Boronated dipeptide borotrimethylglycylphenylalanine as a potential boron carrier in boron neutron capture therapy for malignant brain tumors.

abstract：:The relationship between the intracellular glutathione (GSH) concentration and the aerobic radiation response was studied in Chinese hamster ovary cells. Various degrees of GSH depletion were produced by exposure to buthionine sulfoximine (BSO) and/or diethyl maleate (DEM). Diethyl maleate did not act as a classical r...

journal_title：Radiation research

authors： Saunders EL,Meredith MJ,Eisert DR,Freeman ML

更新日期：1991-03-01 00:00:00

abstract：:The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is the key functional element in the DNA-PK complex that drives nonhomologous end joining (NHEJ), the predominant DNA double-strand break (DSB) repair mechanism operating to rejoin such breaks in mammalian cells after exposure to ionizing radiation. It h...

journal_title：Radiation research

authors： Nagasawa H,Little JB,Lin YF,So S,Kurimasa A,Peng Y,Brogan JR,Chen DJ,Bedford JS,Chen BP

更新日期：2011-01-01 00:00:00

abstract：:To evaluate the usefulness of the transgenic Muta mouse for investigating radiation-induced mutations in vivo, we have examined the effects of whole-body X irradiation and compared them to the effects of ultraviolet light. The spontaneous mutation frequencies in young adults were about 7 x 10(-5) in the spleen, liver ...

journal_title：Radiation research

authors： Ono T,Ikehata H,Hosoi Y,Shung BS,Kurishita A,Wang X,Yamamoto K,Suzuki T,Sofuni T

更新日期：1997-08-01 00:00:00

abstract：:Human cancers have multiple alterations in cell signaling pathways that promote resistance to cytotoxic therapy such as X rays. Parthenolide is a sesquiterpene lactone that has been shown to inhibit several pro-survival cell signaling pathways, induce apoptosis, and enhance chemotherapy-induced cell killing. We invest...

journal_title：Radiation research

authors： Mendonca MS,Chin-Sinex H,Gomez-Millan J,Datzman N,Hardacre M,Comerford K,Nakshatri H,Nye M,Benjamin L,Mehta S,Patino F,Sweeney C

更新日期：2007-12-01 00:00:00

abstract：:We recently reported that daily dietary supplementation with 100 µg selenium (a dose exceeding a rat's nutritional requirement by about 33-fold) initiated immediately after total-body irradiation (TBI) and maintained for 21 weeks mitigates radiation nephropathy in a rat model as indicated by blood urea nitrogen (BUN) ...

journal_title：Radiation research

authors： Sieber F,Muir SA,Cohen EP,Fish BL,Mäder M,Schock AM,Althouse BJ,Moulder JE

更新日期：2011-09-01 00:00:00

abstract：:We previously described an enhanced sensitivity for cell killing and gamma-H2AX focus induction after both high-dose-rate and continuous low-dose-rate gamma irradiation in 14 primary fibroblast strains derived from hereditary-type retinoblastoma family members (both affected RB1(+/-) probands and unaffected RB1(+/+) p...

journal_title：Radiation research

authors： Wilson PF,Nagasawa H,Fitzek MM,Little JB,Bedford JS

更新日期：2010-01-01 00:00:00

abstract：:Synthetic lysophospholipids represent a variety of analogs of the naturally occurring 2-lysophosphatidylcholine. Some of these compounds showed significant therapeutic effects on the survival of mice following radiation injury when administered after various doses of whole-body X irradiation. Such therapeutic effects ...

journal_title：Radiation research

authors： Berdel WE,Schick P,Sedlmeier H,Fink U,Rastetter J,Messerschmidt O

更新日期：1983-04-01 00:00:00

abstract：:The high-energy neutron component of the space radiation environment in thick structures such as the International Space Station contributes to the total radiation dose received by an astronaut. Detector design constraints such as size and mass have limited the energy range of neutron spectrum measurements in orbit to...

journal_title：Radiation research

authors： Kinnison JD,Maurer RH,Roth DR,Haight RC

更新日期：2003-02-01 00:00:00

abstract：:The Radiological Research Accelerator Facility (RARAF) is in its 50th year of operation. It was commissioned on April 1, 1967 as a collaboration between the Radiological Research Laboratory (RRL) of Columbia University, and members of the Medical Research Center of Brookhaven National Laboratory (BNL). It was initiall...

journal_title：Radiation research

authors： Marino SA

更新日期：2017-04-01 00:00:00

abstract：:The dependence of relative biological effectiveness (RBE) on photon energy is a topic of extensive discussions. The increasing amount of in vitro data in the low-energy region indicates this to be a complex dependence that is influenced by the end point and cell line studied. In the present investigation, the RBE of 1...

journal_title：Radiation research

authors： Lehnert A,Dörr W,Lessmann E,Pawelke J

更新日期：2008-03-01 00:00:00

abstract：:We present measurements of low-energy (<18 eV) electron-stimulated desorption of anions from acetamide (CH(3)CONH(2)) and dimethyl disulfide [DMDS: (CH(3)S)(2)] films. Electron irradiation of physisorbed CH(3)CONH(2) produces H(-), CH(3)(-) and O(-) anions, whereas the H(-), CH(2)(-), CH(3)(-), S(-), SH(-) and SCH(3)(...

journal_title：Radiation research

authors： Abdoul-Carime H,Cecchini S,Sanche L

更新日期：2002-07-01 00:00:00

abstract：:Low doses of ionizing radiation to cells and animals may induce adaptive responses that reduce the risk of cancer. However, there are upper dose thresholds above which these protective adaptive responses do not occur. We have now tested the hypothesis that there are similar lower dose thresholds that must be exceeded ...

journal_title：Radiation research

authors： Mitchel RE,Burchart P,Wyatt H

更新日期：2008-12-01 00:00:00

abstract：:Radiation nephropathy is one of the common late effects in cancer survivors who received radiotherapy as well as in victims of radiation accidents. The clinical manifestations of radiation nephropathy occur months after exposure. To date, there are no known early biomarkers to predict the future development of radiati...

journal_title：Radiation research

authors： Bhayana S,Song F,Jacob J,Fadda P,Denko NC,Xu-Welliver M,Chakravarti A,Jacob NK

更新日期：2017-12-01 00:00:00

abstract：:The possibility of a large-scale acute radiation exposure necessitates the development of new methods that could provide rapid individual dose estimates with high sample throughput. The focus of the study was an intercomparison of laboratories' dose-assessment performances using gene expression assays. Lithium-heparin...

journal_title：Radiation research

authors： Badie C,Kabacik S,Balagurunathan Y,Bernard N,Brengues M,Faggioni G,Greither R,Lista F,Peinnequin A,Poyot T,Herodin F,Missel A,Terbrueggen B,Zenhausern F,Rothkamm K,Meineke V,Braselmann H,Beinke C,Abend M

更新日期：2013-08-01 00:00:00

abstract：:To improve radioimmunotherapy with Auger electron emitters, we assessed whether the biological efficiency of (125)I varied according to its localization. A-431 and SK-OV-3 carcinoma cells were incubated with increasing activities (0-4 MBq/ml) of (125)I-labeled vectors targeting the cell membrane, the cytoplasm or the ...

journal_title：Radiation research

authors： Pouget JP,Santoro L,Raymond L,Chouin N,Bardiès M,Bascoul-Mollevi C,Huguet H,Azria D,Kotzki PO,Pèlegrin M,Vivès E,Pèlegrin A

更新日期：2008-08-01 00:00:00

abstract：:Gleevec, a selective tyrosine kinase inhibitor, retarded the growth of anaplastic thyroid cancer cell lines in vitro and in vivo through selective inhibition of ABL tyrosine kinase activity. In the present study, we investigated the ability of Gleevec to modulate the in vitro and in vivo radiation response of anaplast...

journal_title：Radiation research

authors： Podtcheko A,Ohtsuru A,Namba H,Saenko V,Starenki D,Palona I,Sedliarou I,Rogounovitch T,Yamashita S

更新日期：2006-01-01 00:00:00

abstract：:Radiation-induced complications in bone and cartilage are of increasing concern due to potential long-term effects in cancer survivors. Healthy articular cartilage may be exposed to radiation during either chondrosarcoma treatment or in-field radiotherapy of tumors located in close proximity to articulation. Cartilage...

journal_title：Radiation research

authors： Saintigny Y,Cruet-Hennequart S,Hamdi DH,Chevalier F,Lefaix JL

更新日期：2015-02-01 00:00:00

abstract：:The distribution and kinetics of proximal tubular cells with abnormally large nuclei, which were observed in irradiated mouse kidneys before any other obvious histological effects, were investigated. Six months after the administration of 13 or 15 Gy, little histopathological change was noted, in the kidneys of C3H mi...

journal_title：Radiation research

authors： Otsuka M,Meistrich ML,Brock WA

更新日期：1988-07-01 00:00:00

abstract：:The effect of acute exposure to ultrawideband (UWB) electromagnetic radiation on the Primate Equilibrium Platform (PEP) task, where the monkey's task is to manipulate a joystick control to compensate for the random perturbations in the pitch plane that are generated by a computer at unpredictable intervals, was examin...

journal_title：Radiation research

authors： Sherry CJ,Blick DW,Walters TJ,Brown GC,Murphy MR

更新日期：1995-07-01 00:00:00

abstract：:Radiation sensitivity was measured by the micronucleus assay in T lymphocytes of the spleen and in fibroblasts derived from three inbred strains of mice, BALB/c, A/J and C3H/He. A linear correlation between the surviving fraction and the micronucleus frequency was obtained. There were clear differences in the radiosen...

journal_title：Radiation research

authors： Kinashi Y,Ono K,Abe M

更新日期：1997-10-01 00:00:00

abstract：:This report presents the results of an investigation of changes in the number of erythroid and granulocyte-macrophage colony-forming cells (GM-CFC) that had occurred in tissues of normal B6D2F1 mice 20 h after administration of a radioprotective dose (150 ng) of human recombinant interleukin-1 (rIL-1). Neutrophilia in...

journal_title：Radiation research

authors： Schwartz GN,Patchen ML,Neta R,MacVittie TJ

更新日期：1990-02-01 00:00:00

abstract：:To evaluate the function of the reticuloendothelial system and macrophage-monocyte system, blood samples from Thorotrast patients and age-matched healthy controls were used to determine the titer of plasma antibodies to lipid A and the numbers of several lymphocyte subclasses in peripheral blood and for an autoradiogr...

journal_title：Radiation research

authors： Abe H,Kawahara T,Gondou K,Sakisaka S,Sata M

更新日期：1999-12-01 00:00:00

abstract：:The current status of particle radiotherapy from a historical perspective is presented. This is done with a personal view and contains personal references and memories during the development of particle radiotherapy. The particles covered are fast neutrons, neutron capture therapy, protons, helium ions, pions and heav...

journal_title：Radiation research

authors： Raju MR

更新日期：1996-04-01 00:00:00

abstract：:Single-strand breaks (SSBs) and double-strand breaks (DSBs) induced in DNA under phosphorus K-shell resonant absorption have been studied using supercoiled plasmids. The kinetics of the production of SSBs and DSBs exhibits a linear and a quadratic dependence, respectively, on photon fluence. Cross sections and quantum...

journal_title：Radiation research

authors： Le Sech C,Frohlich H,Saint-Marc C,Charlier M

更新日期：1996-05-01 00:00:00

abstract：:Domestic radon risk estimates are typically based either on data for uranium miners or on data derived from A-bomb survivors; comparison of domestic radon risk estimates derived from these two disparate sources represents an important test of their reliability. There is currently a significant discrepancy of about a f...

journal_title：Radiation research

authors： Brenner DJ,Miller RC,Huang Y,Hall EJ

更新日期：1995-04-01 00:00:00

abstract：:The modification of methylglyoxal bis(guanylhydrazone) (MGBG) by 42 degrees C hyperthermia-and/or radiation-induced cell killing was examined in Chinese hamster V-79 cells. At concentrations of more than 10 microM, cell survival decreased exponentially with increased MGBG exposure times. Cell lethality of MGBG (10 mic...

journal_title：Radiation research

authors： Miyakoshi J,Heki S

更新日期：1983-12-01 00:00:00

abstract：:Data are presented for a subset of lymphocytes characterized by FISH as missing painted chromosomal material. These lymphocytes occur in both control and irradiated subjects. These cells have a much greater frequency of one-way translocations than cells in which all of the painted chromosomal material is present. Thei...

journal_title：Radiation research

authors： Edwards A,Maznik N,Moquet J,Hone P,Vinnikov V,Lloyd D,Cox R

更新日期：2002-04-01 00:00:00

abstract：:Vascular change by the combined treatments of radiation and hyperthermia was studied. The legs of rats were irradiated with 2000 rad of X rays in a single dose and heated at 43.0 degrees C for 1 hr at various times after irradiation, and the blood flow and vascular volume in the skin and muscle were determined with 12...

journal_title：Radiation research

authors： Song CW,Kim JH,Rhee JG,Levitt SH

更新日期：1983-05-01 00:00:00

abstract：:Characteristic of damage introduced in DNA by ionizing radiation is the induction of a wide range of lesions. Single-strand breaks (SSBs) and base damages outnumber double-strand breaks (DSBs). If unrepaired, these lesions can lead to DSBs and increased mutagenesis. XRCC1 and DNA polymerase beta (polbeta) are thought ...

journal_title：Radiation research

authors： Vens C,Hofland I,Begg AC

更新日期：2007-09-01 00:00:00

abstract：:This continues the series of periodic general reports on cancer mortality in the cohort of A-bomb survivors followed by the Radiation Effects Research Foundation. The follow-up is extended by the 5 years 1986-1990, and analysis includes an additional 10,500 survivors with recently estimated radiation doses. Together t...

journal_title：Radiation research

authors： Pierce DA,Shimizu Y,Preston DL,Vaeth M,Mabuchi K

更新日期：1996-07-01 00:00:00