Abstract：
:Studies have causally linked external thyroid radiation exposure in childhood with thyroid cancer. In 1995, investigators conducted relative risk analyses of pooled data from seven epidemiologic studies. Doses were mostly <10 Gy, although childhood cancer therapies can result in thyroid doses >50 Gy. We pooled data from 12 studies of thyroid cancer patients who were exposed to radiation in childhood (ages <20 years), more than doubling the data, including 1,070 (927 exposed) thyroid cancers and 5.3 million (3.4 million exposed) person-years. Relative risks increased supralinearly through 2-4 Gy, leveled off between 10-30 Gy and declined thereafter, remaining significantly elevated above 50 Gy. There was a significant relative risk trend for doses <0.10 Gy (P < 0.01), with no departure from linearity (P = 0.36). We observed radiogenic effects for both papillary and nonpapillary tumors. Estimates of excess relative risk per Gy (ERR/Gy) were homogeneous by sex (P = 0.35) and number of radiation treatments (P = 0.84) and increased with decreasing age at the time of exposure. The ERR/Gy estimate was significant within ten years of radiation exposure, 2.76 (95% CI, 0.94-4.98), based on 42 exposed cases, and remained elevated 50 years and more after exposure. Finally, exposure to chemotherapy was significantly associated with thyroid cancer, with results supporting a nonsynergistic (additive) association with radiation.
journal_name
Radiat Resjournal_title
Radiation researchauthors
Veiga LH,Holmberg E,Anderson H,Pottern L,Sadetzki S,Adams MJ,Sakata R,Schneider AB,Inskip P,Bhatti P,Johansson R,Neta G,Shore R,de Vathaire F,Damber L,Kleinerman R,Hawkins MM,Tucker M,Lundell M,Lubin JHdoi
10.1667/RR14213.1subject
Has Abstractpub_date
2016-05-01 00:00:00pages
473-84issue
5eissn
0033-7587issn
1938-5404journal_volume
185pub_type
杂志文章,meta分析abstract：:Cognitive impairments after brain irradiation seriously affect quality of life for patients, and there is currently no effective treatment. In this study using an irradiated rat model, the role of electroacupuncture was investigated for treatment of radiation-induced brain injury. Animals received 10 Gy exposure to th...
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journal_title：Radiation research
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更新日期：1987-04-01 00:00:00
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更新日期：1994-04-01 00:00:00
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doi：
更新日期：1988-04-01 00:00:00
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更新日期：1984-05-01 00:00:00
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更新日期：1998-12-01 00:00:00
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doi：
更新日期：1988-01-01 00:00:00
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doi：
更新日期：1994-10-01 00:00:00
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更新日期：1993-03-01 00:00:00
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doi：
更新日期：1985-07-01 00:00:00
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更新日期：2010-12-01 00:00:00
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更新日期：1997-09-01 00:00:00
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更新日期：2012-07-01 00:00:00
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doi：
更新日期：1987-11-01 00:00:00
