50 Years of the Radiological Research Accelerator Facility (RARAF).

abstract：:The exposure of peripheral blood mononuclear cells (PBMCs) was performed in a 10-T static magnetic field. Without lymphocyte stimulation, there were no significant differences in the viability of the exposed and unexposed CD4(+) T cells, CD8(+) T cells, B cells, and natural killer (NK) cells. The expression of Th1 typ...

journal_title：Radiation research

authors： Onodera H,Jin Z,Chida S,Suzuki Y,Tago H,Itoyama Y

更新日期：2003-06-01 00:00:00

abstract：:The non-random distribution of DNA breakage in PFGE (pulsed-field gel electrophoresis) experiments poses a problem of proper subtraction of the background DNA damage to obtain a fragment-size distribution due to radiation only. A naive bin-to-bin subtraction of the background signal will not result in the right DNA ma...

journal_title：Radiation research

authors： Ponomarev AL,Belli M,Hahnfeldt PJ,Hlatky L,Sachs RK,Cucinotta FA

更新日期：2006-12-01 00:00:00

abstract：:Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy and environmental nuclear contamination as well as for Earth-orbit and space missions. Analyses of transcriptome prof...

journal_title：Radiation research

authors： Lowe XR,Bhattacharya S,Marchetti F,Wyrobek AJ

更新日期：2009-01-01 00:00:00

abstract：:The A31-11 mouse BALB/3T3 cell system was adapted for the study of malignant transformation induced by 5.3 MeV alpha particles from a specially constructed 238Pu source. The biologic effects were compared to those of 220 kVp X rays. The alpha-radiation survival curve showed a D0 of 70 rad and a relative biological eff...

journal_title：Radiation research

authors： Robertson JB,Koehler A,George J,Little JB

更新日期：1983-11-01 00:00:00

abstract：:Potentially lethal damage (PLD) repair has been defined as that property conferring the ability of cells to recover from DNA damage depending on the postirradiation environment. Using a novel cyclin dependent kinase 1 inhibitor RO-3306 to arrest cells in the G2 phase of the cell cycle, examined PLD repair in G2 in cul...

journal_title：Radiation research

authors： Maeda J,Bell JJ,Genet SC,Fujii Y,Genet MD,Brents CA,Genik PC,Kato TA

更新日期：2014-10-01 00:00:00

abstract：:Cells that have been grown as multicell tumor spheroids exhibit radioresistance compared to the same cells grown in monolayers. Comparison of potentially lethal damage (PLD) repair and its kinetics was made between 9L cells grown as spheroids and confluent monolayers. Survival curves of cells plated immediately after ...

journal_title：Radiation research

authors： Rodriguez A,Alpen EL,Mendonca M,DeGuzman RJ

更新日期：1988-06-01 00:00:00

abstract：:Genetic and epigenetic profile changes associated with individual radiation sensitivity are well documented and have led to enhanced understanding of the mechanisms of the radiation-induced DNA damage response. However, the search continues to identify reliable biomarkers of individual radiation sensitivity. Herein, w...

journal_title：Radiation research

authors： Bryant J,White L,Coen N,Shields L,McClean B,Meade AD,Lyng FM,Howe O

更新日期：2020-06-01 00:00:00

abstract：:Clustered DNA damage is considered an important factor in determining the biological consequences of ionizing radiation. In this study, we successfully estimated the localization of abasic sites (APs) in DNA exposed to ionizing radiation using fluorescence resonance energy transfer (FRET) without any involvement of re...

journal_title：Radiation research

authors： Akamatsu K,Shikazono N,Saito T

更新日期：2015-01-01 00:00:00

abstract：:Human cancers have multiple alterations in cell signaling pathways that promote resistance to cytotoxic therapy such as X rays. Parthenolide is a sesquiterpene lactone that has been shown to inhibit several pro-survival cell signaling pathways, induce apoptosis, and enhance chemotherapy-induced cell killing. We invest...

journal_title：Radiation research

authors： Mendonca MS,Chin-Sinex H,Gomez-Millan J,Datzman N,Hardacre M,Comerford K,Nakshatri H,Nye M,Benjamin L,Mehta S,Patino F,Sweeney C

更新日期：2007-12-01 00:00:00

abstract：:Mathematical analysis of cell survival allows parameter estimation for radiobiological models and selection of an appropriate model. To our knowledge, no rigorous comparisons on the accuracy of various methods used for such analysis have been performed. In this study we compared three methods: 1. maximization of binom...

journal_title：Radiation research

authors： Shuryak I,Sun Y,Balajee AS

更新日期：2016-03-01 00:00:00

abstract：:As part of a long-term study of the effects of irradiation during development, prenatal and early neonatal mortality were evaluated for beagles exposed in utero at 8 days postcoitus (dpc), 28 dpc, 55 dpc, or 2 days postpartum. Mean doses used were 0,0.16, or 0.83 Gy. A decrease in whelping rates was observed for femal...

journal_title：Radiation research

authors： Angleton GM,Benjamin SA,Lee AC

更新日期：1988-07-01 00:00:00

abstract：:Two very different techniques for measuring the energy of neutrons in the energy range 0.1-10 MeV are presented and compared. A recoil-proton spectrometer is used to determine the energy spectra of neutrons produced by the d(4)-Be and p(4)-Be reactions down to the low-energy threshold of 0.7 MeV. The same radiation fi...

journal_title：Radiation research

authors： Folkard M,Makrigiorgos G,Roper MJ,Waker AJ,Michael BD

更新日期：1989-04-01 00:00:00

abstract：:The effects of reoxygenation on repair of potentially lethal radiation damage were investigated using MG-63 human osteosarcoma cells in vitro. When exponentially growing MG-63 cells were cultured under hypoxic conditions for 24 h, cells stopped growing and remained at a low density. The hypoxic cells were then reoxyge...

journal_title：Radiation research

authors： Iizuka M,Ando K,Aruga T,Furusawa Y,Itsukaichi H,Fukutsu K,Nagasawa H,Moriya H

更新日期：1997-02-01 00:00:00

abstract：:Ion microscopy was used for subcellular quantitative imaging of the isotopes 10B and 11B in the same cell to evaluate boron delivery using a mixture of two neutron capture therapy drugs, p-boronophenylalanine-fructose (BPA-F) and sodium borocaptate (BSH). The application of 10B-labeled BPA-F and 11B-labeled BSH allowe...

journal_title：Radiation research

authors： Chandra S,Lorey II DR,Smith DR

更新日期：2002-06-01 00:00:00

abstract：:These studies examined the effects of X radiation and interleukin 3 (IL-3), which is an effective cytokine for the generation of megakaryocytopoiesis from X-irradiated hematopoietic stem/progenitor cells, on the terminal process of human megakaryocytopoiesis and thrombopoiesis. Mature megakaryocytes were induced by cu...

journal_title：Radiation research

authors： Monzen S,Osuda K,Miyazaki Y,Hayashi N,Takahashi K,Kashiwakura I

更新日期：2009-09-01 00:00:00

abstract：:An induction-type radiofrequency generator was used to heat thigh implants of the VX2 rabbit carcinoma. The tumor temperature could be easily raised to over 50 degrees C, while the temperature of normal adjacent muscle generally remained at about 43 degrees C. The marked hypovascularity of the tumor, as demonstrated a...

journal_title：Radiation research

authors： Bookstein JJ

更新日期：1983-02-01 00:00:00

abstract：:On future missions into deep space, astronauts will be required to work more autonomously than on previous missions, and thus their ability to perform executive functions could be critical to mission success. In this study, we determined the effect that ≤15 cGy of 600 MeV/n 56Fe particles has on attentional set-shifti...

journal_title：Radiation research

authors： Jewell JS,Duncan VD,Fesshaye A,Tondin A,Macadat E,Britten RA

更新日期：2018-12-01 00:00:00

abstract：:The induction of chromosome aberrations in human lymphocytes irradiated in vitro with X rays generated at a tube voltage of 29 kV was examined to assess the maximum low-dose RBE (RBE(M)) relative to higher-energy X rays or 60Co gamma rays. Since blood was taken from the same male donor whose blood had been used for pr...

journal_title：Radiation research

authors： Schmid E,Regulla D,Kramer HM,Harder D

更新日期：2002-12-01 00:00:00

abstract：:Cellular and molecular repair was studied at 23 degrees C using split-dose recovery and alkaline elution techniques, respectively, as a function of cellular oxygen and nutrient conditions. Hypoxic cells (0.001% O2) in full medium showed a partial reduction in the level of sublethal damage (SLD) repair relative to aera...

journal_title：Radiation research

authors： Spiro IJ,Kennedy KA,Stickler R,Ling CC

更新日期：1985-01-01 00:00:00

abstract：:X rays have been shown to induce two forms of potentially lethal damage (PLD), "fast-repairing" PLD and "slowly repairing" PLD, whose repair is completed in 1 h and 4-6 h, respectively. In this study three modes of treatment with hypertonic solutions containing different NaCl concentrations for different durations (0....

journal_title：Radiation research

authors： Ikebuchi M,Kimura H,Hill CK,Aoyama T

更新日期：1995-01-01 00:00:00

abstract：:Normal human fibroblasts in plateau phase ( congruent with 95% G(1) phase) were stained with the vital nuclear dye Hoechst 33342 (blue fluorescence) or the vital cytoplasmic dye Cell Tracker Orange (orange fluorescence) and plated at a ratio of 1:1. Only the blue-fluorescing nuclei were microbeam-irradiated with a def...

journal_title：Radiation research

authors： Ponnaiya B,Jenkins-Baker G,Brenner DJ,Hall EJ,Randers-Pehrson G,Geard CR

更新日期：2004-10-01 00:00:00

abstract：:Dose-response curves for micronucleus (MN) formation were measured in Chinese hamster V79 and xrs6 (Ku80(-)) cells and in human mammary epithelial MCF10A cells in the dose range of 0.05-1 Gy. The Chinese hamster cells were exposed to 1 GeV/nucleon iron ions, 600 MeV/nucleon iron ions, and 300 MeV/nucleon iron ions (LE...

journal_title：Radiation research

authors： Groesser T,Chun E,Rydberg B

更新日期：2007-12-01 00:00:00

abstract：:Radiation-induced free radical damage in solid-state DNA arises from direct-type damage mechanisms. In the present study, free radical yields in film and lyophilized Na DNA model systems are compared. The free radical yields in lyophilized samples are significantly greater than those in films. Since DNA conformation c...

journal_title：Radiation research

authors： Milano MT,Bernhard WA

更新日期：1999-08-01 00:00:00

abstract：:Previous studies identified radiation therapy as a key modifier of basal cell carcinoma (BCC) risk in survivors of hematopoietic cell transplantation (HCT). In the present analysis, risk of BCC was analyzed in relation to age at transplant, attained age, race, total-body irradiation (TBI), and radiation fractionation ...

journal_title：Radiation research

authors： Schwartz JL,Kopecky KJ,Mathes RW,Leisenring WM,Friedman DL,Deeg HJ

更新日期：2009-02-01 00:00:00

abstract：:While the link between risk of leukemia and acute radiation exposure is well established for large doses received acutely, uncertainty remains around the translation of these risk estimates to occupational exposure scenarios where the doses are low and accumulated over time, possibly over many years. We present leukem...

journal_title：Radiation research

authors： Gillies M,Haylock R,Hunter N,Zhang W

更新日期：2019-11-01 00:00:00

abstract：:Determinations of the LET distribution, phi(L), of charged particles within a spacecraft in low-Earth orbit have been made. One method used a cylindrical tissue-equivalent proportional counter (TEPC), with the assumption that for each measured event, lineal energy, y, is equal to LET and thus phi(L) = phi(y). The othe...

journal_title：Radiation research

authors： Doke T,Hayashi T,Borak TB

更新日期：2001-09-01 00:00:00

abstract：:There is experimental evidence that ultrasoft X rays (0.1-5 keV) show a higher biological effectiveness than high-energy photons. Similar to high-LET radiation, this is attributed to a rather localized dose distribution associated with a considerably smaller range of secondary electrons, which results in an increasing...

journal_title：Radiation research

authors： Buch T,Scifoni E,Krämer M,Durante M,Scholz M,Friedrich T

更新日期：2018-01-01 00:00:00

abstract：:These experiments were designed to study the kinetics and magnitude of cell repair and repopulation in tissues whose damage results in the tumor bed effect. The right hind thighs of mice were irradiated with single doses or two equal gamma-ray fractions. Interfraction intervals ranging from 30 min to 24 h (to measure ...

journal_title：Radiation research

authors： Terry NH,Ang KK,Hunter NR,Milas L

更新日期：1988-06-01 00:00:00

abstract：:Ionizing radiation can induce chromosome instability that is transmitted over many generations after irradiation in the progeny of surviving cells, but it remains unclear why this instability can be transmitted to the progeny. To acquire knowledge about the transmissible nature of genomic instability, we transferred a...

journal_title：Radiation research

authors： Mukaida N,Kodama S,Suzuki K,Oshimura M,Watanabe M

更新日期：2007-06-01 00:00:00

abstract：:A dose-response relationship was established in normal unanesthetized cats for emetic incidence, latency to onset of vomiting, and duration of emetic activity over a period of 24 h after whole-body exposure to 60Co radiation at selected doses between 7.5 and 90 Gy. Each episode of vomiting, i.e., retching and expulsio...

journal_title：Radiation research

authors： Borison HL,McCarthy LE,Douple EB,Johnson J,Borison R

更新日期：1987-03-01 00:00:00