Nicaraven, a Potential Radioprotective Agent, has Very Limited Effects on the Survival of Cancer Cells and the Growth of Established Tumors.

abstract：:To investigate the effects of ionizing radiation on an isolated neuronal network without complicating systemic factors, slices of hippocampus from the guinea pig were isolated and studied in vitro. Slices were irradiated with a 60Co source and compared to paired, sham-irradiated controls. Electrophysiological activity...

journal_title：Radiation research

authors： Tolliver JM,Pellmar TC

更新日期：1987-12-01 00:00:00

abstract：:Radiation is an independent risk factor for cardiovascular and cerebrovascular disease in cancer patients. Modern radiotherapy techniques reduce the volume of the heart and major coronary vessels exposed to high doses, but some exposure is often unavoidable. Radiation damage to the myocardium is caused primarily by in...

journal_title：Radiation research

authors： Stewart FA,Hoving S,Russell NS

更新日期：2010-12-01 00:00:00

abstract：:The anoxic sensitization of bacterial spores by added H2O2 has been studied. Two mechanistic pathways for damage from H2O2 were found; one of these requires the presence of OH radicals. For this kind of damage, the relationship between H2O2 and OH appears to be that they are reactants. O-2 (and/or HO2), the product of...

journal_title：Radiation research

authors： Ewing D

更新日期：1983-04-01 00:00:00

abstract：:Gemcitabine (dFdCyd) shows broad antitumor activity in solid tumors in chemotherapeutic regimens or when combined with ionizing radiation (radiosensitization). While it is known that mismatches in DNA are necessary for dFdCyd radiosensitization, the critical event resulting in radiosensitization has not been identifie...

journal_title：Radiation research

authors： Im MM,Flanagan SA,Ackroyd JJ,Knapp B,Kramer A,Shewach DS

更新日期：2016-11-01 00:00:00

abstract：:Nearly 2% of the male population of Estonia aged 20-39 years were sent to Chernobyl to assist in the cleanup activities after the reactor accident. A cohort of 4,833 cleanup workers was assembled based on multiple and independent sources of information. Information obtained from 3,704 responses to a detailed questionn...

journal_title：Radiation research

authors： Tekkel M,Rahu M,Veidebaum T,Hakulinen T,Auvinen A,Rytömaa T,Inskip PD,Boice JD Jr

更新日期：1997-05-01 00:00:00

abstract：:The investigation of fragment length distributions of plasmid DNA gives insight into the influence of localized energy distribution on the induction of DNA damage, particularly the clustering of double-strand breaks. We present an approach that determines the fragment length distributions of plasmid DNA after heavy-io...

journal_title：Radiation research

authors： Elsässer T,Brons S,Psonka K,Scholz M,Gudowska-Nowak E,Taucher-Scholz G

更新日期：2008-06-01 00:00:00

abstract：:In the event of a radiation accident or attack, it will be imperative to quickly assess the amount of radiation exposure to accurately triage victims for appropriate care. RNA-based radiation dosimetry assays offer the potential to rapidly screen thousands of individuals in an efficient and cost-effective manner. Howe...

journal_title：Radiation research

authors： Pogosova-Agadjanyan EL,Fan W,Georges GE,Schwartz JL,Kepler CM,Lee H,Suchanek AL,Cronk MR,Brumbaugh A,Engel JH,Yukawa M,Zhao LP,Heimfeld S,Stirewalt DL

更新日期：2011-02-01 00:00:00

abstract：:Hyperthermia sensitization or tolerance is subject to cellular events that may occur at membrane, nuclear, and cytoplasmic sites. We have studied the effects of elevated temperatures on the oxidative-reductive state of the cell by measuring and altering glutathione (GSH) concentrations. GSH plays a pivotal role in mai...

journal_title：Radiation research

authors： Mitchell JB,Russo A

更新日期：1983-09-01 00:00:00

abstract：:The mechanisms underlying hepatocellular damage after irradiation are obscure. We identified genes induced by radiation in isolated rat hepatocytes in vitro by cDNA array gene expression analysis and then screened in vivo experiments with those same genes using real-time PCR and Western blotting. Hepatocytes were irra...

journal_title：Radiation research

authors： Christiansen H,Batusic D,Saile B,Hermann RM,Dudas J,Rave-Frank M,Hess CF,Schmidberger H,Ramadori G

更新日期：2006-03-01 00:00:00

abstract：:Rat females were exposed to a single 4.0-Gy gamma-ray dose and treated postradiation with a mixture of ATP-AET-mexamine at daily doses of 24, 12, and 3 mg/kg body wt, respectively, in drinking water throughout the period of their survival. With the radiation dose used, life shortening appeared primarily attributable t...

journal_title：Radiation research

authors： Benova DK,Kiradzhiev GD,Troitskaya MN,Anisimov VN

更新日期：1985-01-01 00:00:00

abstract：:Experimental measurements of the radial restricted linear energy transfer (LETr) for alpha beams of 18.3 MeV/n in tissue-equivalent gas were presented. The radial dose distribution for the alpha beam was deduced from the restricted LET measurements. A differential W value for the alpha particle in the tissue-equivalen...

journal_title：Radiation research

authors： Kanai T,Kawachi K

更新日期：1987-12-01 00:00:00

abstract：:The molecular basis of radiotherapy-related multidrug resistance (MDR) is still unclear. Here we report on a study investigating the effect of fractionated irradiation on expression of the MDR-associated proteins P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), and lung resistance-related protein ...

journal_title：Radiation research

authors： Bottke D,Koychev D,Busse A,Heufelder K,Wiegel T,Thiel E,Hinkelbein W,Keilholz U

更新日期：2008-07-01 00:00:00

abstract：:This work provides a description of a new interaction, cross-section-based model for radiation-induced cellular inactivation, sublethal damage, DNA repair and cell survival, with the ability to more accurately elucidate different radiation-response phenomena. The principal goal of this work is to describe the damage-i...

journal_title：Radiation research

authors： Brahme A

更新日期：2020-09-16 00:00:00

abstract：:Hypoxic BP-8 murine sarcoma cells were exposed to misonidazole and/or radiation and the kinetics and extent of cell death were evaluated with the [125I]iododeoxyuridine-prelabeling assay. Cell death after treatment with lethal doses of misonidazole was rapid and essentially complete within 2 or 3 days after drug expos...

journal_title：Radiation research

authors： Hofer KG,Friedland JL,Dynlacht J,Hofer MG

更新日期：1987-07-01 00:00:00

abstract：:Radiation exposure leads to a risk for long-term deterministic and stochastic late effects. Two individuals exposed to protracted photon radiation in the radiological accident at the Lilo Military site in Georgia in 1997 received follow-up treatment and resection of several chronic radiation ulcers in the Bundeswehr H...

journal_title：Radiation research

authors： Scherthan H,Abend M,Müller K,Beinke C,Braselmann H,Zitzelsberger H,Köhn FM,Pillekamp H,Schiener R,Das O,Peter RU,Herzog G,Tzschach A,Dörr HD,Fliedner TM,Meineke V

更新日期：2007-05-01 00:00:00

abstract：:Hypoadrenocorticism, known as Addison's disease in humans, was diagnosed in six beagles after inhalation of at least 1.7 kBq/g lung of 238PuO2. Histological examination of adrenal gland specimens obtained at necropsy revealed marked adrenal cortical atrophy in all cases. Autoradiographs showed only slight alpha-partic...

journal_title：Radiation research

authors： Weller RE,Buschbom RL,Dagle GE,Park JF,Ragan HA,Watson CR

更新日期：1996-12-01 00:00:00

abstract：:A yeast-based frameshift/stop codon assay for examining ATM (ataxia telangiectasia mutated) mutations was established. Each of six fragments of a PCR-amplified coding sequence for ATM is inserted in frame by homologous recombination into a yeast URA3 fusion protein gene, and the transformants are assayed for growth in...

journal_title：Radiation research

authors： Tsuchida R,Yamada T,Takagi M,Shimada A,Ishioka C,Katsuki Y,Igarashi T,Chessa L,Delia D,Teraoka H,Mizutani S

更新日期：2002-08-01 00:00:00

abstract：:Potentially lethal damage (PLD) repair has been defined as that property conferring the ability of cells to recover from DNA damage depending on the postirradiation environment. Using a novel cyclin dependent kinase 1 inhibitor RO-3306 to arrest cells in the G2 phase of the cell cycle, examined PLD repair in G2 in cul...

journal_title：Radiation research

authors： Maeda J,Bell JJ,Genet SC,Fujii Y,Genet MD,Brents CA,Genik PC,Kato TA

更新日期：2014-10-01 00:00:00

abstract：:A study has been made of methods for rapidly inactivating cells of E. coli at neutral pH to prevent enzymatic, chemical, or physical modification to DNA damaged by irradiation. The radiation was delivered in a fraction of a second using an electron accelerator. Cell inactivation was with ethanol or a solution (CSE) co...

journal_title：Radiation research

authors： Tilby MJ,Loverock PS

更新日期：1983-11-01 00:00:00

abstract：:Breast tissue is very susceptible to radiation-induced carcinogenesis, and mammary stem/progenitor cells are potentially important targets of this. The mammary epithelium is maintained as two mostly independent lineages of luminal and basal cells. To elucidate their immediate radiation responses, we analyzed the mamma...

journal_title：Radiation research

authors： Kudo KI,Takabatake M,Nagata K,Nishimura Y,Daino K,Iizuka D,Nishimura M,Suzuki K,Kakinuma S,Imaoka T

更新日期：2020-07-08 00:00:00

abstract：:There is a need for minimally invasive biomarkers that can accurately and quickly quantify radiation exposure. Radiation-responsive proteins have applications in clinical medicine and for mass population screenings after a nuclear or radiological incident where the level of radiation exposure and exposure pattern comp...

journal_title：Radiation research

authors： Sproull M,Kramp T,Tandle A,Shankavaram U,Camphausen K

更新日期：2015-07-01 00:00:00

abstract：:The effect of X irradiation on the respiration of rat thymocytes was studied. An increase in the rate of O2 uptake was observed 1 h after cells were irradiated with doses of 6-10 Gy. The radiation-induced increase in respiration could be blocked by oligomycin, an inhibitor of mitochondrial ATP synthase, suggesting con...

journal_title：Radiation research

authors： Gudz TI,Pandelova IG,Novgorodov SA

更新日期：1994-04-01 00:00:00

abstract：:The dependence of relative biological effectiveness (RBE) on photon energy is a topic of extensive discussions. The increasing amount of in vitro data in the low-energy region indicates this to be a complex dependence that is influenced by the end point and cell line studied. In the present investigation, the RBE of 1...

journal_title：Radiation research

authors： Lehnert A,Dörr W,Lessmann E,Pawelke J

更新日期：2008-03-01 00:00:00

abstract：:A plasma membrane-rich fraction has been separated from liver cells and cells of two solid rat tumors. D23 hepatoma and MC7 sarcoma. On the basis of marker enzyme activity the membranes separating at the 31-41% interface on the discontinuous sucrose gradient were enriched 15- to 19-fold. No significant differences in ...

journal_title：Radiation research

authors： Barker CJ,Bowler K

更新日期：1991-01-01 00:00:00

abstract：:An understanding of proton radiobiology is critical for optimization of both proton radiotherapy and assessment of carcinogenesis risk from space radiation. Although the physical aspects of proton beam radiobiology is well understood, the biological aspects, particularly the complex biological end points, have been un...

journal_title：Radiation research

authors： Girdhani S,Sachs R,Hlatky L

更新日期：2013-03-01 00:00:00

abstract：:Tissue-incorporated radionuclides impart radiation energy over extended periods of time depending on their effective half-lives. The capacity of vitamin A dissolved in soybean oil to protect against the biological effects caused by internal radionuclides is investigated. The radiochemicals examined are DNA-binding 125...

journal_title：Radiation research

authors： Harapanhalli RS,Narra VR,Yaghmai V,Azure MT,Goddu SM,Howell RW,Rao DV

更新日期：1994-07-01 00:00:00

abstract：:The structural maintenance of chromosome 1 (Smc1) protein is a member of the highly conserved cohesin complex and is involved in sister chromatid cohesion. In response to ionizing radiation, Smc1 is phosphorylated at two sites, Ser-957 and Ser-966, and these phosphorylation events are dependent on the ATM protein kina...

journal_title：Radiation research

authors： Ivey RG,Moore HD,Voytovich UJ,Thienes CP,Lorentzen TD,Pogosova-Agadjanyan EL,Frayo S,Izaguirre VK,Lundberg SJ,Hedin L,Badiozamani KR,Hoofnagle AN,Stirewalt DL,Wang P,Georges GE,Gopal AK,Paulovich AG

更新日期：2011-03-01 00:00:00

abstract：:Synchronous Chinese hamster ovary cells were treated in G1 or S phase with cycloheximide or procaine hydrochloride before and during heating at 43 degrees C. Cycloheximide and procaine apparently act by different mechanisms, with cycloheximide inhibiting protein synthesis and procaine hydrochloride supposedly affectin...

journal_title：Radiation research

authors： Dewey WC,Li XL,Wong RS

更新日期：1990-06-01 00:00:00

abstract：:Takagaki, M., Ono, K., Masunaga, S-I., Kinashi, Y., Oda, Y., Miyatake, S-I., Hashimoto, N., Powell, W., Sood, A. and Spielvogel, B. F. Boronated Dipeptide Borotrimethylglycylphenylalanine as a Potential Boron Carrier in Boron Neutron Capture Therapy for Malignant Brain Tumors. Radiat. Res. 156, 118-122 (2001).A borona...

journal_title：Radiation research

authors： Takagaki M,Powell W,Sood A,Spielvogel BF,Hosmane NS,Kirihata M,Ono K,Masunaga SI,Kinashi Y,Miyatake SI,Hashimoto N

更新日期：2001-07-01 00:00:00

abstract：:There is an ongoing and significant need for radiation countermeasures to reduce morbidities and mortalities associated with exposure of the heart and lungs from a radiological or nuclear incidents. Radiation-induced late effects occur months to years after exposure, stemming from significant tissue damage and remodel...

journal_title：Radiation research

authors： Rabender C,Mezzaroma E,Mauro AG,Mullangi R,Abbate A,Anscher M,Hart B,Mikkelsen R

更新日期：2016-11-01 00:00:00