Abstract：
:We report results for chromosomal aberrations in human peripheral blood lymphocytes after they were exposed to high-energy iron ions with or without shielding at the HIMAC, AGS and NSRL accelerators. Isolated lymphocytes were exposed to iron ions with energies between 200 and 5000 MeV/nucleon in the 0.1-1-Gy dose range. Shielding materials consisted of polyethylene, lucite (PMMA), carbon, aluminum and lead, with mass thickness ranging from 2 to 30 g/cm2. After exposure, lymphocytes were stimulated to grow in vitro, and chromosomes were prematurely condensed using a phosphatase inhibitor (calyculin A). Aberrations were scored using FISH painting. The yield of total interchromosomal exchanges (including dicentrics, translocations and complex rearrangements) increased linearly with dose or fluence in the range studied. Shielding decreased the effectiveness per unit dose of iron ions. The highest RBE value was measured with the 1 GeV/nucleon iron-ion beam at NSRL. However, the RBE for the induction of aberrations apparently is not well correlated with the mean LET. When shielding thickness was increased, the frequency of aberrations per particle incident on the shield increased for the 500 MeV/nucleon ions and decreased for the 1 GeV/nucleon ions. Maximum variation at equal mass thickness was obtained with light materials (polyethylene, carbon or PMMA). Variations in the yield of chromosomal aberrations per iron particle incident on the shield follow variations in the dose per incident particle behind the shield but can be modified by the different RBE of the mixed radiation field produced by nuclear fragmentation. The results suggest that shielding design models should be benchmarked using both physics and biological data.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Durante M,George K,Gialanella G,Grossi G,La Tessa C,Manti L,Miller J,Pugliese M,Scampoli P,Cucinotta FAdoi
10.1667/rr3362.1subject
Has Abstractpub_date
2005-10-01 00:00:00pages
571-6issue
4 Pt 2eissn
0033-7587issn
1938-5404pii
RR3362journal_volume
164pub_type
杂志文章abstract：:Hemodynamic shear stress is defined as the physical force exerted by the continuous flow of blood in the vascular system. Endothelial cells, which line the inner layer of blood vessels, sense this physiological force through mechanotransduction signaling and adapt to maintain structural and functional homeostasis. Hem...
journal_title：Radiation research
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更新日期：2016-08-01 00:00:00
abstract：:Studies have causally linked external thyroid radiation exposure in childhood with thyroid cancer. In 1995, investigators conducted relative risk analyses of pooled data from seven epidemiologic studies. Doses were mostly <10 Gy, although childhood cancer therapies can result in thyroid doses >50 Gy. We pooled data fr...
journal_title：Radiation research
pub_type： 杂志文章,meta分析
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更新日期：2016-05-01 00:00:00
abstract：:We showed previously that autosomal recessive determinants control the development of pulmonary fibrosis in mice during the early and late phases after irradiation. The extent of fibrosis was inversely correlated with the intrinsic lung activity of both plasminogen activator (PLA) and angiotensin-converting enzyme (AC...
journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：:Soil microorganisms in general and biocontrol agents in particular are very sensitive to UV light. The packaging of biocontrol microorganisms into cellular solids has been developed as a means of reducing loss caused by exposure to environmental UV radiation. The bacterial and fungal biocontrol agents Pantoea agglomer...
journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3027
更新日期：2003-08-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Clustered DNA damage is considered an important factor in determining the biological consequences of ionizing radiation. In this study, we successfully estimated the localization of abasic sites (APs) in DNA exposed to ionizing radiation using fluorescence resonance energy transfer (FRET) without any involvement of re...
journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3289
更新日期：2005-02-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2003-02-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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更新日期：2011-09-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/rr3053
更新日期：2003-10-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2014-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-05-01 00:00:00
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更新日期：2006-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：10.1667/RR1617.1
更新日期：2009-12-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
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journal_title：Radiation research
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
