00:00:00

abstract：:The severe combined immune deficiency (SCID) mouse shows two kinds of phenotypic abnormalities, a high radiosensitivity and an abnormal immunoglobulin gene recombination. A genetic study has revealed that a mutation exists in chromosome 16. However, several attempts to isolate the gene responsible for these phenotypes...

journal_title：Radiation research

authors： Itoh M,Hamatani K,Komatsu K,Araki R,Takayama K,Abe M

更新日期：1993-06-01 00:00:00

abstract：:The appearance of prostaglandins and thromboxane in mouse serum after X irradiation was observed by simultaneous quantitative analysis using gas chromatography/mass spectrometry/selected ion monitoring with stable isotope dilution methods. Mice of two strains (C57BL/CN Jcl and BALB/c) showed similar responses to X irr...

journal_title：Radiation research

authors： Yamaoka K,Obata T,Iriyama K,Iwasaki T,Hoshi Y

更新日期：1998-01-01 00:00:00

abstract：:A nested case-control study was conducted among workers at five U.S. nuclear facilities to evaluate leukemia mortality risk (excluding chronic lymphocytic) from ionizing radiation using worksite doses and adjusting for potential confounding. Conditional logistic regression was used to estimate the relative risk (RR) o...

journal_title：Radiation research

authors： Schubauer-Berigan MK,Daniels RD,Fleming DA,Markey AM,Couch JR,Ahrenholz SH,Burphy JS,Anderson JL,Tseng CY

更新日期：2007-02-01 00:00:00

abstract：:The percentage of T lymphocytes of atomic bomb survivors showed no change as a function of age or exposure dose. The percentage of T cells was slightly lower in malignant-tumor patients than in the control group, but was significantly higher in the group with chromosomal aberrations than in the control group. The perc...

journal_title：Radiation research

authors： Akiyama M,Yamakido M,Kobuke K,Dock DS,Hamilton HB,Awa AA,Kato H

更新日期：1983-03-01 00:00:00

abstract：:We studied the effects of extremely low-frequency (50 Hz) electromagnetic fields (EMFs) on peripheral human blood lymphocytes and DBY747 Saccharomyces cerevisiae. Graded exposure to 50 Hz magnetic flux density was obtained with a Helmholtz coil system set at 1, 10 or 100 microT for 18 h. The effects of EMFs on DNA dam...

journal_title：Radiation research

authors： Luceri C,De Filippo C,Giovannelli L,Blangiardo M,Cavalieri D,Aglietti F,Pampaloni M,Andreuccetti D,Pieri L,Bambi F,Biggeri A,Dolara P

更新日期：2005-09-01 00:00:00

abstract：:New Zealand rabbits, fasted for 12 hours, were subjected to 500 rads of whole-body irradiation. K+-palmitate-1-14C oxidation was assayed with the 600 X g supernatant of thymus and liver homogenates, in the presence of ATP, at various time intervals from irradiation. For a period of 24 hours following irradiation, oxid...

journal_title：Radiation research

authors： Miras CJ,Mantzos JD,Legakis NJ,Levis GM

更新日期：1968-11-01 00:00:00

abstract：:This commentary considers modulation as a factor of potential biological importance in assessment of risk of radiofrequency (RF) energy emitted by communications systems and other technologies. Modulation introduces a spread of frequencies into a carrier waveform, but in nearly all cases this spread is small compared ...

journal_title：Radiation research

authors： Foster KR,Repacholi MH

更新日期：2004-08-01 00:00:00

abstract：:Aberrant expression of microRNAs (miRNAs) is frequently associated with a variety of cancers, including breast cancer. We and others have demonstrated that radiation-induced rat mammary cancer exhibits a characteristic gene expression profile and a random increase in aberrant DNA copy number; however, the role of aber...

journal_title：Radiation research

authors： Iizuka D,Imaoka T,Nishimura M,Kawai H,Suzuki F,Shimada Y

更新日期：2013-02-01 00:00:00

abstract：:We have previously published the techniques and preliminary results of an SV40 viral probe assay for gamma-radiation-induced single- and double-strand DNA breaks and their intracellular repair in higher cells (Radiat. Res. 101, 356-372, 1985). Those experiments with SV40 infected CV-1 monkey kidney cells suggested tha...

journal_title：Radiation research

authors： Krisch RE,Flick MB

更新日期：1988-12-01 00:00:00

abstract：:Acute thermotolerance was induced in Chinese hamster ovary cells by heating at 43 degrees C for 45 min followed by incubation at 37 degrees C for up to 85 h. The degree of thermotolerance induced was quantified by a second heat exposure at 43 degrees C. To study the interaction of thermotolerance and thermosensitizati...

journal_title：Radiation research

authors： Jung H

更新日期：1994-09-01 00:00:00

abstract：:In higher eukaryotes, DNA double-strand breaks (DSBs) induced by ionizing radiation activate checkpoints that delay progression through the cell cycle. Compared to delays in other phases of the cell cycle, delays induced in G(2) are longer and frequently correlate with resistance to killing by radiation. Therefore, mo...

journal_title：Radiation research

authors： Fan X,Cheong N,Iliakis G

更新日期：2010-10-01 00:00:00

abstract：:Radiation-induced acute myeloid leukemia (rAML) in C3H mice is commonly developed through inactivation of PU.1 transcription factor encoded in Sfpi1 on chromosome 2. PU.1 inactivation involves two steps: hemizygous deletion of the Sfpi1 gene (DSG) and point mutation of the allele Sfpi1 gene (PMASG). In this study, we ...

journal_title：Radiation research

authors： Ojima M,Hirouchi T,Etani R,Ariyoshi K,Fujishima Y,Kai M

更新日期：2019-12-01 00:00:00

abstract：:These studies examined the effects of X radiation and interleukin 3 (IL-3), which is an effective cytokine for the generation of megakaryocytopoiesis from X-irradiated hematopoietic stem/progenitor cells, on the terminal process of human megakaryocytopoiesis and thrombopoiesis. Mature megakaryocytes were induced by cu...

journal_title：Radiation research

authors： Monzen S,Osuda K,Miyazaki Y,Hayashi N,Takahashi K,Kashiwakura I

更新日期：2009-09-01 00:00:00

abstract：:These experiments were designed to study the kinetics and magnitude of cell repair and repopulation in tissues whose damage results in the tumor bed effect. The right hind thighs of mice were irradiated with single doses or two equal gamma-ray fractions. Interfraction intervals ranging from 30 min to 24 h (to measure ...

journal_title：Radiation research

authors： Terry NH,Ang KK,Hunter NR,Milas L

更新日期：1988-06-01 00:00:00

abstract：:Chemical and structural modifications in multilayer liposomes of synthetic phosphatidylcholine induced by gamma irradiation are investigated with different techniques. Fluorescence anisotropy of the DPH probe and differential scanning calorimetry reveal a broadening of the main lipid transition and the disappearance o...

journal_title：Radiation research

authors： Ianzini F,Guidoni L,Indovina PL,Viti V,Erriu G,Onnis S,Randaccio P

更新日期：1984-04-01 00:00:00

abstract：:To evaluate the usefulness of the transgenic Muta mouse for investigating radiation-induced mutations in vivo, we have examined the effects of whole-body X irradiation and compared them to the effects of ultraviolet light. The spontaneous mutation frequencies in young adults were about 7 x 10(-5) in the spleen, liver ...

journal_title：Radiation research

authors： Ono T,Ikehata H,Hosoi Y,Shung BS,Kurishita A,Wang X,Yamamoto K,Suzuki T,Sofuni T

更新日期：1997-08-01 00:00:00

abstract：:A dose of heat which renders 98% of a population of Chinese hamster ovary cells reproductively dead has no significant effect on their Na+, K+, or Mg2+ content by 28 h postheat. In contrast, the cellular Ca2+ content increases in a dose-dependent manner as observed at 22 h after heating for 15-35 min at 45 degrees C. ...

journal_title：Radiation research

authors： Vidair CA,Dewey WC

更新日期：1986-02-01 00:00:00

abstract：:Chinese hamster ovary (CHO) cells became thermotolerant after treatment with either heat for 10 min at 45.5 degrees C or incubation in 100 microM sodium arsenite for 1 h at 37 degrees C. Thermotolerance was tested using heat treatment at 45 degrees C or 43 degrees C administered 6-12 h after the inducing agent. At 45 ...

journal_title：Radiation research

authors： Lee YJ,Perlaky L,Dewey WC,Armour EP,Corry PM

更新日期：1990-03-01 00:00:00

abstract：:While nontargeted and low-dose effects such as the bystander effect are now accepted, the mechanisms underlying the response have yet to be elucidated. It has been shown that the transfer of irradiated cell conditioned medium (ICCM) can kill cells that are not directly irradiated; however, to date the effect of ICCM c...

journal_title：Radiation research

authors： Ryan LA,Smith RW,Seymour CB,Mothersill CE

更新日期：2008-02-01 00:00:00

abstract：:If the limited life span of hematopoietic tissues in vitro is due to a finite proliferative capacity of individual stem cells, one might expect tissues of young donors to possess a greater proliferative capacity and to contain a larger population of primitive stem cells than those of older donors. To test this hypothe...

journal_title：Radiation research

authors： Schmidt CM,Doran GA,Crouse DA,Sharp JG

更新日期：1987-10-01 00:00:00

abstract：:A recent publication by Leith et al. (Cancer Res. 51, 4111-4113, 1991) showed that administration of epidermal growth factor (EGF) (0.25 mg/kg; q.i.d. x 7) to mice bearing xenografted A431 human epidermoid cancers produced increased tumor growth and a reduction of the percentage of hypoxic cells within neoplasms. In c...

journal_title：Radiation research

authors： Leith JT,Padfield G,Michelson S

更新日期：1992-11-01 00:00:00

abstract：:The exposure of peripheral blood mononuclear cells (PBMCs) was performed in a 10-T static magnetic field. Without lymphocyte stimulation, there were no significant differences in the viability of the exposed and unexposed CD4(+) T cells, CD8(+) T cells, B cells, and natural killer (NK) cells. The expression of Th1 typ...

journal_title：Radiation research

authors： Onodera H,Jin Z,Chida S,Suzuki Y,Tago H,Itoyama Y

更新日期：2003-06-01 00:00:00

abstract：:Human cancers have multiple alterations in cell signaling pathways that promote resistance to cytotoxic therapy such as X rays. Parthenolide is a sesquiterpene lactone that has been shown to inhibit several pro-survival cell signaling pathways, induce apoptosis, and enhance chemotherapy-induced cell killing. We invest...

journal_title：Radiation research

authors： Mendonca MS,Chin-Sinex H,Gomez-Millan J,Datzman N,Hardacre M,Comerford K,Nakshatri H,Nye M,Benjamin L,Mehta S,Patino F,Sweeney C

更新日期：2007-12-01 00:00:00

abstract：:Radon is recognized as a public health concern for indoor exposure. Precise quantification derived from occupational exposure in miners is still needed for estimating the risk and the factors that modify the dependence on cumulated exposure. The present paper reports on relationship between radon exposure and lung can...

journal_title：Radiation research

authors： Tomasek L,Rogel A,Tirmarche M,Mitton N,Laurier D

更新日期：2008-02-01 00:00:00

abstract：:Radiation is an independent risk factor for cardiovascular and cerebrovascular disease in cancer patients. Modern radiotherapy techniques reduce the volume of the heart and major coronary vessels exposed to high doses, but some exposure is often unavoidable. Radiation damage to the myocardium is caused primarily by in...

journal_title：Radiation research

authors： Stewart FA,Hoving S,Russell NS

更新日期：2010-12-01 00:00:00

abstract：:Trypanothione is a unique diglutathionyl-spermidine conjugate found in abundance in trypanosomes but not in other eukaryotes. Because trypanothione is a naturally occurring polyamine thiol reminiscent of the synthetic drug amifostine, it may be a useful protector against radiation and oxidative stress. For these reaso...

journal_title：Radiation research

authors： Fitzgerald MP,Madsen JM,Coleman MC,Teoh ML,Westphal SG,Spitz DR,Radi R,Domann FE

更新日期：2010-09-01 00:00:00

abstract：:Mathematical analysis of cell survival allows parameter estimation for radiobiological models and selection of an appropriate model. To our knowledge, no rigorous comparisons on the accuracy of various methods used for such analysis have been performed. In this study we compared three methods: 1. maximization of binom...

journal_title：Radiation research

authors： Shuryak I,Sun Y,Balajee AS

更新日期：2016-03-01 00:00:00