Abstract:
:A total of 1170 rats comprised of 65 male and 65 female Han Wistar rats per group were exposed for 2 h/day, 5 days/ week for up to 104 weeks to GSM or DCS wireless communication signals at three nominal SARs of 0.44, 1.33 and 4.0 W/kg. A preliminary study confirmed that the highest exposure level was below that which was capable of causing a measurable increase in the core temperature of the rat. Additional groups for each modulation were sham exposed, and there was also an unrestrained, unexposed (cage) control group. Fifteen male and 15 female rats per group were killed after 52 weeks. From the remaining 50 male and 50 female rats per group, surviving animals were killed after 104 weeks. Evaluations during the study included mortality rate, clinical signs, recording of palpable masses, body weight, food consumption, ophthalmoscopic examination, and clinical pathological investigations. Terminal investigations included organ weight measurement and macroscopic and microscopic pathology examinations. There was no adverse response to the wireless communication signals. In particular, there were no significant differences in the incidence of primary neoplasms, the number of rats with more than one primary neoplasm, the multiplicity and latency of neoplasms, the number of rats with metastases, and the number of benign and malignant neoplasms between the rats exposed to wireless communication signals and rats that were sham exposed.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Smith P,Kuster N,Ebert S,Chevalier HJdoi
10.1667/RR0680.1subject
Has Abstractpub_date
2007-10-01 00:00:00pages
480-92issue
4eissn
0033-7587issn
1938-5404pii
RR0680journal_volume
168pub_type
杂志文章abstract::Well-defined protocols and quality management standards are indispensable for biological dosimetry laboratories. Participation in periodic proficiency testing by interlaboratory comparisons is also required. This harmonization is essential if a cooperative network is used to respond to a mass casualty event. Here we p...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR2425.1
更新日期:2011-05-01 00:00:00
abstract::Previous investigations have demonstrated an increased release of von Willebrand factor (VWF; also known as vWF) in endothelial cells after high single-dose irradiation in vitro. We have also found increased levels of Vwf protein in mouse glomeruli after a high single dose of renal irradiation in vivo. In addition, in...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2000)154[0375:ivaive]2.0.co;2
更新日期:2000-10-01 00:00:00
abstract::Chomentowski, M., Kellerer, A. M. and Pierce, D. A. Radiation Dose Dependences in the Atomic Bomb Survivor Cancer Mortality Data: A Model-Free Visualization. The standard approach to obtaining nominal risk coefficients for radiation-related cancer involves fitting linear or linear-quadratic dose-response functions. Th...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2000)153[0289:rddita]2.0.co;2
更新日期:2000-03-01 00:00:00
abstract::Our data (Reddy et al., Radiat. Res. 141, 252-258, 1995) on the kinetics of the repair of potentially lethal damage in log-phase Chinese hamster V79 cells are used to test some predictions which arise from the different assumptions of the repair-misrepair (RMR) (C. A. Tobias, Radiat. Res. 104, S77-S95, 1985), lethal-p...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::We studied the spatial and temporal distributions of foci of the phosphorylated form of the histone protein H2AX (gamma-H2AX), which is known to be activated by double-strand breaks after irradiation of human fibroblast cells with high-energy silicon (54 keV/microm) and iron (176 keV/microm) ions. Here we present data...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3431.1
更新日期:2005-10-01 00:00:00
abstract::These experiments were designed to study the kinetics and magnitude of cell repair and repopulation in tissues whose damage results in the tumor bed effect. The right hind thighs of mice were irradiated with single doses or two equal gamma-ray fractions. Interfraction intervals ranging from 30 min to 24 h (to measure ...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
abstract::We have investigated tumor response to low-dose-rate irradiation from an implanted 125I source alone or in conjunction with intratumoral drug administration. The drug (cis-DDP or 5-FU) was incorporated homogeneously into the co-polymer CPP-SA, 20:80, and the polymer/drug rods were implanted in the RIF-1 fibrosarcomas ...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3204
更新日期:2004-07-01 00:00:00
abstract::Survival of colony-forming units-spleen (CFU-S) was measured after single doses of photons or heavy charged particles from the BEVALAC. The purposes were to define the radiosensitivity to heavy ions used medically and to evaluate relationships between relative biological effectiveness (RBE) and dose-averaged linear en...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract::Pulse radiolysis and 60Co gamma radiolysis were used to study the effects of ionizing radiations on the activity of glutamate dehydrogenase. Hydroxyl radicals are considerably more effective than hydrated electrons in causing loss of enzymatic activity. Evidence is also presented that the free radical anions (SCN)-.2,...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::The nature of the primary biochemical defect in the human radiosensitive and cancer-prone syndrome, ataxia telangiectasia (AT), has remained obscure despite many efforts to elucidate it. In this study, AT complementation group D cells and a nearly isogenic corrected AT-hamster hybrid derivative have been analyzed for ...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract::The cellular sites for damage in mammalian cells caused by 193-nm radiation from an argon fluoride excimer laser were investigated. The ability of Chinese hamster ovary cells to reduce a tetrazolium dye (MTT) was decreased to 37% of unirradiated control by 2.5 x 10(3) J/m2 of 193-nm radiation when measured either 4 or...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract::Mice were irradiated with 1 Gy of fission neutrons. At intervals up to 15 days after irradiation undifferentiated spermatogonia were counted in whole mounts of seminiferous tubules in up to eight stages of the epithelial cycle. From Day 6 onward lower numbers of spermatogonia were found in the areas which were in stag...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
abstract::We present measurements of low-energy (<18 eV) electron-stimulated desorption of anions from acetamide (CH(3)CONH(2)) and dimethyl disulfide [DMDS: (CH(3)S)(2)] films. Electron irradiation of physisorbed CH(3)CONH(2) produces H(-), CH(3)(-) and O(-) anions, whereas the H(-), CH(2)(-), CH(3)(-), S(-), SH(-) and SCH(3)(...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/0033-7587(2002)158[0023:aopsib]2.0.co;2
更新日期:2002-07-01 00:00:00
abstract::Radiation therapy is an essential component of cancer treatment. Currently, tumor control and normal tissue complication probabilities derived from a general patient population guide radiation treatment. Its outcome could be improved if radiation biomarkers could be incorporated into approaches to treatment. A substan...
journal_title:Radiation research
pub_type: 杂志文章,评审
doi:10.1667/RR15553.1
更新日期:2020-03-01 00:00:00
abstract::We used Restriction Landmark Genome Scanning (RLGS) to assess, on a genome-wide basis, the mutation induction rate in mouse germ cells after radiation exposure. Analyses of 1,115 autosomal NotI DNA fragments per mouse for reduced spot intensity, indicative of loss of one copy, in 506 progeny derived from X-irradiated ...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3146
更新日期:2004-04-01 00:00:00
abstract::Exposure of the major salivary glands to ionizing radiation often results in severe alterations in structure and function. The mechanism of these effects is still unknown, and no adequate prevention or treatment is yet available. The purpose of this study was to examine a mechanism based on the assumption that redox-a...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::The induction of thymic lymphomas by whole-body X irradiation with four doses of 1.8 Gy (total dose: 7.2 Gy) in C57BL/6 mice was suppressed from a high frequency (90%) to 63% by preirradiation with 0.075 Gy X rays given 6 h before each 1.8-Gy irradiation. This level was further suppressed to 43% by continuous whole-bo...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3289
更新日期:2005-02-01 00:00:00
abstract::Clinicians involved in conventional radiation therapy are very concerned about the dose-response relationships of normal tissues. Before proceeding to new clinical protocols, radiation biologists involved with conformal proton therapy believe it is necessary to quantify the dose response and tolerance of the organs an...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/r3016
更新日期:2003-07-01 00:00:00
abstract::The radiation environment in low-Earth orbit is a complex mixture of galactic cosmic radiation, particles of trapped belts and secondary particles generated in both the spacecraft and Earth's atmosphere. Infrequently, solar energetic particles are injected into the Earth's magnetosphere and can penetrate into low-Eart...
journal_title:Radiation research
pub_type: 杂志文章,评审
doi:
更新日期:1997-11-01 00:00:00
abstract::We report results for chromosomal aberrations in human peripheral blood lymphocytes after they were exposed to high-energy iron ions with or without shielding at the HIMAC, AGS and NSRL accelerators. Isolated lymphocytes were exposed to iron ions with energies between 200 and 5000 MeV/nucleon in the 0.1-1-Gy dose rang...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/rr3362.1
更新日期:2005-10-01 00:00:00
abstract::We present theoretical arguments to explain observations of a "reversal" of the RBE at relatively large doses; that is, the RBE of high-LET vs low-LET radiation is less than one. Numerical examples are given and the results of Bogo et al. (Radiat. Res. 118, 341-352, 1989) are discussed qualitatively. ...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Radiotherapy is one of the major treatment modalities for the management of various cancers, however, it is limited by the severe side effects and complications experienced by some patients. Nicaraven, a chemically synthesized hydroxyl radical-specific scavenger, has been shown to protect normal tissues from radiation...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR14614.1
更新日期:2017-02-22 00:00:00
abstract::To determine the linear energy transfer (LET) dependence of the biological effects of densely ionizing radiation in relation to changes in the ionization density along the track, we measured the yields and spectrum of clustered DNA damages induced by charged particles of different atomic number but similar kinetic ene...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR2093.1
更新日期:2010-08-01 00:00:00
abstract::The purpose of this study was to develop a rat orthotopic lung tumor model with a solitary intrapulmonary nodule to study the effects of high-dose radiation. A549-Luc non-small cell lung cancer (NSCLC) cells were implanted into nude rats in the intercostal space between ribs 5 and 6 of the right lung. Bioluminescence ...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR2157.1
更新日期:2010-07-01 00:00:00
abstract::The relationship between apoptosis induced by gamma radiation and glutathione in cells of two human cancer cell lines, HeLa from cervix carcinoma and MCF-7 from mammary carcinoma, was examined. MCF-7 cells appeared to be more radioresistant than HeLa cells, and radiation-induced apoptosis, which was monitored by asses...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR0578.1
更新日期:2007-03-01 00:00:00
abstract::It is well known that ionizing radiation-induced toxicity to normal tissue has functional consequences in the brain. However, the underlying molecular alterations have yet to be elucidated. We have previously reported cognitive impairments with concomitant changes in dendritic complexity, spine density and inflammatio...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR15061.1
更新日期:2018-11-01 00:00:00
abstract::The structural maintenance of chromosome 1 (Smc1) protein is a member of the highly conserved cohesin complex and is involved in sister chromatid cohesion. In response to ionizing radiation, Smc1 is phosphorylated at two sites, Ser-957 and Ser-966, and these phosphorylation events are dependent on the ATM protein kina...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR2402.1
更新日期:2011-03-01 00:00:00
abstract::Deep-space travel presents risks of exposure to ionizing radiation composed of a spectrum of low-fluence protons (1H) and high-charge and energy (HZE) iron nuclei (e.g., 56Fe). When exposed to galactic cosmic rays, each cell in the body may be traversed by 1H every 3-4 days and HZE nuclei every 3-4 months. The effects...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR14667.1
更新日期:2017-08-01 00:00:00
abstract::V79 Chinese hamster cells were irradiated in the presence of different amounts of boric acid with thermal neutrons at the Medical Research Reactor at Brookhaven National Laboratory. From the linear dose-survival curves observed, a D0 value of 66 rad for the 10B(n, alpha) 7Li neutron capture reaction was obtained. No d...
journal_title:Radiation research
pub_type: 杂志文章
doi:
更新日期:1984-05-01 00:00:00
abstract::While lifespan studies provide basic information for estimating the risk of ionizing radiation, findings on the effect of low-dose/low-dose-rate irradiation on the lifespan of mammals are controversial. Here we evaluate the effect of continuous exposure to low-dose-rate γ radiation on the lifespan of mice with acceler...
journal_title:Radiation research
pub_type: 杂志文章
doi:10.1667/RR2977.1
更新日期:2013-06-01 00:00:00