Vascular damage as an underlying mechanism of cardiac and cerebral toxicity in irradiated cancer patients.

Abstract:

:Radiation is an independent risk factor for cardiovascular and cerebrovascular disease in cancer patients. Modern radiotherapy techniques reduce the volume of the heart and major coronary vessels exposed to high doses, but some exposure is often unavoidable. Radiation damage to the myocardium is caused primarily by inflammatory changes in the microvasculature, leading to microthrombi and occlusion of vessels, reduced vascular density, perfusion defects and focal ischemia. This is followed by progressive myocardial cell death and fibrosis. Clinical studies also demonstrate regional perfusion defects in non-symptomatic breast cancer patients after radiotherapy. The incidence and extent of perfusion defects are related to the volume of left ventricle included in the radiation field. Irradiation of endothelial cells lining large vessels also increases expression of inflammatory molecules, leading to adhesion and transmigration of circulating monocytes. In the presence of elevated cholesterol, invading monocytes transform into activated macrophages and form fatty streaks in the intima, thereby initiating the process of atherosclerosis. Experimental studies have shown that radiation predisposes to the formation of inflammatory plaque, which is more likely to rupture and cause a fatal heart attack or stroke. This paper presents a brief overview of the current knowledge on mechanisms for development of radiation-induced cardiovascular and cerebrovascular damage. It does not represent a comprehensive review of the literature, but reference is made to several excellent recent reviews on the topic.

journal_name

Radiat Res

journal_title

Radiation research

authors

Stewart FA,Hoving S,Russell NS

doi

10.1667/RR1862.1

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

865-9

issue

6

eissn

0033-7587

issn

1938-5404

pii

10.1667/RR1862.1

journal_volume

174

pub_type

杂志文章,评审
  • Effects of the interaction between carbogen and nicotinamide on R3230 Ac tumor blood flow in Fischer 344 rats.

    abstract::Braun, R. D., Lanzen, J. L., Turnage, J. A., Rosner, G. and Dewhirst, M. W. Effects of the Interaction between Carbogen and Nicotinamide on R3230 Ac Tumor Blood Flow in Fischer 344 Rats. Radiat. Res. 155, 724-733 (2001). The purpose of this study was to determine whether there are interactions between carbogen breathi...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/0033-7587(2001)155[0724:eotibc]2.0.co;2

    authors: Braun RD,Lanzen JL,Turnage JA,Rosner G,Dewhirst MW

    更新日期:2001-05-01 00:00:00

  • Prevalence of anti-hepatitis C virus antibody and chronic liver disease among atomic bomb survivors.

    abstract::To investigate whether exposure to atomic bomb radiation altered the prevalence of hepatitis C virus (HCV) infection or accelerated the progress toward chronic hepatitis after HCV infection, the seropositivity of antibody to hepatitis C virus (anti-HCV) was determined for 6,121 participants in the Adult Health Study o...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/0033-7587(2000)154[0012:poahcv]2.0.co;2

    authors: Fujiwara S,Kusumi S,Cologne J,Akahoshi M,Kodama K,Yoshizawa H

    更新日期:2000-07-01 00:00:00

  • Vascular permeability and late radiation fibrosis in mouse lung.

    abstract::It has been suggested that fibrosis which develops after irradiation is caused by increases in vascular permeability. Plasma proteins leak into irradiated tissue where fibrinogen may be converted into fibrin which is gradually replaced by fibrous tissue. Vascular and fibrotic changes in mouse lung were investigated af...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Law MP

    更新日期:1985-07-01 00:00:00

  • Differences in thermotolerance induced by heat or sodium arsenite: cell killing and inhibition of protein synthesis.

    abstract::Chinese hamster ovary (CHO) cells became thermotolerant after treatment with either heat for 10 min at 45.5 degrees C or incubation in 100 microM sodium arsenite for 1 h at 37 degrees C. Thermotolerance was tested using heat treatment at 45 degrees C or 43 degrees C administered 6-12 h after the inducing agent. At 45 ...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Lee YJ,Perlaky L,Dewey WC,Armour EP,Corry PM

    更新日期:1990-03-01 00:00:00

  • A model relating cell survival to DNA fragment loss and unrepaired double-strand breaks.

    abstract::The model of radiation action that is presented relates the surviving fraction of irradiated cells to unrepaired DNA double-strand breaks (DSBs). The following assumptions are made in the model: (i) A DNA fragment created by the induced DSBs may move out of its chromosome (become lost), and the probability of that pro...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Ostashevsky JY

    更新日期:1989-06-01 00:00:00

  • Wortmannin sensitizes mammalian cells to radiation by inhibiting the DNA-dependent protein kinase-mediated rejoining of double-strand breaks.

    abstract::Wortmannin has been shown to be an efficient radiosensitizer. Since wortmannin is able to inhibit DNA-dependent protein kinase (DNA-PK) and double-strand break (DSB) rejoining, it is believed that its mechanism of radiation sensitization is through the inhibition of DNA-PK-mediated repair of DSBs. However, since wortm...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Chernikova SB,Wells RL,Elkind MM

    更新日期:1999-02-01 00:00:00

  • Effects of extracellular and intracellular pH on repair of potentially lethal damage, chromosome aberrations and DNA double-strand breaks in irradiated plateau-phase A549 cells.

    abstract::Plateau-phase A549 cells exhibit a high capacity for repair of potentially lethal radiation damage (PLD). Previously it was found that PLD repair could be partially inhibited by increasing the extracellular pH (pHe) of the spent medium from its normal value of 6.7-6.8 to 7.6 during postirradiation holding. The present...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Jayanth VR,Bayne MT,Varnes ME

    更新日期:1994-08-01 00:00:00

  • DNA damage caused by chronic transgenerational exposure to low dose gamma radiation in Medaka fish ( Oryzias latipes ).

    abstract::The effect of transgenerational exposure to low dose rate (2.4 and 21 mGy/day) gamma irradiation on the yield of DNA double-strand breaks and oxidized guanine (8-hydroxyguanine) has been studied in the muscle and liver tissue of a model organism, the Japanese medaka fish. We found the level of unrepaired 8-hydroxyguan...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR3190.1

    authors: Grygoryev D,Moskalenko O,Hinton TG,Zimbrick JD

    更新日期:2013-09-01 00:00:00

  • Mechanism for 193-nm laser radiation-induced effects on mammalian cells.

    abstract::The cellular sites for damage in mammalian cells caused by 193-nm radiation from an argon fluoride excimer laser were investigated. The ability of Chinese hamster ovary cells to reduce a tetrazolium dye (MTT) was decreased to 37% of unirradiated control by 2.5 x 10(3) J/m2 of 193-nm radiation when measured either 4 or...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Kochevar IE,Walsh AA,Held KD,Gallo RL,Mirro J

    更新日期:1990-05-01 00:00:00

  • Education and training for radiation scientists: radiation research program and American Society of Therapeutic Radiology and Oncology Workshop, Bethesda, Maryland, May 12-14, 2003.

    abstract::Current and potential shortfalls in the number of radiation scientists stand in sharp contrast to the emerging scientific opportunities and the need for new knowledge to address issues of cancer survivorship and radiological and nuclear terrorism. In response to these challenges, workshops organized by the Radiation R...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/rr3096

    authors: Coleman CN,Stone HB,Alexander GA,Barcellos-Hoff MH,Bedford JS,Bristow RG,Dynlacht JR,Fuks Z,Gorelic LS,Hill RP,Joiner MC,Liu FF,McBride WH,McKenna WG,Powell SN,Robbins ME,Rockwell S,Schiff PB,Shaw EG,Siemann DW,Tr

    更新日期:2003-12-01 00:00:00

  • Estimation of the SAR in the human head and body due to radiofrequency radiation exposure from handheld mobile phones with hands-free accessories.

    abstract::It was reported by others that hands-free accessories increase the absorption of RF energy in a human head compared to a handset alone. The results of this study show that the opposite is observed when proper dosimetric methods are employed. It is pointed out that for correct estimation of the exposure level it is nec...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/0033-7587(2003)159[0550:eotsit]2.0.co;2

    authors: Bit-Babik G,Chou CK,Faraone A,Gessner A,Kanda M,Balzano Q

    更新日期:2003-04-01 00:00:00

  • Hydrogen peroxide-induced base damage in deoxyribonucleic acid.

    abstract::Aqueous solutions of calf thymus deoxyribonucleic acid (DNA) were exposed to hydrogen peroxide in the presence of air. Base products formed in DNA were identified and quantitated following acid hydrolysis and trimethylsilylation using gas chromatography-mass spectrometry. The yields of these products were dependent up...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Blakely WF,Fuciarelli AF,Wegher BJ,Dizdaroglu M

    更新日期:1990-03-01 00:00:00

  • Thyroid Cancer after Childhood Exposure to External Radiation: An Updated Pooled Analysis of 12 Studies.

    abstract::Studies have causally linked external thyroid radiation exposure in childhood with thyroid cancer. In 1995, investigators conducted relative risk analyses of pooled data from seven epidemiologic studies. Doses were mostly <10 Gy, although childhood cancer therapies can result in thyroid doses >50 Gy. We pooled data fr...

    journal_title:Radiation research

    pub_type: 杂志文章,meta分析

    doi:10.1667/RR14213.1

    authors: Veiga LH,Holmberg E,Anderson H,Pottern L,Sadetzki S,Adams MJ,Sakata R,Schneider AB,Inskip P,Bhatti P,Johansson R,Neta G,Shore R,de Vathaire F,Damber L,Kleinerman R,Hawkins MM,Tucker M,Lundell M,Lubin JH

    更新日期:2016-05-01 00:00:00

  • Cellular and molecular changes in mammary epithelial cells following irradiation.

    abstract::The present paper describes experiments conducted over the last several years which have focused primarily on the development of mammary tumors in BALB/c mice after neutron and gamma irradiation. Time-dose relationships for induction of mammary and lung tumors following irradiation with fission-spectrum neutrons and 1...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Ullrich RL

    更新日期:1991-10-01 00:00:00

  • Measurement of DNA damage and apoptosis in Molt-4 cells after in vitro exposure to radiofrequency radiation.

    abstract::To determine whether exposure to radiofrequency (RF) radiation can induce DNA damage or apoptosis, Molt-4 T lymphoblastoid cells were exposed with RF fields at frequencies and modulations of the type used by wireless communication devices. Four types of frequency/modulation forms were studied: 847.74 MHz code-division...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/rr3127

    authors: Hook GJ,Zhang P,Lagroye I,Li L,Higashikubo R,Moros EG,Straube WL,Pickard WF,Baty JD,Roti Roti JL

    更新日期:2004-02-01 00:00:00

  • Calorimetric measurement of the carbon kerma factor for 14.6-MeV neutrons.

    abstract::A spherical graphite calorimeter was used to determine the ratio of kerma to influence (kerma factor) for neutrons whose mean energy was approximately 14.6 MeV. The calorimeter was used to measure carbon kerma, while activation foils of Al and Au were used to determine the neutron fluence. The calorimeter was construc...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: McDonald JC

    更新日期:1987-01-01 00:00:00

  • Antimutagenicity of WR-1065 in L5178Y cells exposed to accelerated (56)Fe ions.

    abstract::The ability of the aminothiol WR-1065 [N-(2-mercaptoethyl)-1,3-diaminopropane] to protect L5178Y (LY) cells against the cytotoxic and mutagenic effects of exposure to accelerated (56)Fe ions (1.08 GeV/nucleon) was determined. It was found that while WR-1065 reduced the mutagenicity in both cell lines when it was prese...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/0033-7587(2002)158[0110:aowilc]2.0.co;2

    authors: Evans HH,Evans TE,Horng MF

    更新日期:2002-07-01 00:00:00

  • Global comparison of radiation and chemotherapy dose-response curves with a test for interaction.

    abstract::In the analysis of the effects of radiation or drugs on clonogenic survival data of mammalian cells, it is often advantageous to compare entire dose-response curves generated under different experimental conditions rather than to conduct single-dose comparisons. We propose a two-stage method for the global comparison ...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Lindstrom MJ,Kunugi KA,Kinsella TJ

    更新日期:1993-08-01 00:00:00

  • The physical and radiobiological basis of the local effect model: a response to the commentary by R. Katz.

    abstract::The physical and biological basis of our model to calculate the biological effects of charged particles, termed the local effect model (LEM), has recently been questioned in a commentary by R. Katz. Major objections were related to the definition of the target size and the use of the term cross section. Here we show t...

    journal_title:Radiation research

    pub_type: 评论,杂志文章

    doi:10.1667/rr3174

    authors: Scholz M,Kraft G

    更新日期:2004-05-01 00:00:00

  • Bystander cell death and stress response is inhibited by the radical scavenger α(1)-microglobulin in irradiated cell cultures.

    abstract::Alpha-particle irradiation of cells damages not only the irradiated cells but also nontargeted bystander cells. It has been proposed that the bystander effect is caused by oxidants and free radicals generated by the radiation. Recent studies have shown that α(1)-microglobulin protects against cell damage caused by oxi...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR2213.1

    authors: Olsson MG,Nilsson EJ,Rutardóttir S,Paczesny J,Pallon J,Akerström B

    更新日期:2010-11-01 00:00:00

  • Evidence of the formation of different hydroperoxides in irradiated gamma-linolenate solutions: effect of micelle formation.

    abstract::Peroxidation of unconjugated polyunsaturated fatty acids such as linolenic acid proceeds through a free radical chain mechanism and is accompanied by the formation of conjugated dienes such as hydroperoxides. In an investigation of radiation-induced oxidation of aqueous linolenate, we have measured two indexes of pero...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/0033-7587(2000)153[0201:eotfod]2.0.co;2

    authors: Hindo J,Hauville C,Rémita S,Thérond P,Couturier M,Jore D,Gardès-Albert M

    更新日期:2000-02-01 00:00:00

  • Cerebrovascular Remodeling and Neuroinflammation is a Late Effect of Radiation-Induced Brain Injury in Non-Human Primates.

    abstract::Fractionated whole-brain irradiation (fWBI) is a mainstay of treatment for patients with intracranial neoplasia; however late-delayed radiation-induced normal tissue injury remains a major adverse consequence of treatment, with deleterious effects on quality of life for affected patients. We hypothesize that cerebrova...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR14616.1

    authors: Andrews RN,Metheny-Barlow LJ,Peiffer AM,Hanbury DB,Tooze JA,Bourland JD,Hampson RE,Deadwyler SA,Cline JM

    更新日期:2017-05-01 00:00:00

  • GSM and DCS wireless communication signals: combined chronic toxicity/carcinogenicity study in the Wistar rat.

    abstract::A total of 1170 rats comprised of 65 male and 65 female Han Wistar rats per group were exposed for 2 h/day, 5 days/ week for up to 104 weeks to GSM or DCS wireless communication signals at three nominal SARs of 0.44, 1.33 and 4.0 W/kg. A preliminary study confirmed that the highest exposure level was below that which ...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR0680.1

    authors: Smith P,Kuster N,Ebert S,Chevalier HJ

    更新日期:2007-10-01 00:00:00

  • Induction of adaptive response in human blood lymphocytes exposed to radiofrequency radiation.

    abstract::The incidence of micronuclei was evaluated to assess the induction of an adaptive response to non-ionizing radiofrequency (RF) radiation in peripheral blood lymphocytes collected from five different human volunteers. After stimulation with phytohemagglutinin for 24 h, the cells were exposed to an adaptive dose of 900 ...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR1687.1

    authors: Sannino A,Sarti M,Reddy SB,Prihoda TJ,Vijayalaxmi,Scarfì MR

    更新日期:2009-06-01 00:00:00

  • In situ detection of chromosome bridge formation and delayed reproductive death in normal human embryonic cells surviving X irradiation.

    abstract::We investigated delayed reproductive death and chromosome bridge formation in mitotic cells in colonies of normal human embryonic cells which survived exposure to 6 Gy of X rays. Eighteen primary clones each derived from control and irradiated cultures were isolated and secondary colonies were grown up. Six of the pri...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Suzuki K,Takahara R,Kodama S,Watanabe M

    更新日期:1998-10-01 00:00:00

  • Radiation-induced chromosome aberrations in ataxia telangiectasia cells: high frequency of deletions and misrejoining detected by fluorescence in situ hybridization.

    abstract::The mechanisms underlying the hyper-radiosensitivity of AT cells were investigated by analyzing chromosome aberrations in the G(2) and M phases of the cell cycle using a combination of chemically induced premature chromosome condensation (PCC) and fluorescence in situ hybridization (FISH) with chromosome painting prob...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/0033-7587(2003)159[0597:rcaiat]2.0.co;2

    authors: Kawata T,Ito H,George K,Wu H,Uno T,Isobe K,Cucinotta FA

    更新日期:2003-05-01 00:00:00

  • A robust procedure for removing background damage in assays of radiation-induced DNA fragment distributions.

    abstract::The non-random distribution of DNA breakage in PFGE (pulsed-field gel electrophoresis) experiments poses a problem of proper subtraction of the background DNA damage to obtain a fragment-size distribution due to radiation only. A naive bin-to-bin subtraction of the background signal will not result in the right DNA ma...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR0663.1

    authors: Ponomarev AL,Belli M,Hahnfeldt PJ,Hlatky L,Sachs RK,Cucinotta FA

    更新日期:2006-12-01 00:00:00

  • The delayed manifestation of T-cell receptor (TCR) variants in X-irradiated mice depends on Trp53 status.

    abstract::The influence of Trp53 on the radiation-induced elevation of T-cell receptor (TCR) variant fractions was examined in splenic T lymphocytes of Trp53-proficient and -deficient mice. Wild-type Trp53+/+, heterozygous Trp53+/- and null Trp53-/- mice were exposed to 3 Gy of X rays at 8 weeks of age. The fraction of TCR-defe...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR3583.1

    authors: Igari K,Igari Y,Okazaki R,Kato F,Ootsuyama A,Norimura T

    更新日期:2006-07-01 00:00:00

  • Variation of radiation sensitivity of Friend erythroleukemia cells cultured in the presence of the differentiation inducer DMSO.

    abstract::Differentiation of Friend erythroleukemia cells (FELC) was induced with 1.5% dimethyl sulfoxide (DMSO) in the culture medium. Cell growth, erythroid differentiation, and radiosensitivity of the proliferative capacity of the cells were measured and compared to a noninduced control culture of identical age. Induced cell...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:

    authors: Einspenner M,Boulton JE,Borsa J

    更新日期:1984-01-01 00:00:00

  • Optimization of Alanine Measurements for Fast and Accurate Dosimetry in FLASH Radiation Therapy.

    abstract::FLASH radiation therapy (FLASH-RT) reference dosimetry to obtain traceability, repeatability and stability of irradiations cannot be performed with conventional dosimetric methods, such as monitor chambers or ionization chambers. Until now, only passive dosimeters have provided the necessary dosimetric data. Alanine d...

    journal_title:Radiation research

    pub_type: 杂志文章

    doi:10.1667/RR15568.1

    authors: Gondré M,Jorge PG,Vozenin MC,Bourhis J,Bochud F,Bailat C,Moeckli R

    更新日期:2020-12-01 00:00:00